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anti-Mouse (Murine) GJA1 Antibodies:
anti-Rat (Rattus) GJA1 Antibodies:
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Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967717
Giepmans, Hengeveld, Postma, Moolenaar: Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Chicken Monoclonal GJA1 Primary Antibody for IHC (f), IF - ABIN967718
Loo, Berestecky, Kanemitsu, Lau: pp60src-mediated phosphorylation of connexin 43, a gap junction protein. in The Journal of biological chemistry 1995
Show all 5 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN388369
Li, Zhang, Jiao, Zou: Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. in Microvascular research 2009
Show all 9 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC - ABIN965918
Solan, Fry, TenBroek, Lampe: Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. in Journal of cell science 2003
Show all 4 Pubmed References
Human Polyclonal GJA1 Primary Antibody for ICC, IHC (fro) - ABIN5518645
Peng, Dai, Ji, Dai: The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. in European journal of pharmacology 2010
Show all 3 Pubmed References
Human Polyclonal GJA1 Primary Antibody for IHC (p), WB - ABIN3043758
Li, Tang, Liang, Li, Wang, Song, Zheng, Xi, Zhang, Hescheler, Zhu: Coculture of embryonic ventricular myocytes and mouse embryonic stem cell enhance intercellular signaling by upregulation of connexin43. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013
Show all 3 Pubmed References
Human GJA1 Primary Antibody for IHC - ABIN965917
Matsushita, Kurihara, Watanabe, Okada, Sakai, Amano: Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006
Show all 2 Pubmed References
Chicken Polyclonal GJA1 Primary Antibody for WB - ABIN2473077
Donovan: Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig. in British journal of pharmacology 1975
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Dog (Canine) Polyclonal GJA1 Primary Antibody for IF (p), IHC (p) - ABIN671451
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
Show all 2 Pubmed References
Bird (Avian) Polyclonal GJA1 Primary Antibody for WB - ABIN152643
Sahin, Akdemir, Tuzcu, Sahin, Onderci, Ozercan, Ilhan, Kilic, Seren, Kucuk: Genistein suppresses spontaneous oviduct tumorigenesis in quail. in Nutrition and cancer 2010
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b (show HSP47 Antibodies) is molecularly and functionally downstream of cx43. The gene serpinh1b (show HSP47 Antibodies) codes for a protein called Hsp47 (show HSP47 Antibodies), a molecular chaperone (show HSP90AA1 Antibodies) responsible for proper folding of procollagen molecules.
Hapln1a (show HAPLN1 Antibodies)-ECM (show MMRN1 Antibodies) stabilizes the secreted growth factor (show WNT2 Antibodies) Semaphorin3d (Sema3d (show SEMA3D Antibodies)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a (show HAPLN1 Antibodies) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
Sema3d (show SEMA3D Antibodies) functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (show COL6A1 Antibodies)) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R (show IGF1R Antibodies) and AT-1R in AT-II and IGF-1 (show IGF1 Antibodies)-induced Cx43 expression in SV SMCs involving Erk 1 (show MAPK3 Antibodies)/2 and downstream activation of the AP-1 (show JUN Antibodies) transcription factor.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (show GJC1 Antibodies).
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
These findings indicated that Cx43/miR (show MYLIP Antibodies)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
we performed cotransfections of AP-1 (show JUN Antibodies) expression plasmids with different mouse Gja1 promoter/luciferase reporter constructs within TM3 (show TPM1 Antibodies) Leydig and TM4 (show TPM4 Antibodies) Sertoli cells.We showed that a functional cooperation between cJun (show JUN Antibodies) and cFos activates Gja1 expression and requires an AP-1 (show JUN Antibodies) DNA regulatory element located between -132 and -26 bp
weightlessness simulated by using a random position machine promoted the retention of Cx43 in the Golgi apparatus
show that knockout of the gap junction subunit connexin 43 in astrocytes throughout the brain causes excessive sleepiness and fragmented wakefulness during the nocturnal active phase.
For the first time in astrocytes, we demonstrated that hemichannel activity depends on the intracellular calcium concentration and is associated with D-serine release. Blocking hemichannel activity reduced the LTP (show SCP2 Antibodies) of these excitatory synaptic currents triggered by high-frequency stimulation. These observations may be particularly relevant in the PFC (show CFP Antibodies), where D-serine and its converting enzyme are highly expressed.
Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
These findings imply that enteric glia activation via Cx43 and P2X receptors is a significant modulator of morphine-related inflammation and constipation.
Lower expression of connexin43 in vascular cells contributes to impaired vasomotor control in experimental diabetes.
Blocking of connexin32 (show GJB1 Antibodies) or connexin43 hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.
deletion of connexin 43 (Cx43, also known as GJA1) in astrocytes inhibits OPC proliferation by decreasing matrix glucose levels without impacting on OPC hemichannel properties, a process that also occurs in corpus callosum from acute brain slices.
Relative to Gja1(+/-) controls, male Gja1(-/K258Stop) mice have a cortical bone phenotype that is remarkably similar to those reported for deletion of the entire Cx43 gene in osteoblasts.
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA (show RHOA Antibodies) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 (show TGFB1 Antibodies) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Antibodies), Cx32 (show GJB1 Antibodies), and Cx43
CBN (show CALB1 Antibodies) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin (show CDH1 Antibodies) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
Study identify a role for Cx43 formed gap junction channels in the regulation of T lymphocyte proliferation and pro-inflammatory cytokines release during hypertension.
The article findings propose a novel, lactate-handling role for Cx43 (GJA1 gene) which may be particularly critical in acidotic regions of tumours.
We conclude that the targeted action of JM2 (show FOXP3 Antibodies) on Cx43 channels may improve the tolerance of implanted tissue-engineered constructs against the innate inflammatory response.
Cx45 (show GJC1 Antibodies) mutant p.R75H is responsible for a novel disease entity of progressive atrial conduction system defects associated with craniofacial and dentodigital malformation.
Connexin 43 expression is increased in human fetal membrane defects after fetoscopic surgery compared to controls, with preferential distribution in the fibroblast layer compared with the epithelial layer.
Results show stark differences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphorylation, and hemichannel activity among Cx43 variants, as well as subtle differences in myofibroblast differentiation.
These observations point to Cx43 as a novel profibrotic factor in asthma progression.
results show that Cx43 expression is reduced in the diabetic retinas and Cx43 reduction is associated with increased vascular cell death; findings suggest that diabetes decreases retinal Cx43 expression and that the development of pericyte loss and acellular capilaries is associated with reduced Cx43 expression in diabetic retinopathy
Reduced expression of Cx26 (show GJB2 Antibodies) and Cx43 is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26 (show GJB2 Antibodies), the ganglionic bowel in Hirschsprung's disease.
Results suggest polymorphisms of Cx37 (show GJA4 Antibodies) rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of essential hypertension.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (show CDK4 Antibodies) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
alpha 1 gap junction protein
, connexin 43
, gap junction alpha-1 protein
, gap junction protein, alpha 1
, short fin protein
, alpha 1 connexin
, gap junction 43 kDa heart protein
, gap junction membrane channel protein alpha 1
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1
, gap junction protein, alpha 1, 43kDa
, alpha 3 connexin
, gap junction alpha-3 protein
, gap junction membrane channel protein alpha 3
, connexin 32
, gap junction beta-1 protein
, gap junction membrane channel protein beta 1