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Rat (Rattus) MAPT ELISA Kit for Sandwich ELISA - ABIN416529
Ekici, Uysal, Cikriklar, Özbek, Turgut Cosan, Baydemir, Kazanci, Hafizo?lu: Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury. in European review for medical and pharmacological sciences 2014
Human MAPT ELISA Kit for Sandwich ELISA - ABIN415122
Lasek-Bal, Jedrzejowska-Szypulka, Rozycka, Bal, Kowalczyk, Holecki, Dulawa, Lewin-Kowalik: The presence of Tau protein in blood as a potential prognostic factor in stroke patients. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2016
Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB ELISA Kits), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.
Pin1 (show PIN1 ELISA Kits) serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Here, the authors identify another Wnt (show WNT2 ELISA Kits) signaling amplifier, CKIepsilon (show CSNK1E ELISA Kits), which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta (show CSNK1D ELISA Kits).
PGRN (show GRN ELISA Kits) decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B ELISA Kits)-contaning NMDA receptors
These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A (show MAP1A ELISA Kits), induces reduction of Otx2 (show OTX2 ELISA Kits) expression, increases prenatal cell death, and accordingly leads to selective loss of VTA DA neurons in the early postnatal stage.
High-glucose induces tau hyperphosphorylation through activation of TLR9 (show TLR9 ELISA Kits)-P38 MAPK (show MAPK14 ELISA Kits) pathway.
these results uncover a novel role for mDia1 in Abeta-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are driving factors for the induction of tau-mediated neuronal damage.
The authors show here that miR (show MLXIP ELISA Kits)-132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5-trisphosphate 3-kinase B (ITPKB (show ITPKB ELISA Kits)) upregulation in an Alzheimer's disease mouse model.
TIA1 (show TIA1 ELISA Kits) knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 (show TIA1 ELISA Kits) induces tau misfolding and stimulates neurodegeneration.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 (show HDAC6 ELISA Kits) protein).
ROS (show ROS1 ELISA Kits) produced by 1,2-diacetylbenzene causes tau hyperphosphorylation via GSK-3beta (show GSK3b ELISA Kits) phosphorylation and it might be related to impaired memory deficit.
Results demonstrate a strong association between progranulin (show GRN ELISA Kits) deficiency and reduction of Tau protein expression that could lead to severe neuronal and glial dysfunctions; also indicate that this frontotemporal lobar degeneration (FTLD)-TDP-GRN (show GRN ELISA Kits) subgroup could be part as a distinct entity of FTLD classification.
Study identified the binding site between tau and fyn (show FYN ELISA Kits)-SH3 may facilitate the development of compounds that can inhibit tau-fyn (show FYN ELISA Kits) interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn (show FYN ELISA Kits) is not present in Alzheimer's disease brain.
The results emphasize an additional level of complexity in the regulation of the interaction between BIN1 (show BIN1 ELISA Kits) and Tau dependent on the BIN1 (show BIN1 ELISA Kits) isoforms.
There is a link between regional MAPT expression and selective vulnerability of functional brain networks to neurodegeneration.
TDP-43 (show TARDBP ELISA Kits) suppressed tau expression by promoting its mRNA instability through the UG repeats of its 3-UTR (show UTS2R ELISA Kits). Neurodegenerative diseases-causing TDP-43 (show TARDBP ELISA Kits) mutations affected tau mRNA instability differentially, in that some promoted and others did not significantly affect tau mRNA instability.The level of TDP-43 (show TARDBP ELISA Kits), which is decreased in AD brains, was found to correlate negatively with the tau level in human brain.
Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates.
results show that neuroinflammation promotes neuronal autophagy and that chronic mild TLR4 (show TLR4 ELISA Kits) stimulation attenuates Alzheimer's disease-related tauopathy, likely by activating neuronal autophagy
Mutation of MAPT is a common cause of FTD (show FTL ELISA Kits) in mainland China.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by HDAC6 (histone deacetylase 6 (show HDAC6 ELISA Kits) protein).
The data of this study provided strong evidence that soluble forms of tau and Abeta (show APP ELISA Kits) co-localise early in AD and are closely linked to disease progression and cognitive decline.
Findings suggest that the endothelin-1 (show EDN1 ELISA Kits)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A ELISA Kits)) diminishes NaV1.7 (show SCN9A ELISA Kits)-related catecholamine secretion and dephosphorylation of tau.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN ELISA Kits).
show that cathepsin D (show CTSD ELISA Kits) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP ELISA Kits) are involved in the pathogenesis of Alzheimer's disease
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
We conclude that GSK3beta (show GSK3b ELISA Kits) phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.
age-related increase in cAMP-dependent protein kinase (show CDK7 ELISA Kits) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 ELISA Kits)+)-storing spine apparatus.
We found that inversion of the MAPT region is similarly polymorphic in other great ape (show CCDC88A ELISA Kits) species, and we present evidence that the inversions occurred independently in chimpanzees and humans
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
, tau-like protein-2
, microtubule-associated protein tau
, Microtubule-associated protein tau
, CKI, epsilon
, KC1 epsilon
, casein kinase I isoform epsilon
, G protein beta1/gamma2 subunit-interacting factor 1
, neurofibrillary tangle protein
, paired helical filament-tau
, microtubule associated protein tau
, Neurofibrillary tangle protein
, Paired helical filament-tau
, Tau microtubule-associated protein