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Browse our MAPK14 Proteins (MAPK14)

Full name:
Mitogen-Activated Protein Kinase 14 Proteins (MAPK14)
On are 34 Mitogen-Activated Protein Kinase 14 (MAPK14) Proteins from 15 different suppliers available. Additionally we are shipping MAPK14 Antibodies (187) and MAPK14 Kits (38) and many more products for this protein. A total of 290 MAPK14 products are currently listed.
186F5S, anon-sts23, AP22.98, AP22_98, ATMPK14, BG:DS00797.3, CG7393, CRK1, csbp, Csbp1, Csbp2, CSPB1, D-p38, D-p38 MAPK, D-p38b, Dmel\\CG7393, Dmp38b, Dm p38b, Dp38, dp38b, ESTS:186F5S, Exip, Hog, mapk14a, mitogen-activated protein kinase 14, Mpk34C, mxi2, p38, p38 beta, p38 MAPK, p38-alpha, p38a, p38alpha, p38B, p38beta, p38Hog, p38Kb, p38MAPK, Prkm14, Prkm15, RK, sapk2, sapk2a
list all proteins Gene Name GeneID UniProt
MAPK14 1432 Q16539
MAPK14 26416 P47811
MAPK14 81649  

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MAPK14 Proteins (MAPK14) by Origin

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Top referenced MAPK14 Proteins

  1. Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2003173 : Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000 (PubMed)
    Show all 3 references for ABIN2003173

  2. Human MAPK14 Protein expressed in Escherichia coli (E. coli) - ABIN667983 : Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: Generation and characterization of p38beta (MAPK11) gene-targeted mice. in Molecular and cellular biology 2005 (PubMed)
    Show all 2 references for ABIN667983

More Proteins for MAPK14 Interaction Partners

Cow (Bovine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. cross-talk between p(38)MAPK (show MAPK1 Proteins) and Gialpha play a pivotal role for full activation of cPLA2 (show PLA2G4A Proteins) during ET-1 (show EDN1 Proteins) stimulation of pulmonary artery smooth muscle cells.

  2. MAPK14 signalling pathway is largely involved in heat-induced sperm damage.

  3. p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.

  4. Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.

  5. p38 phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  6. These data suggest that the p38 and JNK (show MAPK8 Proteins) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  7. findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of p38 and JNK (show MAPK8 Proteins) MAPKs

  8. These data suggest a differential requirement of JNK1 (show MAPK8 Proteins) and p38 MAPK in TNF (show TNF Proteins) regulation of E2F1 (show E2F1 Proteins). Targeted inactivation of JNK1 (show MAPK8 Proteins) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (show TNF Proteins)-mediated EC dysfunction.

  9. p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.

  10. involvement of p38 MAP kinase activities and caldesmon (show CALD1 Proteins) phosphorylation in the MLCK (show MYLK Proteins)-independent regulation of thrombin (show F2 Proteins)-induced endothelial cell permeability.

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. ROS (show ROS1 Proteins)/JNK (show MAPK8 Proteins)/p38/Upd (show UROD Proteins) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  2. Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.

  3. Data show that the genetic interaction between p38b MAPK (show MAPK1 Proteins) and Rack1 (show GNB2L1 Proteins) controls muscle aggregate formation, locomotor function, and longevity.

  4. The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (show MAPK1 Proteins) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.

  5. found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles

  6. Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.

  7. The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.

  8. p38b MAPK (show MAPK1 Proteins) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.

  9. the D-p38b gene is regulated by the DREF (show ZBED1 Proteins) pathway and DREF (show ZBED1 Proteins) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (show NFS1 Proteins) and progenitors

Horse (Equine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.

  2. p38 Mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) is essential for drug-induced COX-2 (show PTGS2 Proteins) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.

  3. These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.

  4. Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.

Human Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. Expression of GALNT3 (show GALNT3 Proteins) was reduced in CAD patients, and down regulation of GALNT3 (show GALNT3 Proteins) contributed to endothelial injury by promoting apoptosis and up-regulating the expression of MMP-2 (show MMP2 Proteins) and MMP-14 (show MMP14 Proteins) genes via p38 MAPK activation.

  2. Specific inhibition of BRAF (show BRAF Proteins) oncogene (show RAB1A Proteins), MEK (show MAP2K1 Proteins) or p38 (show CRK Proteins) signaling was associated with decreases in DIO3 (show DIO3 Proteins) expression in papillary thyroid cancer cells

  3. FAM172A protein is expressed at high levels in human papillary thyroid carcinoma, which may promote cell proliferation via activation of the p38 MAPK signaling pathway.

  4. MKK3 (show MAP2K3 Proteins) overexpression upregulated the cyclin-dependent kinase (show CDK1 Proteins) inhibitors, p16 INK4A and p15 INK4B (show CDKN2B Proteins) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 (show MAP2K3 Proteins) overexpression.

  5. Suppression of ATAD2 (show ATAD2 Proteins) impaired the growth of HepG2 and Hep3B subcutaneous xenografts, by enhancing apoptosis and p-p53 (show TP53 Proteins) and p-p38 (show CRK Proteins) levels.

  6. Findings indicate that CARMA3 (show CARD10 Proteins) may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65 (show GORASP1 Proteins)) in the nucleus.

  7. stichoposide D inhibits growth of experimental leukemia by activating Fas (show FAS Proteins)/ceramide synthase 6 (show CERS6 Proteins)/p38 (show CRK Proteins) kinase in lipid rafts

  8. The obtained results strongly indicate the pyrazolobenzothiazine core as a new p38alpha inhibitor chemotype worthy of future chemical optimization efforts directed toward identifying a new generation of anti-inflammatory agents.

  9. a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger centriolar satellite remodelling after cell stress.

  10. p38alpha MAPK (show MAPK1 Proteins) plays a critical role in the regulation of BACE1 (show BACE Proteins) degradation and Abeta (show APP Proteins) generation in Alzheimer Disease pathogenesis

Mouse (Murine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis

  2. SB203580 increases G-CSF (show CSF3 Proteins) expression in macrophages by increasing the stability of G-CSF (show CSF3 Proteins) mRNA via its 3'UTR, and the effect was not due to its inhibition of p38 MAPK activity.

  3. Suggest p38alpha MAPK (show MAPK1 Proteins) as a transcriptional regulator of skeletal muscle differentiation.

  4. Cold exposure promoted the osteogenic differentiation of mesenchymal stem cells partially via the p38 MAPK pathway.

  5. the regulation of the p38 mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) signal pathway is capable of modulating MMP activity after stroke.

  6. we also demonstrated that Rac1 via P38 MAPK signaling ensures timely epithelial apoptotic death at postimplantation.

  7. Results indicate that Ang III (show AGT Proteins) produces nociceptive behavior similar to Ang II (show AGT Proteins), and suggest that the phosphorylation of p38 MAPK mediated through AT1 (show SLC33A1 Proteins) receptors on spinal astrocytes and neurons contributes to Ang II (show AGT Proteins)- and III-induced nociceptive behavior

  8. Increased expression of myostatin (show MSTN Proteins) in heart muscle cells caused interstitial fibrosis via activation of the TAK-1 (show NR2C2 Proteins)-MKK3 (show MAP2K3 Proteins)/6-p38 (show CRK Proteins) signaling pathway

  9. This study shows that lactate regulates Fgf21 (show FGF21 Proteins) expression through a NADH/NAD-independent pathway, but requires active p38-MAPK (mitogen activated protein kinase (show MAPK1 Proteins)) signalling.

  10. blocking MPTP (show PTPN2 Proteins)-mediated TNF (show TNF Proteins) signaling through intrathecal administration of TNF (show TNF Proteins)-neutralizing antibody prevented Trx1 (show TXN Proteins) oxidation and downstream ASK1 (show MAP3K5 Proteins)-p38 MAPK activation

Rabbit Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. These findings suggest that the TQ-induced production of ROS (show ROS1 Proteins) causes dedifferentiation through the ERK (show MAPK1 Proteins) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.

  2. These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 (show TP53 Proteins) and caspase-3 (show CASP3 Proteins) activation.

Pig (Porcine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (show IL10 Proteins) production through p38 MAPK activation.

  2. JNK (show MAPK8 Proteins) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]

  3. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

Xenopus laevis Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. cytochrome c (show CYCS Proteins) microinjection induces p38 phosphorylation through caspase-3 (show CASP3 Proteins) activation, and caspase (show CASP3 Proteins) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock

MAPK14 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with MAPK14

  • mitogen-activated protein kinase 14 (MPK14)
  • mitogen-activated protein kinase 14 (MAPK14)
  • mitogen-activated protein kinase 14 (Mapk14)
  • CG7393 gene product from transcript CG7393-RA (p38b)
  • mitogen activated protein kinase 14 (Mapk14)
  • mitogen-activated protein kinase 14 (mapk14)
  • 186F5S protein
  • anon-sts23 protein
  • AP22.98 protein
  • AP22_98 protein
  • ATMPK14 protein
  • BG:DS00797.3 protein
  • CG7393 protein
  • CRK1 protein
  • csbp protein
  • Csbp1 protein
  • Csbp2 protein
  • CSPB1 protein
  • D-p38 protein
  • D-p38 MAPK protein
  • D-p38b protein
  • Dmel\\CG7393 protein
  • Dmp38b protein
  • Dm p38b protein
  • Dp38 protein
  • dp38b protein
  • ESTS:186F5S protein
  • Exip protein
  • Hog protein
  • mapk14a protein
  • mitogen-activated protein kinase 14 protein
  • Mpk34C protein
  • mxi2 protein
  • p38 protein
  • p38 beta protein
  • p38 MAPK protein
  • p38-alpha protein
  • p38a protein
  • p38alpha protein
  • p38B protein
  • p38beta protein
  • p38Hog protein
  • p38Kb protein
  • p38MAPK protein
  • Prkm14 protein
  • Prkm15 protein
  • RK protein
  • sapk2 protein
  • sapk2a protein

Protein level used designations for MAPK14

MAP kinase 14 , MAP kinase p38 alpha , MAPK 14 , mitogen-activated protein kinase p38 alpha , p38 mitogen activated protein kinase , CG7393-PA , p38 mitogen-activated protein kinase , p38b-PA , stress-activated p38b MAP kinase , p38 mitogen-activated kinase , cytokine suppressive anti-inflammatory drug binding protein 1 , mitogen activated protein kinase 14 , p38 MAP kinase alpha , p38 MAPK , p38 alpha , tRNA synthetase cofactor p38 , CSAIDS-binding protein 1 , mitogen-activated protein kinase 14A , stress-activated protein kinase 2a , Csaids binding protein , MAP kinase 2 , MAP kinase Mxi2 , MAX-interacting protein 2 , cytokine suppressive anti-inflammatory drug binding protein , cytokine-supressive anti-inflammatory drug binding protein , mitogen-activated protein kinase 14 , p38 MAP kinase , p38alpha Exip , reactive kinase , stress-activated protein kinase 2A , MAPK p38 , MPK2 , Mitogen-activated protein kinase 2 , mitogen-activated Mitogen-activated protein kinase 2

829797 Arabidopsis thaliana
534492 Bos taurus
403856 Canis lupus familiaris
100723285 Cavia porcellus
34780 Drosophila melanogaster
100063532 Equus caballus
421183 Gallus gallus
1432 Homo sapiens
26416 Mus musculus
100341695 Oryctolagus cuniculus
450161 Pan troglodytes
81649 Rattus norvegicus
100156630 Sus scrofa
379992 Xenopus laevis
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