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Browse our CYP27B1 Proteins (CYP27B1)

Full name:
Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 Proteins (CYP27B1)
On are 4 Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) Proteins from 2 different suppliers available. Additionally we are shipping CYP27B1 Antibodies (29) and CYP27B1 Kits (12) and many more products for this protein. A total of 48 CYP27B1 products are currently listed.
Cp2b, Cyp1, CYP1alpha, Cyp27b, Cyp40, P450c1, Pddr, Vdd1, Vddr, VddrI, Vdr
list all proteins Gene Name GeneID UniProt
CYP27B1 1594 O15528
CYP27B1 114700 O35132
CYP27B1 13115 O35084

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CYP27B1 Proteins (CYP27B1) by Origin

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More Proteins for CYP27B1 Interaction Partners

Cow (Bovine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue.

Human Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. A Case of Vitamin-D-Dependent Rickets Type 1A with Normal 1,25-Dihydroxyvitamin D Caused by Two Novel Mutations of the CYP27B1 Gene.

  2. The aim of the present study was to investigate the mRNA expression levels of the CYP24A1 (show CYP24A1 Proteins) and CYP27B1 genes in malignant and normal breast tissues. The results demonstrated that the mRNA expression of CYP27B1 was downregulated in the tumor tissues, compared with the adjacent normal tissues (P<0.01), whereas the mRNA expression of CYP24A1 (show CYP24A1 Proteins) was significantly upregulated in the tumor tissues (P<0.01).

  3. findings do not support a role of an independent effect of the investigated vitamin D-related gene variants, VDBP (show GC Proteins) and CYP27B1, in the risk of Multiple Sclerosis

  4. In Sjogren's syndrome (SS) patients, EULAR Sjogren's syndrome disease activity index (ESSDAI) is negatively associated with serum levels of 25(OH)-D3 and positively associated with BAFF (show TNFSF13B Proteins).

  5. This study reveals no association between CYP27B1 polymorphisms and blood levels of 1alpha,25-hydroxyvitamin D.

  6. this study indicates rs8176345 in CYP27B1 gene is significantly correlated with erlotinib-induced skin rash in patients with advanced non-small cell lung cancer

  7. Vitamin D-binding protein (show GC Proteins) SNPs are associated with prostate cancer; low 25(OH)D metabolism score and CYP24A1 (show CYP24A1 Proteins) and CYP27B1 variants are associated with grade

  8. Increased CYP27B1 expression and local duodenal 1,25(OH)2D3 production during puberty may be a metabolic adaptation that promotes dietary calcium absorption.

  9. Data show that cytochrome P450 CYP27B1 and CYP24A1 (show CYP24A1 Proteins) expression were significantly different between tumor and normal tissues in non-small cell lung cancer (NSCLC).

  10. Data suggest compound heterozygous mutations in CYP27B1 (missense/frameshift mutations) in 2 brothers are associated with vitamin D-dependent rickets type 1A; entering puberty urinary calcium is marker for secondary hyperparathyroidism. [CASE REPORT]

Mouse (Murine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E (show APOE Proteins)-/- mice and wild-type mice, was investigated.

  2. P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling.

  3. Throughout the male reproductive tract specific bands of CYP27B1 are determined.

  4. observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 (show FGF23 Proteins) null/1alpha-Luc mice

  5. Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1 (show CYP2R1 Proteins)) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE).

  6. These results confirm the expression of vitamin D receptor (show VDR Proteins) and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury.

  7. Bone formation parameters were increased significantly in all pups fed by dams on the rescue diet but were still lower in 1alpha(OH)ase(-/-) pups than in 1alpha(OH)ase(+/-) pups.

  8. regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation

  9. study shows CYP27B1 can hydroxylate 25-hydroxyvitamin D2 & 25-hydroxyvitamin D3 associated with phospholipid membranes; low activity found at higher membrane levels of 25-hydroxyvitamin D; substrate inhibition may contribute to enzyme activity regulation

  10. findings demonstrate that regulation of both the 25-hydroxyvitamin D-1 alpha-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase (show CYP24A1 Proteins) genes by phosphorus is disordered in hypophosphatemic mice at the level of renal mRNA expression

CYP27B1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Alternative names and synonyms associated with CYP27B1

  • cytochrome P450, family 27, subfamily B, polypeptide 1 (cyp27b1)
  • cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1)
  • cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1)
  • Cp2b protein
  • Cyp1 protein
  • CYP1alpha protein
  • Cyp27b protein
  • Cyp40 protein
  • P450c1 protein
  • Pddr protein
  • Vdd1 protein
  • Vddr protein
  • VddrI protein
  • Vdr protein

Protein level used designations for CYP27B1

cytochrome P450, family 27, subfamily B, polypeptide 1 , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial , mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase , 1alpha(OH)ase , 25 hydroxyvitamin D3-1-alpha hydroxylase , 25-OHD-1 alpha-hydroxylase , VD3 1A hydroxylase , calcidiol 1-monooxygenase , cytochrome P450 subfamily XXVIIB polypeptide 1 , cytochrome P450C1 alpha , cytochrome P450VD1-alpha , cytochrome p450 27B1 , 25-hydroxyvitamin D(3) 1-alpha-hydroxylase , P450C1 alpha , P450VD1-alpha , cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1 , cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450, subfamily 27b, polypeptide 1 , 25(OH)D 1alpha-hydroxylase , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) , 25-hydroxyvitamin D3 1alpha-hydroxylase , P450VD1alpha , cytochrome P450, 27b1

448754 Xenopus (Silurana) tropicalis
452027 Pan troglodytes
539630 Bos taurus
715747 Macaca mulatta
100034100 Equus caballus
1594 Homo sapiens
114700 Rattus norvegicus
13115 Mus musculus
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