JNK Protein (GST tag)

Catalog No. ABIN7317765

Product Details

Target: JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This JNK protein is labelled with GST tag.

Purpose: Recombinant Human JNK1/MAPK8 Protein (GST Tag)

Sequence: Met 1-Arg 427

Characteristics: A DNA sequence encoding the full length of human MAPK8 isoform JNK1 alpha 2 (NP_620637.1) (Met 1-Arg 427) was expressed with the GST tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 25 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))

Alternative Name: JNK1/MAPK8 (MAPK8 Products)

Synonyms: JNK Protein, JNK-46 Protein, JNK1 Protein, JNK1A2 Protein, JNK21B1/2 Protein, PRKM8 Protein, SAPK1 Protein, SAPK1c Protein, AI849689 Protein, Prkm8 Protein, BSK Protein, BSK/DJNK Protein, Bsk Protein, CG5680 Protein, D-JNK Protein, D-junk Protein, DBSK/JNK Protein, DJNK Protein, DJNK/bsk Protein, Dmel\\CG5680 Protein, JNK/SAPK Protein, Jnk Protein, Junk Protein, SAPKa Protein, c-Jun Protein, dJNK Protein, jnk Protein, T10F20.15 Protein, jnk1 Protein, sapk1 Protein, mapk8 Protein, zgc:112379 Protein, JNKb Protein, mapk8b Protein, mitogen-activated protein kinase 8 Protein, Stress-activated protein kinase jnk-1 Protein, basket Protein, Protein kinase superfamily protein Protein, mitogen-activated protein kinase 8 L homeolog Protein, mitogen-activated protein kinase 8b Protein, mitogen-activated protein kinase 8B-like Protein, MAPK8 Protein, jnk-1 Protein, Mapk8 Protein, bsk Protein, ATMPK8 Protein, mapk8.L Protein, mapk8b Protein, LOC109094263 Protein

Background:

Background: Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. Genetic analysis indicates that the effects of JNK1 can be separated from effects of JNK1 on obesity. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in the hypoxic cellular damage. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.

Synonym: JNK,JNK-46,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1,SAPK1c

Molecular Weight: 75 kDa

NCBI Accession: NP_620637

Pathways: MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins