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Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493
Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015
Human JNK Protein expressed in Wheat germ - ABIN1310303
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
Data show that JNK signalling inhibits the growth of losers, while JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (show EGFR Proteins)) pathway in the lateral epidermis for sustained dpp (show TGFb Proteins) expression in the LE. Specifically, we demonstrate that Egfr (show EGFR Proteins) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (show ETS1 Proteins)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Proteins), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (show ROS1 Proteins)/JNK/p38 (show MAPK14 Proteins)/Upd (show UROD Proteins) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Proteins)-Src (show SRC Proteins) synergy.
This study demonstrated that the mechanism by which Bsk (show FRK Proteins) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Proteins) Fasciclin II (show NCAM2 Proteins) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Proteins)-PNP (show NP Proteins)) and magnesium.
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
PRDM5 (show PRDM5 Proteins) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (show PRDM5 Proteins) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (show IL32 Proteins) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (show IRF6 Proteins)-induced IL-32 (show IL32 Proteins) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (show TLR4 Proteins)/JNK/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) signaling pathway.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK, AP-1 (show FOSB Proteins), and CHOP (show DDIT3 Proteins) may interfere with complete autophagy.
The findings indicate that ERK (show EPHB2 Proteins) and JNK signaling pathways, as well as NF-kappaB (show NFKB1 Proteins)-mediated signaling are important contributors to the pathogenesis of Kashin-Beck disease.
The data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP (show G3BP1 Proteins) and facilitates the efficient recruitment of Tudor-SN into stress granules under conditions of sodium arsenite-induced oxidative stress.
Taken together, our data demonstrate that JNK regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 (show NOTCH1 Proteins) signaling via activation of c-Jun (show JUN Proteins) and indicate that JNK/c-Jun/Notch1 (show NOTCH1 Proteins) signaling is a potential therapeutic target for TNBC
Here, the authors show that the CDK (show CDK4 Proteins) inhibitor p21 (CDKN1A (show CDKN1A Proteins)) maintains the viability of DNA damage-induced senescent cells. Upon p21 (show CDKN1A Proteins) knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (show ATM Proteins)) and nuclear factor (NF)-kappaB (show NFKB1 Proteins) kinase, leading to decreased cell survival. NF-kappaB (show NFKB1 Proteins) activation induced TNF-alpha (show TNF Proteins) secretion and JNK activation to mediate death of senescent cells in a...
Results indicate that cordycepin promotes caveolin-1 (CAV1 (show CAV1 Proteins))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A (show FOXO3 Proteins) protein (Foxo3a (show FOXO3 Proteins)) signaling pathway activation, inducing apoptosis in lung cancer cells.
The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1 (show MCL1 Proteins)) expression and c-Jun N-terminal kinase 1 (JNK1) activation and subsequent Bcl-xL (show BCL2L1 Proteins) protein degradation.
identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 (show NEIL1 Proteins)
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (show NLRP3 Proteins) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (show NLRP3 Proteins) inflammasome activation.
The purpose of this study was to investigate mechanisms that govern the regulation of Npnt (show NPNT Proteins) gene expression by IL-1beta (show IL1B Proteins) in osteoblasts.
Doxorubicin (Dox)-administration to cardiomyocytes increased the levels of reactive oxygen species (ROS (show ROS1 Proteins)) in a time-dependent manner that followed the activation of stress-induced proteins p53 (show TP53 Proteins), p38 (show CRK Proteins) and JNK MAPKs, culminating in an increase in autophagy and apoptosis markers.
IL-6 (show IL6 Proteins) likely up-regulates IRP1 (show ACO1 Proteins) and DMT1 (show SLC11A2 Proteins) expression and down-regulates FPN1 (show SLC40A1 Proteins) expression in BV2 microglial cells through JNK signaling pathways
Study examined whether JNK is present at the presynaptic site and its activity after presynaptic NMDA receptors stimulation; found that JNK, via the JBD domain, acts as a physiological effector on T-SNARE (show VTI1B Proteins) proteins; data suggest that JNK-dependent phosphorylation of T-SNARE (show VTI1B Proteins) proteins may have an important functional role in synaptic plasticity.
JNK signaling, which is inversely correlated with WNT4 (show WNT4 Proteins), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin (show CDH1 Proteins) junctions between oocytes in mouse ovaries.
It was concluded that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.
JNK1 activation suppresses antifungal immunity in mice. JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.
activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1 (show XBP1 Proteins).
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Proteins)-dependent Proteolysis of JNK1-2 and Bid (show BID Proteins).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Proteins).
Data show that the death pathway is independent of ERK (show MAPK1 Proteins) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Proteins) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Proteins))+ and ROS (show ROS1 Proteins) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Proteins))+/CaMs and MAP kinase (show MAPK1 Proteins) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Proteins) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (show MAPK14 Proteins) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (show AXIN1 Proteins)/JNK signaling and its inhibitor Aida (show AIDA Proteins) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (show MMP13 Proteins) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (show INS Proteins)-IGF-1 (show IGF1 Proteins) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Proteins) MAPK (show MAPK1 Proteins) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Proteins) MAPK (show MAPK1 Proteins) kinase (MAPKK), and KGB-1 (show KCNJ3 Proteins) JNK-like MAPK (show MAPK1 Proteins).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8