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Browse our CYP17A1 Proteins (CYP17A1)

Full name:
Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 Proteins (CYP17A1)
On are 5 Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) Proteins from 4 different suppliers available. Additionally we are shipping CYP17A1 Antibodies (112) and CYP17A1 Kits (11) and many more products for this protein. A total of 133 CYP17A1 products are currently listed.
CPT7, Cyp17, cyp17a1, CYPXVII, P450-C17, p450c17, P45017A1, S17AH, wu:fi13g04, wu:fi17b11, wu:fi31c08, zgc:66494, zgc:136516
list all proteins Gene Name GeneID UniProt
CYP17A1 1586 P05093
CYP17A1 13074 P27786
CYP17A1 25146 P11715

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CYP17A1 Proteins (CYP17A1) by Origin

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More Proteins for CYP17A1 Interaction Partners

Zebrafish Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) interaction partners

  1. Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1 (show CYP11B2 Proteins), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.

  2. In vivo, clotrimazole induced a concentration-dependent increase of cyp17a1 gene expression and Cyp17-I protein synthesis in zebrafish testis.

  3. Effects of sexual steroids on the expression of foxl2 (show FOXL2 Proteins) in Gobiocypris rarus

  4. the enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine

Pig (Porcine) Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) interaction partners

  1. The immunolocalization of P450c17, detected in the ovaries of pregnant pigs and fetal porcine gonads, indicates the potential sites of androgen synthesis.

  2. LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 gene. Maximal transcriptional responsiveness requires proximal Sp1 (show SP1 Proteins) and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.

  3. Synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene.

  4. effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone

  5. These results demonstrate the differential effects of two forms of CYB5 (show CYB5A Proteins) on the three activities of porcine CYP17A1 and show that CYB5B (show CYB5B Proteins) does not stimulate the andien-beta synthase activity of CYP17A1.

Human Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) interaction partners

  1. The results showed that CYP17A1 gene was not conclusively linked to either Insulin (show INS Proteins) resistance (IR) or its associated increased androgen secretion in non-obese women with polycystic ovarian syndrome (PCOS). We propose that an increased sensitivity of insulin (show INS Proteins) on the ovarian cells may be the predominant reason for the clinical effects and symptoms of androgen excess observed in non-obese PCOS patients in our region.

  2. CYP17A1 defects were associated with amenorrhea, ovarian macrocysts and the diagnosis of 46, XX syndrome.

  3. For the naturally occurring P450 (show CYP2B6 Proteins) 17A1 mutations E305G and R347H, which impair 17,20-lyase activity, cytochrome b5 (show CYB5A Proteins) failed to rescue the poor coupling with 17-hydroxypregnenolone (2-4%). When the conserved active-site threonine was mutated to alanine (T306A), both the activity and coupling were markedly decreased with all substrates.

  4. Mechanism of 17alpha,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.

  5. The intensity of menopausal symptoms related to mood is higher among postmenopausal women presenting the GG genotype of the rs743572 polymorphism of the CYP17 A1 gene.

  6. The analyzed polymorphisms in CYP17A1 do not seem to be correlated with clinical outcome of castration-resistant prostate cancer patients treated with abiraterone.

  7. The common genetic variant rs2486758 in CYP17A1 was negatively associated with a biochemical response to and time to biochemical progression in patients treatment on abiraterone acetate and prednisone within metastatic castration-resistant prostate cancer.

  8. The steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage enzyme (show CYP11A1 Proteins) (P450scc (show CYP11A1 Proteins)), cytochrome P450 17 alpha (show CYP19A1 Proteins)-hydroxylase (P450c17) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show CHST3 Proteins)) showed immunoreactivity in 9/20 (45.0 %), 15/20 (75.0 %) and 13/20 (65.0 %), respectively, of ovarian-type stroma from pancreatic mucinous cystic neoplasm cases.

  9. CYP17 Gene Polymorphism is not associated with Breast Cancer.

  10. CYP17 Gene Polymorphism is associated with Pancreatic Cancer.

Cow (Bovine) Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) interaction partners

  1. BMP6 (show BMP6 Proteins) has a role in downregulating INSL3 (show INSL3 Proteins) and CYP17A1 and other proteins that modulate ovarian androgen production

  2. The binding of SF-1 (show NR5A1 Proteins) to the CYP17 and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.

  3. Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW]

  4. the bovine genome contains three paralogous copies of the CYP17A1 gene, of which two (CYP17A1b and CYP17A1x) might be silenced by epigenetic modification (promoter methylation).

  5. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (show CYP19A1 Proteins), HSD3B1 (show HSD3B1 Proteins), and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

  6. effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone [P450c17]

  7. Serum free culture conditions significantly enhanced Cyp17 and Csh1 (show PRL3D1 Proteins) but not Hsd3b (show HSD3B1 Proteins) expression in trophoblast.

Mouse (Murine) Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) interaction partners

  1. Demonstration of the physiologic importance of cytochrome b5 (show CYB5A Proteins) activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.

  2. TRalpha (show GNAT1 Proteins)/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 (show NR4A1 Proteins) transactivation on these promoters.

  3. ata indicate that androgen receptor (AR (show AR Proteins)) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.

  4. Data suggest that newly synthesized protein(s) are required for cAMP induction of CYP17 and 3-beta-HSD (show HSD3B1 Proteins) mRNA levels (but not of CYP11A (show CYP11A1 Proteins) mRNA levels). [REVIEW]

  5. Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.

  6. Mamld1 (show MAMLD1 Proteins) enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3 (show HES3 Proteins)-related non-canonical Notch (show NOTCH1 Proteins) signaling

  7. Fxr (show NR1H4 Proteins)-/-Shp (show LAMC1 Proteins)-/- mice exhibited cholestasis and liver injury as early as 3 weeks of age with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1)

  8. Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (show CYP11A1 Proteins), P450 (show POR Proteins)(17alpha) and 17beta-HSD (show HSD17B1 Proteins) in mice.

  9. cAMP induces expression of Cyp17 by a PKA-mediated mechanism which is inhibited by MIS (show AMH Proteins) signal transduction

  10. CYP17, in addition to its 17alpha-hydroxylase/17,20-lyase activity, critical in androgen formation, also expresses a secondary activity, squalene monooxygenase (show SQLE Proteins) (epoxidase).

CYP17A1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.

Alternative names and synonyms associated with CYP17A1

  • cytochrome P450 17A1 (CpipJ_CPIJ010537)
  • cytochrome P450 17A1 (CpipJ_CPIJ010543)
  • cytochrome P450 17A1 (PTRG_02047)
  • cytochrome P450, family 17, subfamily A, polypeptide 1 (cyp17a1)
  • steroidogenic cytochrome P450 17-hydroxylase/lyase (cyp17)
  • cytochrome P-450 17 alpha-hydroxylase/C17,20-lyase (CYP17A1)
  • cytochrome P450 17A1 (CYP17A1)
  • cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)
  • cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1)
  • cytochrome P450c17 (CYP17A1)
  • CPT7 protein
  • Cyp17 protein
  • cyp17a1 protein
  • CYPXVII protein
  • P450-C17 protein
  • p450c17 protein
  • P45017A1 protein
  • S17AH protein
  • wu:fi13g04 protein
  • wu:fi17b11 protein
  • wu:fi31c08 protein
  • zgc:66494 protein
  • zgc:136516 protein

Protein level used designations for CYP17A1

cytochrome P450 17A1 , steroid 17-alpha-hydroxylase/17,20 lyase , CYPXVII , cytochrome P450c17 , cytochrome P450-C17 , cytochrome P450 XVIIA1 , steroid 17-alpha-monooxygenase , steroidogenic cytochrome P450 17-hydroxylase/lyase , Cytochrome P450 17A1 , Steroid 17-alpha-hydroxylase/17,20 lyase , cytochrome P450 steroid 17-alpha-hydroxylase/17,20 lyase , cytochrome P450, family 17, subfamily A, polypeptide 1 , 17-alpha-hydroxyprogesterone aldolase , 17-alpha-hydroxylase cytochrome P450 , cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia , cytochrome p450 XVIIA1 , cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase , cytochrome P450, subfamily XVII , steroid 17-alpha-hydroxylase , cytochrome P450, 17 , cytochrome P450, 17a1 , steroid 17-alpha hydroxylase , Cytochrome P450, subfamily XVII , P450-C17 , P45017alpha , P450c17 , cytochrome P450, subfamily 17 , cytochrome P450 17 alpha-hydroxylase

6043058 Culex quinquefasciatus
6043064 Culex quinquefasciatus
6339667 Pyrenophora tritici-repentis Pt-1C-BFP
100137017 Oncorhynchus mykiss
100313515 Ictalurus punctatus
399692 Danio rerio
100036774 Xenopus laevis
100145650 Xenopus (Silurana) tropicalis
100034232 Equus caballus
403330 Sus scrofa
1586 Homo sapiens
477807 Canis lupus familiaris
493967 Felis catus
281739 Bos taurus
13074 Mus musculus
25146 Rattus norvegicus
425056 Gallus gallus
493968 Ovis aries
450141 Pan troglodytes
678693 Macaca mulatta
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