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Browse our RPS6KA1 Proteins (RPS6KA1)

Full name:
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 Proteins (RPS6KA1)
On are 9 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Proteins from 6 different suppliers available. Additionally we are shipping RPS6KA1 Antibodies (381) and RPS6KA1 Kits (9) and many more products for this protein. A total of 409 RPS6KA1 products are currently listed.
CLS, hu-1, HU-3, ISPK-1, mapkapk1a, MAPKAPK1B, MRX19, p90-RSK2, p90rsk, pp90RSK2, RPS6KA, RSK, rsk1, RSK2, S6K-alpha3
list all proteins Gene Name GeneID UniProt
RPS6KA1 20111  
Rat RPS6KA1 RPS6KA1 81771 Q63531
RPS6KA1 6195 Q15418

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RPS6KA1 Proteins (RPS6KA1) by Origin

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More Proteins for RPS6KA1 Interaction Partners

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) interaction partners

  1. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 Proteins))-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  2. IL-6 (show IL6 Proteins) induces the activation of the Stat3 (show STAT3 Proteins) signaling and promotes the downmodulation of the p90RSK/eEF2 (show EEF2 Proteins) and mTOR (show FRAP1 Proteins)/p70S6K (show RPS6KB1 Proteins) axes, while it does not affect the activation of AKT (show AKT1 Proteins).

  3. analysis of p38 (show CRK Proteins)-MK2 (show KCNA2 Proteins)-activated Rsk signaling in toll (show TLR4 Proteins)-like receptor-stimulated dendritic cells

  4. These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (show EPHB2 Proteins), which for quetiapine occurs via an EGFR (show EGFR Proteins)-linked mechanism, possibly indicating involvement of this system in its action.

  5. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (show SLC9A1 Proteins) induces cardiomyocyte apoptosis.

  6. RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.

  7. Our study highlights the importance of the p90RSK/ERK5 (show MAPK7 Proteins) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.

  8. Results show increased protein levels of Rsk1 and Rsk2 (show RPS6KA3 Proteins) in the striatum of Huntington disease (show HTT Proteins) mice and and striatal cells transfected with full-length mutant Huntingtin (show HTT Proteins).

  9. Type I keratin (show KRT12 Proteins) 17 (show KRT17 Proteins) protein is phosphorylated on serine 44 by p90 (show GPAM Proteins) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion

  10. RSK plays a crucial role in regulating local cardiac renin (show REN Proteins), which contributes to I/R induced cardiac injury and dysfunction.

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) interaction partners

  1. Results showed that RSK2 (show RPS6KA3 Proteins) gene was overexpressed in osteosarcoma patients cells and its knockdown increased cell apoptosis, enhanced cell chemosensitivity, inhibits proliferation and migration, and weakened tumor formation.

  2. Upregulated expression of RSK2 (show RPS6KA3 Proteins) is associated with breast cancer.

  3. The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (show BID Proteins) may serve as an alternative cancer treatment in NSCLC.

  4. RSK1 binds to EBP50 (show SLC9A3R1 Proteins) at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 (show SLC9A3R1 Proteins) at T156, an event that is crucial for its nuclear localization

  5. Data show that the 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinases RSK1 and RSK2 (show RPS6KA3 Proteins) play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.

  6. RSK1 and 3 but not RSK2 (show RPS6KA3 Proteins) are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.

  7. This case is one of the few examples where RPS6KA3 (show RPS6KA3 Proteins) mutations are associated with a non-specific X-linked mental retardation.

  8. PKD2 (show PKD2 Proteins) and RSK1 regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.

  9. Results indicate that the phosphorylation of EphA2 (show EPHA2 Proteins) at Ser (show SIGLEC1 Proteins)-897 is controlled by RSK and the RSK-EphA2 (show EPHA2 Proteins) axis might contribute to cell motility and promote tumour malignant progression.

  10. miR (show MLXIP Proteins)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9 (show CDK9 Proteins), NOTCH2 (show NOTCH2 Proteins), and RPS6KA3 (show RPS6KA3 Proteins).

RPS6KA1 Protein Profile

Protein Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA1

  • ribosomal protein S6 kinase polypeptide 1 (Rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
  • CLS protein
  • hu-1 protein
  • HU-3 protein
  • ISPK-1 protein
  • mapkapk1a protein
  • MAPKAPK1B protein
  • MRX19 protein
  • p90-RSK2 protein
  • p90rsk protein
  • pp90RSK2 protein
  • RPS6KA protein
  • RSK protein
  • rsk1 protein
  • RSK2 protein
  • S6K-alpha3 protein

Protein level used designations for RPS6KA1

90 kDa ribosomal protein S6 kinase 1 , MAP kinase-activated protein kinase 1a , MAPK-activated protein kinase 1a , MAPKAP kinase 1a , MAPKAPK-1a , RSK-1 , S6K-alpha-1 , p90-RSK 1 , p90RSK1 , p90S6K , ribosomal S6 kinase 1 , ribosomal protein S6 kinase alpha-1 , ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1 , MAPKAPK1A , S6 protein kinase (Rsk-1) , S6K-alpha 1 , pp90RSK1 , dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1) , ribosomal protein S6 kinase alpha 1 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , S6KII-alpha , p90-RSK , ribosomal protein S6 kinase 2 alpha , ribosomal protein S6 kinase II alpha , P90-RSK , S6 kinase II beta , S6KII-beta , ribosomal protein S6 kinase 2 beta , ribosomal protein S6 kinase II beta , MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , insulin-stimulated protein kinase 1 , p90-RSK 3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase alpha-3

20111 Mus musculus
81771 Rattus norvegicus
533908 Bos taurus
6195 Homo sapiens
386579 Gallus gallus
487353 Canis lupus familiaris
100057166 Equus caballus
100523972 Sus scrofa
445821 Xenopus laevis
6197 Homo sapiens
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