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Browse our anti-MAP2K1 (MAP2K1) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase 1 Antibodies (MAP2K1)
On www.antibodies-online.com are 622 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Antibodies from 31 different suppliers available. Additionally we are shipping MAP2K1 Kits (28) and MAP2K1 Proteins (21) and many more products for this protein. A total of 710 MAP2K1 products are currently listed.
Synonyms:
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557
list all antibodies Gene Name GeneID UniProt
MAP2K1 170851 Q01986
MAP2K1 5604 Q02750
MAP2K1 26395 P31938

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Top referenced anti-MAP2K1 Antibodies

  1. Human Monoclonal MAP2K1 Primary Antibody for IP, WB - ABIN2853620 : Riesmeier, Willmitzer, Frommer: Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning. in The EMBO journal 1994 (PubMed)
    Show all 6 references for ABIN2853620

  2. Chicken Monoclonal MAP2K1 Primary Antibody for BI, IP - ABIN967762 : Aplin, Stewart, Assoian, Juliano: Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. in The Journal of cell biology 2001 (PubMed)
    Show all 5 references for ABIN967762

  3. Human Polyclonal MAP2K1 Primary Antibody for EIA, IHC (p) - ABIN358157 : Ohren, Chen, Pavlovsky, Whitehead, Zhang, Kuffa, Yan, McConnell, Spessard, Banotai, Mueller, Delaney, Omer, Sebolt-Leopold, Dudley, Leung, Flamme, Warmus, Kaufman, Barrett, Tecle, Hasemann: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. in Nature structural & molecular biology 2004 (PubMed)
    Show all 5 references for ABIN358157

  4. Human Polyclonal MAP2K1 Primary Antibody for EIA - ABIN358538 : Naegele, Morley: Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN358538

  5. Human Polyclonal MAP2K1 Primary Antibody for IHC (p), WB - ABIN197388 : Zebisch, Staber, Delavar, Bodner, Hiden, Fischereder, Janakiraman, Linkesch, Auner, Emberger, Windpassinger, Schimek, Hoefler, Troppmair, Sill: Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia. in Cancer research 2006 (PubMed)
    Show all 3 references for ABIN197388

  6. Human Polyclonal MAP2K1 Primary Antibody for IHC (p), WB - ABIN196944 : Shen, Ouyang, Qu, Alonso, Sperzel, Mustelin, Kaplan, Feng: Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. in Molecular and cellular biology 2002 (PubMed)
    Show all 2 references for ABIN196944

  7. Human Polyclonal MAP2K1 Primary Antibody for EIA, WB - ABIN360367 : Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. in Blood 2003 (PubMed)
    Show all 2 references for ABIN360367

  8. Cow (Bovine) Polyclonal MAP2K1 Primary Antibody for WB - ABIN372665 : Adams, Sweatt: Molecular psychology: roles for the ERK MAP kinase cascade in memory. in Annual review of pharmacology and toxicology 2002 (PubMed)

More Antibodies against MAP2K1 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Specific inhibition of BRAF (show BRAF Antibodies) oncogene (show RAB1A Antibodies), MEK or p38 (show CRK Antibodies) signaling was associated with decreases in DIO3 (show DIO3 Antibodies) expression in papillary thyroid cancer cells

  2. Data show that Ba/F3 cells transformed with mutant HRAS (show HRAS Antibodies) protien indicated equal sensitivity towards Map kinase (show MAPK1 Antibodies) kinase (MEK) and mTOR (show FRAP1 Antibodies) serine-threonine kinase (show TLK2 Antibodies) (mTOR (show FRAP1 Antibodies)) inhibition.

  3. Our data demonstrate that MEK inhibitors can inhibit breast cancer stem cells and may have clinical potential for the prevention of metastasis in certain cases in which tumors are MAPK (show MAPK1 Antibodies) dependent.

  4. Data show that src (show SRC Antibodies) kinases (SRC (show SRC Antibodies)) and mitogen-activated protein kinase kinase 1 (MEK) co-inhibition by saracatinib and PD0325901 respectively can be broadly effective in tumor growth control of a wide panel of non-small cell lung cancer (NSCLC) cell lines.

  5. at clinically relevant concentrations, cDDP binds to and inhibits MEK1/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1/2

  6. Endocytosis separates EGF (show EGF Antibodies) receptors from endogenous fluorescently labeled HRas (show HRAS Antibodies) and diminishes receptor signaling to MAP kinases in endosomes.

  7. Studies indicate that concurrent inhibition of proto-oncogene (show RAB1A Antibodies) protein B (show LEPREL2 Antibodies)-raf (BRAF (show BRAF Antibodies)) and Map kinase (show MAPK1 Antibodies) kinase (MEK) improved the most effective therapeutic modality as compared as single BRAF (show BRAF Antibodies) or MEK inhibition for patients with metastatic melanoma (MM).

  8. Findings suggest that triple therapy directed against BRAF (show BRAF Antibodies)/MEK/ErbB3 (show ERBB3 Antibodies) may be able to provide durable control of BRAF (show BRAF Antibodies) mutated metastatic melanoma.

  9. MEK1 levels are upregulated at transcriptional level whereas MEK2 (show MAP2K2 Antibodies) levels are downregulated at posttranslational level.

  10. NOTCH1 (show NOTCH1 Antibodies), TP53 (show TP53 Antibodies), and MAP2K1 mutations in splenic diffuse red pulp small B-cell lymphoma are associated with progressive disease.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. MEK1 and MEK2 (show MAP2K2 Antibodies) can substitute for each other but a minimum amount of MEK (show MDK Antibodies) is critical for placenta development and embryo survival

  2. Aberrant phosphorylation of AKT (show AKT1 Antibodies) and MEK (show MDK Antibodies) signalling pathways was identified in cells carrying mutant huntingtin (show HTT Antibodies).

  3. An essential function for MEK1 in macrophages in regulating the ERK1/2 (show MAPK1/3 Antibodies) and STAT4 (show STAT4 Antibodies) pathways in response to TLR4 (show TLR4 Antibodies) activation.

  4. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Antibodies)), inhibiting adipogenesis and disrupting ERK (show EPHB2 Antibodies) signaling.

  5. MEK1 is inhibited by phosphorylation at Thr (show TRH Antibodies)-292/286 by Cdk5 (show CDK5 Antibodies), ERK (show EPHB2 Antibodies), and Cdk1 (show CDK1 Antibodies).

  6. The effect of Akt1 (show AKT1 Antibodies) and Mek1 on extracellular matrix synthesis was reconciled through the activation of p70 S6-kinase (show PRKACB Antibodies).

  7. Homologous recombination efficiency enhanced by inhibition of MEK (show MDK Antibodies) and GSK3beta (show GSK3b Antibodies).

  8. Data show that Treg cell-specific expression of activated MAP Kinase Kinase 1 (MEK1) led to dysregulation of Treg function.

  9. Both ACE (show ACE Antibodies) inhibition and MEK1/2 inhibition have beneficial effects on left ventricular function in Lmna (show LMNA Antibodies)(H222P/H222P) mice and both drugs together have a synergistic benefit when initiated after the onset of left ventricular dysfunction.

  10. both MEK1 and MEK2 (show MAP2K2 Antibodies) have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. in FGFR1 (show FGFR1 Antibodies) signalling JNK1 (show MAPK8 Antibodies) phosphorylation depends on ERK2 (show MAPK1 Antibodies)

  2. The data demonstrate that ERK (show MAPK1 Antibodies) phosphorylation of UBF prevents DNA bending by its first two HMG (show SSRP1 Antibodies) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (show MAPK1 Antibodies) phosphorylation of Vg1RBP (show IGF2BP3 Antibodies) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Extracellular signal-regulated kinase (ERK (show MAPK1 Antibodies)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (show KSR1 Antibodies) interacts with a regulatory Raf (show RAF1 Antibodies) molecule in cis (show CISH Antibodies) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Antibodies) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data indicate that MEKK2 (show MAP3K2 Antibodies) is required for the mekk1 (show MAP3K1 Antibodies), mkk1 mkk2 (show MAP2K2 Antibodies), and mpk4 (show MAPK4 Antibodies) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (show MAP3K1 Antibodies)-MKK1/MKK2 (show MAP2K2 Antibodies)-MPK4 (show MAPK4 Antibodies) kinase cascade negatively regulates MEKK2 (show MAP3K2 Antibodies) and activation of MEKK2 (show MAP3K2 Antibodies) triggers SUMM2-mediated immune responses.

  3. miR (show MYLIP Antibodies)-1826 plays an important role as tumor suppressor via CTNNB1 (show CTNNB1 Antibodies)/MEK1/VEGFC (show VEGFC Antibodies) downregulation in bladder cancer.

  4. ETS1 (show ETS1 Antibodies) is probably mediating high CIP2A (show KIAA1524 Antibodies) expression in human cancers with increased EGFR (show EGFR Antibodies)-MEK1/2-ERK (show MAPK1 Antibodies) pathway activity

  5. An analysis of the interation of MEKK1 (show MAP3K1 Antibodies) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (show SUMO1 Antibodies) foci is regulated by the MEK-ERK (show MAPK1 Antibodies) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (show MAP2K2 Antibodies) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (show MAP3K1 Antibodies) and mpk4 (show MAPK4 Antibodies) mutants

  10. Activation of MPK4 (show MAPK4 Antibodies) by flg22 is impaired in the mkk1 mkk2 (show MAP2K2 Antibodies) double mutants, suggesting that MKK1 and MKK2 (show MAP2K2 Antibodies) function together with MPK4 (show MAPK4 Antibodies) and MEKK1 (show MAP3K1 Antibodies) in a MAP kinase (show MAPK1 Antibodies) cascade to negatively regulate innate immune responses in plants.

MAP2K1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1) antibody
  • mitogen-activated protein kinase kinase 1 (MAP2K1) antibody
  • mitogen-activated protein kinase kinase 1 (Map2k1) antibody
  • mitogen-activated protein kinase kinase 1 (map2k1) antibody
  • mitogen-activated protein kinase kinase 1 (MEK1) antibody
  • ATMEK1 antibody
  • CFC3 antibody
  • F20B18.180 antibody
  • F20B18_180 antibody
  • MAP kinase/ ERK kinase 1 antibody
  • MAPKK1 antibody
  • MEK antibody
  • mek-2 antibody
  • MEK1 antibody
  • MEKK1 antibody
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE antibody
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antibody
  • MKK1 antibody
  • NMAPKK antibody
  • Prkmk1 antibody
  • si:ch211-242m18.2 antibody
  • wu:fj56a12 antibody
  • wu:fj61b01 antibody
  • zgc:56557 antibody

Protein level used designations for MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

GENE ID SPECIES
170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
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