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Browse our MAPT Proteins (MAPT)

Full name:
Microtubule-Associated Protein tau Proteins (MAPT)
On are 56 Microtubule-Associated Protein tau (MAPT) Proteins from 12 different suppliers available. Additionally we are shipping MAPT Antibodies (1085) and MAPT Kits (71) and many more products for this protein. A total of 1255 MAPT products are currently listed.
AI413597, AI426939, AI551861, AW045860, AW457082, CK1epsilon, CKIe, DDPAC, FTDP-17, KC1epsilon, MAPT, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF-tau, PPND, pTau, RNPTAU, Tau, xtp
list all proteins Gene Name GeneID UniProt
MAPT 27373 Q9JMK2
MAPT 4137 P10636
MAPT 29477  

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MAPT Proteins (MAPT) by Origin

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Top referenced MAPT Proteins

  1. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN667432 : Cross, Vial, Maccioni: A tau-like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines. in Journal of cell science 1993 (PubMed)
    Show all 2 references for ABIN667432

  2. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN2001992 : Weingarten, Lockwood, Hwo, Kirschner: A protein factor essential for microtubule assembly. in Proceedings of the National Academy of Sciences of the United States of America 1975 (PubMed)

More Proteins for MAPT Interaction Partners

Xenopus laevis Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB Proteins), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.

Mouse (Murine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Fllowing severe closed head traumatic brain injury (sCHI), increasing levels of biochemically assayed T-Tau and P-Tau in the brains were associated with the PrPC (show PRNP Proteins) expression levels, -Tau concentration in the blood was associated with PrPC (show PRNP Proteins) expression in the absence of significant T-Tau changes; relationship was demonstrated between the presence/absence of PrPC (show PRNP Proteins), the levels of P-Tau and cognitive dysfunction

  2. cognitive decline was significantly correlated with increased levels of caspase (show CASP3 Proteins) activity and tau truncated by caspase-3 (show CASP3 Proteins)

  3. Orthopedic surgery induces Abeta (show APP Proteins) accumulation and tau phosphorylation in the hippocampus.

  4. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta, down-regulation of AChE-R and increase in Abeta (show APP Proteins) and total and phosphorylated tau protein levels.

  5. geniposide may regulate tau phosphorylation through leptin (show LEP Proteins) signaling

  6. an inverse correlation was found between Ang-(1 (show ANGPT1 Proteins)-7) level and tau hyperphosphorylation, a pathological hallmark of Alzheimer's disease, in cerebral cortex and hippocampus of SAMP8 mice.

  7. APP (show APP Proteins), tau, and synaptophysin (show SYP Proteins) were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 maters relative to the B6D2F1 and BXB1 non-maters,suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior.

  8. These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip (show HSPA5 Proteins) and SIL1 (show SIL1 Proteins), in Alzheimer's disease-like tau hyperphosphorylation.

  9. Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3 (show TRAF3 Proteins).

  10. This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 (show DAPK1 Proteins) mediates spine damage and the subsequent neuronal death in ischemic stroke.

Human Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Results suggest that t-Tau protein assay is of significant importance as a second marker in identifying 14-3-3 (show YWHAQ Proteins) false-positive results among sporadic Creutzfeldt-Jakob disease probable cases

  2. Silencing GSK-3beta may have a positive effect on inhibiting the pathologic progression of Alzheimer disease through down-regulating the level of p-Tau

  3. Using deletion mutants, the acidic C-terminal region of alpha-synuclein and the basic central region of Tau were identified as binding regions. Introduction of alpha-synuclein fibrils into cells overexpressing Tau induced Tau aggregation, raising the possibility that alpha-synuclein fibrils interact with Tau, inhibit its function to stabilize microtubules, and also promote Tau aggregation, leading to dysfunction of neu...

  4. Increased expression levels of MAPT and GRIN3A (show GRIN3A Proteins) may lead to the abnormal pathologic condition of nerve tissue in macrodactyly and, to a certain extent, may have potential applications in nerve regeneration.

  5. MAPT rs242557 is marginally associated with PD.

  6. our data demonstrate that htau accumulation decreases cell viability and causes degeneration via enhancing mitofusin (show MFN2 Proteins)-associated mitochondrial fusion, which provides new insights into the molecular mechanisms underlying tauopathies.

  7. repression of BAG2 (show BAG2 Proteins) expression or BAG2 (show BAG2 Proteins) activity by cold-sensitive pathways, as modeled in undifferentiated and differentiated cells, respectively, may be a causal factor in the accumulation of cytotoxic hyperphosphorylated tau protein.

  8. In 3xTg-AD transgenic mice, carrying three transgenes encoding APPSWE, S1M146V, and TauP301L proteins, accumulation of Abeta (show APP Proteins) triggers an inflammatory environment revealed by the activation of astrocytes, the expression of inflammatory cytokines (TNF-alpha (show TNF Proteins) and IL-18 (show IL18 Proteins)), which might be involved in the activation of SAPK (show MAPK9 Proteins)/JNK (show MAPK8 Proteins) and Cdk5 (show CDK5 Proteins), leading to a sequential hyperphosphorylation of TauP301L as a function of age

  9. Data support the idea that sequestration of ERalpha (show ESR1 Proteins) by tau protein underlies the loss of estrogen neuroprotection during the course of Alzheimer's disease.

  10. According to the flow-related diverging dynamics of blood-derived and brain-derived proteins in CSF (show CSF2 Proteins), the concentrations of Tau and pTau tended to be lower in lumbar compared to cisternal CSF (show CSF2 Proteins) fractions after a spinal tap of 40 ml. The differences reached statistical significance for pTau only. The small differences will not affect clinical interpretation of markers of dementia in the vast majority of cases

Cow (Bovine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Findings suggest that the endothelin-1 (show EDN1 Proteins)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A Proteins)) diminishes NaV1.7 (show SCN9A Proteins)-related catecholamine secretion and dephosphorylation of tau.

  2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN Proteins).

  3. show that cathepsin D (show CTSD Proteins) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP Proteins) are involved in the pathogenesis of Alzheimer's disease

  4. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  5. We conclude that GSK3beta phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.

Rhesus Monkey Microtubule-Associated Protein tau (MAPT) interaction partners

  1. age-related increase in cAMP-dependent protein kinase (show CDK7 Proteins) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 Proteins)+)-storing spine apparatus.

Chimpanzee Microtubule-Associated Protein tau (MAPT) interaction partners

  1. We found that inversion of the MAPT region is similarly polymorphic in other great ape species, and we present evidence that the inversions occurred independently in chimpanzees and humans

MAPT Protein Profile

Protein Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Alternative names and synonyms associated with MAPT

  • microtubule-associated protein tau (mapt)
  • microtubule-associated protein tau (MAPT)
  • microtubule-associated protein tau (AaeL_AAEL015538)
  • microtubule-associated protein tau (AaeL_AAEL012206)
  • microtubule-associated protein tau (CpipJ_CPIJ013260)
  • Microtubule-associated protein tau (tau)
  • casein kinase 1, epsilon (Csnk1e)
  • microtubule-associated protein tau (Mapt)
  • AI413597 protein
  • AI426939 protein
  • AI551861 protein
  • AW045860 protein
  • AW457082 protein
  • CK1epsilon protein
  • CKIe protein
  • DDPAC protein
  • FTDP-17 protein
  • KC1epsilon protein
  • MAPT protein
  • MAPTL protein
  • MSTD protein
  • Mtapt protein
  • MTBT1 protein
  • MTBT2 protein
  • PHF-tau protein
  • PPND protein
  • pTau protein
  • RNPTAU protein
  • Tau protein
  • xtp protein

Protein level used designations for MAPT

tau-like protein , tau-like protein-2 , microtubule-associated protein tau , Microtubule-associated protein tau , CKI, epsilon , CKI-epsilon , KC1 epsilon , casein kinase I isoform epsilon , G protein beta1/gamma2 subunit-interacting factor 1 , PHF-tau , neurofibrillary tangle protein , paired helical filament-tau , microtubule associated protein tau , Neurofibrillary tangle protein , Paired helical filament-tau , Tau microtubule-associated protein

398307 Xenopus laevis
426737 Gallus gallus
5579355 Aedes aegypti
5580230 Aedes aegypti
6046480 Culex quinquefasciatus
100054638 Equus caballus
100306810 Salmo salar
27373 Mus musculus
4137 Homo sapiens
281296 Bos taurus
17762 Mus musculus
100860820 Capra hircus
29477 Rattus norvegicus
480488 Canis lupus familiaris
574327 Macaca mulatta
450177 Pan troglodytes
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