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Browse our anti-MCL-1 (MCL1) Antibodies

Full name:
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Antibodies (MCL1)
On www.antibodies-online.com are 339 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) Antibodies from 31 different suppliers available. Additionally we are shipping MCL-1 Kits (16) and MCL-1 Proteins (9) and many more products for this protein. A total of 383 MCL-1 products are currently listed.
Synonyms:
AW556805, bcl2-L-3, BCL2L3, EAT, mcl-1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM

Most Popular Reactivities for anti-MCL-1 (MCL1) Antibodies

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anti-Mouse (Murine) MCL-1 Antibodies:

anti-Rat (Rattus) MCL-1 Antibodies:

anti-Human MCL-1 Antibodies:

All available anti-MCL-1 Antibodies

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Top referenced anti-MCL-1 Antibodies

  1. Human Polyclonal MCL-1 Primary Antibody for FACS, IHC (p) - ABIN388105 : Nijhawan, Fang, Traer, Zhong, Gao, Du, Wang: Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. in Genes & development 2003 (PubMed)
    Show all 5 references for ABIN388105

  2. Human Polyclonal MCL-1 Primary Antibody for IHC (p), WB - ABIN657627 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 3 references for ABIN657627

  3. Human Polyclonal MCL-1 Primary Antibody for IP, IHC - ABIN222889 : Wang, Chen, Zeng, Bai, Tesfaigzi, Belinsky, Lin: Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. in Molecular cancer therapeutics 2008 (PubMed)
    Show all 2 references for ABIN222889

  4. Human Polyclonal MCL-1 Primary Antibody for IF, IHC (p) - ABIN303283 : Kozopas, Yang, Buchan, Zhou, Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)

  5. Human Polyclonal MCL-1 Primary Antibody for EIA, IF - ABIN500256 : Edwards, Derouet, Howse, Moots: Regulation of neutrophil apoptosis by Mcl-1. in Biochemical Society transactions 2004 (PubMed)

  6. Human Polyclonal MCL-1 Primary Antibody for ELISA, WB - ABIN185242 : Opferman, Letai, Beard, Sorcinelli, Ong, Korsmeyer: Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. in Nature 2003 (PubMed)

  7. Human Polyclonal MCL-1 Primary Antibody for EIA, IHC (p) - ABIN356822 : Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. in Blood 2006 (PubMed)

More Antibodies against MCL-1 Interaction Partners

Mouse (Murine) Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (show MAPK1 Antibodies) signaling pathway is the primary mediator of Mcl-1 expression.

  2. MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell

  3. Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies) overexpressing B cell progenitors.

  4. MCL-1 loss in early B-lymphoid progenitors delayed MYC (show MYC Antibodies)-driven lymphomagenesis.

  5. High Mcl-1 levels enhanced mTOR (show FRAP1 Antibodies) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (show CD8A Antibodies) T cells.

  6. Data suggest Leishmania donovani exploits host anti-apoptotic protein MCL-1 to prevent apoptosis of host macrophages upon treatment with antiparasitic agents; thus, L. donovani protects its host, a factor in progression of visceral leishmaniasis.

  7. Data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation.

  8. a mechanism of inverse coregulation between BECN1 (show BECN1 Antibodies) and MCL1 significantly contributes to their opposing roles in tumorigenesis

  9. There is a non-redundant pathway linking IL-15 (show IL15 Antibodies) to Mcl1 in the maintenance of NK cells and innate immune responses in vivo.

  10. Authors recognize MCL-1 as the essential survival factor required for conservation of the postnatal PMF pool, growing follicle survival and effective oocyte mitochondrial function.

Human Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) interaction partners

  1. In particular, the treatment with the cocrystal MetH(2 (show ADAMTS8 Antibodies))(++)*2DCA(-) induced a synergistic apoptotic cell death coupled to a marked down-modulation of the anti-apoptotic Mcl-1 protein.

  2. these findings provided that in lung cancer cells, tumor suppressor miR (show MLXIP Antibodies)-451 enhanced DPP (show DSPP Antibodies) sensitivity via regulation of Mcl-1 expression, which could be served as a novel therapeutic target for the treatment of chemotherapy resistant in lung cancer.

  3. This review covers findings on how the mitochondrial fission and fusion machinery may intersect apoptotic pathways focusing on recent advances on the key role played by Mcl-1. [review]

  4. However, because mitotic degradation of Mcl-1 appears not to be under the control of an E3 ligase, we suggest that the notion of network crosstalk is used with caution.

  5. Results indicated that the pro-survival Bcl-2 (show BCL2 Antibodies) family protein MCL-1 may be the key target for reversing the cisplatin-resistance in non-small cell lung cancer cells.

  6. we demonstrate that M. tuberculosis infection leads to downregulation of miR-17 and concomitant upregulation of its targets Mcl-1 and STAT3 (show STAT3 Antibodies), a transcriptional activator of Mcl-1. Forced expression of miR-17 reduces expression of Mcl-1 and STAT3 (show STAT3 Antibodies) and also the interaction between Mcl-1 and Beclin-1 (show BECN1 Antibodies)

  7. By the pharmacologic targeting of BCL2 (show BCL2 Antibodies), MCL1, and BCL-XL (show BCL2L1 Antibodies), we demonstrated that diffuse large B-cell lymphoma can be divided into BCL2 (show BCL2 Antibodies)-dependent and MCL1-dependent subgroups with a less pronounced role left for BCL-XL (show BCL2L1 Antibodies).

  8. Inhibition of Mcl-1 is required for apoptosis induction in ATRA differentiation-responsive AML (show RUNX1 Antibodies) cells. ATRA and sorafenib can be developed as a novel drug combination therapy for AML (show RUNX1 Antibodies) patients because this drug combination augments apoptosis by inhibiting Bcl-2 (show BCL2 Antibodies) and Mcl-1.

  9. miR (show MLXIP Antibodies)-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer cells via targeting BCL2 (show BCL2 Antibodies), BCL2L12 (show BCL2L12 Antibodies) and Mcl-1.

  10. JAK3 (show JAK3 Antibodies) and MCL-1 were down-regulated in patient CD8 (show CD8A Antibodies)(+) T cells versus their normal counterparts, likely due to defective suppressor activity of miR (show MLXIP Antibodies)-29b and miR (show MLXIP Antibodies)-198 in RCC (show XRCC1 Antibodies) CD8 (show CD8A Antibodies)(+) T cells.

MCL-1 (MCL1) Antigen Profile

Antigen Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Alternative names and synonyms associated with MCL-1 (MCL1)

  • myeloid cell leukemia sequence 1 (Mcl1) antibody
  • myeloid cell leukemia sequence 1 (BCL2-related) (MCL1) antibody
  • AW556805 antibody
  • bcl2-L-3 antibody
  • BCL2L3 antibody
  • EAT antibody
  • mcl-1 antibody
  • MCL1-ES antibody
  • mcl1/EAT antibody
  • MCL1L antibody
  • MCL1S antibody
  • TM antibody

Protein level used designations for MCL1

bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog , bcl-2-like protein 3 , induced myeloid leukemia cell differentiation protein Mcl-1 , myeloid cell leukemia ES , myeloid cell leukemia protein 1

GENE ID SPECIES
17210 Mus musculus
60430 Rattus norvegicus
4170 Homo sapiens
403537 Canis lupus familiaris
493970 Felis catus
397648 Sus scrofa
788087 Bos taurus
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