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study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
STMN1 gene and miRNA-223 expression profiles in non-tumor liver tissues were predictive of the risk for multicentric hepatocellular carcinoma recurrence.
The crucial role of FOXM1 (show FOXM1 ELISA Kits) and STMN1 in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 and FOXM1 (show FOXM1 ELISA Kits) in NSCLC cells.
Our finding demonstrates that RSK2 (show RPS6KA3 ELISA Kits) directly phosphorylates stathmin and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2 (show RPS6KA3 ELISA Kits)-stathmin pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.
stathmin expression was significantly associated with shorter progression-free survival and overall survival for all analyzed cases of endometrial cancer; findings demonstrate that high stathmin expression is a poor prognostic marker in endometrial cancer
Integrin beta1 appears to serve as a partner of Stathmin induction of ERK (show EPHB2 ELISA Kits) and Akt (show AKT1 ELISA Kits) signaling by inhibiting apoptosis in the cholangiocarcinoma cell.
STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in gastric cancer (GC) and could be a novel therapeutic target in metastatic GC.
STMN1,COF1 (show CFL1 ELISA Kits) and PAIRBP1 (show SERBP1 ELISA Kits) thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 (show THBS2 ELISA Kits) and POSTN (show POSTN ELISA Kits) were connected to low grade tumors with better prognosis
The phosphorylation-specific association of STMN1 with GRP78 (show HSPA5 ELISA Kits) promotes breast cancer metastasis.
hese results suggested that STMN1 plays an important role in proliferation and migration of hypopharyngeal squamous cell carcinoma and may be used as a potential prognostic biomarker or therapeutic target of hypopharyngeal squamous cell carcinoma (HSCC) .
EGFR (show EGFR ELISA Kits) suppression of mitotic regulators including Rcc2 and Stathmin 1 are a mechanism for catagen induction in mouse skin
We identified stathmin as a key molecule aiding in septin (show SEPT6 ELISA Kits)-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7 (show SEPT7 ELISA Kits)-null fibroblasts
Overexpressing stathmin reduces complement receptor 3 (show ITGAM ELISA Kits)-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages.
Stathmin cooperates with p27(kip1 (show CDKN1B ELISA Kits)) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.
The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation.
Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons
Stathmin mutations disrupt changes in microtubule stability, GluA2 (show GRIA2 ELISA Kits) localization, synaptic plasticity and memory.
Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA (show SMN1 ELISA Kits) pathology.
stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers.
results demonstrate the mechanism of stathmin-dependent control of MT dynamics, Rho signaling, and permeability
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
, stathmin 1 a
, stathmin 1/oncoprotein 18
, stathmin 1/oncoprotein 18b
, stathmin 1
, leukemia-associated phosphoprotein p18
, phosphoprotein 19
, phosphoprotein p19
, transmembrane protein C1orf215
, leukemia associated phosphoprotein p18
, leukemia-associated gene protein
, leukemia-associated cytosolic phosphoprotein stathmin