Browse our HSD17B4 Proteins (HSD17B4)

Full name:
Hydroxysteroid (17-Beta) Dehydrogenase 4 Proteins (HSD17B4)
On are 8 Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) Proteins from 3 different suppliers available. Additionally we are shipping HSD17B4 Antibodies (90) and HSD17B4 Kits (1) and many more products for this protein. A total of 104 HSD17B4 products are currently listed.
4, 17-beta-HSD, 17[b]-HSD, CG3415, DBP, Dmel\\CG3415, DmMFE-2, MFE-2, Mfp-2, MFP2, MPF-2, perMFE-2, PRLTS1, SDR8C1, zgc:55545, zgc:77300
list all proteins Gene Name GeneID UniProt
HSD17B4 3295 P51659
HSD17B4 15488 P51660
HSD17B4 79244 P97852

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HSD17B4 Proteins (HSD17B4) by Origin

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Zebrafish Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. The knockdown of dbp (show GC Proteins) in zebrafish phenocopied clinical manifestations of its deficiency in human.

Fruit Fly (Drosophila melanogaster) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (show UCN3 Proteins)-2L (sterol carrier protein 2 (show SCP2 Proteins)-like) domain in human and C. elegans proteins.

Human Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2 (show LARS2 Proteins), CLPP (show CLPP Proteins) and C10orf2 (show C10ORF2 Proteins)

  2. Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells and activated NF-kappaB (show NFKB1 Proteins) co-localized with the NF-kappaB (show NFKB1 Proteins)-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC (show FAM126A Proteins) progression.

  3. Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III.

  4. Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Proteins) type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency.

  5. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (show RAG1AP1 Proteins)-2L (sterol carrier protein 2 (show SCP2 Proteins)-like) domain in human and C. elegans proteins.

  6. Epistasis between the HSD17B4 and thyroglobulin (show TG Proteins) polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF (show POF1B Proteins)

  7. The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established.

  8. MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center

  9. Perrault syndrome and DBP (show GC Proteins) deficiency overlap clinically and Perrault syndrome is genetically heterogeneous.

  10. rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma.

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation in mice.

  2. bile acid biosynthesis, estimated by the ratio of C27/C24-bile acids, is more severely affected in double knock-out mice as compared with DBP (show GC Proteins)-/- mice but was normal in LBP (show LBP Proteins)-/- mice

  3. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility

  4. Loss of MFP2 leads to attenuation of up-regulations of SREBP2 (show SREBF2 Proteins) and HMGCR (show HMGCR Proteins) involved in cholesterol synthesis.

Pig (Porcine) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Leptin (show LEP Proteins) in elevated doses, by stimulatory effect on CYP11A1 (show CYP11A1 Proteins) and 17b-HSD (show HAL Proteins) protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.

HSD17B4 Protein Profile

Protein Summary

The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.

Alternative names and synonyms associated with HSD17B4

  • hydroxysteroid (17-beta) dehydrogenase 4 (hsd17b4)
  • hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4)
  • peroxisomal Multifunctional enzyme type 2 (Mfe2)
  • hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4)
  • 4 protein
  • 17-beta-HSD protein
  • 17[b]-HSD protein
  • CG3415 protein
  • DBP protein
  • Dmel\\CG3415 protein
  • DmMFE-2 protein
  • MFE-2 protein
  • Mfp-2 protein
  • MFP2 protein
  • MPF-2 protein
  • perMFE-2 protein
  • PRLTS1 protein
  • SDR8C1 protein
  • zgc:55545 protein
  • zgc:77300 protein

Protein level used designations for HSD17B4

peroxisomal multifunctional enzyme type 2 , CG3415-PA , Mfe2-PA , 17-beta-HSD 4 , 17-beta-HSD IV , 17-beta-hydroxysteroid dehydrogenase 4 , 17beta-estradiol dehydrogenase type IV , 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase , D-3-hydroxyacyl-CoA dehydratase , D-bifunctional protein, peroxisomal , beta-hydroxyacyl dehydrogenase , beta-keto-reductase , multifunctional protein 2 , peroxisomal multifunctional protein 2 , short chain dehydrogenase/reductase family 8C, member 1 , D-bifunctional protein , DBP , MFE-2 , peroxisomal multifunctional enzyme type II , 17-beta-hydroxysteroid dehydrogenase type IV , 17beta-estradiol dehydrogenase , mutifunctional protein2

393105 Danio rerio
474630 Canis lupus familiaris
32582 Drosophila melanogaster
3295 Homo sapiens
15488 Mus musculus
79244 Rattus norvegicus
395785 Gallus gallus
397574 Sus scrofa
493643 Bos taurus
100379226 Cavia porcellus
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