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Human YAP1 Protein expressed in Wheat germ - ABIN1325497
Zhao, Zhou, Xue, Zhang, Zhan: Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). in PLoS ONE 2014
YAP was confirmed as indispensable transcription factor involved in CTGF (show CTGF Proteins) synthesis. Nuclear localization of YAP and TAZ (show TAZ Proteins) was reduced in DMOG-treated cells.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Proteins) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Proteins)) elasticity and cell shape.
miR (show MLXIP Proteins)-361 targets 3'UTR of YAP mRNA to depress the proliferation of lung cancer cells
T425A retained YAP in the cytoplasm without affecting the phosphorylation of YAP S127
SRSF3 (show SRSF3 Proteins)-regulated miR (show MLXIP Proteins)-132/212 controls cell migration and invasion by targeting YAP1
findings indicate that HIF-2alpha (show EPAS1 Proteins) increases cancer cell growth by up-regulating YAP1 activity
Results uncover a novel PKCiota-AMOT (show AMOT Proteins)-YAP1 signaling axis that promotes OSC (show LSS Proteins) tumor growth.
YAP inhibition significantly enhances the antitumor efficacy of a pan-RAF inhibitor, LY3009120, in KRAS-mutant pancreatic cancer.
High YAP expression is associated with pancreatic ductal adenocarcinoma.
High YAP1 expression is associated with triple-negative breast cancer.
identify the mesenchymal requirement of YAP/TAZ (show TAZ Proteins) in the gastrointestinal tract and highlight the functional interplays between Hippo and Hedgehog (show SHH Proteins) signaling underlying temporal and spatial control of tissue growth and specification in developing gut (show GUSB Proteins)
found that epidermal YAP activity drives GLI2 nuclear accumulation in the skin of YAP2-5SA-DeltaC mice, which depends on epidermal beta-catenin (show CTNNB1 Proteins) activation
Yap and Taz (show TAZ Proteins) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This study identifies YAP/TAZ as central mediators of VEGF signaling
These results suggest that YAP promotes muscle differentiation by activating the Abl (show ABL1 Proteins)/Src (show SRC Proteins)/MEKK3 (show MAP3K3 Proteins)/MEK5 (show MAP2K5 Proteins)/ERK5 (show MAPK7 Proteins) kinase cascade.
data demonstrate that Yap1 is a required factor for proper differentiation of mouse embryonic stem cells, while remaining dispensable for self-renewal
these results identify a novel function of YAP in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (show BMP2 Proteins)-YAP-SMAD1 (show SMAD1 Proteins) pathway underlying astrocytic differentiation in the developing mouse neocortex.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Epicardial YAP/TAZ (show TAZ Proteins) orchestrate an immunosuppressive response following myocardial infarction
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
The encoded gene product presumably interacts with YY1 protein\; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms.
Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, 65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, yes-associated protein, 65 kDa
, YY1-associated protein 1
, hepatocellular carcinoma susceptibility protein
, hepatocellular carcinoma-associated protein 2