Browse our RPS6KA1 Proteins (RPS6KA1)

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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 Proteins (RPS6KA1)
On are 12 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Proteins from 8 different suppliers available. Additionally we are shipping RPS6KA1 Antibodies (393) and RPS6KA1 Kits (10) and many more products for this protein. A total of 426 RPS6KA1 products are currently listed.
CLS, hu-1, HU-3, ISPK-1, mapkapk1a, MAPKAPK1B, MRX19, p90-RSK2, p90rsk, pp90RSK2, RPS6KA, RSK, rsk1, RSK2, S6K-alpha3
list all proteins Gene Name GeneID UniProt
RPS6KA1 20111  
Rat RPS6KA1 RPS6KA1 81771 Q63531
RPS6KA1 6195 Q15418

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RPS6KA1 Proteins (RPS6KA1) by Origin

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More Proteins for RPS6KA1 Interaction Partners

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) interaction partners

  1. In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (show PER1 Proteins)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery

  2. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 Proteins))-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  3. IL-6 (show IL6 Proteins) induces the activation of the Stat3 (show STAT3 Proteins) signaling and promotes the downmodulation of the p90RSK/eEF2 (show EEF2 Proteins) and mTOR (show FRAP1 Proteins)/p70S6K (show RPS6KB1 Proteins) axes, while it does not affect the activation of AKT (show AKT1 Proteins).

  4. analysis of p38 (show CRK Proteins)-MK2 (show KCNA2 Proteins)-activated Rsk signaling in toll (show TLR4 Proteins)-like receptor-stimulated dendritic cells

  5. These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (show EPHB2 Proteins), which for quetiapine occurs via an EGFR (show EGFR Proteins)-linked mechanism, possibly indicating involvement of this system in its action.

  6. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (show SLC9A1 Proteins) induces cardiomyocyte apoptosis.

  7. RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.

  8. Our study highlights the importance of the p90RSK/ERK5 (show MAPK7 Proteins) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.

  9. Results show increased protein levels of Rsk1 and Rsk2 (show RPS6KA3 Proteins) in the striatum of Huntington disease (show HTT Proteins) mice and and striatal cells transfected with full-length mutant Huntingtin (show HTT Proteins).

  10. Type I keratin (show KRT12 Proteins) 17 (show KRT17 Proteins) protein is phosphorylated on serine 44 by p90 (show GPAM Proteins) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) interaction partners

  1. Inhibition of RSK2 (show RPS6KA3 Proteins) was used to investigate the function of RSK2 (show RPS6KA3 Proteins) on PDK1 (show PDK1 Proteins)-induced inflammation. The phosphorylation of RSK2 (show RPS6KA3 Proteins) was detected when PDK1 (show PDK1 Proteins) was inhibited. Inhibition of RSK2 (show RPS6KA3 Proteins) reduced the PDK1 (show PDK1 Proteins)-induced cell invasion and cytokines secretion in human rheumatoid arthritis synovial MH7A cells. In response to TNF-alpha (show TNF Proteins), PDK1 (show PDK1 Proteins) could phosphorylate RSK2 (show RPS6KA3 Proteins) and activated RSK2 (show RPS6KA3 Proteins), then promoting the activation of NF-kappaB (show NFKB1 Proteins).

  2. Our finding demonstrates that RSK2 (show RPS6KA3 Proteins) directly phosphorylates stathmin (show STMN1 Proteins) and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2 (show RPS6KA3 Proteins)-stathmin (show STMN1 Proteins) pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.

  3. Data suggest that UBR5 down-regulates levels of TRAF3 (show TRAF3 Proteins), a key component of Toll (show TLR4 Proteins)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5; p90RSK phosphorylates UBR5 as required for translational repression of TRAF3 (show TRAF3 Proteins) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (show TRAF3 Proteins) = TNF receptor-associated factor 3 (show TRAF3 Proteins); p90RSK = 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins))

  4. Data indicate that BTG2 (show BTG2 Proteins), MAP3K11 (show MAP3K11 Proteins), RPS6KA1 and PRDM1 (show PRDM1 Proteins) as putative targets of microRNA miR (show MLXIP Proteins)-125b.

  5. VEGF-A (show VEGFA Proteins) driven Mdm2 (show MDM2 Proteins) phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK signaling pathway in primary human endothelial cells.

  6. we discuss the function of the RSK2 (show RPS6KA3 Proteins) signaling axis by interactions with binding partners in cancer development--{REVIEW}

  7. Results showed that RSK2 (show RPS6KA3 Proteins) gene was overexpressed in osteosarcoma patients cells and its knockdown increased cell apoptosis, enhanced cell chemosensitivity, inhibits proliferation and migration, and weakened tumor formation.

  8. Upregulated expression of RSK2 (show RPS6KA3 Proteins) is associated with breast cancer.

  9. The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (show BID Proteins) may serve as an alternative cancer treatment in NSCLC.

  10. RSK1 binds to EBP50 (show SLC9A3R1 Proteins) at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 (show SLC9A3R1 Proteins) at T156, an event that is crucial for its nuclear localization

RPS6KA1 Protein Profile

Protein Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA1

  • ribosomal protein S6 kinase polypeptide 1 (Rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
  • CLS protein
  • hu-1 protein
  • HU-3 protein
  • ISPK-1 protein
  • mapkapk1a protein
  • MAPKAPK1B protein
  • MRX19 protein
  • p90-RSK2 protein
  • p90rsk protein
  • pp90RSK2 protein
  • RPS6KA protein
  • RSK protein
  • rsk1 protein
  • RSK2 protein
  • S6K-alpha3 protein

Protein level used designations for RPS6KA1

90 kDa ribosomal protein S6 kinase 1 , MAP kinase-activated protein kinase 1a , MAPK-activated protein kinase 1a , MAPKAP kinase 1a , MAPKAPK-1a , RSK-1 , S6K-alpha-1 , p90-RSK 1 , p90RSK1 , p90S6K , ribosomal S6 kinase 1 , ribosomal protein S6 kinase alpha-1 , ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1 , MAPKAPK1A , S6 protein kinase (Rsk-1) , S6K-alpha 1 , pp90RSK1 , dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1) , ribosomal protein S6 kinase alpha 1 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , S6KII-alpha , p90-RSK , ribosomal protein S6 kinase 2 alpha , ribosomal protein S6 kinase II alpha , P90-RSK , S6 kinase II beta , S6KII-beta , ribosomal protein S6 kinase 2 beta , ribosomal protein S6 kinase II beta , MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , insulin-stimulated protein kinase 1 , p90-RSK 3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase alpha-3

20111 Mus musculus
81771 Rattus norvegicus
533908 Bos taurus
6195 Homo sapiens
386579 Gallus gallus
487353 Canis lupus familiaris
100057166 Equus caballus
100523972 Sus scrofa
445821 Xenopus laevis
6197 Homo sapiens
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