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Human IGFBP3 Protein expressed in Human Cells - ABIN2002834
Cubbage, Suwanichkul, Powell: Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. in The Journal of biological chemistry 1990
Show all 4 Pubmed References
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (show BMP4 Proteins) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
The results of this study, while not clearly supporting associations between these obesity-related biomarkers and renal cell carcinoma (show MOK Proteins) risk, are consistent with previously reported findings for adiponectin, and suggest an association with elevated IGFBP-3 among obese individuals
our results reveal a new function of IGFBP2, providing a novel insight into the mechanism of adipogenic differentiation and identifying a potential target mediator for improving adipose tissue engineering based on Wharton's jelly of the umbilical cord (WJCMSCs).
Increased IGFBP3 level as associated with decreased risk of frailty in men.
Report serum IGF1 (show IGF1 Proteins)/IGFBP3 levels in relation to clinical/pathobiological features of squamous cell carcinomas of the head and neck.
Functional IGFBP-3 was significantly lower in postmenopausal women than in premenopausal women, for both patients with rheumatoid arthritis and controls. There was a significant decrease in plasma functional IGFBP-3 levels in postmenopausal RA in comparison to healthy premenopausal subjects.
study suggests high-order interactions of the IGFBP-3 rs2854744 AA genotype, BMI>/=24kg/m2, and DISI<9.85 mg/day on increased BC risk, particularly among postmenopausal women
IGFBP2 and IGFBP3 may serve as compensatory biomarkers for CA19-9. Early diagnosis with this marker combination may improve the prognosis of invasive ductal adenocarcinoma of pancreas patients.
The stratification of individuals by gender revealed that Slovak males carrying IGFBP-3 G alleles (G32G or GG) had marginally increased risk for developing MDD as compared to CC homozygous males (p=0.09). In women, inverse association was observed between SNP rs1042522 and MDD risk (p=0.04 for recessive model).
this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci.
these findings suggest that IGFBP-3 suppresses transcription of EGR1 (show EGR1 Proteins) and its target genes bFGF (show FGF2 Proteins) and PDGF (show PDGFA Proteins) through inhibiting IGF-1 (show IGF1 Proteins)-dependent ERK (show EPHB2 Proteins) and AKT (show AKT1 Proteins) activation.
High Igfbp3 expression is associated with skin squamous cell carcinoma.
The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt (show WNT2 Proteins) pathway and depends upon the presence of CD44 (show CD44 Proteins), a receptor protein known to modulate Wnt (show WNT2 Proteins) signaling.
IGFBP-3 influences severity of DSS (show PMP22 Proteins)-induced colitis.
our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 Proteins) migration.
Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 Proteins) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (show INS Proteins) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 Proteins) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 Proteins) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (show THBS1 Proteins) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (show IGF1 Proteins) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (show IGF1 Proteins), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (show IGF1 Proteins), its receptor (IGF-1R (show IGF1R Proteins)), and a well known IGF-1 (show IGF1 Proteins) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 Proteins) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (show LRP1 Proteins) mRNA and protein levels were dramatically reduced in LRP-1 (show LRP1 Proteins)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (show LRP1 Proteins)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (show BRD2 Proteins) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (show IGF1 Proteins)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (show MAPK1 Proteins) pathways.
TAF4b may thus be the TFIID (show TBP Proteins) component that binds to the TBP (show TBP Proteins) site on the IGFBP-3 promoter and is essential for FSH (show BRD2 Proteins) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (show C6orf134 Proteins) in Chinese breeds was over 50%; allelic frequency of GGC (show GGCT Proteins) was over 50% in all European breeds. TAT/TAT (show C6orf134 Proteins) pigs scored higher in meat color than GGC/GGC (show GGCT Proteins) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)