Browse our anti-MCL-1 (MCL1) Antibodies

Full name:
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Antibodies (MCL1)
On www.antibodies-online.com are 337 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies from 32 different suppliers available. Additionally we are shipping MCL-1 Kits (20) and MCL-1 Proteins (12) and many more products for this protein. A total of 389 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM

Most Popular Reactivities for anti-MCL-1 (MCL1) Antibodies

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anti-Mouse (Murine) MCL-1 Antibodies:

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Top referenced anti-MCL-1 Antibodies

  1. Human Monoclonal MCL-1 Primary Antibody for IP, WB - ABIN967637 : Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 6 references for 967637

  2. Human Polyclonal MCL-1 Primary Antibody for FACS, IHC (p) - ABIN388105 : Nijhawan, Fang, Traer, Zhong, Gao, Du, Wang: Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. in Genes & development 2003 (PubMed)
    Show all 5 references for 388105

  3. Human Polyclonal MCL-1 Primary Antibody for IF (p), IHC (p) - ABIN675369 : Zhang, Liu, Xia, Zhang, Zhang, Zhao, Chao, Jiang, Jiang: Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. in International journal of molecular medicine 2013 (PubMed)
    Show all 4 references for 675369

  4. Human Polyclonal MCL-1 Primary Antibody for IHC (p), WB - ABIN657627 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 3 references for 657627

  5. Human Polyclonal MCL-1 Primary Antibody for IP, IHC - ABIN222889 : Wang, Chen, Zeng, Bai, Tesfaigzi, Belinsky, Lin: Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for 222889

  6. Human Polyclonal MCL-1 Primary Antibody for ELISA, WB - ABIN185242 : Opferman, Letai, Beard, Sorcinelli, Ong, Korsmeyer: Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. in Nature 2003 (PubMed)

  7. Human Polyclonal MCL-1 Primary Antibody for EIA, IHC (p) - ABIN356822 : Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. in Blood 2006 (PubMed)

  8. Human Polyclonal MCL-1 Primary Antibody for IF, IHC (p) - ABIN303283 : Kozopas, Yang, Buchan, Zhou, Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

More Antibodies against MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. miR (show MLXIP Antibodies)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.

  2. GSK3B (show GSK3b Antibodies)-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.

  3. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Antibodies) signaling pathway is the primary mediator of Mcl-1 expression.

  4. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  5. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies) overexpressing B cell progenitors.

  6. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Antibodies)-driven lymphomagenesis.

  7. High Mcl-1 levels enhanced mTOR (show FRAP1 Antibodies) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Antibodies) T cells.

  8. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

  9. Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.

  10. a mechanism of inverse coregulation between BECN1 (show BECN1 Antibodies) and MCL1 significantly contributes to their opposing roles in tumorigenesis

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. review summarizes the role of MCL-1 in B- and T-cell lymphoma

  2. Inhibition of SPHK1 (show SPHK1 Antibodies) in human acute myeloid leukemia (show BCL11A Antibodies) cells induces MCL1 degradation and caspase (show CASP3 Antibodies)-dependent cell death.

  3. bone marrow stroma is capable of inducing Mcl-1 dependence through the production of the plasma cell survival cytokine interleukin-6 (IL-6 (show IL6 Antibodies)).

  4. Mcl-1 is required for endothelial cell survival and the regulation of Ang II (show AGT Antibodies)-induced endothelial cell death.

  5. Repression of Mcl-1 and disruption of the Mcl-1/Bak (show BAK1 Antibodies) interaction in myeloma cells couple ER stress to mitochondrial apoptosis triggered by thapsigargin.

  6. The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1) expression and c-Jun N-terminal kinase 1 (JNK1 (show MAPK8 Antibodies)) activation and subsequent Bcl-xL (show BCL2L1 Antibodies) protein degradation.

  7. Knockdown of endogenous Mcl-1 by RNA interference significantly accelerated the repair of DNA lesions in glycochenodeoxycholate-treated cells. However, unlike XRCC1 (show XRCC1 Antibodies), poly(ADP-ribose) polymerase (show PARP1 Antibodies) was induced following Mcl-1 knockdown. Conversely, poly(ADP-ribose) polymerase (show PARP1 Antibodies) suppression was observed following glycochenodeoxycholate treatment of cells overexpressing Mcl-1

  8. identified the apoptotic regulator MCL-1 as the only pro-survival BCL-2 (show BCL2 Antibodies) family member to be highly expressed throughout all human T-NHL (show RTEL1 Antibodies) subtypes

  9. these results suggest that SIRT6 (show SIRT6 Antibodies) enhances cell aggressiveness in PTC (show F9 Antibodies) via BRAF (show BRAF Antibodies)/ERK (show EPHB2 Antibodies)/Mcl1 pathway, and thus may be a promising target in the treatment of the disease.

  10. The expression of MCL-1 in prostate cancer tissues was much higher than that in normal prostate tissues.

MCL-1 (MCL1) Antigen Profile

Antigen Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1) antibody
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) antibody
  • AW556805 antibody
  • bcl2-L-3 antibody
  • BCL2L3 antibody
  • EAT antibody
  • mcl-1 antibody
  • MCL1-ES antibody
  • mcl1/EAT antibody
  • MCL1L antibody
  • MCL1S antibody
  • TM antibody

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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