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Browse our anti-MCL-1 (MCL1) Antibodies

Full name:
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Antibodies (MCL1)
On www.antibodies-online.com are 303 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies from 31 different suppliers available. Additionally we are shipping MCL-1 Kits (15) and MCL-1 Proteins (8) and many more products for this protein. A total of 345 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM

Most Popular Reactivities for anti-MCL-1 (MCL1) Antibodies

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anti-Mouse (Murine) MCL-1 Antibodies:

anti-Rat (Rattus) MCL-1 Antibodies:

anti-Human MCL-1 Antibodies:

All available anti-MCL-1 Antibodies

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Top referenced anti-MCL-1 Antibodies

  1. Human Polyclonal MCL-1 Primary Antibody for FACS, IHC (p) - ABIN388105 : Nijhawan, Fang, Traer, Zhong, Gao, Du, Wang: Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. in Genes & development 2003 (PubMed)
    Show all 5 references for ABIN388105

  2. Human Polyclonal MCL-1 Primary Antibody for IHC (p), WB - ABIN657627 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 3 references for ABIN657627

  3. Human Polyclonal MCL-1 Primary Antibody for IP, IHC - ABIN222889 : Wang, Chen, Zeng, Bai, Tesfaigzi, Belinsky, Lin: Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for ABIN222889

  4. Human Polyclonal MCL-1 Primary Antibody for ELISA, WB - ABIN185242 : Opferman, Letai, Beard, Sorcinelli, Ong, Korsmeyer: Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. in Nature 2003 (PubMed)

  5. Human Polyclonal MCL-1 Primary Antibody for IF, IHC (p) - ABIN303283 : Kozopas, Yang, Buchan, Zhou, Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

  6. Human Polyclonal MCL-1 Primary Antibody for EIA, IF - ABIN500256 : Edwards, Derouet, Howse, Moots: Regulation of neutrophil apoptosis by Mcl-1. in Biochemical Society transactions 2004 (PubMed)

  7. Human Polyclonal MCL-1 Primary Antibody for EIA, IHC (p) - ABIN356822 : Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. in Blood 2006 (PubMed)

More Antibodies against MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. High Mcl-1 levels enhanced mTOR (show FRAP1 Antibodies) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Antibodies) T cells.

  2. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

  3. Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.

  4. a mechanism of inverse coregulation between BECN1 (show BECN1 Antibodies) and MCL1 significantly contributes to their opposing roles in tumorigenesis

  5. There is a non-redundant pathway linking IL-15 (show IL15 Antibodies) to Mcl1 in the maintenance of NK cells and innate immune responses in vivo.

  6. Authors recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF pool, growing follicle survival and effective oocyte mitochondrial function.

  7. Tax (show CNTN2 Antibodies) interacted with and activated TRAF6 (show TRAF6 Antibodies), and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin (show UBB Antibodies) chains

  8. deletion of Mir155 prevents Fas (show FAS Antibodies)-induced hepatocyte apoptosis and liver injury through the up-regulation of Mcl1.

  9. Inverse co-regulation of Beclin 1 (show BECN1 Antibodies) and Mcl-1 represents a mechanism of functional counteraction in cancer.

  10. miR (show MLXIP Antibodies)-29a is involved in the pathogenesis of ulcerative colitis by regulating intestinal epithelial apoptosis via Mcl-1.

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1 (show MAP2K1 Antibodies)/2 inhibitors in melanoma.

  2. identify high copy number gain of MCL1 (chromosome 1q) and loss of CDKN2A (P16 (show CDKN2A Antibodies), chromosome 9p) in metastatic BRAF (show BRAF Antibodies)

  3. Our data demonstrate a critical role of Mcl-1 in Her2 (show ERBB2 Antibodies)-positive BC cell survival under hypoxic conditions and provide the preclinical framework for the therapeutic use of novel Mcl-1- targeting agents to improve patient outcome in breast cancer .

  4. miR (show MLXIP Antibodies)-193b sensitizes MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1

  5. Co-administration of the mTORC1/TORC2 (show CRTC2 Antibodies) inhibitor INK128 and the Bcl-2 (show BCL2 Antibodies)/Bcl-xL (show BCL2L1 Antibodies) antagonist ABT-737 kills human myeloid leukemia (show BCL11A Antibodies) cells through Mcl-1 down-regulation and AKT (show AKT1 Antibodies) inactivation.

  6. Bak (show BAK1 Antibodies) activates upon loss of anti-apoptotic Bcl-XL (show BCL2L1 Antibodies) and Mcl-1 but in the absence of active BH3-only (show BBC3 Antibodies) proteins.

  7. LA provoked a down regulation of two anti-apoptotic proteins, Mcl-1 and Bcl-xL (show BCL2L1 Antibodies) protein and a strong induction of the BH3-only (show BBC3 Antibodies) protein Bim (show BCL2L11 Antibodies).

  8. AZD5582 draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 (show BIRC2 Antibodies) and XIAP (show XIAP Antibodies) in human pancreatic cancer

  9. the FoxM1 (show FOXM1 Antibodies)/Mcl-1 pathway may overcome cispaltin resistance of gastric cancer and provide a new therapeutic target for the treatment of gastric cancer

  10. Upregulation of miR (show MLXIP Antibodies)-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR (show MLXIP Antibodies)-125b elicits these responses by directly targeting MCL1, which results in a marked reduction in MCL1 expression.

MCL-1 (MCL1) Antigen Profile

Antigen Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1) antibody
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) antibody
  • AW556805 antibody
  • bcl2-L-3 antibody
  • BCL2L3 antibody
  • EAT antibody
  • mcl-1 antibody
  • MCL1-ES antibody
  • mcl1/EAT antibody
  • MCL1L antibody
  • MCL1S antibody
  • TM antibody

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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