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Human CAMK1 Protein expressed in Wheat germ - ABIN1347913
Mallampalli, Kaercher, Snavely, Pulijala, Chen, Coon, Zhao, Agassandian: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. in Cellular signalling 2013
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Characterization of extensive electrostatic and hydrophobic contacts between calmodulin (CaM (show CALM Proteins)) and the CaM (show CALM Proteins)-binding domain peptide allows a detailed analysis of the structural basis of the kinase activation process.
The mRNA expressions of PPP3CB (show PPP3CB Proteins) and MEF2C (show MEF2C Proteins) were significantly up-regulated, and CAMK1 and PPP3R1 (show PPP3R1 Proteins) were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (show PPP3CB Proteins), MEF2C (show MEF2C Proteins) and PLCE1 (show PLCE1 Proteins) compared to aortic valve disease patients
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2 (show RIPK2 Proteins)) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha).
CAMK1 functional regulation subnetwork in hepatocellular carcinoma
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Proteins)-PP2A (show PPP2R4 Proteins) and CaMKI and PME-1 (show PPME1 Proteins) networks may function in fine-tuning cell proliferation and stress response.
It is one of Ca(2 (show CA2 Proteins)+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2 (show CA2 Proteins)+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD.
Fbxl12 (show FBXL12 Proteins)-induced CaMKI degradation attenuates p27 (show PAK2 Proteins) phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 (show PAK2 Proteins) phosphorylation appears to be upstream to other p27 (show PAK2 Proteins) phosphorylation events
structures of three CaMKIalpha truncates in apo (show C9orf3 Proteins) form and in complexes with ATP
CaMKI was significantly upregulated in adrenal adenomas.
variants in doublecortin (show DCX Proteins)- and calmodulin (show CALM1 Proteins) kinase like 1, a gene up-regulated by BDNF (show BDNF Proteins), have roles in memory and general cognitive abilities
CaMKI is involved in angiotensin II and K(+) stimulation of CYP11B2 (show CYP11B2 Proteins) transcription and the capacity of the adrenal to produce aldosterone
report that Parvalbumin (show PVALB Proteins) positive interneurons employ a novel CaMK (show CAMK2G Proteins)-dependent pathway to trigger CREB (show CREB1 Proteins) phosphorylation and gene expression.
the CaMKK (show CAMKK2 Proteins)-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a (show WNT5A Proteins) during neuronal polarization.
CaMKIalpha regulates AMP (show TMPRSS5 Proteins) kinase-dependent, TORC-1 (show CRTC1 Proteins)-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
CaMKI vies with CRM1/exportin 1 (show XPO1 Proteins) for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta (show YWHAZ Proteins)-CCTalpha (show PCYT1A Proteins) complex is a key effector mechanism that drives nuclear CCTalpha (show PCYT1A Proteins) translocation.
CaMKIalpha signaling is integral to the Mvarphi responding to LPS (show TLR4 Proteins) and may also be operant in vivo in regulating the inflammation and organ dysfunction consequent to sepsis.
Inflammatory acidic environments activate Trpv1 (show TRPV1 Proteins), leading to an up-regulation of CGRP (show CALCA Proteins) expression via CaMK (show CAMK2G Proteins)-CREB (show CREB1 Proteins) cascade, a series of events that may be associated with inflammatory pain.
calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences
ERK (show EPHB2 Proteins) activation and neurite outgrowth in response to depolarization are mediated by CaMKK (show CAMKK2 Proteins) activation of CaMKI
Full-length cDNA encoded am amino acid sequence similar to that of calmodulin kinase I.
Interaction of MARK2 (show MARK2 Proteins) with CaMKI results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.
, calmodulin-dependent kinase
, caM kinase I alpha
, calcium/calmodulin-dependent protein kinase type 1
, G alpha interacting protein
, regulator of G-protein signalling 19
, Ca++/calmodulin-dependent protein kinase 2 delta subunit
, Ca++/calmodulin-dependent protein kinase II delta subunit
, Ca++/calmodulin-dependent protein kinase II, delta subunit
, caM kinase II subunit delta
, caM-kinase II delta chain
, caMK-II subunit delta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
, calcium/calmodulin-dependent protein kinase type II delta chain
, calcium/calmodulin-dependent protein kinase type II subunit delta