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Browse our MAPK14 Proteins (MAPK14)

Full name:
Mitogen-Activated Protein Kinase 14 Proteins (MAPK14)
On are 34 Mitogen-Activated Protein Kinase 14 (MAPK14) Proteins from 15 different suppliers available. Additionally we are shipping MAPK14 Antibodies (185) and MAPK14 Kits (40) and many more products for this protein. A total of 290 MAPK14 products are currently listed.
186F5S, anon-sts23, AP22.98, AP22_98, ATMPK14, BG:DS00797.3, CG7393, CRK1, csbp, Csbp1, Csbp2, CSPB1, D-p38, D-p38 MAPK, D-p38b, Dmel\\CG7393, Dmp38b, Dm p38b, Dp38, dp38b, ESTS:186F5S, Exip, Hog, mapk14a, mitogen-activated protein kinase 14, Mpk34C, mxi2, p38, p38 beta, p38 MAPK, p38-alpha, p38a, p38alpha, p38B, p38beta, p38Hog, p38Kb, p38MAPK, Prkm14, Prkm15, RK, sapk2, sapk2a
list all proteins Gene Name GeneID UniProt
MAPK14 1432 Q16539
MAPK14 26416 P47811
MAPK14 81649  

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MAPK14 Proteins (MAPK14) by Origin

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Top referenced MAPK14 Proteins

  1. Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2003173 : Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000 (PubMed)
    Show all 3 references for ABIN2003173

  2. Human MAPK14 Protein expressed in Escherichia coli (E. coli) - ABIN667983 : Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: Generation and characterization of p38beta (MAPK11) gene-targeted mice. in Molecular and cellular biology 2005 (PubMed)
    Show all 2 references for ABIN667983

More Proteins for MAPK14 Interaction Partners

Cow (Bovine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. results suggest that ET-1 (show EDN1 Proteins)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Proteins)-PKCalpha (show PKCa Proteins)-p(38)MAPK (show MAPK1 Proteins) and NFkappaB-MT1MMP (show MMP14 Proteins) signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Proteins) expression in the cells

  2. cross-talk between p(38)MAPK (show MAPK1 Proteins) and Gialpha play a pivotal role for full activation of cPLA2 (show PLA2G4A Proteins) during ET-1 (show EDN1 Proteins) stimulation of pulmonary artery smooth muscle cells.

  3. MAPK14 signalling pathway is largely involved in heat-induced sperm damage.

  4. p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.

  5. Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.

  6. p38 phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  7. These data suggest that the p38 and JNK (show MAPK8 Proteins) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  8. findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of p38 and JNK (show MAPK8 Proteins) MAPKs

  9. These data suggest a differential requirement of JNK1 (show MAPK8 Proteins) and p38 MAPK in TNF (show TNF Proteins) regulation of E2F1 (show E2F1 Proteins). Targeted inactivation of JNK1 (show MAPK8 Proteins) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (show TNF Proteins)-mediated EC dysfunction.

  10. p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. ROS (show ROS1 Proteins)/JNK (show MAPK8 Proteins)/p38/Upd (show UROD Proteins) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  2. Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.

  3. Data show that the genetic interaction between p38b MAPK (show MAPK1 Proteins) and Rack1 (show GNB2L1 Proteins) controls muscle aggregate formation, locomotor function, and longevity.

  4. The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (show MAPK1 Proteins) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.

  5. found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles

  6. Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.

  7. The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.

  8. p38b MAPK (show MAPK1 Proteins) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.

  9. the D-p38b gene is regulated by the DREF (show ZBED1 Proteins) pathway and DREF (show ZBED1 Proteins) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (show NFS1 Proteins) and progenitors

Horse (Equine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.

  2. p38 Mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) is essential for drug-induced COX-2 (show PTGS2 Proteins) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.

  3. These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.

  4. Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.

Human Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. E2F5/p38 (show CRK Proteins) axis played a cardinal (show CARD8 Proteins) role in uncontrolled cellular proliferation in prostate cancer through pSMAD3L activation.

  2. EphA2 (show EPHA2 Proteins) have the ability to negatively regulate the radiosensitivity of HCC (show FAM126A Proteins) 97H cells, which mainly depends on 38MAPK-mediated signal pathways.

  3. According to the information mentioned above, we now report the design and synthesis of some series of new urea derivatives that were then evaluated for their inhibitory activities against MAPKAPK2 (show MAPKAPK2 Proteins), TNF-a (show TNF Proteins), and p38a

  4. this study shows that IL-10 (show IL10 Proteins) production by CD20 (show MS4A1 Proteins)+ B cells among peripheral blood mononuclear cell is enhanced by bendamustine via p38 MAP kinase-Sp1 (show PSG1 Proteins) pathway

  5. the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 (show CRK Proteins) and LOX (show LOX Proteins) signaling pathways, but also by decreasing the generation of ROS (show ROS1 Proteins) and nitrate/nitrite.

  6. Taken together, these data indicate that resveratrol plays an important role in suppressing hyperglycemia-driven ROS (show ROS1 Proteins)-induced pancreatic cancer progression by inhibiting the ERK (show EPHB2 Proteins) and p38 MAPK signaling pathways, providing evidence that resveratrol might be a potential candidate for chemoprevention of pancreatic cancer.

  7. Taken together, our results suggested that decreased LAPTM5 (show LAPTM5 Proteins) inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 (show CRK Proteins) in BCa (show BLNK Proteins) cells

  8. Data indicate that STK40 (show STK40 Proteins) was a direct target of microRNA miR (show MLXIP Proteins)-130a, and overexpressing miR (show MLXIP Proteins)-130a significantly upregulated NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins), SOX9 (show SOX9 Proteins), JNK (show MAPK8 Proteins) and p38MAPK proteins.

  9. our study demonstrated that ATRA cound promote differentiation while inhibit proliferation of acute promyelocytic leukemia (show PML Proteins) NB4 cells via activating p38a protein after recruiting p38a-combinded NLS (show ALDH1A2 Proteins)-RARa (show RARA Proteins), while NLS (show ALDH1A2 Proteins)-RARa (show RARA Proteins) could inhibit the effects of ATRA in the process.

  10. Results suggest that curcumin induced the apoptosis of retinoblastoma Y79 cells through the activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK (show MAPK1 Proteins)) pathways.

Mouse (Murine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. These results confirmed the anti-inflammatory effect and protective role of WIN55 212-2 on the mice with experimental colitis, and revealed that this agent exercises its action at least partially by inhibiting p38MAPK.

  2. In silico analyses and experimental validation demonstrated that the kinase activity of p38(MAPK) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and duration. p38(MAPK) and MK2 (show KCNA2 Proteins) concentrations and responsiveness toward IL-1beta (show IL1B Proteins) were quantitatively compared between hepatocytes and macrophages

  3. Src (show SRC Proteins) family kinases, p38 MAPK, ERK1/2 and GSK3beta are required for the transition between mES (show PTCH1 Proteins) and EPL cells.

  4. A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-kappaB (show NFKB1 Proteins) and p38 MAPK Pathways in BV2 Microglia

  5. this study shows that stearoyl lysophosphatidylcholine increases macrophages phagocytosis of bacteria through activation of the AMPK (show PRKAA1 Proteins)/p38 MAPK pathway

  6. Adh (show AVP Proteins) binds to OR5M11, which enhances Actinobacillus pleuropneumoniae pathogenicity by activating p38 (show CRK Proteins) which induces apoptosis of PAMs and IL-8 (show IL8 Proteins) release

  7. The results indicated that the anti-inflammatory effect of 5-Aminosalicylic acid was mainly regulated by the inhibition of the JNKs, p38 (show CRK Proteins) pathways rather than NF-kappaB (show NFKB1 Proteins) pathway.

  8. MANF (show MANF Proteins) decreased the proinflammatory cytokines of IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins), and IFN-gamma induced (show SAMHD1 Proteins) by LPS (show TLR4 Proteins) by regulating NF-kappaB (show NFKB1 Proteins) and phosphorylation of p38 (show CRK Proteins)-mitogen-activated protein kinases (MAPKs) pathways

  9. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (show SELP Proteins) in platelets, followed by activation and secretion of Asm (show SMPD1 Proteins) and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK acts downstream from P-selectin (show SELP Proteins) and is necessary for the secretion of Asm (show SMPD1 Proteins).

  10. Angptl7 is a factor that promotes pro-inflammatory responses in macrophages through the P38 MAPK signaling pathway

Rabbit Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. These findings suggest that the TQ-induced production of ROS (show ROS1 Proteins) causes dedifferentiation through the ERK (show MAPK1 Proteins) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.

  2. These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 (show TP53 Proteins) and caspase-3 (show CASP3 Proteins) activation.

Pig (Porcine) Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (show IL10 Proteins) production through p38 MAPK activation.

  2. JNK (show MAPK8 Proteins) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]

  3. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.

Xenopus laevis Mitogen-Activated Protein Kinase 14 (MAPK14) interaction partners

  1. cytochrome c (show CYCS Proteins) microinjection induces p38 phosphorylation through caspase-3 (show CASP3 Proteins) activation, and caspase (show CASP3 Proteins) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock

MAPK14 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with MAPK14

  • mitogen-activated protein kinase 14 (MPK14)
  • mitogen-activated protein kinase 14 (MAPK14)
  • mitogen-activated protein kinase 14 (Mapk14)
  • CG7393 gene product from transcript CG7393-RA (p38b)
  • mitogen activated protein kinase 14 (Mapk14)
  • mitogen-activated protein kinase 14 (mapk14)
  • 186F5S protein
  • anon-sts23 protein
  • AP22.98 protein
  • AP22_98 protein
  • ATMPK14 protein
  • BG:DS00797.3 protein
  • CG7393 protein
  • CRK1 protein
  • csbp protein
  • Csbp1 protein
  • Csbp2 protein
  • CSPB1 protein
  • D-p38 protein
  • D-p38 MAPK protein
  • D-p38b protein
  • Dmel\\CG7393 protein
  • Dmp38b protein
  • Dm p38b protein
  • Dp38 protein
  • dp38b protein
  • ESTS:186F5S protein
  • Exip protein
  • Hog protein
  • mapk14a protein
  • mitogen-activated protein kinase 14 protein
  • Mpk34C protein
  • mxi2 protein
  • p38 protein
  • p38 beta protein
  • p38 MAPK protein
  • p38-alpha protein
  • p38a protein
  • p38alpha protein
  • p38B protein
  • p38beta protein
  • p38Hog protein
  • p38Kb protein
  • p38MAPK protein
  • Prkm14 protein
  • Prkm15 protein
  • RK protein
  • sapk2 protein
  • sapk2a protein

Protein level used designations for MAPK14

MAP kinase 14 , MAP kinase p38 alpha , MAPK 14 , mitogen-activated protein kinase p38 alpha , p38 mitogen activated protein kinase , CG7393-PA , p38 mitogen-activated protein kinase , p38b-PA , stress-activated p38b MAP kinase , p38 mitogen-activated kinase , cytokine suppressive anti-inflammatory drug binding protein 1 , mitogen activated protein kinase 14 , p38 MAP kinase alpha , p38 MAPK , p38 alpha , tRNA synthetase cofactor p38 , CSAIDS-binding protein 1 , mitogen-activated protein kinase 14A , stress-activated protein kinase 2a , Csaids binding protein , MAP kinase 2 , MAP kinase Mxi2 , MAX-interacting protein 2 , cytokine suppressive anti-inflammatory drug binding protein , cytokine-supressive anti-inflammatory drug binding protein , mitogen-activated protein kinase 14 , p38 MAP kinase , p38alpha Exip , reactive kinase , stress-activated protein kinase 2A , MAPK p38 , MPK2 , Mitogen-activated protein kinase 2 , mitogen-activated Mitogen-activated protein kinase 2

829797 Arabidopsis thaliana
534492 Bos taurus
403856 Canis lupus familiaris
100723285 Cavia porcellus
34780 Drosophila melanogaster
100063532 Equus caballus
421183 Gallus gallus
1432 Homo sapiens
26416 Mus musculus
100341695 Oryctolagus cuniculus
450161 Pan troglodytes
81649 Rattus norvegicus
100156630 Sus scrofa
379992 Xenopus laevis
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