Browse our anti-MCL-1 (MCL1) Antibodies

Full name:
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Antibodies (MCL1)
On www.antibodies-online.com are 340 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies from 32 different suppliers available. Additionally we are shipping MCL-1 Kits (21) and MCL-1 Proteins (13) and many more products for this protein. A total of 394 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM

Most Popular Reactivities for anti-MCL-1 (MCL1) Antibodies

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anti-Mouse (Murine) MCL-1 Antibodies:

anti-Rat (Rattus) MCL-1 Antibodies:

anti-Human MCL-1 Antibodies:

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Top referenced anti-MCL-1 Antibodies

  1. Human Monoclonal MCL-1 Primary Antibody for IP, WB - ABIN967637 : Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 6 references for 967637

  2. Human Polyclonal MCL-1 Primary Antibody for FACS, IHC (p) - ABIN388105 : Nijhawan, Fang, Traer, Zhong, Gao, Du, Wang: Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. in Genes & development 2003 (PubMed)
    Show all 5 references for 388105

  3. Human Polyclonal MCL-1 Primary Antibody for IF (p), IHC (p) - ABIN675369 : Zhang, Liu, Xia, Zhang, Zhang, Zhao, Chao, Jiang, Jiang: Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. in International journal of molecular medicine 2013 (PubMed)
    Show all 4 references for 675369

  4. Human Polyclonal MCL-1 Primary Antibody for IHC (p), WB - ABIN657627 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 3 references for 657627

  5. Human Polyclonal MCL-1 Primary Antibody for IP, IHC - ABIN222889 : Wang, Chen, Zeng, Bai, Tesfaigzi, Belinsky, Lin: Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for 222889

  6. Human Polyclonal MCL-1 Primary Antibody for EIA, IHC (p) - ABIN356822 : Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. in Blood 2006 (PubMed)

  7. Human Polyclonal MCL-1 Primary Antibody for ELISA, WB - ABIN185242 : Opferman, Letai, Beard, Sorcinelli, Ong, Korsmeyer: Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. in Nature 2003 (PubMed)

  8. Human Polyclonal MCL-1 Primary Antibody for IF, IHC (p) - ABIN303283 : Kozopas, Yang, Buchan, Zhou, Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

More Antibodies against MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells

  2. BCL-XL (show BCL2L1 Antibodies) expression promotes survival of immature B cells, expression of BCL-2 (show BCL2 Antibodies) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.

  3. miR (show MLXIP Antibodies)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.

  4. GSK3B (show GSK3b Antibodies)-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.

  5. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Antibodies) signaling pathway is the primary mediator of Mcl-1 expression.

  6. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  7. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies) overexpressing B cell progenitors.

  8. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Antibodies)-driven lymphomagenesis.

  9. High Mcl-1 levels enhanced mTOR (show FRAP1 Antibodies) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Antibodies) T cells.

  10. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells

  2. MACC1 (show MACC1 Antibodies) regulates Fas (show FAS Antibodies) mediated apoptosis through STAT1 (show STAT1 Antibodies)/3 - Mcl-1 signaling in solid cancers.

  3. dual inhibition of Mcl-1 via decreased expression and the induction of its antagonist NOXA (show PMAIP1 Antibodies) by the combination of carfilzomib and TG02 is active in myeloma

  4. Our findings establish a pivotal role for Mcl-1 degradation in the response of colon cancer cells to targeted therapeutics, and they provide a useful rational platform to develop Mcl-1-targeting agents that can overcome drug resistance

  5. comparison of patient samples prior to and following sunitinib treatment suggested that increases in MCL-1 levels and mTORC1 activity correlate with resistance to sunitinib in patients.

  6. Overexpression of catalytically-active Akt (show AKT1 Antibodies) or knockdown of glycogen synthase kinase-3 (GSK3)-beta (show GSK3b Antibodies), a substrate for Akt (show AKT1 Antibodies), had little effect on Mcl-1 downregulation caused by S6K2 (show RPS6KB2 Antibodies) deficiency

  7. review summarizes the role of MCL-1 in B- and T-cell lymphoma

  8. Inhibition of SPHK1 (show SPHK1 Antibodies) in human acute myeloid leukemia (show BCL11A Antibodies) cells induces MCL1 degradation and caspase (show CASP3 Antibodies)-dependent cell death.

  9. bone marrow stroma is capable of inducing Mcl-1 dependence through the production of the plasma cell survival cytokine interleukin-6 (IL-6 (show IL6 Antibodies)).

  10. Mcl-1 is required for endothelial cell survival and the regulation of Ang II (show AGT Antibodies)-induced endothelial cell death.

MCL-1 (MCL1) Antigen Profile

Antigen Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1) antibody
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) antibody
  • AW556805 antibody
  • bcl2-L-3 antibody
  • BCL2L3 antibody
  • EAT antibody
  • mcl-1 antibody
  • MCL1-ES antibody
  • mcl1/EAT antibody
  • MCL1L antibody
  • MCL1S antibody
  • TM antibody

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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