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Rat (Rattus) MAPT ELISA Kit for Sandwich ELISA - ABIN416529
Ekici, Uysal, Cikriklar, Özbek, Turgut Cosan, Baydemir, Kazanci, Hafizo?lu: Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury. in European review for medical and pharmacological sciences 2014
Human MAPT ELISA Kit for Sandwich ELISA - ABIN415122
Lasek-Bal, Jedrzejowska-Szypulka, Rozycka, Bal, Kowalczyk, Holecki, Dulawa, Lewin-Kowalik: The presence of Tau protein in blood as a potential prognostic factor in stroke patients. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2016
Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB ELISA Kits), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.
Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn (show FYN ELISA Kits)-mediated local protein translation.
The authors concluded that the FcgammaRIIb-SHIP2 (show INPPL1 ELISA Kits) axis links Abeta (show APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
Pin1 (show PIN1 ELISA Kits) serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Here, the authors identify another Wnt (show WNT2 ELISA Kits) signaling amplifier, CKIepsilon (show CSNK1E ELISA Kits), which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta (show CSNK1D ELISA Kits).
PGRN (show GRN ELISA Kits) decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B ELISA Kits)-contaning NMDA receptors
These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A (show MAP1A ELISA Kits), induces reduction of Otx2 (show OTX2 ELISA Kits) expression, increases prenatal cell death, and accordingly leads to selective loss of VTA DA neurons in the early postnatal stage.
High-glucose induces tau hyperphosphorylation through activation of TLR9 (show TLR9 ELISA Kits)-P38 MAPK (show MAPK14 ELISA Kits) pathway.
these results uncover a novel role for mDia1 in Abeta-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are driving factors for the induction of tau-mediated neuronal damage.
The authors show here that miR (show MLXIP ELISA Kits)-132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5-trisphosphate 3-kinase B (ITPKB (show ITPKB ELISA Kits)) upregulation in an Alzheimer's disease mouse model.
TIA1 (show TIA1 ELISA Kits) knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 (show TIA1 ELISA Kits) induces tau misfolding and stimulates neurodegeneration.
Our findings unmask tau-mediated perturbations of specific pathways associated with neuronal vulnerability, revealing potential early disease biomarkers and therapeutic targets for FTD (show FTL ELISA Kits) and other tauopathies.
Our studies also provide mechanistic insight into the increased level and activity of secreted MMP-9 (show MMP9 ELISA Kits) in cortical neurons derived from FTD (show FTL ELISA Kits) patient-specific iPSCs with MAPT mutations. The increase seems to be mediated by ERK (show EPHB2 ELISA Kits)-pathway activation.
The authors found that TRIM28 regulates alpha-Synuclein and tau nuclear levels and that its reduction rescues toxicity in animal models of tau- and alpha-Synuclein-mediated degeneration.
In the Brazilian population studied, the frequency of GRN (show GRN ELISA Kits) mutations was 9.6% and that of MAPT mutations was 7.1%. Among familial cases of FTD (show FTL ELISA Kits), the frequency of GRN (show GRN ELISA Kits) mutations was 31.5% and that of MAPT mutations was 10.5%.
Association of human and mouse P-tau with amyloid PrPSc (show PRNP ELISA Kits) did not diminish survival time following prion (show PRNP ELISA Kits) infection in these mice. By analogy, human P-tau may not affect prion (show PRNP ELISA Kits) disease progression in humans.
Besides being associated with tau pathology, CSF (show CSF2 ELISA Kits) YKL-40 (show CHI3L1 ELISA Kits) adds to the growing array of biomarkers reflecting distinct molecular brain mechanisms potentially useful for stratifying individuals for biomarker-guided, targeted anti-inflammatory therapies emerging from precision medicine.
Study shows that the microtubule-associated protein tau H1 haplotype was associated with Parkinson's disease susceptibility.
This study demonstrated that no significant group differences in the total group or the MAPT group at follow-up.
Results demonstrate a strong association between progranulin (show GRN ELISA Kits) deficiency and reduction of Tau protein expression that could lead to severe neuronal and glial dysfunctions; also indicate that this frontotemporal lobar degeneration (FTLD)-TDP-GRN (show GRN ELISA Kits) subgroup could be part as a distinct entity of FTLD classification.
Study identified the binding site between tau and fyn (show FYN ELISA Kits)-SH3 may facilitate the development of compounds that can inhibit tau-fyn (show FYN ELISA Kits) interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn (show FYN ELISA Kits) is not present in Alzheimer's disease brain.
Findings suggest that the endothelin-1 (show EDN1 ELISA Kits)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A ELISA Kits)) diminishes NaV1.7 (show SCN9A ELISA Kits)-related catecholamine secretion and dephosphorylation of tau.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN ELISA Kits).
show that cathepsin D (show CTSD ELISA Kits) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP ELISA Kits) are involved in the pathogenesis of Alzheimer's disease
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
We conclude that GSK3beta (show GSK3b ELISA Kits) phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.
age-related increase in cAMP-dependent protein kinase (show CDK7 ELISA Kits) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 ELISA Kits)+)-storing spine apparatus.
We found that inversion of the MAPT region is similarly polymorphic in other great ape (show CCDC88A ELISA Kits) species, and we present evidence that the inversions occurred independently in chimpanzees and humans
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
G protein beta1/gamma2 subunit-interacting factor 1
, neurofibrillary tangle protein
, paired helical filament-tau
, CKI, epsilon
, KC1 epsilon
, casein kinase I isoform epsilon
, Tau microtubule-associated protein
, microtubule associated protein tau
, tau-like protein
, tau-like protein-2
, microtubule-associated protein tau
, Microtubule-associated protein tau
, Neurofibrillary tangle protein
, Paired helical filament-tau
, sodium- and chloride-dependent taurine transporter
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6b
, taurine transporter