You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our ROCK1 Proteins (ROCK1)

Full name:
rho-Associated, Coiled-Coil Containing Protein Kinase 1 Proteins (ROCK1)
On are 6 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Proteins from 5 different suppliers available. Additionally we are shipping ROCK1 Antibodies (120) and ROCK1 Kits (1) and many more products for this protein. A total of 133 ROCK1 products are currently listed.
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta
list all proteins Gene Name GeneID UniProt
ROCK1 19877 P70335
ROCK1 81762 Q63644
ROCK1 6093 Q13464

Show all synonyms

ROCK1 Proteins (ROCK1) by Origin

Select your origin of interest

More Proteins for ROCK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Proteins) homolog Knittrig in controlling macrophage migration

  2. Atonal and EGFR (show EGFR Proteins) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  3. The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.

  4. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  5. CD44 (show CD44 Proteins) interaction with p115RhoGEF (show ARHGEF1 Proteins) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Proteins)-kinase membrane localization, AKT (show AKT1 Proteins) signaling, and cytokine (M-CSF (show CSF1R Proteins)) production during HA-mediated breast cancer progression

  6. Drok and Drosophila Lim (show ZYX Proteins)-kinase interact in the developing nervous system

  7. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  8. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

  9. In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Extracellular vesicle-encapsulated caspase-3 (show CASP3 Proteins) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  2. indicates that the up-regulation of ROCK1 activity in RhoA (show RHOA Proteins)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (show CASP3 Proteins)

  3. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

  4. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM).

  5. doxorubicin induces caspase (show CASP3 Proteins) activation, necrosis, and actin cytoskeleton alterations largely through ROCK1-dependent and oxidative stress-independent pathways

  6. Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR (show PTPRF Proteins) and RPTPsigma (show PTPRS Proteins) and Modulation of the Rho/ROCK Pathway.

  7. A very rapid reduction in p27 (show CDKN1B Proteins)-phospho-Ser10 levels at the onset of atherogenesis, which contributes to early plaque build-up through RhoA (show RHOA Proteins)/ROCK-induced integrin expression, is reported.

  8. RhoA (show RHOA Proteins) and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

  9. ROCK1-dependent changes in hyaluronan may contribute to ROCK1's role in O3-induced AHR (show AHR Proteins), the role of ROCK2 (show ROCK2 Proteins) is downstream of inflammation, likely at the level of airway smooth muscle contraction.

  10. the RhoA (show RHOA Proteins)/ROCK signaling pathway is involved in insulin (show INS Proteins) release through the up-regulation of Cx36 (show GJD2 Proteins) expression in 3D-cultured MIN6 cells.

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. This is the first study to examine the involvement of ROCK1 and ROCK2 (show ROCK2 Proteins) gene variations in the risk of primary open-angle glaucoma development.

  2. the ROCK1 rs35996865 G variant allele was significantly more frequent in male colorectal cancer (CRC (show CALR Proteins)) patients (p = 0.028) than in the control group; finding points to a possible gender-related modulation by the ROCK1 gene in CRC (show CALR Proteins) susceptibility

  3. These findings suggested that miR (show MLXIP Proteins)-198 may act not only as a novel prognostic marker, but also as a potential target for molecular therapy of osteosarcoma.

  4. The RhoA (show RHOA Proteins)/ROCK signalling pathway has a key role in Ca2 (show CA2 Proteins)+ sensitisation in smooth muscle.

  5. Together, the data of the present study demonstrated that miR144 acts as a tumor suppressor by targeting ROCK1, and indicates the potential of miR144 as a novel biomarker and target in the treatment of rectal cancer.

  6. Galectin-9 (show LGALS9 Proteins) stimulated migration in human NK-92 cells by affecting F-actin polarization through the Rho/ROCK1 signaling pathway.

  7. These results indicate that miR (show MLXIP Proteins)-584 could inhibit the expression of ROCK1, and ROCK1 knockdown would further affect the migration ability of K1 cells.

  8. We speculate that the drop of the ROCK-to-MLCK (show MYLK Proteins) ratio may occur as an attempt to compensate for the increased Rho kinase activity.

  9. This study report that protein levels of the Rho-associated protein kinases (ROCK1) was increased in Progressive Supranuclear Palsy and Corticobasal Degeneration brains.

  10. We identified ROCK1 as a potential drug target for BRAF (show BRAF Proteins) mutant melanoma. ROCK1 silencing increased melanoma cell elimination when combined with BRAF (show BRAF Proteins) or ERK (show EPHB2 Proteins) inhibitor treatment.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. Results indicate that ROCK1 and ROCK2 (show ROCK2 Proteins) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) interaction partners

  1. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  2. p38 (show MAPK14 Proteins) phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  3. The RhoA (show RHOA Proteins)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  4. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.

  5. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Proteins) vasorum endothelial cells, is reported.

ROCK1 Protein Profile

Protein Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794)
  • Rho-kinase (rok)
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1)
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1)
  • 1110055K06Rik protein
  • CG9774 protein
  • Dmel\\CG9774 protein
  • DRhk protein
  • drok protein
  • LOC100229794 protein
  • p160ROCK protein
  • Rhk protein
  • RhoK protein
  • Rock protein
  • ROCK-1 protein
  • ROCK-I protein
  • ROCK1 protein
  • Rok protein
  • ROKalpha/beta protein

Protein level used designations for ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
Selected quality suppliers for ROCK1 Proteins (ROCK1)
Did you look for something else?