Browse our MAPT Proteins (MAPT)

Full name:
Microtubule-Associated Protein tau Proteins (MAPT)
On are 57 Microtubule-Associated Protein tau (MAPT) Proteins from 12 different suppliers available. Additionally we are shipping MAPT Antibodies (1044) and MAPT Kits (73) and many more products for this protein. A total of 1217 MAPT products are currently listed.
AI413597, AI426939, AI551861, AW045860, AW457082, CK1epsilon, CKIe, DDPAC, FTDP-17, KC1epsilon, MAPT, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF-tau, PPND, pTau, RNPTAU, Tau, xtp
list all proteins Gene Name GeneID UniProt
MAPT 27373 Q9JMK2
MAPT 4137 P10636
MAPT 29477  

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MAPT Proteins (MAPT) by Origin

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Top referenced MAPT Proteins

  1. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN667432 : Cross, Vial, Maccioni: A tau-like protein interacts with stress fibers and microtubules in human and rodent cultured cell lines. in Journal of cell science 1993 (PubMed)
    Show all 2 references for 667432

  2. Human MAPT Protein expressed in Escherichia coli (E. coli) - ABIN2001992 : Weingarten, Lockwood, Hwo, Kirschner: A protein factor essential for microtubule assembly. in Proceedings of the National Academy of Sciences of the United States of America 1975 (PubMed)

More Proteins for MAPT Interaction Partners

Xenopus laevis Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (show TUBB Proteins), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.

Mouse (Murine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. tau overexpression mediates the excitatory toxicity induced by E-NMDAR (show GRIN1 Proteins) activation through inhibiting ERK (show EPHB2 Proteins) phosphorylation.

  2. Data suggest that a presumed diffusion barrier within axon initial segment (AIS (show AR Proteins)) regulates wild-type Tau sorting: retrograde (axon-to-soma) and anterograde (soma-to-axon) sorting of Tau. Tau isoforms without N-terminal inserts are sorted efficiently into axons; a longer isoform (2N4R-Tau) is partially retained in cell bodies/dendrites and accelerates spine/dendrite growth.

  3. Upregulating HSF1 (show HSF1 Proteins) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (show DDIT3 Proteins) and increasing HSP70 (show HSP70 Proteins) a5 (BiP/GRP78 (show HSPA5 Proteins)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Proteins) being one likely key player in both systems.

  4. Results may provide support for the hypothesis that enhanced expression of tau following lipopolysaccharide administration is a protective measure by hippocampal neurons to compensate for the loss of the microtubule-stabilizing protein due to phosphorylation. More importantly, our results support the hypothesis that blocking the production of Abeta (show APP Proteins) that follows inflammation also leads to reduced tau phosphorylation

  5. Study identified microtubule-associated protein tau as a highly sensitive constituent of the cytoskeleton in the presence of experimental stroke, thus providing novel evidence for a pivotal role of cytoskeletal elements under ischemic conditions

  6. These findings suggest that TDP-43 (show TARDBP Proteins) promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43 (show TARDBP Proteins), truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 (show TARDBP Proteins) mislocalization to the cytoplasm.

  7. Abeta (show APP Proteins) monomers physiologically favor Tau activity and dendritic sprouting, whereas their excess causes Tau pathology

  8. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e (show CSNK1E Proteins) may contribute to individual differences in von Frey filament response.

  9. Loss of endothelial NO plays an important role in the generation of p25 (show CDK5R1 Proteins) and resulting tau phosphorylation in neuronal tissue. Endothelial nitric oxide synthase (eNOS (show NOS3 Proteins))-deficient (eNOS (show NOS3 Proteins)-/-) mice display increased levels of p25 (show CDK5R1 Proteins), an aberrant activator of cyclin-dependent kinase 5 (show CDK5 Proteins), which is one of the primary kinases responsible for tau hyperphosphorylation, and a statistically higher p25/p35 (show CDK5R1 Proteins) ratio.

  10. Fllowing severe closed head traumatic brain injury (sCHI), increasing levels of biochemically assayed T-Tau and P-Tau in the brains were associated with the PrPC (show PRNP Proteins) expression levels, -Tau concentration in the blood was associated with PrPC (show PRNP Proteins) expression in the absence of significant T-Tau changes; relationship was demonstrated between the presence/absence of PrPC (show PRNP Proteins), the levels of P-Tau and cognitive dysfunction

Human Microtubule-Associated Protein tau (MAPT) interaction partners

  1. A phosphomimetic mutation S262E within tau microtubule-binding sites impairs EB1 (show MAPRE2 Proteins)/tau interaction. This S262E-tau mutant does not inhibit the formation of EB comets. Our results further show that the parameters of microtubule dynamics change depending on the combined activities of EB1 (show MAPRE2 Proteins) and tau proteins. Taken together, our data support a novel mechanism by which tau directly regulates EB1 (show MAPRE2 Proteins) properties at microtubule ends.

  2. Our data suggest that although (18)F-AV-1451 SUVR curves do not reach a plateau and are still increasing in AD, an SUVR calculated over an imaging window of 80-100 min (as currently used in clinical studies) provides estimates of paired helical filament tau burden in good correlation with BPND, whereas SUVR sensitivity to regional cerebral blood changes needs further investigation.

  3. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta (show APP Proteins)). Because Abeta (show APP Proteins) and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

  4. Data suggest that a presumed diffusion barrier within axon initial segment (AIS (show AR Proteins)) regulates wild-type Tau sorting: retrograde (axon-to-soma) and anterograde (soma-to-axon) sorting of Tau. Tau isoforms without N-terminal inserts are sorted efficiently into axons; a longer isoform (2N4R-Tau) is partially retained in cell bodies/dendrites and accelerates spine/dendrite growth.

  5. a complete screening for mutations in MAPT, GRN (show GRN Proteins) and C9ORF72 (show C9ORF72 Proteins) genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  6. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 (show ARF6 Proteins) signaling.

  7. The data indicate that microtubule-bound tau is resistant to 14-3-3zeta (show YWHAZ Proteins)-induced tau aggregation and suggest that tau phosphorylation promotes tau aggregation in the brain by detaching tau from microtubules and thus making it accessible to 14-3-3zeta (show YWHAZ Proteins).

  8. This study for the first time reports the concentration of Tau and p-Tau181 in serum of AD and MCI (show MCIN Proteins) patients. The cutoff values of Tau and p-Tau181 of AD and MCI (show MCIN Proteins) patients with sensitivity and specificity reveal that serum level of these proteins can be used as a predictive marker for AD and MCI (show MCIN Proteins).

  9. our study demonstrated that miR (show MLXIP Proteins)-186 regulates the chemoresistance of NSCLC cells by modulating the MAPT expression level both in vitro and in vivo.

  10. MAPT-AS1 (show PTGDR Proteins) and DNMT1 (show DNMT1 Proteins) have been identified as potential epigenetic regulators of MAPT expression in PD across four different brain regions. Our data also suggest that increased MAPT expression could be associated with disease state, but not with PD neuropathology severity.

Cow (Bovine) Microtubule-Associated Protein tau (MAPT) interaction partners

  1. Findings suggest that the endothelin-1 (show EDN1 Proteins)-induced down-regulation of NaV1.7 (SCN9A (show SCN9A Proteins)) diminishes NaV1.7 (show SCN9A Proteins)-related catecholamine secretion and dephosphorylation of tau.

  2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN Proteins).

  3. show that cathepsin D (show CTSD Proteins) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (show APP Proteins) are involved in the pathogenesis of Alzheimer's disease

  4. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  5. We conclude that GSK3beta phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.

Rhesus Monkey Microtubule-Associated Protein tau (MAPT) interaction partners

  1. age-related increase in cAMP-dependent protein kinase (show CDK7 Proteins) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (show CA2 Proteins)+)-storing spine apparatus.

Chimpanzee Microtubule-Associated Protein tau (MAPT) interaction partners

  1. We found that inversion of the MAPT region is similarly polymorphic in other great ape species, and we present evidence that the inversions occurred independently in chimpanzees and humans

MAPT Protein Profile

Protein Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Alternative names and synonyms associated with MAPT

  • microtubule-associated protein tau (mapt)
  • microtubule-associated protein tau (MAPT)
  • microtubule-associated protein tau (AaeL_AAEL015538)
  • microtubule-associated protein tau (AaeL_AAEL012206)
  • microtubule-associated protein tau (CpipJ_CPIJ013260)
  • Microtubule-associated protein tau (tau)
  • casein kinase 1, epsilon (Csnk1e)
  • microtubule-associated protein tau (Mapt)
  • AI413597 protein
  • AI426939 protein
  • AI551861 protein
  • AW045860 protein
  • AW457082 protein
  • CK1epsilon protein
  • CKIe protein
  • DDPAC protein
  • FTDP-17 protein
  • KC1epsilon protein
  • MAPT protein
  • MAPTL protein
  • MSTD protein
  • Mtapt protein
  • MTBT1 protein
  • MTBT2 protein
  • PHF-tau protein
  • PPND protein
  • pTau protein
  • RNPTAU protein
  • Tau protein
  • xtp protein

Protein level used designations for MAPT

tau-like protein , tau-like protein-2 , microtubule-associated protein tau , Microtubule-associated protein tau , CKI, epsilon , CKI-epsilon , KC1 epsilon , casein kinase I isoform epsilon , G protein beta1/gamma2 subunit-interacting factor 1 , PHF-tau , neurofibrillary tangle protein , paired helical filament-tau , microtubule associated protein tau , Neurofibrillary tangle protein , Paired helical filament-tau , Tau microtubule-associated protein

398307 Xenopus laevis
426737 Gallus gallus
5579355 Aedes aegypti
5580230 Aedes aegypti
6046480 Culex quinquefasciatus
100054638 Equus caballus
100306810 Salmo salar
27373 Mus musculus
4137 Homo sapiens
281296 Bos taurus
17762 Mus musculus
100860820 Capra hircus
29477 Rattus norvegicus
480488 Canis lupus familiaris
574327 Macaca mulatta
450177 Pan troglodytes
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