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Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Increased myocardial CgA (show CGA ELISA Kits) glycosylation and impaired CgA (show CGA ELISA Kits) processing to catestatin in heart failure be considered detrimental because CST (show CORT ELISA Kits) reduces diastolic Ca2 (show CA2 ELISA Kits)+ leak via direct CaMKIIdelta inhibition.
performance of CgA (show CGA ELISA Kits)-deficient Chga-KO mice in treadmill exercise was impaired. CgA (show CGA ELISA Kits) deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (show GYS1 ELISA Kits) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (show LEP ELISA Kits) and CST (show CORT ELISA Kits) modulation of SGLT1 (show SLC5A1 ELISA Kits) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (show IAPP ELISA Kits) precursor (IAPP (show IAPP ELISA Kits)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 ELISA Kits)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8 (show CD8A ELISA Kits)(+) T cells in NOD.beta2m(null).HHD (show ATP2C1 ELISA Kits) mice.
Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide (show BNP ELISA Kits)) and CST (show GAL3ST1 ELISA Kits) levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA (show CGA ELISA Kits) is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA (show CGA ELISA Kits) can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B (show CHGB ELISA Kits) may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
we could provide evidence that established stress-related biomarkers ET-1 (show EDN1 ELISA Kits), MCP-1 (show CCL2 ELISA Kits), CGA (show CGA ELISA Kits) were differentially regulated among patients with AF compared to healthy controls.
Combined plasma CgA (show CGA ELISA Kits) concentrations and World Health Organization grading may assist in better stratification of PNET patients in terms of the risk of recurrence.
Metastatic castration-resistant prostate cancer patients with an early high CGA (show CGA ELISA Kits) rise may demonstrate a subgroup with poor outcome due to underlying small cell/neuroendocrine cell transformation.
genetic association studies in population in India: Data suggest that common polymorphisms (SNPs) in CHGA promoter are associated with cardiometabolic disorders; c-Rel (show NFkBP65 ELISA Kits) has a role in activating CHGA promoter haplotype 2 (variant T alleles at -1018 and -57 bp) under basal and pathophysiological conditions. (CHGA = chromogranin A; c-Rel (show NFkBP65 ELISA Kits) = c-Rel proto-oncogene protein)
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (show CHGB ELISA Kits)), synaptophysin (show SYP ELISA Kits), and insulin (show INS ELISA Kits) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (show BTG1 ELISA Kits)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (show AGTR2 ELISA Kits).
chromogranin A has a role in the IP(3)-mediated Ca(2 (show CA2 ELISA Kits)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (show CA2 ELISA Kits)+ channel (InsP3R (show ITPR1 ELISA Kits))in the Ca2 (show CA2 ELISA Kits)+-dependent ciliary movement
involvement of CGA (show CGA ELISA Kits) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 ELISA Kits)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I