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Browse our anti-MAP2K4 (MAP2K4) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase 4 Antibodies (MAP2K4)
On www.antibodies-online.com are 307 Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibodies from 28 different suppliers available. Additionally we are shipping MAP2K4 Proteins (10) and MAP2K4 Kits (8) and many more products for this protein. A total of 342 MAP2K4 products are currently listed.
Synonyms:
2, 142758_at, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, CG9738, CT27508, CT38386, D-MKK4, DmelCG12798, Dmel\\CG9738, dMkk4, F19C24.26, F19C24_26, hep, JNKK, JNKK1, Jnkk2, map2k4, MAP KINASE KINASE 4, MAPKK4, Mapkk7, MEK4, Mek7, mitogen-activated protein kinase kinase 4, MKK4, MKK4A-l, Mkk7, Mpk4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SEK1/MKK4, Serk1, SKK1, xmek2, zgc:136500
list all antibodies Gene Name GeneID UniProt
MAP2K4 287398  
MAP2K4 6416 P45985
MAP2K4 26398 P47809

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Most Popular Reactivities for anti-MAP2K4 (MAP2K4) Antibodies

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anti-Rat (Rattus) MAP2K4 Antibodies:

anti-Human MAP2K4 Antibodies:

anti-Mouse (Murine) MAP2K4 Antibodies:

All available anti-MAP2K4 Antibodies

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Top referenced anti-MAP2K4 Antibodies

  1. Human Polyclonal MAP2K4 Primary Antibody for EIA, IHC (p) - ABIN360303 : Robinson, Shalhav, Otto, Kawai, Gorospe, Rinker-Schaeffer: Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines. in Molecular cancer research : MCR 2008 (PubMed)
    Show all 3 references for ABIN360303

  2. Human Polyclonal MAP2K4 Primary Antibody for IHC (p), WB - ABIN658838 : Finegan, Tournier: The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. in Cancer research 2010 (PubMed)
    Show all 2 references for ABIN658838

  3. Human Monoclonal MAP2K4 Primary Antibody for FACS, IHC - ABIN969268 : Song, Coffa, Fu, Gurevich: How does arrestin assemble MAPKs into a signaling complex? in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969268

  4. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN196908 : Wang, Chen, Liao, Deng, Zhou, Huang, Sun: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. in Molecular and cellular biology 2002 (PubMed)
    Show all 2 references for ABIN196908

  5. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN197322 : Leung, Lassam: The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for ABIN197322

  6. Human Polyclonal MAP2K4 Primary Antibody for ELISA, WB - ABIN1533737 : Lin, Minden, Martinetto, Claret, Lange-Carter, Mercurio, Johnson, Karin: Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 2 references for ABIN1533737

  7. Human Polyclonal MAP2K4 Primary Antibody for IHC, ELISA - ABIN1531968 : Dérijard, Raingeaud, Barrett, Wu, Han, Ulevitch, Davis: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 2 references for ABIN1531968

  8. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN196910 : Park, Kim, Huh, Park, Chung, Kang, Choi: Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against MAP2K4 Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. in Drosophila both MAPKKs, Hep/Mkk7 (show MAP2K7 Antibodies) and Mkk4, are required to induce JNK (show MAPK8 Antibodies) upon TNF (show TNF Antibodies) or pro-inflammatory stimulation

Human Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.

  2. MAP2K4 increases human prostate cancer metastasis, and prolonged over expression induces long term changes in cell signaling pathways leading to independence from p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies).

  3. MKK4 is activated in vitro by reduced Trx (show VAC14 Antibodies) but not oxidized Trx (show VAC14 Antibodies) in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys (show DNAJC5 Antibodies)-246 and Cys (show DNAJC5 Antibodies)-266 by Trx (show VAC14 Antibodies).

  4. Data suggest a genetic interaction between MAP2K4 and HLA-DRB1 (show HLA-DRB1 Antibodies), and the importance of rs10468473 and MAP2K4 splice variants in the development of autoantibody-positive RA.

  5. knockdown of Sec8 (show EXOC4 Antibodies) enhances the binding of JIP4 (show SPAG9 Antibodies) to MAPK (show MAPK1 Antibodies) kinase 4, thereby decreasing the phosphorylation of MAPK (show MAPK1 Antibodies) kinase 4, JNK (show MAPK8 Antibodies), and p38 (show CRK Antibodies).

  6. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (show TGFB1 Antibodies) signaling associated with atrial remodeling and arrhythmogenesis with age.

  7. MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells.

  8. Lipopolysaccharide induced miR (show MLXIP Antibodies)-181a promotes pancreatic cancer cell migration via targeting PTEN (show PTEN Antibodies) and MAP2K4.

  9. Single nucleotide polymorphisms in MAP2K4 gene is associated with gastric cancer.

  10. Arrestin-3 (show ARRB2 Antibodies) directly interacts with MKK7 (show MAP2K7 Antibodies) and promotes JNK3alpha2 phosphorylation by both MKK4 and MKK7 (show MAP2K7 Antibodies) in vitro as well as in intact cells.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (show TGFB1 Antibodies) signaling associated with atrial remodeling and arrhythmogenesis with age.

  2. This study provides compelling evidence for the pivotal roles of the ZPK/DLK (show MAP3K12 Antibodies) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.

  3. The loss of mkk4 and mkk7 (show MAP2K7 Antibodies) locks damaged exocrine cells in a permanently de-differentiated state.

  4. Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.

  5. MicroRNA-92a negatively regulates Toll (show TLR4 Antibodies)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase

  6. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.

  7. MKK4/7 and JNK1 (show MAPK8 Antibodies)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.

  8. These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.

  9. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 (show GJA1 Antibodies) reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

  10. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot (show MAP3K8 Antibodies) and MKK4

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. our data indicate that EDR1 (show PHC1 Antibodies) physically associates with MKK4/MKK5 (show MAP2K5 Antibodies) and negatively regulates the MAPK (show MAPK1 Antibodies) cascade to fine-tune plant innate immunity.

  2. Results suggest that the YDA-MKK4/MKK5 (show MAP2K5 Antibodies)-MPK3 (show MAPK3 Antibodies)/MPK6 (show MAPK6 Antibodies) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.

  3. MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (show MAPK3 Antibodies) activity.

  4. MKK4 is a key regulator of stomatal development and patterning.

MAP2K4 Antigen Profile

Antigen Summary

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Alternative names and synonyms associated with MAP2K4

  • mitogen-activated protein kinase kinase 4 (map2k4) antibody
  • MAP kinase kinase 4 (Mkk4) antibody
  • CG12798 (CG12798) antibody
  • mitogen activated protein kinase kinase 4 (Map2k4) antibody
  • mitogen activated protein kinase kinase 7 (Map2k7) antibody
  • mitogen-activated protein kinase kinase 4 (MAP2K4) antibody
  • mitogen-activated protein kinase kinase 4 (Map2k4) antibody
  • mitogen-activated protein kinase kinase 4 (MKK4) antibody
  • mitogen-activated protein kinase kinase 4a (map2k4a) antibody
  • 2 antibody
  • 142758_at antibody
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 antibody
  • ATMEK4 antibody
  • ATMKK4 antibody
  • CG9738 antibody
  • CT27508 antibody
  • CT38386 antibody
  • D-MKK4 antibody
  • DmelCG12798 antibody
  • Dmel\\CG9738 antibody
  • dMkk4 antibody
  • F19C24.26 antibody
  • F19C24_26 antibody
  • hep antibody
  • JNKK antibody
  • JNKK1 antibody
  • Jnkk2 antibody
  • map2k4 antibody
  • MAP KINASE KINASE 4 antibody
  • MAPKK4 antibody
  • Mapkk7 antibody
  • MEK4 antibody
  • Mek7 antibody
  • mitogen-activated protein kinase kinase 4 antibody
  • MKK4 antibody
  • MKK4A-l antibody
  • Mkk7 antibody
  • Mpk4 antibody
  • PRKMK4 antibody
  • SAPKK-1 antibody
  • SAPKK1 antibody
  • SEK1 antibody
  • SEK1/MKK4 antibody
  • Serk1 antibody
  • SKK1 antibody
  • xmek2 antibody
  • zgc:136500 antibody

Protein level used designations for MAP2K4

CG9738-PA , CG9738-PB , CG9738-PC , JNK kinase 2 , Map kinase kinase 4 , Mkk4-PA , Mkk4-PB , Mkk4-PC , drosophila MAP kinase kinase 4 , CG12798 , CG12798-PA , MAP2K4delta , SAPK/ERK kinase 1 , dual specificity mitogen-activated protein kinase kinase 4 , JNK-activating kinase 2 , JNKK 2 , MAP kinase kinase 7 , MAPK/ERK kinase 7 , MAPKK 7 , MEK 7 , c-Jun N-terminal kinase kinase 2 , dual specificity mitogen-activated protein kinase kinase 7 , JNK activating kinase 1 , JNK-activated kinase 1 , JNK-activating kinase 1 , MAP kinase kinase 4 , MAPK/ERK kinase 4 , MAPKK 4 , MEK 4 , c-Jun N-terminal kinase kinase 1 , stress-activated protein kinase kinase 1 , C-JUN N-terminal kinase kinase 1 , JNK kinase 1 , JNKK 1 , SAPK/Erk/kinase 1 , mitogen activated protein kinase kinase 4, variant 1 , mitogen-activated protein kinase kinase 4 , mkk4a

GENE ID SPECIES
100135013 Xenopus (Silurana) tropicalis
41020 Drosophila melanogaster
3355004 Drosophila melanogaster
287398 Rattus norvegicus
363855 Rattus norvegicus
6416 Homo sapiens
26398 Mus musculus
489508 Canis lupus familiaris
841591 Arabidopsis thaliana
403052 Danio rerio
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