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Browse our MAPK14 Proteins (MAPK14)

Full name:
Mitogen-Activated Protein Kinase 14 Proteins (MAPK14)
On are 34 Mitogen-Activated Protein Kinase 14 (MAPK14) Proteins from 15 different suppliers available. Additionally we are shipping MAPK14 Antibodies (176) and MAPK14 Kits (47) and many more products for this protein. A total of 288 MAPK14 products are currently listed.
186F5S, anon-sts23, AP22.98, AP22_98, ATMPK14, BG:DS00797.3, CG7393, CRK1, csbp, Csbp1, Csbp2, CSPB1, D-p38, D-p38 MAPK, D-p38b, Dmel\\CG7393, Dmp38b, Dm p38b, Dp38, dp38b, ESTS:186F5S, Exip, Hog, mapk14a, mitogen-activated protein kinase 14, Mpk34C, mxi2, p38, p38 beta, p38 MAPK, p38-alpha, p38a, p38alpha, p38B, p38beta, p38Hog, p38Kb, p38MAPK, Prkm14, Prkm15, RK, sapk2, sapk2a
list all proteins Gene Name GeneID UniProt
MAPK14 1432 Q16539
MAPK14 26416 P47811
MAPK14 81649  

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MAPK14 Proteins (MAPK14) by Origin

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Top referenced MAPK14 Proteins

  1. Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2002027 : Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000 (PubMed)
    Show all 4 references for ABIN2002027

  2. Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2003173 : Han, Richter, Li, Kravchenko, Ulevitch: Molecular cloning of human p38 MAP kinase. in Biochimica et biophysica acta 1995 (PubMed)
    Show all 3 references for ABIN2003173

  3. Human MAPK14 Protein expressed in Escherichia coli (E. coli) - ABIN667983 : Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: Generation and characterization of p38beta (MAPK11) gene-targeted mice. in Molecular and cellular biology 2005 (PubMed)
    Show all 2 references for ABIN667983

More Proteins for MAPK14 Interaction Partners

Cow (Bovine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. results suggest that ET-1 (show EDN1 Proteins)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP (show MMP14 Proteins) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells

  2. cross-talk between p(38)MAPK (show MAPK1 Proteins) and Gialpha play a pivotal role for full activation of cPLA2 (show PLA2G4A Proteins) during ET-1 (show EDN1 Proteins) stimulation of pulmonary artery smooth muscle cells.

  3. MAPK14 signalling pathway is largely involved in heat-induced sperm damage.

  4. p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.

  5. Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.

  6. p38 phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  7. These data suggest that the p38 and JNK (show MAPK8 Proteins) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  8. findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of p38 and JNK (show MAPK8 Proteins) MAPKs

  9. These data suggest a differential requirement of JNK1 (show MAPK8 Proteins) and p38 MAPK in TNF (show TNF Proteins) regulation of E2F1 (show E2F1 Proteins). Targeted inactivation of JNK1 (show MAPK8 Proteins) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (show TNF Proteins)-mediated EC dysfunction.

  10. p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. ROS (show ROS1 Proteins)/JNK (show MAPK8 Proteins)/p38/Upd (show UROD Proteins) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  2. Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.

  3. Data show that the genetic interaction between p38b MAPK (show MAPK1 Proteins) and Rack1 (show GNB2L1 Proteins) controls muscle aggregate formation, locomotor function, and longevity.

  4. The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (show MAPK1 Proteins) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.

  5. found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles

  6. Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.

  7. The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.

  8. p38b MAPK (show MAPK1 Proteins) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.

  9. the D-p38b gene is regulated by the DREF (show ZBED1 Proteins) pathway and DREF (show ZBED1 Proteins) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (show NFS1 Proteins) and progenitors

Horse (Equine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.

  2. p38 Mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) is essential for drug-induced COX-2 (show PTGS2 Proteins) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.

  3. These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.

  4. Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.

Human Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. Interestingly, pre-treatment of cells with reactive oxygen species inhibitor and p38 (show CRK Proteins) inhibitor significantly decreases bauerenol-induced cytotoxicity, Bax (show BAX Proteins) upregulation, and p38 (show CRK Proteins) activation

  2. P38 MAPK, phosphorylated P38 MAPK, and RAC2 (show RAC2 Proteins) regulated in mutual feedback and negative feedback regulatory pathways, resulting in the radioresistance of G0 cells.

  3. Nur77 (show NR4A1 Proteins) decreases ET-1 (show EDN1 Proteins) expression by suppressing NF-kappaB (show NFKB1 Proteins) and p38 MAPK.

  4. The antioxidant N-acetylcysteine (NAC) blocked the AF-induced increase of reactive oxygen species (ROS (show ROS1 Proteins)) production, the reduction of total EGFR (show EGFR Proteins), and the phosphorylation of multiple nodes in EGFR (show EGFR Proteins)/MAPK (show MAPK1 Proteins) signaling pathway. P38MAPK inhibitor SB203580, but not inhibitors of EGFR (show EGFR Proteins) (erlotinib), ERK (show EPHB2 Proteins) (FR180204) and JNK (show MAPK8 Proteins) (SP600125), suppressed AF-induced phosphorylation of EGFR (show EGFR Proteins)/p38MAPK/MAPKAPK2 (show MAPKAPK2 Proteins)/Hsp27 (show HSPB1 Proteins)

  5. Potassium supplementation has a blocking effect against salt-loading-induced IL-17A (show IL17A Proteins) production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK-SGK1 (show SGK1 Proteins) pathway.

  6. Alpha-toxin (show PLC Proteins)-mediated permeabilization of the plasma membrane of airway epithelial cells to small cations in association with membrane potential changes results in the activation of p38 MAP kinase.

  7. A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14.

  8. LDL(-) promotes p38 MAPK phosphorylation through TLR4 (show TLR4 Proteins) and PI3k (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathways. Phosphorylation of p38 MAPK is involved in NF-kB, AP-1 (show FOSB Proteins) and CREB (show CREB1 Proteins) activation, leading to LDL(-)-induced cytokine release in monocytes.

  9. acetyl-CoA carboxylase 1 and senescence regulation in human fibroblasts involves oxidant mediated p38 MAPK activation

  10. We found out that the link between CIRP (show CIRBP Proteins) and Snail (show SNAI1 Proteins) is mediated by ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) pathways. EMT (show ITK Proteins) is a critical component of carcinoma metastasis and invasion. As demonstrated in this study, the biological role of CIRP (show CIRBP Proteins) in EMT (show ITK Proteins) may explain why CIRP (show CIRBP Proteins) overexpression has been associated with a bad prognosis in cancer patients.

Mouse (Murine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. miR (show MLXIP Proteins)-128 overexpression significantly downregulated the expression levels of P38 (show CRK Proteins) andP-P38 (show CRK Proteins).

  2. Phosphorylation levels of P38 (show CRK Proteins) and JNK (show MAPK8 Proteins) in siRNA-TMEM16A (show ANO1 Proteins) group were lower than that of the Model group. Thus, TMEM16A (show ANO1 Proteins) is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.

  3. Findings revealed that fluoxetine protects against IL-1beta (show IL1B Proteins)-induced neuronal apoptosis via p38 (show CRK Proteins)-p53 (show TP53 Proteins) dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke

  4. Data indicate that in baicalein (BAI)-treated groups following AngII-infusion, p38-MAPK and JNK (show MAPK8 Proteins) signaling were attenuated.

  5. Cathepsin S (show CTSS Proteins) activity controls injury-related vascular remodeling via TLR2/p38MAPK/PI3K/Akt (show AKT1 Proteins)/p-HDAC6 (show HDAC6 Proteins) signaling pathway.

  6. TRADD (show TRADD Proteins) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 Proteins)/p38 MAPK but not AKT (show AKT1 Proteins) phosphorylation

  7. p38alpha MAPK (show MAPK1 Proteins) facilitates plasma membrane insertion of MRP2 (show ABCC2 Proteins) by cAMP, whereas p38beta (show MAPK11 Proteins) MAPK (show MAPK1 Proteins) mediates retrieval of PM-MRP2 (show ABCC2 Proteins) by taurolithocholate.

  8. propose that active p38-Mapk14/11 act as enablers, and Erk1/2 as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.

  9. Double deficiency of p38alpha and p38beta (show MAPK11 Proteins) in naive CD4 (show CD4 Proteins)(+) T cells resulted in an attenuation of MAPK (show MAPK1 Proteins)-activated protein kinase (show CDK7 Proteins) (MK)-dependent mTOR (show FRAP1 Proteins) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.

  10. Wnt3a (show WNT3A Proteins) induces Osx (show SP7 Proteins) expression via p38 MAPK signaling in dental follicle cells. Wnt3a (show WNT3A Proteins)-induced Osx (show SP7 Proteins) expression was inhibited in the presence of p38 mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.

Rabbit Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. These findings suggest that the TQ-induced production of ROS (show ROS1 Proteins) causes dedifferentiation through the ERK (show MAPK1 Proteins) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.

  2. These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 (show TP53 Proteins) and caspase-3 (show CASP3 Proteins) activation.

Pig (Porcine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (show IL10 Proteins) production through p38 MAPK activation.

  2. JNK (show MAPK8 Proteins) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]

  3. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

Xenopus laevis Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. cytochrome c (show CYCS Proteins) microinjection induces p38 phosphorylation through caspase-3 (show CASP3 Proteins) activation, and caspase (show CASP3 Proteins) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock

MAPK14 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with MAPK14

  • mitogen-activated protein kinase 14 (MPK14)
  • mitogen-activated protein kinase 14 (MAPK14)
  • mitogen-activated protein kinase 14 (Mapk14)
  • CG7393 gene product from transcript CG7393-RA (p38b)
  • mitogen activated protein kinase 14 (Mapk14)
  • mitogen-activated protein kinase 14 (mapk14)
  • 186F5S protein
  • anon-sts23 protein
  • AP22.98 protein
  • AP22_98 protein
  • ATMPK14 protein
  • BG:DS00797.3 protein
  • CG7393 protein
  • CRK1 protein
  • csbp protein
  • Csbp1 protein
  • Csbp2 protein
  • CSPB1 protein
  • D-p38 protein
  • D-p38 MAPK protein
  • D-p38b protein
  • Dmel\\CG7393 protein
  • Dmp38b protein
  • Dm p38b protein
  • Dp38 protein
  • dp38b protein
  • ESTS:186F5S protein
  • Exip protein
  • Hog protein
  • mapk14a protein
  • mitogen-activated protein kinase 14 protein
  • Mpk34C protein
  • mxi2 protein
  • p38 protein
  • p38 beta protein
  • p38 MAPK protein
  • p38-alpha protein
  • p38a protein
  • p38alpha protein
  • p38B protein
  • p38beta protein
  • p38Hog protein
  • p38Kb protein
  • p38MAPK protein
  • Prkm14 protein
  • Prkm15 protein
  • RK protein
  • sapk2 protein
  • sapk2a protein

Protein level used designations for MAPK14

MAP kinase 14 , MAP kinase p38 alpha , MAPK 14 , mitogen-activated protein kinase p38 alpha , p38 mitogen activated protein kinase , CG7393-PA , p38 mitogen-activated protein kinase , p38b-PA , stress-activated p38b MAP kinase , p38 mitogen-activated kinase , cytokine suppressive anti-inflammatory drug binding protein 1 , mitogen activated protein kinase 14 , p38 MAP kinase alpha , p38 MAPK , p38 alpha , tRNA synthetase cofactor p38 , CSAIDS-binding protein 1 , mitogen-activated protein kinase 14A , stress-activated protein kinase 2a , Csaids binding protein , MAP kinase 2 , MAP kinase Mxi2 , MAX-interacting protein 2 , cytokine suppressive anti-inflammatory drug binding protein , cytokine-supressive anti-inflammatory drug binding protein , mitogen-activated protein kinase 14 , p38 MAP kinase , p38alpha Exip , reactive kinase , stress-activated protein kinase 2A , MAPK p38 , MPK2 , Mitogen-activated protein kinase 2 , mitogen-activated Mitogen-activated protein kinase 2

829797 Arabidopsis thaliana
534492 Bos taurus
403856 Canis lupus familiaris
100723285 Cavia porcellus
34780 Drosophila melanogaster
100063532 Equus caballus
421183 Gallus gallus
1432 Homo sapiens
26416 Mus musculus
100341695 Oryctolagus cuniculus
450161 Pan troglodytes
81649 Rattus norvegicus
100156630 Sus scrofa
379992 Xenopus laevis
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