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Human RGS1 Protein expressed in Escherichia coli (E. coli) - ABIN1098296
Bowman, Campbell, Druey, Scheschonka, Kehrl, Butcher: Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. in The Journal of biological chemistry 1998
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Rgs1 has a role in leukocyte trafficking and vascular inflammation
Variations in Gnai2 (show GNAI2 Proteins) and Rgs1 expression affect chemokine receptor (show CCR1 Proteins) signaling and the organization of secondary lymphoid organs.
RGS1 can modulate the expression of costimulatory molecules and cytokine secretion, and interrupt Toll (show TLR4 Proteins) like receptor signal pathways, which suggest that RGS1 may play a role in regulating immune responses.
Rgs1(-/-) mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 (show CXCL12 Proteins) and CXCL13 (show CXCL13 Proteins). Many of the B-cell follicles in the spleens of Rgs1(-/-) mice have germinal centers even in the absence of immune stimulation.
RGS1 as a potential marker of CRC (show CALR Proteins) tissue quality
RGS1 suppresses CXCL12 (show CXCL12 Proteins)-mediated migration and AKT (show AKT1 Proteins) activation in cultured human plasmacytoma cells and plasmablasts.
RGS1 and TNFRSF1A (show TNFRSF1A Proteins) polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis.
RGS1 is largely upregulated, whereas RGS2 (show RGS2 Proteins) is downregulated in the majority of solid tumors, whereas RGS5 (show RGS5 Proteins) transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies
Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders.
Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines
RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease.
Overexpression of RGS1 in progenitor pro-B cells (which have little endogenous RGS1) impairs CXCL12-induced focal adhesion kinase activation, chemotaxis, and adhesion to membrane domains.
RGS1 and RGS13 (show RGS13 Proteins) act together to regulate chemokine receptor (show CCR1 Proteins) signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
regulator of G-protein signaling 1
, regulator of G-protein signaling protein-like
, regulator of G-protein signalling 1
, B-cell activation protein BL34
, early response protein 1R20
, immediate-early response 1, B-cell specific
, Regulator of G-protein signaling 1-like protein