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Browse our MAPT Proteins (MAPT)

Full name:
Microtubule-Associated Protein tau Proteins (MAPT)
On are 55 Microtubule-Associated Protein tau (MAPT) Proteins from 11 different suppliers available. Additionally we are shipping MAPT Antibodies (1038) and MAPT Kits (73) and many more products for this protein. A total of 1209 MAPT products are currently listed.
AI413597, AI426939, AI551861, AW045860, AW457082, CK1epsilon, CKIe, DDPAC, FTDP-17, KC1epsilon, MAPT, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF-tau, PPND, pTau, RNPTAU, Tau, xtp
list all proteins Gene Name GeneID UniProt
MAPT 27373 Q9JMK2
MAPT 4137 P10636
MAPT 29477  

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MAPT Proteins (MAPT) by Origin

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Top referenced MAPT Proteins

  1. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN667432 : Cross, Vial, Maccioni: A tau-like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines. in Journal of cell science 1993 (PubMed)
    Show all 2 references for ABIN667432

  2. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN2001992 : Weingarten, Lockwood, Hwo, Kirschner: A protein factor essential for microtubule assembly. in Proceedings of the National Academy of Sciences of the United States of America 1975 (PubMed)

More Proteins for MAPT Interaction Partners

Xenopus laevis Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB Proteins), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.

Mouse (Murine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. These findings suggest that TDP-43 (show TARDBP Proteins) promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43 (show TARDBP Proteins), truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 (show TARDBP Proteins) mislocalization to the cytoplasm.

  2. Abeta (show APP Proteins) monomers physiologically favor Tau activity and dendritic sprouting, whereas their excess causes Tau pathology

  3. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e (show CSNK1E Proteins) may contribute to individual differences in von Frey filament response.

  4. Loss of endothelial NO plays an important role in the generation of p25 (show CDK5R1 Proteins) and resulting tau phosphorylation in neuronal tissue. Endothelial nitric oxide synthase (eNOS (show NOS3 Proteins))-deficient (eNOS (show NOS3 Proteins)-/-) mice display increased levels of p25 (show CDK5R1 Proteins), an aberrant activator of cyclin-dependent kinase 5 (show CDK5 Proteins), which is one of the primary kinases responsible for tau hyperphosphorylation, and a statistically higher p25/p35 (show CDK5R1 Proteins) ratio.

  5. Fllowing severe closed head traumatic brain injury (sCHI), increasing levels of biochemically assayed T-Tau and P-Tau in the brains were associated with the PrPC (show PRNP Proteins) expression levels, -Tau concentration in the blood was associated with PrPC (show PRNP Proteins) expression in the absence of significant T-Tau changes; relationship was demonstrated between the presence/absence of PrPC (show PRNP Proteins), the levels of P-Tau and cognitive dysfunction

  6. cognitive decline was significantly correlated with increased levels of caspase (show CASP3 Proteins) activity and tau truncated by caspase-3 (show CASP3 Proteins)

  7. Orthopedic surgery induces Abeta (show APP Proteins) accumulation and tau phosphorylation in the hippocampus.

  8. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta, down-regulation of AChE-R and increase in Abeta (show APP Proteins) and total and phosphorylated tau protein levels.

  9. geniposide may regulate tau phosphorylation through leptin (show LEP Proteins) signaling

  10. an inverse correlation was found between Ang-(1 (show ANGPT1 Proteins)-7) level and tau hyperphosphorylation, a pathological hallmark of Alzheimer's disease, in cerebral cortex and hippocampus of SAMP8 mice.

Human Microtubule-Associated Protein tau (MAPT) interaction partners

  1. The authors observed that Tau binds tightly to Dolastatin-10 tubulin (show TUBB Proteins) rings and promotes the formation of Dolastatin-10 ring stacks, implying that Tau can crosslink MT protofilaments laterally.

  2. These findings suggest that TDP-43 (show TARDBP Proteins) promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43 (show TARDBP Proteins), truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 (show TARDBP Proteins) mislocalization to the cytoplasm.

  3. In fact, DnaJC5 (show DNAJC5 Proteins) overexpression induced tau release in cells, neurons, and brain tissue, but only when activity of the chaperone Hsc70 (show HSPA8 Proteins) was intact and when tau was able to associate with this chaperone.

  4. Surprisingly, the authors discover that Pin1 (show PIN1 Proteins) does not promote phosphorylated tau-induced microtubule formation in vitro, refuting the commonly accepted model in which Pin1 (show PIN1 Proteins) binding and catalysis on the A180 epitope restores the function of the Alzheimer's associated phosphorylated tau in tubulin (show TUBB Proteins) assembly.

  5. Importantly, site-specific measurements of Pin1 (show PIN1 Proteins)-catalysis of CDK2 (show CDK2 Proteins)/CycA (show CCNA2 Proteins)-phosphorylated full-length tau reveal a number of sites that are catalyzed simultaneously with different efficiencies.

  6. Study suggests that Tau may contribute to the formation and function of the highly dynamic tunneling nanotubes that may be involved in the prion (show PRNP Proteins)-like propagation of Tau assemblies.

  7. Established evidence from the prion (show PRNP Proteins) field combined with the most recent tau and amyloidogenic protein research suggests that tau is a prion-like protein (show PRNP Proteins), capable of seeding the spread of pathology throughout the brain. [review]

  8. MAPT H1c (show HIST1H1C Proteins) haplotype (rs242557) has previously been identified as a genetic risk factor for progressive supranuclear palsy and corticobasal degeneration. The current findings suggest that plasma tau concentration could be an endophenotype for identifying risk for 4-repeat tauopathies in older individuals.

  9. 18F-AV-1451 positron emission tomography can be used to accurately quantify in vivo the regional distribution of hyperphosphorylated tau protein in MAPT mutation carriers.

  10. These results suggest that tau phosphorylation at Ser262 plays the predominant role in tau stabilization when PAR-1 (show MARK2 Proteins)/MARK activity.

Cow (Bovine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Findings suggest that the endothelin-1 (show EDN1 Proteins)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A Proteins)) diminishes NaV1.7 (show SCN9A Proteins)-related catecholamine secretion and dephosphorylation of tau.

  2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN Proteins).

  3. show that cathepsin D (show CTSD Proteins) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP Proteins) are involved in the pathogenesis of Alzheimer's disease

  4. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  5. We conclude that GSK3beta phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.

Rhesus Monkey Microtubule-Associated Protein tau (MAPT) interaction partners

  1. age-related increase in cAMP-dependent protein kinase (show CDK7 Proteins) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 Proteins)+)-storing spine apparatus.

Chimpanzee Microtubule-Associated Protein tau (MAPT) interaction partners

  1. We found that inversion of the MAPT region is similarly polymorphic in other great ape species, and we present evidence that the inversions occurred independently in chimpanzees and humans

MAPT Protein Profile

Protein Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Alternative names and synonyms associated with MAPT

  • microtubule-associated protein tau (mapt)
  • microtubule-associated protein tau (MAPT)
  • microtubule-associated protein tau (AaeL_AAEL015538)
  • microtubule-associated protein tau (AaeL_AAEL012206)
  • microtubule-associated protein tau (CpipJ_CPIJ013260)
  • Microtubule-associated protein tau (tau)
  • casein kinase 1, epsilon (Csnk1e)
  • microtubule-associated protein tau (Mapt)
  • AI413597 protein
  • AI426939 protein
  • AI551861 protein
  • AW045860 protein
  • AW457082 protein
  • CK1epsilon protein
  • CKIe protein
  • DDPAC protein
  • FTDP-17 protein
  • KC1epsilon protein
  • MAPT protein
  • MAPTL protein
  • MSTD protein
  • Mtapt protein
  • MTBT1 protein
  • MTBT2 protein
  • PHF-tau protein
  • PPND protein
  • pTau protein
  • RNPTAU protein
  • Tau protein
  • xtp protein

Protein level used designations for MAPT

tau-like protein , tau-like protein-2 , microtubule-associated protein tau , Microtubule-associated protein tau , CKI, epsilon , CKI-epsilon , KC1 epsilon , casein kinase I isoform epsilon , G protein beta1/gamma2 subunit-interacting factor 1 , PHF-tau , neurofibrillary tangle protein , paired helical filament-tau , microtubule associated protein tau , Neurofibrillary tangle protein , Paired helical filament-tau , Tau microtubule-associated protein

398307 Xenopus laevis
426737 Gallus gallus
5579355 Aedes aegypti
5580230 Aedes aegypti
6046480 Culex quinquefasciatus
100054638 Equus caballus
100306810 Salmo salar
27373 Mus musculus
4137 Homo sapiens
281296 Bos taurus
17762 Mus musculus
100860820 Capra hircus
29477 Rattus norvegicus
480488 Canis lupus familiaris
574327 Macaca mulatta
450177 Pan troglodytes
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