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Characterization of extensive electrostatic and hydrophobic contacts between calmodulin (CaM) and the CaM-binding domain peptide allows a detailed analysis of the structural basis of the kinase activation process.
The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2 (show RIPK2 Antibodies)) and calcium/calmodulin-dependent protein kinase (show CAMK2 Antibodies) 1alpha (CAMK1alpha).
CAMK1 functional regulation subnetwork in hepatocellular carcinoma
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Antibodies)-PP2A (show PPP2R4 Antibodies) and CaMKI and PME-1 (show PPME1 Antibodies) networks may function in fine-tuning cell proliferation and stress response.
It is one of Ca(2 (show CA2 Antibodies)+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2 (show CA2 Antibodies)+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD.
Fbxl12 (show FBXL12 Antibodies)-induced CaMKI degradation attenuates p27 (show PAK2 Antibodies) phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 (show PAK2 Antibodies) phosphorylation appears to be upstream to other p27 (show PAK2 Antibodies) phosphorylation events
structures of three CaMKIalpha truncates in apo (show C9orf3 Antibodies) form and in complexes with ATP
CaMKI was significantly upregulated in adrenal adenomas.
variants in doublecortin (show DCX Antibodies)- and calmodulin kinase like 1, a gene up-regulated by BDNF (show BDNF Antibodies), have roles in memory and general cognitive abilities
CaMKI is involved in angiotensin II and K(+) stimulation of CYP11B2 (show CYP11B2 Antibodies) transcription and the capacity of the adrenal to produce aldosterone
report that Parvalbumin (show PVALB Antibodies) positive interneurons employ a novel CaMK (show CAMK2G Antibodies)-dependent pathway to trigger CREB (show CREB1 Antibodies) phosphorylation and gene expression.
the CaMKK (show CAMKK2 Antibodies)-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a (show WNT5A Antibodies) during neuronal polarization.
CaMKIalpha regulates AMP (show TMPRSS5 Antibodies) kinase-dependent, TORC-1 (show CRTC1 Antibodies)-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
CaMKI vies with CRM1/exportin 1 (show XPO1 Antibodies) for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta (show YWHAZ Antibodies)-CCTalpha (show PCYT1A Antibodies) complex is a key effector mechanism that drives nuclear CCTalpha (show PCYT1A Antibodies) translocation.
CaMKIalpha signaling is integral to the Mvarphi responding to LPS (show TLR4 Antibodies) and may also be operant in vivo in regulating the inflammation and organ dysfunction consequent to sepsis.
Inflammatory acidic environments activate Trpv1 (show TRPV1 Antibodies), leading to an up-regulation of CGRP (show CALCA Antibodies) expression via CaMK (show CAMK2G Antibodies)-CREB (show CREB1 Antibodies) cascade, a series of events that may be associated with inflammatory pain.
calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences
ERK (show EPHB2 Antibodies) activation and neurite outgrowth in response to depolarization are mediated by CaMKK (show CAMKK2 Antibodies) activation of CaMKI
Full-length cDNA encoded am amino acid sequence similar to that of calmodulin kinase I.
Interaction of MARK2 (show MARK2 Antibodies) with CaMKI results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.
, calmodulin-dependent kinase
, caM kinase I alpha
, calcium/calmodulin-dependent protein kinase type 1
, G alpha interacting protein
, regulator of G-protein signalling 19
, Ca++/calmodulin-dependent protein kinase 2 delta subunit
, Ca++/calmodulin-dependent protein kinase II delta subunit
, Ca++/calmodulin-dependent protein kinase II, delta subunit
, caM kinase II subunit delta
, caM-kinase II delta chain
, caMK-II subunit delta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
, calcium/calmodulin-dependent protein kinase type II delta chain
, calcium/calmodulin-dependent protein kinase type II subunit delta