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polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 Proteins) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH Proteins)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Proteins) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Proteins) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR Proteins) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 Proteins) interaction with p115RhoGEF (show ARHGEF1 Proteins) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Proteins)-kinase membrane localization, AKT (show AKT1 Proteins) signaling, and cytokine (M-CSF (show CSF1R Proteins)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX Proteins)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (show SNRK Proteins) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Proteins), which influenced Ras Homology Family Member A (show CXCL14 Proteins) (RhoA (show RHOA Proteins)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Proteins)).
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Proteins)-133a expression leading to an increase in RhoA (show RHOA Proteins)/Rho kinase (show ROCK2 Proteins) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (show ANXA1 Proteins) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Proteins)-ROCK signaling pathway
the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A Proteins), which induces GSK-3beta phosphorylation and beta-catenin (show CTNNB1 Proteins) accumulation through RhoA (show RHOA Proteins) and ROCK activation.
Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.
While the loss of either Rock1 or Rock2 (show ROCK2 Proteins) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (show ROCK2 Proteins) have been genetically deleted.
Fyn (show FYN Proteins) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (show PXN Proteins) phosphorylation
data suggests that ROCK1 may serve as a potential therapeutic target to enhance current treatment regimens for pancreatic cancer
Genetic variant in ROCK1 gene is associated with progression of prostate cancer.
Results showed that ROCK1 gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 (show ROCK2 Proteins) gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (show PRPH2 Proteins)), and that they could be a risk factor for development of neonatal RDS (show PRPH2 Proteins).
Despite sharing the catalytic domain with ROCK2 (show ROCK2 Proteins), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
RhoA (show RHOA Proteins)/ROCK and Raf-1 (show RAF1 Proteins)/CK2 (show CSNK2A1 Proteins) pathway are responsible for TNF-alpha (show TNF Proteins)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM Proteins) cytoskeleton.
High ROCK1 expression is associated with Clear cell renal cell carcinoma (show MOK Proteins).
Studies showed that ROCK isoforms, ROCK1 and ROCK2 (show ROCK2 Proteins), have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]
BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.
Results indicate that ROCK1 and ROCK2 (show ROCK2 Proteins) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Proteins)/cofilin (show CFL1 Proteins) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 Proteins) phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA Proteins)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Proteins) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1