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Browse our anti-GJA1 (GJA1) Antibodies

Full name:
anti-Gap Junction Protein, alpha 1, 43kDa Antibodies (GJA1)
On www.antibodies-online.com are 304 Gap Junction Protein, alpha 1, 43kDa (GJA1) Antibodies from 29 different suppliers available. Additionally we are shipping GJA1 Kits (60) and GJA1 Proteins (11) and many more products for this protein. A total of 389 GJA1 products are currently listed.
Synonyms:
AI118175, AU042049, AVSD3, AW546267, Cnx32, Cnx43, Cnx46, connexin43, connexin 43, Cx32, CX43, cx43a1, Cx43alpha1, Cx46, DFNB38, Gja-1, Gja-3, gja1, gja1-A, GJAL, Gjb-1, HLHS1, HSS, Npm1, ODDD, zfCx43.3
list all antibodies Gene Name GeneID UniProt
GJA1 14609 P23242
Anti-Rat GJA1 GJA1 24392 P08050
GJA1 2697 P17302

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Most Popular Reactivities for anti-GJA1 (GJA1) Antibodies

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anti-Mouse (Murine) GJA1 Antibodies:

anti-Rat (Rattus) GJA1 Antibodies:

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Top referenced anti-GJA1 Antibodies

  1. Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN388369 : Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009 (PubMed)
    Show all 9 references for ABIN388369

  2. Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967717 : Giepmans, Hengeveld, Postma, Moolenaar: Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN967717

  3. Human Polyclonal GJA1 Primary Antibody for EIA, IHC (p) - ABIN357085 : Spinella, Rosanò, Di Castro, Nicotra, Natali, Bagnato: Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN357085

  4. Dog (Canine) Polyclonal GJA1 Primary Antibody for WB - ABIN372602 : Aronica, Gorter, Jansen, Leenstra, Yankaya, Troost: Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. in Acta neuropathologica 2001 (PubMed)

  5. Dog (Canine) Polyclonal GJA1 Primary Antibody for WB - ABIN452424 : de la Parra, Zenteno: A new GJA1 (connexin 43) mutation causing oculodentodigital dysplasia associated to uncommon features. in Ophthalmic genetics 2007 (PubMed)

  6. Human Polyclonal GJA1 Primary Antibody for ELISA, WB - ABIN1532837 : Boengler, Schulz, Heusch: Connexin 43 signalling and cardioprotection. in Heart (British Cardiac Society) 2006 (PubMed)

  7. Cow (Bovine) Polyclonal GJA1 Primary Antibody for WB - ABIN2774853 : Gellhaus, Dong, Propson, Maass, Klein-Hitpass, Kibschull, Traub, Willecke, Perbal, Lye, Winterhager: Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. in The Journal of biological chemistry 2004 (PubMed)

  8. Human Polyclonal GJA1 Primary Antibody for IHC, ELISA - ABIN1531561 : Fishman, Eddy, Shows, Rosenthal, Leinwand: The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures. in Genomics 1991 (PubMed)

  9. Dog (Canine) Polyclonal GJA1 Primary Antibody for WB - ABIN2774852 : Feller, Wood, Sluiter, Noffke, Raubenheimer, Lemmer, van Rensburg: Report of a black South African child with oculodentodigital dysplasia and a novel GJA1 gene mutation. in American journal of medical genetics. Part A 2008 (PubMed)

More Antibodies against GJA1 Interaction Partners

Zebrafish Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.

  2. serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (show HSP90AA1 Antibodies) responsible for proper folding of procollagen molecules.

  3. Hapln1a (show HAPLN1 Antibodies)-ECM (show MMRN1 Antibodies) stabilizes the secreted growth factor (show WNT2 Antibodies) Semaphorin3d (Sema3d (show SEMA3D Antibodies)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  4. Hapln1a (show HAPLN1 Antibodies) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  5. Sema3d (show SEMA3D Antibodies) functions in a common molecular pathway with Cx43 cell proliferation and joint formation

  6. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Antibodies)) exhibited osteogenic characteristics, in which Cx43 played an important role.

  7. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.

  8. Data demonstrate a cross-talk between IGF-1R (show IGF1R Antibodies) and AT-1R in AT-II and IGF-1 (show IGF1 Antibodies)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Antibodies)/2 and downstream activation of the AP-1 (show JUN Antibodies) transcription factor.

  9. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Antibodies).

  10. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.

Rabbit Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.

  2. Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.

  3. In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart

Mouse (Murine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Cx43 can communicate cylic AMP (show TMPRSS5 Antibodies) (cAMP) between cells and, more importantly, that the communicated cAMP is sufficient to impact signal transduction cascades and the expression of key bone effector molecules between interconnected cells.

  2. The results of this study indicated that the Leu89Pro substitution in the second transmembrane domain of CX32 (show GJB1 Antibodies) disrupts the trafficking of the protein, inhibiting the assembly of CX32 (show GJB1 Antibodies) gap junctions, which in turn may result in peripheral neuropathy.

  3. The results identify new protein-protein interactions between AIF (show AIFM1 Antibodies)-Cx43, ETFB (show ETFB Antibodies)-Cx43 and AIF (show AIFM1 Antibodies)-ETFB (show ETFB Antibodies) as possible players in the regulation of the mitochondrial redox state.

  4. Data show that in the presence of heterogeneous connexin 43 (Cx43) expression, ephaptic coupling can either prevent or promote conduction block (CB) depending on the Cx43 knockout (Cx43KO) content.

  5. Insulin (show INS Antibodies) is cardioprotective against cryoinjury in diabetic mouse model and that this protection is associated with Cx43 gap junction function and phosphorylation in the mouse heart.

  6. Moderate intensity exercise produced significant cardiovascular benefits by improving mitochondrial function through restoration of Cx43 networks and mitochondrial trans-membrane potential and prevention of excessive mitochondrial fission.

  7. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43

  8. Panx3 (show PANX3 Antibodies) functions as an endoplasmic reticulum (ER) Ca(2 (show CA2 Antibodies)+) channel to promote differentiation, and it could rescue mineralization defects in Cx43(-/-) calvarial cells.

  9. Study described a scrapie infection-mediated novel regulatory signaling pathway of Cx43 expression and may suggest a role for Cx43 in the pathogenesis of prion (show PRNP Antibodies) diseases

  10. The results suggest an involvement of Cx43 in the psychosine-mediated apoptosis of primary oligodendrocyte progenitors from wild type or Krabbe disease twitcher (show GALC Antibodies) mice.

Guinea Pig Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.

  2. CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.

Cow (Bovine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.

  2. Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.

  3. RhoA (show RHOA Antibodies) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress

  4. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

  5. Human TGF-beta1 (show TGFB1 Antibodies) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells

  6. Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.

  7. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Antibodies), Cx32 (show GJB1 Antibodies), and Cx43

  8. CBN (show CALB1 Antibodies) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.

  9. Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Antibodies) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Human Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. Caffeic acid phenethyl ester attenuates hypoxia-caused connexin 43 down-regulation and cardiomyocyte death.

  2. our results show that the expression of connexin 43 is localized to the areas of bladder cancer that show squamous differentiation

  3. Loss of CX43 expression is associated with prostate cancer.

  4. CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level

  5. identification of a novel GJA1 gene mutation in a pedigree with syndactyly by exome sequencing

  6. MiR (show MLXIP Antibodies)-206 can regulate the expression of Cx43, the cytobiological activity, and the metastasis of breast cancer through binding to the two binding sites in Cx43-3'UTR (show UTS2R Antibodies).

  7. Stromal Cx43 expression is possible indicator of metastatic potential of colorectal adenocarcinoma

  8. Case Report: missense mutation in connexin 31 (show GJB3 Antibodies) causing erythrokeratoderma variabilis.

  9. AMPK (show PRKAA1 Antibodies) inhibits Cx43 in BSMCs and improves bladder activity under pathological conditions. We propose that strategies that target AMPK (show PRKAA1 Antibodies) can be developed as novel therapeutic approaches for treating bladder dysfunction.

  10. Cx43, which is up-regulated by mechanical stress, seems to function partly via the activation of ERK1/2 (show MAPK1/3 Antibodies) and p38 MAPK (show MAPK14 Antibodies) signals to promote the osteoblastic differentiation of ligament fibroblasts.

Pig (Porcine) Gap Junction Protein, alpha 1, 43kDa (GJA1) interaction partners

  1. The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.

  2. we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

  3. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Antibodies) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

  4. Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.

  5. Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.

  6. These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.

  7. Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.

  8. Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.

  9. During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.

  10. These results indicate that changes of Cx43 expression in the porcine myometrium during the oestrous cycle may be regulated by progesterone concentration and may contribute to the modulation of uterine motility.

GJA1 Antigen Profile

Antigen Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Alternative names and synonyms associated with GJA1

  • gap junction protein, alpha 1, 43kDa (gja1) antibody
  • connexin 43 (cx43) antibody
  • connexin 43 (CX43) antibody
  • CONNEXIN 43 protein (CONNEXIN 43) antibody
  • connexin 43-like (LOC100359132) antibody
  • gap junction protein, alpha 1 (Gja1) antibody
  • gap junction protein, alpha 1, 43kDa (GJA1) antibody
  • gap junction protein, alpha 3 (Gja3) antibody
  • gap junction protein, beta 1 (Gjb1) antibody
  • AI118175 antibody
  • AU042049 antibody
  • AVSD3 antibody
  • AW546267 antibody
  • Cnx32 antibody
  • Cnx43 antibody
  • Cnx46 antibody
  • connexin43 antibody
  • connexin 43 antibody
  • Cx32 antibody
  • CX43 antibody
  • cx43a1 antibody
  • Cx43alpha1 antibody
  • Cx46 antibody
  • DFNB38 antibody
  • Gja-1 antibody
  • Gja-3 antibody
  • gja1 antibody
  • gja1-A antibody
  • GJAL antibody
  • Gjb-1 antibody
  • HLHS1 antibody
  • HSS antibody
  • Npm1 antibody
  • ODDD antibody
  • zfCx43.3 antibody

Protein level used designations for GJA1

alpha 1 gap junction protein , connexin 43 , connexin-43 , etID309742.9 , gap junction alpha-1 protein , gap junction protein, alpha 1 , shf , short fin protein , sof , alpha 1 connexin , gap junction 43 kDa heart protein , gap junction membrane channel protein alpha 1 , cx43 , gap junction protein, alpha 1, 43 kD (connexin 43) , vascular smooth muscle connexin-43 , gap junction protein, alpha 1, 43kDa (connexin 43) , Connexin-43 , gap junction protein alpha 1 , gap junction protein, alpha 1, 43kDa , alpha 3 connexin , connexin-46 , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , connexin 32 , connexin-32 , gap junction beta-1 protein , gap junction membrane channel protein beta 1

GENE ID SPECIES
394450 Xenopus (Silurana) tropicalis
30236 Danio rerio
100067229 Equus caballus
443455 Ovis aries
100359132 Oryctolagus cuniculus
14609 Mus musculus
24392 Rattus norvegicus
100379273 Cavia porcellus
281193 Bos taurus
2697 Homo sapiens
403418 Canis lupus familiaris
100518636 Sus scrofa
100008935 Oryctolagus cuniculus
373664 Xenopus laevis
395278 Gallus gallus
443233 Ovis aries
101100211 Felis catus
14611 Mus musculus
14618 Mus musculus
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