Browse our ATF3 Proteins (ATF3)

Full name:
Activating Transcription Factor 3 Proteins (ATF3)
On www.antibodies-online.com are 12 Activating Transcription Factor 3 (ATF3) Proteins from 6 different suppliers available. Additionally we are shipping ATF3 Antibodies (124) and ATF3 Kits (18) and many more products for this protein. A total of 161 ATF3 products are currently listed.
Synonyms:
atf-3, ATF3, LRF-1, LRFI, LRG-21, zgc:55526
list all proteins Gene Name GeneID UniProt
ATF3 467 P18847
ATF3 11910 Q60765
ATF3 25389 P29596

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ATF3 Proteins (ATF3) by Origin

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Top referenced ATF3 Proteins

  1. Human ATF3 Protein expressed in Wheat germ - ABIN1345929 : Wang, Brennan, Gutierrez, Wang, Wang, Yang: SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. in Journal of cellular biochemistry 2013 (PubMed)
    Show all 3 references for 1345929

  2. Human ATF3 Protein expressed in Escherichia coli (E. coli) - ABIN667497 : Chen, Liang, Whelan, Hai: ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. in The Journal of biological chemistry 1994 (PubMed)
    Show all 2 references for 667497

More Proteins for ATF3 Interaction Partners

Zebrafish Activating Transcription Factor 3 (ATF3) interaction partners

  1. Data show that Atf3 was detected in retinal ganglion cell axons in both the nerve fiber layer and the optic nerve on the injured side.

  2. Data show that ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation.

Human Activating Transcription Factor 3 (ATF3) interaction partners

  1. The microvascular injury phenotypes observed in vitro and in vivo were similar. ATF3 plays an important role in mediating brain microvascular responses to acute and chronic lipotoxic injury and may be an important preventative and therapeutic target for endothelial dysfunction in vascular cognitive impairment .

  2. we have identified ATF3 as an important regulator of cisplatin cytotoxicity and that ATF3 inducers in combination with platins are a potential novel therapeutic approach for NSCLC.

  3. reactivation of ATF3 is an important factor in determining sensitivity to pracinostat treatment, both in vitro and in vivo, and could serve as a potential biomarker of response and provide a rationale for therapeutic utility in HDACi-mediated treatments for bladder cancer.

  4. these findings support roles for both cFOS (indirect) and ATF3 (direct) in effecting MMP13 (show MMP13 Proteins) transcription in human chondrocytes.

  5. We functionally validated several elements for metformin-induced promoter and enhancer activity. These include an enhancer in an ataxia telangiectasia mutated (ATM (show ATM Proteins)) intron that has SNPs in linkage disequilibrium .Using ChIP-seq and siRNA knockdown, we further show that activating transcription factor 3 (ATF3), our top metformin upregulated AMPK (show PRKAA1 Proteins)-dependent gene, could have an important role in gluconeogenesis repression.

  6. ATF3 inhibition significantly increased the expression of proinflammatory cytokines interleukin 6 and interleukin 8 in cigarette smoke extract stimulated human bronchial epithelial cells.

  7. ATF3 overexpression increased PFF-A-mediated cleaved PARP.

  8. Ang II (show AGT Proteins)-induced upregulation of ATF3 and SUMO1 (show SUMO1 Proteins) in vitro and in vivo was blocked by Ang II (show AGT Proteins) type I receptor antagonist olmesartan. Moreover, Ang II (show AGT Proteins) induced ATF3 SUMOylation at lysine 42, which is SUMO1 (show SUMO1 Proteins) dependent.

  9. As a result, ATF3 rather protected the p53 (show TP53 Proteins) wild-type cells from UV-induced apoptosis. Our results thus indicate that ATF3 regulates cell fates upon UV irradiation in a p53 (show TP53 Proteins)-dependent manner.

  10. CARMA1 (show CARD11 Proteins)- and MyD88 (show MYD88 Proteins)-dependent activation of Jun (show JUN Proteins)/ATF-type AP-1 (show FOSB Proteins) complexes is a hallmark of ABC (show ABCB6 Proteins) diffuse large B-cell lymphomas.

Mouse (Murine) Activating Transcription Factor 3 (ATF3) interaction partners

  1. Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5 (show KRT5 Proteins)+CK8 (show KRT8 Proteins)+ epithelial cells.

  2. A novel role for ATF3 in the inhibition of lipopolysaccharide-induced TNF-alpha (show TNF Proteins) and in the impairment of monocyte and macrophage migration, is reported.

  3. ATF3 attenuates the expression of inflammation-related genes after exercise and thus facilitates molecular adaptation to training.

  4. The microvascular injury phenotypes observed in vitro and in vivo were similar. ATF3 plays an important role in mediating brain microvascular responses to acute and chronic lipotoxic injury and may be an important preventative and therapeutic target for endothelial dysfunction in vascular cognitive impairment .

  5. ATF3 upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 (show MAP2K3 Proteins) expression and subsequent p38 (show CRK Proteins)-transforming growth factor-beta signaling.

  6. we have identified ATF3 as an important regulator of cisplatin cytotoxicity and that ATF3 inducers in combination with platins are a potential novel therapeutic approach for NSCLC.

  7. Mechanistic studies showed that in MDSCs, ATF3 was transrepressed by the GC receptor GR through direct binding to the negative GR-response element. S100A9 (show S100A9 Proteins) is the major transcriptional target of ATF3 in Granulocytic Myeloid-derived Suppressor Cells.

  8. These findings suggest that Atf3 is implicated in the pathogenesis of osteoarthritis through modulation of inflammatory cytokine expression in chondrocytes.

  9. cigarette smoke exposure up-regulated the expression of ATF3 in mice

  10. Study shows that ATF3 regulates multiple targets in cardiomyocytes and plays critical roles in hypertrophy, apoptosis and autophagy of cardiomyocyte.

Cow (Bovine) Activating Transcription Factor 3 (ATF3) interaction partners

  1. ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.

  2. ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK (show MAPK8 Proteins) pathway in endothelial cells

Rabbit Activating Transcription Factor 3 (ATF3) interaction partners

  1. Data indicate increasing expression for CREB (show CREB1 Proteins), ATF1 (show AFT1 Proteins), and ATF3 during gastrulation.

ATF3 Protein Profile

Protein Summary

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.

Alternative names and synonyms associated with ATF3

  • activating transcription factor 3 (atf3)
  • activating transcription factor 3 (ATF3)
  • activating transcription factor 3 (Atf3)
  • activating transcription factor 3 (LOC100337749)
  • atf-3 protein
  • ATF3 protein
  • LRF-1 protein
  • LRFI protein
  • LRG-21 protein
  • zgc:55526 protein

Protein level used designations for ATF3

cyclic AMP-dependent transcription factor ATF-3 , activating transcription factor 3 , cAMP-dependent transcription factor ATF-3 , transcription factor LRG-21 , liver regeneration factor 1

GENE ID SPECIES
393939 Danio rerio
469143 Pan troglodytes
710832 Macaca mulatta
467 Homo sapiens
11910 Mus musculus
25389 Rattus norvegicus
447311 Xenopus laevis
612911 Canis lupus familiaris
515266 Bos taurus
100337749 Oryctolagus cuniculus
100722370 Cavia porcellus
100127464 Sus scrofa
101116073 Ovis aries
421369 Gallus gallus
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