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Browse our ROCK1 Proteins (ROCK1)

Full name:
rho-Associated, Coiled-Coil Containing Protein Kinase 1 Proteins (ROCK1)
On are 7 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Proteins from 6 different suppliers available. Additionally we are shipping ROCK1 Antibodies (148) and ROCK1 Kits (2) and many more products for this protein. A total of 162 ROCK1 products are currently listed.
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta
list all proteins Gene Name GeneID UniProt
ROCK1 19877 P70335
ROCK1 81762 Q63644
ROCK1 6093 Q13464

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ROCK1 Proteins (ROCK1) by Origin

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More Proteins for ROCK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Proteins) homolog Knittrig in controlling macrophage migration

  2. Atonal and EGFR (show EGFR Proteins) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  3. The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.

  4. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  5. CD44 (show CD44 Proteins) interaction with p115RhoGEF (show ARHGEF1 Proteins) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Proteins)-kinase membrane localization, AKT (show AKT1 Proteins) signaling, and cytokine (M-CSF (show CSF1R Proteins)) production during HA-mediated breast cancer progression

  6. Drok and Drosophila Lim (show ZYX Proteins)-kinase interact in the developing nervous system

  7. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  8. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

  9. In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.

  2. While the loss of either Rock1 or Rock2 (show ROCK2 Proteins) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (show ROCK2 Proteins) have been genetically deleted.

  3. Fyn (show FYN Proteins) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (show PXN Proteins) phosphorylation

  4. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.

  5. Extracellular vesicle-encapsulated caspase-3 (show CASP3 Proteins) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  6. indicates that the up-regulation of ROCK1 activity in RhoA (show RHOA Proteins)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (show CASP3 Proteins)

  7. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

  8. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM).

  9. doxorubicin induces caspase (show CASP3 Proteins) activation, necrosis, and actin cytoskeleton alterations largely through ROCK1-dependent and oxidative stress-independent pathways

  10. Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR (show PTPRF Proteins) and RPTPsigma (show PTPRS Proteins) and Modulation of the Rho/ROCK Pathway.

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. vThese results suggest that ROCK may be important in IL-1 (show IL1A Proteins)-induced signaling through MKK4 (show MAP2K4 Proteins) to JNK (show MAPK8 Proteins) and the activation of p38 MAPK (show MAPK14 Proteins).

  2. There are 2 isoforms: ROCK1 and ROCK2 (show ROCK2 Proteins). They have different functions in different types of cells and tissues. There is growing evidence that ROCKs contribute to the development of cardiovascular diseases, including cardiac fibrosis, hypertrophy, and subsequent heart failure.

  3. the results suggested that miR335 directly targets Rhoassociated protein kinase (show CDK7 Proteins) 1 (ROCK1) in bladder cancer.

  4. Data suggest that Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632 may be therapeutically useful in tongue squamous cell carcinoma (TSCC).

  5. these findings indicate that miR (show MLXIP Proteins)-145 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of hepatocellular carcinoma (HCC (show FAM126A Proteins))through a mechanism involving ROCK1, suggesting miR (show MLXIP Proteins)-145 as a potential new diagnostic and therapeutic target for the treatment of HCC (show FAM126A Proteins)

  6. Increased ROCK1 expression is associated with breast cancer.

  7. The level of ROCK1 increases in junctional zone smooth muscle cells in patients with adenomyosis.

  8. Significant associations between ROCK1, ROCK2 (show ROCK2 Proteins), RhoA (show RHOA Proteins) and RhoC (show RHOC Proteins) gene polymorphisms and systemic sclerosis were demonstrated.

  9. Data show tht Rho kinase (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia.

  10. Melatonin has shown to be effective in controlling metastatic breast cancer in vitro and in vivo, not only via inhibition of the proliferation of tumor cells but also through direct antagonism of metastatic mechanism of cells rendered by ROCK-1 inhibition.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Results indicate that ROCK1 and ROCK2 (show ROCK2 Proteins) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Proteins)/cofilin (show CFL1 Proteins) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.

  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  3. p38 (show MAPK14 Proteins) phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  4. The RhoA (show RHOA Proteins)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  5. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.

  6. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Proteins) vasorum endothelial cells, is reported.

ROCK1 Protein Profile

Protein Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794)
  • Rho-kinase (rok)
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1)
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1)
  • 1110055K06Rik protein
  • CG9774 protein
  • Dmel\\CG9774 protein
  • DRhk protein
  • drok protein
  • LOC100229794 protein
  • p160ROCK protein
  • Rhk protein
  • RhoK protein
  • Rock protein
  • ROCK-1 protein
  • ROCK-I protein
  • ROCK1 protein
  • Rok protein
  • ROKalpha/beta protein

Protein level used designations for ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
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