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Browse our JNK Proteins (MAPK8)

Full name:
Mitogen-Activated Protein Kinase 8 Proteins (MAPK8)
On are 24 Mitogen-Activated Protein Kinase 8 (MAPK8) Proteins from 9 different suppliers available. Additionally we are shipping JNK Antibodies (397) and JNK Kits (18) and many more products for this protein. A total of 471 JNK products are currently listed.
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
list all proteins Gene Name GeneID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185

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JNK Proteins (MAPK8) by Origin

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Top referenced JNK Proteins

  1. Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN2003397 : Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN2003397

  2. Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493 : Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015 (PubMed)

  3. Human JNK Protein expressed in Wheat germ - ABIN1310303 : Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014 (PubMed)

More Proteins for JNK Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (show ETS1 Proteins)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Proteins), all acting downstream of Jun-N-terminal kinase.

  2. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  3. ROS (show ROS1 Proteins)/JNK/p38 (show MAPK14 Proteins)/Upd (show UROD Proteins) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  4. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Proteins)-Src (show SRC Proteins) synergy.

  5. This study demonstrated that the mechanism by which Bsk (show FRK Proteins) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Proteins) Fasciclin II (show NCAM2 Proteins) (FasII)

  6. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Proteins)-PNP (show NP Proteins)) and magnesium.

  7. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  8. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (show TARDBP Proteins)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (show MAPK14 Proteins) signaling dictates phenotypic outcome to TDP-43 (show TARDBP Proteins) expression in Drosophila.

  9. Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src (show SRC Proteins)-induced apoptosis or tissue overgrowth by restricting JNK activation.

  10. In a genetic screen, we identified signaling by the EGFR (show EGFR Proteins) pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. targeting JNK signaling favors TGF-beta (show TGFB1 Proteins) to block HBx-induced cell growth promotion in well-differentiated HCC (show FAM126A Proteins) cells. As an adjunct to anti-viral therapy, the combination of TGF-beta (show TGFB1 Proteins) and inhibition of JNK signaling is a potential therapy for HBV-infected HCC (show FAM126A Proteins).

  2. Streptococcus pyogenes toxin NAD glycohydrolase elicits necrosis through two different mechanisms depending on its NADase activity, i.e., metabolic (NADase(+)) or programmed (NADase(-)) via JNK1 activation.

  3. Uniaxial stretch activates JNK1 via RhoA (show RHOA Proteins) and ROCK pathways in human bladder smooth muscle cells.

  4. Knockdown of endogenous EGR-1 (show EGR1 Proteins) by small interfering RNA (siRNA) somewhat reduced Tax (show CNTN2 Proteins)-mediated JNK-1 transcription.

  5. It was shown that newly synthesized H2O2 invigorates the phosphorylation and action of ERK-1 (show MAPK3 Proteins)/Erk2 (show MAPK1 Proteins) in E. coli phagocytosis, while phospho-JNK and phospho-p38 (show CRK Proteins) appear to regulate H2O2 production.

  6. JNK/c-Jun activation and BIM (show BCL2L11 Proteins) induction is a late pro-apoptotic response of glioma cells treated with alkylating anticancer drugs.

  7. Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis through P38 MAPK (show MAPK14 Proteins) and JNK1/2 pathways, and therefore may prove to be an adjuvant to the treatment of non-small cell lung cancer

  8. The crystal structure of JNK1 bound to the catalytic domain of MKP7 (show DUSP16 Proteins) at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported.

  9. Data show that caspase recruitment domain-containing protein 11 (show CARD11 Proteins)/B-cell CLL/lymphoma 10 (show BCL10 Proteins)/mucosa-associated lymphoid tissue lymphoma translocation gene 1 (show MALT1 Proteins) signaling drives lymphoproliferation (show FAS Proteins) through NF-kappa B (show NFKB1 Proteins) and c-Jun N-terminal kinase activation.

  10. These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK (show PTK2 Proteins)/JNK-mediated MMP-9 (show MMP9 Proteins) expression

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Activated JNK promotes mitochondrial dysfunction and acute hepatotoxicity through robust phosphorylation of numerous mitochondrial proteins.

  2. Reactive oxygen species induce autophagy to counteract apoptosis in mesenchymal stem cells by activation of JNK.

  3. In hepatocytes, JNK1 and JNK2 (show MAPK9 Proteins) appear to have combined effects in protecting from drug-induced liver injury.

  4. The findings suggest that JNK and P38 (show CRK Proteins) could be key regulatory element for Fam83h expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h expression through the regulation of JNK and p38 (show CRK Proteins) signaling pathways.

  5. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  6. Role of JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding

  7. Taken together, our findings demonstrate that salicortin inhibits NF-kappaB (show NFKB1 Proteins) and NFATc1 (show NFATC1 Proteins) activation, leading to attenuation of osteoclastogenesis and bone resorption.

  8. Rotavirus infection in macrophages depend on MAVS (show MAVS Proteins) but not involve the NLRP3 (show NLRP3 Proteins) inflammasome nor JNK and p38 (show CRK Proteins) signal pathway.

  9. results suggest that JNK is a major negative regulator in mAChR (show CHRM3 Proteins)-induced intestinal secretion.

  10. although JNK activation and RIP3 expression are induced by FS, neither contributes to the liver injury.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Proteins)-dependent Proteolysis of JNK1-2 and Bid (show BID Proteins).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Proteins).

  3. Data show that the death pathway is independent of ERK (show MAPK1 Proteins) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Proteins) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Proteins))+ and ROS (show ROS1 Proteins) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Proteins))+/CaMs and MAP kinase (show MAPK1 Proteins) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Proteins) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (show MAPK14 Proteins) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (show AXIN1 Proteins)/JNK signaling and its inhibitor Aida (show AIDA Proteins) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (show MMP13 Proteins) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  2. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  3. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Proteins) MAPK (show MAPK1 Proteins) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Proteins) MAPK (show MAPK1 Proteins) kinase (MAPKK), and KGB-1 (show KCNJ3 Proteins) JNK-like MAPK (show MAPK1 Proteins).

JNK (MAPK8) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk)
  • mitogen-activated protein kinase 8 (MAPK8)
  • mitogen-activated protein kinase 8 (Mapk8)
  • mitogen-activated protein kinase 8 (mapk8)
  • mitogen-activated protein kinase 8 (ATMPK8)
  • mitogen-activated protein kinase 8b (mapk8b)
  • Protein JNK-1 (jnk-1)
  • AI849689 protein
  • Bsk protein
  • BSK/DJNK protein
  • c-Jun protein
  • CG5680 protein
  • D-JNK protein
  • D-junk protein
  • DBSK/JNK protein
  • dJNK protein
  • DJNK/bsk protein
  • Dmel\\CG5680 protein
  • jnk protein
  • JNK-46 protein
  • JNK/SAPK protein
  • jnk1 protein
  • JNK1A2 protein
  • JNK21B1/2 protein
  • Junk protein
  • mapk8 protein
  • Prkm8 protein
  • sapk1 protein
  • SAPK1c protein
  • SAPKa protein
  • T10F20.15 protein
  • zgc:112379 protein

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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