Browse our anti-MAPT (MAPT) Antibodies

Full name:
anti-Microtubule-Associated Protein tau Antibodies (MAPT)
On www.antibodies-online.com are 1044 Microtubule-Associated Protein tau (MAPT) Antibodies from 37 different suppliers available. Additionally we are shipping MAPT Kits (73) and MAPT Proteins (57) and many more products for this protein. A total of 1217 MAPT products are currently listed.
Synonyms:
AI413597, AI426939, AI551861, AW045860, AW457082, CK1epsilon, CKIe, DDPAC, FTDP-17, KC1epsilon, MAPT, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF-tau, PPND, pTau, RNPTAU, Tau, xtp
list all antibodies Gene Name GeneID UniProt
MAPT 27373 Q9JMK2
MAPT 4137 P10636
Anti-Rat MAPT MAPT 29477  

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Top referenced anti-MAPT Antibodies

  1. Rat (Rattus) Monoclonal MAPT Primary Antibody for BI, IF - ABIN968103 : Alonso, Grundke-Iqbal, Iqbal: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. in Nature medicine 1996 (PubMed)
    Show all 5 references for 968103

  2. Human Polyclonal MAPT Primary Antibody for IF, IHC (p) - ABIN388782 : Yoshiyama, Zhang, Bruce, Trojanowski, Lee: Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 (PubMed)
    Show all 4 references for 388782

  3. Human Polyclonal MAPT Primary Antibody for EIA, WB - ABIN356907 : Beck, Rohrer, Campbell, Isaacs, Morrison, Goodall, Warrington, Stevens, Revesz, Holton, Al-Sarraj, King, Scahill, Warren, Fox, Rossor, Collinge, Mead: A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. in Brain : a journal of neurology 2008 (PubMed)
    Show all 3 references for 356907

  4. Human Polyclonal MAPT Primary Antibody for ELISA, WB - ABIN1531990 : Lee, Neve, Kosik: The microtubule binding domain of tau protein. in Neuron 1990 (PubMed)
    Show all 2 references for 1531990

  5. Human Monoclonal MAPT Primary Antibody for IHC (p), WB - ABIN1108149 : Andreadis, Brown, Kosik: Structure and novel exons of the human tau gene. in Biochemistry 1992 (PubMed)

  6. Human Polyclonal MAPT Primary Antibody for IHC (p), WB - ABIN388191 : McCulloch, Kay, Factor, Samii, Nutt, Higgins, Griffith, Roberts, Leis, Montimurro, Zabetian, Payami: Exploring gene-environment interactions in Parkinson's disease. in Human genetics 2008 (PubMed)

  7. Human Polyclonal MAPT Primary Antibody for IHC, WB - ABIN2783223 : Reynolds, Lukas, Berry, Binder: Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms. in Biochemistry 2006 (PubMed)

More Antibodies against MAPT Interaction Partners

Xenopus laevis Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB Antibodies), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.

Mouse (Murine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Data suggest that a presumed diffusion barrier within axon initial segment (AIS (show AR Antibodies)) regulates wild-type Tau sorting: retrograde (axon-to-soma) and anterograde (soma-to-axon) sorting of Tau. Tau isoforms without N-terminal inserts are sorted efficiently into axons; a longer isoform (2N4R-Tau) is partially retained in cell bodies/dendrites and accelerates spine/dendrite growth.

  2. Upregulating HSF1 (show HSF1 Antibodies) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (show DDIT3 Antibodies) and increasing HSP70 (show HSP70 Antibodies) a5 (BiP/GRP78 (show HSPA5 Antibodies)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Antibodies) being one likely key player in both systems.

  3. Results may provide support for the hypothesis that enhanced expression of tau following lipopolysaccharide administration is a protective measure by hippocampal neurons to compensate for the loss of the microtubule-stabilizing protein due to phosphorylation. More importantly, our results support the hypothesis that blocking the production of Abeta (show APP Antibodies) that follows inflammation also leads to reduced tau phosphorylation

  4. Study identified microtubule-associated protein tau as a highly sensitive constituent of the cytoskeleton in the presence of experimental stroke, thus providing novel evidence for a pivotal role of cytoskeletal elements under ischemic conditions

  5. These findings suggest that TDP-43 (show TARDBP Antibodies) promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43 (show TARDBP Antibodies), truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 (show TARDBP Antibodies) mislocalization to the cytoplasm.

  6. Abeta (show APP Antibodies) monomers physiologically favor Tau activity and dendritic sprouting, whereas their excess causes Tau pathology

  7. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e (show CSNK1E Antibodies) may contribute to individual differences in von Frey filament response.

  8. Loss of endothelial NO plays an important role in the generation of p25 (show CDK5R1 Antibodies) and resulting tau phosphorylation in neuronal tissue. Endothelial nitric oxide synthase (eNOS (show NOS3 Antibodies))-deficient (eNOS (show NOS3 Antibodies)-/-) mice display increased levels of p25 (show CDK5R1 Antibodies), an aberrant activator of cyclin-dependent kinase 5 (show CDK5 Antibodies), which is one of the primary kinases responsible for tau hyperphosphorylation, and a statistically higher p25/p35 (show CDK5R1 Antibodies) ratio.

  9. Fllowing severe closed head traumatic brain injury (sCHI), increasing levels of biochemically assayed T-Tau and P-Tau in the brains were associated with the PrPC (show PRNP Antibodies) expression levels, -Tau concentration in the blood was associated with PrPC (show PRNP Antibodies) expression in the absence of significant T-Tau changes; relationship was demonstrated between the presence/absence of PrPC (show PRNP Antibodies), the levels of P-Tau and cognitive dysfunction

  10. cognitive decline was significantly correlated with increased levels of caspase (show CASP3 Antibodies) activity and tau truncated by caspase-3 (show CASP3 Antibodies)

Human Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Our data suggest that although (18)F-AV-1451 SUVR curves do not reach a plateau and are still increasing in AD, an SUVR calculated over an imaging window of 80-100 min (as currently used in clinical studies) provides estimates of paired helical filament tau burden in good correlation with BPND, whereas SUVR sensitivity to regional cerebral blood changes needs further investigation.

  2. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta (show APP Antibodies)). Because Abeta (show APP Antibodies) and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

  3. Data suggest that a presumed diffusion barrier within axon initial segment (AIS (show AR Antibodies)) regulates wild-type Tau sorting: retrograde (axon-to-soma) and anterograde (soma-to-axon) sorting of Tau. Tau isoforms without N-terminal inserts are sorted efficiently into axons; a longer isoform (2N4R-Tau) is partially retained in cell bodies/dendrites and accelerates spine/dendrite growth.

  4. a complete screening for mutations in MAPT, GRN (show GRN Antibodies) and C9ORF72 (show C9ORF72 Antibodies) genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  5. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 (show ARF6 Antibodies) signaling.

  6. The data indicate that microtubule-bound tau is resistant to 14-3-3zeta (show YWHAZ Antibodies)-induced tau aggregation and suggest that tau phosphorylation promotes tau aggregation in the brain by detaching tau from microtubules and thus making it accessible to 14-3-3zeta (show YWHAZ Antibodies).

  7. This study for the first time reports the concentration of Tau and p-Tau181 in serum of AD and MCI (show MCIN Antibodies) patients. The cutoff values of Tau and p-Tau181 of AD and MCI (show MCIN Antibodies) patients with sensitivity and specificity reveal that serum level of these proteins can be used as a predictive marker for AD and MCI (show MCIN Antibodies).

  8. our study demonstrated that miR (show MLXIP Antibodies)-186 regulates the chemoresistance of NSCLC cells by modulating the MAPT expression level both in vitro and in vivo.

  9. MAPT-AS1 (show PTGDR Antibodies) and DNMT1 (show DNMT1 Antibodies) have been identified as potential epigenetic regulators of MAPT expression in PD across four different brain regions. Our data also suggest that increased MAPT expression could be associated with disease state, but not with PD neuropathology severity.

  10. age and H2 are associated with higher parkinsonism score and decreased total MAPT RNA expression. Additionally, we found that H2 and parkinsonism are associated with altered expression levels of specific isoforms. These findings may contribute to the understanding of the association between MAPT locus and parkinsonism in elderly subjects and in some extent to age-related neurodegenerative diseases.

Cow (Bovine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Findings suggest that the endothelin-1 (show EDN1 Antibodies)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A Antibodies)) diminishes NaV1.7 (show SCN9A Antibodies)-related catecholamine secretion and dephosphorylation of tau.

  2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN Antibodies).

  3. show that cathepsin D (show CTSD Antibodies) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP Antibodies) are involved in the pathogenesis of Alzheimer's disease

  4. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  5. We conclude that GSK3beta (show GSK3b Antibodies) phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.

Rhesus Monkey Microtubule-Associated Protein tau (MAPT) interaction partners

  1. age-related increase in cAMP-dependent protein kinase (show CDK7 Antibodies) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 Antibodies)+)-storing spine apparatus.

Chimpanzee Microtubule-Associated Protein tau (MAPT) interaction partners

  1. We found that inversion of the MAPT region is similarly polymorphic in other great ape (show CCDC88A Antibodies) species, and we present evidence that the inversions occurred independently in chimpanzees and humans

MAPT Antigen Profile

Antigen Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Alternative names and synonyms associated with MAPT

  • microtubule-associated protein tau (mapt) antibody
  • microtubule-associated protein tau (MAPT) antibody
  • microtubule-associated protein tau (AaeL_AAEL015538) antibody
  • microtubule-associated protein tau (AaeL_AAEL012206) antibody
  • microtubule-associated protein tau (CpipJ_CPIJ013260) antibody
  • Microtubule-associated protein tau (tau) antibody
  • casein kinase 1, epsilon (Csnk1e) antibody
  • microtubule-associated protein tau (Mapt) antibody
  • AI413597 antibody
  • AI426939 antibody
  • AI551861 antibody
  • AW045860 antibody
  • AW457082 antibody
  • CK1epsilon antibody
  • CKIe antibody
  • DDPAC antibody
  • FTDP-17 antibody
  • KC1epsilon antibody
  • MAPT antibody
  • MAPTL antibody
  • MSTD antibody
  • Mtapt antibody
  • MTBT1 antibody
  • MTBT2 antibody
  • PHF-tau antibody
  • PPND antibody
  • pTau antibody
  • RNPTAU antibody
  • Tau antibody
  • xtp antibody

Protein level used designations for MAPT

tau-like protein , tau-like protein-2 , microtubule-associated protein tau , Microtubule-associated protein tau , CKI, epsilon , CKI-epsilon , KC1 epsilon , casein kinase I isoform epsilon , G protein beta1/gamma2 subunit-interacting factor 1 , PHF-tau , neurofibrillary tangle protein , paired helical filament-tau , microtubule associated protein tau , Neurofibrillary tangle protein , Paired helical filament-tau , Tau microtubule-associated protein

GENE ID SPECIES
398307 Xenopus laevis
426737 Gallus gallus
5579355 Aedes aegypti
5580230 Aedes aegypti
6046480 Culex quinquefasciatus
100054638 Equus caballus
100306810 Salmo salar
27373 Mus musculus
4137 Homo sapiens
281296 Bos taurus
17762 Mus musculus
100860820 Capra hircus
29477 Rattus norvegicus
480488 Canis lupus familiaris
574327 Macaca mulatta
450177 Pan troglodytes
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