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Rat (Rattus) MAPT ELISA Kit for Sandwich ELISA - ABIN416529
Ekici, Uysal, Cikriklar, Özbek, Turgut Cosan, Baydemir, Kazanci, Hafizo?lu: Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury. in European review for medical and pharmacological sciences 2014
Human MAPT ELISA Kit for Sandwich ELISA - ABIN415122
Lasek-Bal, Jedrzejowska-Szypulka, Rozycka, Bal, Kowalczyk, Holecki, Dulawa, Lewin-Kowalik: The presence of Tau protein in blood as a potential prognostic factor in stroke patients. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2016
Insulin (show INS ELISA Kits) is accumulated and retained as oligomers in hyperphosphorylated tau-bearing neurons in Alzheimer's disease and in several of the most prevalent human tauopathies.
Inhibition of CaN attenuated the hTau-induced CREB (show CREB1 ELISA Kits) dephosphorylation with improved synapse and memory functions.
Study describes a protocol to extract and measure tau seeding activity from small volumes (.04 mm(3)) of formaldehyde-fixed tissue immediately adjacent to that used for immunohistochemistry, validated this method with the PS19 transgenic mouse model, and easily observed seeding well before the development of phospho-tau pathology. Also accurately isolated two tau strains, DS9 and DS10, from fixed brain tissues in mice.
evidence that JNK (show MAPK8 ELISA Kits) signaling pathway is an upstream regulator of hyperosmotic stress-induced Tau cleavage and apoptosis in SH-SY5Y through the control of caspase-3 (show CASP3 ELISA Kits) activation.
Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was characterized extensively in human plasma, including by single molecule array technology with 303 subjects. In human plasma, tau was explicitly identified within L1CAM exoso (show L1CAM ELISA Kits)mes. In contrast to Alzheimer's patients, L1CAM exosomal tau was significantly higher in Parkinson's patients than controls and correlated with cerebrospinal fluid tau.
Our findings unmask tau-mediated perturbations of specific pathways associated with neuronal vulnerability, revealing potential early disease biomarkers and therapeutic targets for FTD (show FTL ELISA Kits) and other tauopathies.
Our studies also provide mechanistic insight into the increased level and activity of secreted MMP-9 (show MMP9 ELISA Kits) in cortical neurons derived from FTD (show FTL ELISA Kits) patient-specific iPSCs with MAPT mutations. The increase seems to be mediated by ERK (show EPHB2 ELISA Kits)-pathway activation.
The authors found that TRIM28 regulates alpha-Synuclein and tau nuclear levels and that its reduction rescues toxicity in animal models of tau- and alpha-Synuclein-mediated degeneration.
In the Brazilian population studied, the frequency of GRN (show GRN ELISA Kits) mutations was 9.6% and that of MAPT mutations was 7.1%. Among familial cases of FTD (show FTL ELISA Kits), the frequency of GRN (show GRN ELISA Kits) mutations was 31.5% and that of MAPT mutations was 10.5%.
Association of human and mouse P-tau with amyloid PrPSc (show PRNP ELISA Kits) did not diminish survival time following prion (show PRNP ELISA Kits) infection in these mice. By analogy, human P-tau may not affect prion (show PRNP ELISA Kits) disease progression in humans.
Csnk1e (show CSNK1E ELISA Kits) deletion increased mu opioid receptor (show OPRM1 ELISA Kits)-dependent behaviors.
Study demonstrates a mechanistic link between brain Abeta (show APP ELISA Kits) deposition and CSF (show CSF2 ELISA Kits) tau, and thus, CSF (show CSF2 ELISA Kits) tau may present an important readout of Abeta (show APP ELISA Kits) deposition in mouse models and likely in Alzheimer's disease.
Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. The efflux of Tau, including a fraction via CNS-derived L1CAM (show L1CAM ELISA Kits) exosomes, was observed in mice. Tau is readily transported from the brain to the blood.
Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn (show FYN ELISA Kits)-mediated local protein translation.
The authors concluded that the FcgammaRIIb-SHIP2 (show INPPL1 ELISA Kits) axis links Abeta (show APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
Pin1 (show PIN1 ELISA Kits) serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Here, the authors identify another Wnt (show WNT2 ELISA Kits) signaling amplifier, CKIepsilon (show CSNK1E ELISA Kits), which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta (show CSNK1D ELISA Kits).
PGRN (show GRN ELISA Kits) decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B ELISA Kits)-contaning NMDA receptors
These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A (show MAP1A ELISA Kits), induces reduction of Otx2 (show OTX2 ELISA Kits) expression, increases prenatal cell death, and accordingly leads to selective loss of VTA DA neurons in the early postnatal stage.
High-glucose induces tau hyperphosphorylation through activation of TLR9 (show TLR9 ELISA Kits)-P38 MAPK (show MAPK14 ELISA Kits) pathway.
Findings suggest that the endothelin-1 (show EDN1 ELISA Kits)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A ELISA Kits)) diminishes NaV1.7 (show SCN9A ELISA Kits)-related catecholamine secretion and dephosphorylation of tau.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN ELISA Kits).
show that cathepsin D (show CTSD ELISA Kits) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP ELISA Kits) are involved in the pathogenesis of Alzheimer's disease
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
We conclude that GSK3beta (show GSK3b ELISA Kits) phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.
Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB ELISA Kits), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.
We found that inversion of the MAPT region is similarly polymorphic in other great ape (show CCDC88A ELISA Kits) species, and we present evidence that the inversions occurred independently in chimpanzees and humans
age-related increase in cAMP-dependent protein kinase (show CDK7 ELISA Kits) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 ELISA Kits)+)-storing spine apparatus.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
G protein beta1/gamma2 subunit-interacting factor 1
, neurofibrillary tangle protein
, paired helical filament-tau
, CKI, epsilon
, KC1 epsilon
, casein kinase I isoform epsilon
, Tau microtubule-associated protein
, microtubule associated protein tau
, tau-like protein
, tau-like protein-2
, microtubule-associated protein tau
, Microtubule-associated protein tau
, Neurofibrillary tangle protein
, Paired helical filament-tau
, sodium- and chloride-dependent taurine transporter
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6b
, taurine transporter