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Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1 (show CYP11B2 Proteins), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.
In vivo, clotrimazole induced a concentration-dependent increase of cyp17a1 gene expression and Cyp17-I protein synthesis in zebrafish testis.
Effects of sexual steroids on the expression of foxl2 (show FOXL2 Proteins) in Gobiocypris rarus
the enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine
The immunolocalization of P450c17, detected in the ovaries of pregnant pigs and fetal porcine gonads, indicates the potential sites of androgen synthesis.
LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 gene. Maximal transcriptional responsiveness requires proximal Sp1 (show SP1 Proteins) and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.
Synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone
These results demonstrate the differential effects of two forms of CYB5 (show CYB5A Proteins) on the three activities of porcine CYP17A1 and show that CYB5B (show CYB5B Proteins) does not stimulate the andien-beta synthase activity of CYP17A1.
A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase (show TXNRD1 Proteins) and cytochrome b5 (show CYB5A Proteins) compete for the same binding site on cytochrome P450c17. (Review)
Nominally significant parental genetic effects were found between the SNPs rs11191548 (CYP17A1) (paternal, beta = 2.78+/-1.49, P = 6.1x10-2 for SBP (show SHBG Proteins) and beta = 3.60+/-1.24, P = 3.7x10-3 for DBP (show GC Proteins)), rs17367504 (MTHFR (show MTHFR Proteins)) (paternal, beta = 2.42+/-0.93, P = 9.3x10-3 for SBP (show SHBG Proteins) and beta = 1.89+/-0.80, P = 1.8x10-2 for DBP (show GC Proteins) and maternal, beta = -1.32+/-0.60, P = 2.9x10-2 and beta = -1.97+/-0.77, P = 1.0x10-2, for SBP (show SHBG Proteins) and DBP (show GC Proteins) respecti...
Wild-type CYP17 allele when combined with LOH/MSI (show MSI1 Proteins) in steroid metabolism genes may play a role in ER and/or PR negative breast cancers.
Data suggest CYP17A1, with electron donor NADPH-P450 reductase (show POR Proteins), is inherently distributive enzyme but that some processivity is present; some 17alpha-hydroxy pregnenolone formed does not dissociate from CYP17A1 before conversion to dehydroepiandrosterone; CYP5A does not enhance reaction by decreasing k(off) of ligands of CYP17A1. (CYP17A1 = cytochrome P450, family 17, subfamily A, polypeptide 1; CYP5A = cytochrome b5 (show CYB5A Proteins))
we identified a novel (K144del) and a widely reported (Y329 fs) heterozygous mutations of CYP17A1 gene from a 17OHD patient. Haplotyping analysis showed the common mutation Y329 fs in China came from the same ancestor, which explains the reason that 17OHD was the second cause of congenital adrenal hyperplasia in China.
Thus, although Mn-b5 binds to CYP17A1, it is unable to enhance the lyase reaction, strongly suggesting that cyt b5 has a redox effector role in enhancement of the CYP17A1 mediated lyase reaction necessary for androgen synthesis.
The activities of P450 (show CYP2B6 Proteins) 17A1 are regulated by cyt b5 that enhances the 17,20-lyase reaction by promoting the coupling of P450 (show CYP2B6 Proteins) 17A1 and cytochrome P450 reductase (CPR (show POR Proteins)), allosterically. Cyt b5 can also act as an electron donor to enhance the 16-ene-synthase activity of human P450 (show CYP2B6 Proteins) 17A1.
The results showed that CYP17A1 gene was not conclusively linked to either Insulin (show INS Proteins) resistance (IR) or its associated increased androgen secretion in non-obese women with polycystic ovarian syndrome (PCOS). We propose that an increased sensitivity of insulin (show INS Proteins) on the ovarian cells may be the predominant reason for the clinical effects and symptoms of androgen excess observed in non-obese PCOS patients in our region.
CYP17A1 defects were associated with amenorrhea, ovarian macrocysts and the diagnosis of 46, XX syndrome.
For the naturally occurring P450 (show CYP2B6 Proteins) 17A1 mutations E305G and R347H, which impair 17,20-lyase activity, cytochrome b5 (show CYB5A Proteins) failed to rescue the poor coupling with 17-hydroxypregnenolone (2-4%). When the conserved active-site threonine was mutated to alanine (T306A), both the activity and coupling were markedly decreased with all substrates.
BMP6 (show BMP6 Proteins) has a role in downregulating INSL3 (show INSL3 Proteins) and CYP17A1 and other proteins that modulate ovarian androgen production
The binding of SF-1 (show NR5A1 Proteins) to the CYP17 and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW]
the bovine genome contains three paralogous copies of the CYP17A1 gene, of which two (CYP17A1b and CYP17A1x) might be silenced by epigenetic modification (promoter methylation).
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (show CYP19A1 Proteins), HSD3B1 (show HSD3B1 Proteins), and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone [P450c17]
Serum free culture conditions significantly enhanced Cyp17 and Csh1 (show PRL3D1 Proteins) but not Hsd3b (show HSD3B1 Proteins) expression in trophoblast.
Demonstration of the physiologic importance of cytochrome b5 (show CYB5A Proteins) activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
TRalpha (show GNAT1 Proteins)/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 (show NR4A1 Proteins) transactivation on these promoters.
ata indicate that androgen receptor (AR (show AR Proteins)) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Data suggest that newly synthesized protein(s) are required for cAMP induction of CYP17 and 3-beta-HSD (show HSD3B1 Proteins) mRNA levels (but not of CYP11A (show CYP11A1 Proteins) mRNA levels). [REVIEW]
Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.
Mamld1 (show MAMLD1 Proteins) enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3 (show HES3 Proteins)-related non-canonical Notch (show NOTCH1 Proteins) signaling
Fxr (show NR1H4 Proteins)-/-Shp (show LAMC1 Proteins)-/- mice exhibited cholestasis and liver injury as early as 3 weeks of age with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1)
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (show CYP11A1 Proteins), P450 (show POR Proteins)(17alpha) and 17beta-HSD (show HSD17B1 Proteins) in mice.
cAMP induces expression of Cyp17 by a PKA-mediated mechanism which is inhibited by MIS (show AMH Proteins) signal transduction
CYP17, in addition to its 17alpha-hydroxylase/17,20-lyase activity, critical in androgen formation, also expresses a secondary activity, squalene monooxygenase (show SQLE Proteins) (epoxidase).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
cytochrome P450 17A1
, steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450c17
, cytochrome P450-C17
, cytochrome P450 XVIIA1
, steroid 17-alpha-monooxygenase
, steroidogenic cytochrome P450 17-hydroxylase/lyase
, Cytochrome P450 17A1
, Steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450 steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450, family 17, subfamily A, polypeptide 1
, 17-alpha-hydroxyprogesterone aldolase
, 17-alpha-hydroxylase cytochrome P450
, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
, cytochrome p450 XVIIA1
, cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase
, cytochrome P450, subfamily XVII
, steroid 17-alpha-hydroxylase
, cytochrome P450, 17
, cytochrome P450, 17a1
, steroid 17-alpha hydroxylase
, Cytochrome P450, subfamily XVII
, cytochrome P450, subfamily 17
, cytochrome P450 17 alpha-hydroxylase