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Browse our anti-MCL-1 (MCL1) Antibodies

Full name:
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Antibodies (MCL1)
On www.antibodies-online.com are 331 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies from 32 different suppliers available. Additionally we are shipping MCL-1 Kits (20) and MCL-1 Proteins (12) and many more products for this protein. A total of 383 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM

Most Popular Reactivities for anti-MCL-1 (MCL1) Antibodies

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anti-Mouse (Murine) MCL-1 Antibodies:

anti-Rat (Rattus) MCL-1 Antibodies:

anti-Human MCL-1 Antibodies:

All available anti-MCL-1 Antibodies

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Top referenced anti-MCL-1 Antibodies

  1. Human Polyclonal MCL-1 Primary Antibody for FACS, IHC (p) - ABIN388105 : Nijhawan, Fang, Traer, Zhong, Gao, Du, Wang: Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. in Genes & development 2003 (PubMed)
    Show all 5 references for ABIN388105

  2. Human Polyclonal MCL-1 Primary Antibody for IHC (p), WB - ABIN657627 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 3 references for ABIN657627

  3. Human Polyclonal MCL-1 Primary Antibody for IP, IHC - ABIN222889 : Wang, Chen, Zeng, Bai, Tesfaigzi, Belinsky, Lin: Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for ABIN222889

  4. Human Polyclonal MCL-1 Primary Antibody for ELISA, WB - ABIN185242 : Opferman, Letai, Beard, Sorcinelli, Ong, Korsmeyer: Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. in Nature 2003 (PubMed)

  5. Human Polyclonal MCL-1 Primary Antibody for IF, IHC (p) - ABIN303283 : Kozopas, Yang, Buchan, Zhou, Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

  6. Human Polyclonal MCL-1 Primary Antibody for EIA, IF - ABIN500254 : Edwards, Derouet, Howse, Moots: Regulation of neutrophil apoptosis by Mcl-1. in Biochemical Society transactions 2004 (PubMed)

  7. Human Polyclonal MCL-1 Primary Antibody for EIA, IHC (p) - ABIN356822 : Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. in Blood 2006 (PubMed)

More Antibodies against MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. miR (show MLXIP Antibodies)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.

  2. GSK3B (show GSK3b Antibodies)-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.

  3. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Antibodies) signaling pathway is the primary mediator of Mcl-1 expression.

  4. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  5. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies) overexpressing B cell progenitors.

  6. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Antibodies)-driven lymphomagenesis.

  7. High Mcl-1 levels enhanced mTOR (show FRAP1 Antibodies) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Antibodies) T cells.

  8. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

  9. Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.

  10. a mechanism of inverse coregulation between BECN1 (show BECN1 Antibodies) and MCL1 significantly contributes to their opposing roles in tumorigenesis

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. Therefore, the present data support a model whereby MCL-1 depletion increases 53BP1 (show TP53BP1 Antibodies) and RIF1 (show INSL6 Antibodies) colocalization at DNA double-strand break.

  2. in addition to MCL-1, BCL-XL (show BCL2L1 Antibodies) is heterogeneously expressed in HMCLs and patient samples. The expression profile of BCL-XL (show BCL2L1 Antibodies) relative to BCL-2 (show BCL2 Antibodies) and MCL-1 may be an important predictor of response to venetoclax sensitivity as a monotherapy and in combination with bortezomib.

  3. chidamide promotes Mcl-1 degradation through the ubiquitin-proteasome pathway, suppressing the maintenance of mitochondrial aerobic respiration by Mcl-1, and resulting in inhibition of pancreatic cancer cell proliferation.

  4. Bufalin induced cell apoptosis in H1975 cells may be through downregulation of Mcl-1. Proteasomal degradation of Mcl-1 via GSK-3beta (show GSK3b Antibodies) activation was involved in bufalin-induced apoptosis.

  5. BRAF (show BRAF Antibodies)(V600E)-mediated MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) activation can upregulate MCL-1 by phosphorylation/stabilization to confer apoptosis resistance that can be reversed by MCL-1 antagonism combined with cobimetinib, suggesting a novel therapeutic strategy against BRAF (show BRAF Antibodies)(V600E)-mutant CRCs

  6. sorafenib overcomes TRAIL resistance in renal cell carcinoma (show MOK Antibodies) by a mechanism that does not rely on Mcl-1 down-regulation but involves ROS (show ROS1 Antibodies) accumulation and increased activation of caspase-8 (show CASP8 Antibodies)

  7. These results suggest that mitochondrial Mcl-1 is an essential signaling mediator regulating the activation of autophagy and apoptosis during T. gondii infection.

  8. MCL1 has a role in lung cancer cell survival via chaperone-mediated autophagy

  9. this study reveals a vital role of MCL1 in retinoic acid -mediated survival of normal B cells

  10. knockdown of MCL-1 in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells

MCL-1 (MCL1) Antigen Profile

Antigen Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1) antibody
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) antibody
  • AW556805 antibody
  • bcl2-L-3 antibody
  • BCL2L3 antibody
  • EAT antibody
  • mcl-1 antibody
  • MCL1-ES antibody
  • mcl1/EAT antibody
  • MCL1L antibody
  • MCL1S antibody
  • TM antibody

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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