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Human ATF3 Protein expressed in Wheat germ - ABIN1345929
Wang, Brennan, Gutierrez, Wang, Wang, Yang: SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. in Journal of cellular biochemistry 2013
Show all 3 references for ABIN1345929
Human ATF3 Protein expressed in Escherichia coli (E. coli) - ABIN667497
Chen, Liang, Whelan, Hai: ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. in The Journal of biological chemistry 1994
Show all 2 references for ABIN667497
Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.
Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.
ATF3 inhibition significantly increased the expression of proinflammatory cytokines interleukin 6 and interleukin 8 in cigarette smoke extract stimulated human bronchial epithelial cells.
ATF3 overexpression increased PFF-A-mediated cleaved PARP.
Ang II (show AGT Proteins)-induced upregulation of ATF3 and SUMO1 (show SUMO1 Proteins) in vitro and in vivo was blocked by Ang II (show AGT Proteins) type I receptor antagonist olmesartan. Moreover, Ang II (show AGT Proteins) induced ATF3 SUMOylation at lysine 42, which is SUMO1 (show SUMO1 Proteins) dependent.
As a result, ATF3 rather protected the p53 (show TP53 Proteins) wild-type cells from UV-induced apoptosis. Our results thus indicate that ATF3 regulates cell fates upon UV irradiation in a p53 (show TP53 Proteins)-dependent manner.
CARMA1 (show CARD11 Proteins)- and MyD88 (show MYD88 Proteins)-dependent activation of Jun (show JUN Proteins)/ATF-type AP-1 (show FOSB Proteins) complexes is a hallmark of ABC (show ABCB6 Proteins) diffuse large B-cell lymphomas.
Activating transcription factor 3 represses inflammatory responses by binding to the p65 (show GORASP1 Proteins) subunit of NF-kappaB (show NFKB1 Proteins)
TGRL lipolysis products induce stress protein ATF3 via the TGF-beta (show TGFB1 Proteins) receptor pathway, resulting in induction of apoptosis in aortic endothelial cells
ATF3 regulates canonical TGFbeta and Smad signaling and fibroblast (show TGFB1 Proteins)activation in systemic sclerosis.
ATF3 overexpression leads to an increase of collective cell invasion phenotype in Colorectal Cancer.
Data suggest that after the expression of activating transcription factor 3 (ATF3) and microRNA miR (show MLXIP Proteins)-30c-2-3p elicited by lysophosphatidic acid, miR (show MLXIP Proteins)-30c-2-3p negatively regulates the expression of ATF3 through post-transcriptional silencing.
cigarette smoke exposure up-regulated the expression of ATF3 in mice
Study shows that ATF3 regulates multiple targets in cardiomyocytes and plays critical roles in hypertrophy, apoptosis and autophagy of cardiomyocyte.
ATF3 was up-regulated in brain after reperfusion following transient middle cerebral artery occlusion.
Activating transcription factor 3 represses inflammatory responses by binding to the p65 (show NFkBP65 Proteins) subunit of NF-kappaB (show NFKB1 Proteins)
Knockout of the ATF3 gene reduced the stimulatory effect of TGFbeta (show TGFB1 Proteins) on fibroblasts by interfering with canonical Smad (show SMAD1 Proteins) signalling and protected the mice from experimental fibrosis in two different models.
ATF3 is a key regulator in cardiac hypertrophy through a cross-talk between cardiomyocytes and macrophages.
Data show that activating transcription factor 3 (ATF3) acted as a transcriptional repressor and regulated interferon-beta (IFN-beta (show IFNB1 Proteins)) via direct binding to a regulatory site distal to the Ifnb1 (show IFNB1 Proteins) promoter.
ATF3 binds to carboxyl-terminal modulator protein (show THEM4 Proteins) and suppresses its transcription following brain ischemia.
Involvement of ATF3 in the negative regulation of iNOS (show NOS2 Proteins) expression and NO production in activated macrophages
ATF3 suppresses fibrosis early but not late during infarct-induced heart failure. Although ATF3 deficiency was associated with more fibrosis, this did not occur at the expense of survival, which was higher in the ATF3-null mice.
ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (show MAPK8 Proteins) pathway in endothelial cells
Data indicate increasing expression for CREB (show CREB1 Proteins), ATF1 (show AFT1 Proteins), and ATF3 during gastrulation.
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
cyclic AMP-dependent transcription factor ATF-3
, activating transcription factor 3
, cAMP-dependent transcription factor ATF-3
, transcription factor LRG-21
, liver regeneration factor 1