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Browse our CLASP2 Proteins (CLASP2)

Full name:
Cytoplasmic Linker Associated Protein 2 Proteins (CLASP2)
On www.antibodies-online.com are 3 Cytoplasmic Linker Associated Protein 2 (CLASP2) Proteins from 2 different suppliers available. Additionally we are shipping CLASP2 Antibodies (92) and CLASP2 Kits (4) and many more products for this protein. A total of 101 CLASP2 products are currently listed.
Synonyms:
1500004F14Rik, 8030404L10Rik, C77448, CLASP2beta, DKFZp459M112, mKIAA0627, zgc:77279
list all proteins Gene Name GeneID UniProt
CLASP2 76499  
CLASP2 23122 O75122
Rat CLASP2 CLASP2 114514 Q99JD4

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CLASP2 Proteins (CLASP2) by Origin

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Mouse (Murine) Cytoplasmic Linker Associated Protein 2 (CLASP2) interaction partners

  1. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.

  2. the functional relationship between Abl (show ABL1 Proteins) and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.

  3. The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120 (show CTNND1 Proteins)) in primary basal mouse keratinocytes.

  4. CLASP2 is required for the proper attachment of fibroblasts, HSC (show FUT1 Proteins)-enriched cells, and platelets, indicating a general role for this protein in cell attachment.

  5. CLASP2 directs the delivery of GLUT4 (show SLC2A4 Proteins) to cell cortex landing zones important for insulin (show INS Proteins) action

  6. Short-hairpin RNA-mediated CLASP2 knockdown in mouse neurons decreases axon & dendritic length. It is involved in cytoskeleton-related neuronal polarity & interplay between microtubule stabilization & synapse formation & activity.

  7. the cascade linking agrin (show AGRN Proteins) to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype

  8. Regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts.

Human Cytoplasmic Linker Associated Protein 2 (CLASP2) interaction partners

  1. PAR3 (show F2RL2 Proteins) and aPKC control the organization of the Golgi through CLASP2 phosphorylation.

  2. GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor cluster size through the regulated capture and release of microtubule plus-ends.

  3. Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM (show MMRN1 Proteins), establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.

  4. Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 (show ARPP21 Proteins) and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability.

  5. Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.

  6. The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).

  7. Overexpression of human CLASP2 in mouse neurons caused the formation of multiple axons, enhanced dendritic branching, & Golgi condensation. These morphogenetic changes led to significant functional alterations in synaptic transmission.

  8. propose that Cdk1 (show CDK1 Proteins) and Plk1 mediate a fine CLASP2 "phospho-switch" that temporally regulates kinetochore-microtubule attachment stability

  9. Multisite phosphorylation disrupts arginine-glutamate (show GRIN1 Proteins) salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1 (show MAPRE1 Proteins)).

  10. Data show that CENP-E (show CENPE Proteins)-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1 (show CLASP1 Proteins)/2-depleted cells.

CLASP2 Protein Profile

Protein Summary

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).

Alternative names and synonyms associated with CLASP2

  • cytoplasmic linker associated protein 2 (clasp2)
  • cytoplasmic linker associated protein 2 (CLASP2)
  • CLIP associating protein 2 (Clasp2)
  • cytoplasmic linker associated protein 2 (Clasp2)
  • 1500004F14Rik protein
  • 8030404L10Rik protein
  • C77448 protein
  • CLASP2beta protein
  • DKFZp459M112 protein
  • mKIAA0627 protein
  • zgc:77279 protein

Protein level used designations for CLASP2

CLIP-associating protein 2 , cytoplasmic linker-associated protein 2 , cytoplasmic linker associated protein 2 , CLASP2alpha , CLASP2gamma , CLIP-associating protein CLASP2 , multiple asters (Mast)-like homolog 2 , protein Orbit homolog 2 , CLIP associating protein 2

GENE ID SPECIES
404604 Danio rerio
420724 Gallus gallus
460258 Pan troglodytes
531418 Bos taurus
706519 Macaca mulatta
100055883 Equus caballus
100174066 Pongo abelii
100232474 Taeniopygia guttata
76499 Mus musculus
23122 Homo sapiens
114514 Rattus norvegicus
477012 Canis lupus familiaris
100512630 Sus scrofa
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