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The association between PRKCH 1425G/A and lacunar infarction was independent of traditional stroke risk factors
Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha (show PKCa Proteins), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 Proteins) protein (TRPC6 (show TRPC6 Proteins)) functions.
variant genotypes of PRKCH 1425G/A are an independent prognostic factor for ischemic stroke in the final multivariate Cox (show COX8A Proteins) regression model
Meta-analysis indicated that the 1425G/A SNP in PRKCH may contribute to susceptibility of stroke, especially for ischemic stroke.
PKCeta promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 (show CDKN1A Proteins) and p27Kip1 (show CDKN1B Proteins) and enhance transcription and secretion of IL-6 (show IL6 Proteins).
The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic stroke during a 2-year follow-up period.
PKC-eta associates with NHE3 (show SLC9A3 Proteins) and gamma tubulin (show TUBG1 Proteins) to promote the cell polarity during migration.
the PKC family genes may play a role in the pathogenesis of MS relapse through modulating the association between 25(OH)D and relapse.
Upregulation of PKCeta contributes to breast cancer cell growth and targeting either PKCepsilon (show PRKCE Proteins) or PDK1 (show PDK1 Proteins) triggers PKCeta downregulation
study demonstrates that type V collagen induces the down-regulation of protein kinase C eta
genetic deficiency results in defective suppressive activity of T reg (show KCNH2 Proteins) cells
data suggest that PKCeta shares some redundant roles with PKCtheta (show PRKCQ Proteins); in T cell biology and also performs nonredundant functions that are required for T cell homeostasis and activation
Protein kinase C eta promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 (show CDKN1B Proteins) mRNA through suppression of JNK/c-Jun signaling under stress conditions.
these results establish a previously uncharacterized role forPKC-epsilon, PKC-eta, PKC-theta (show PRKCQ Proteins) in T cell polarity.
ATP1A1 (show ATP1A1 Proteins) interaction with PKCeta and occludin (show OCLN Proteins) was involved in the integrity of the blood-labyrinth-barrier
PKC-eta/Fyn (show FYN Proteins)-dependent pathway leading to keratinocyte growth arrest and differentiation
The expression of specific PKC isotypes was significantly changed as embryonic stem cells differentiated into cardiomyocytes.
Parvovirus infection was found to result in activation of both PDK1 (show PDPK1 Proteins) and PKCeta, as evidenced by changes in their subcellular distribution and overall (auto)phosphorylation.
directs the induction of IRF-4 (show IRF4 Proteins) expression downstream of BLNK (show BLNK Proteins) in the pre-BCR (show BCR Proteins) signaling pathway promoting kappa gene rearrangement
Translational regulation could provide an additional level for controlling the expression of PKC family members.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
protein kinase C, eta
, protein kinase C eta type
, protein kinase C eta type-like
, protein kinase C-eta