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Full name:
Nitric Oxide Synthase 1, Neuronal Proteins (NOS1)
On www.antibodies-online.com are 21 Nitric Oxide Synthase 1, Neuronal (NOS1) Proteins from 6 different suppliers available. Additionally we are shipping NOS1 Antibodies (308) and NOS1 Kits (52) and many more products for this protein. A total of 388 NOS1 products are currently listed.
Synonyms:
2310005C01Rik, bNOS, IHPS1, N-NOS, NC-NOS, nNOS, NO, NOS, Nos-1, NOS-I, NOS1
list all proteins Gene Name GeneID UniProt
NOS1 4842 P29475
NOS1 24598 P29476
NOS1 18125 Q9Z0J4

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Zebrafish Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain

  2. NOS1 is a key regulator of motor axon ontogeny in the developing vertebrate spinal cord.

  3. The distribution pattern of nNOS gene expression showed the highest expression levels in the forebrain followed by the optic tectum, the brainstem and the spinal cord, whereas scarce expression was detected in the cerebellum.

Human Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. nNOS mediates the human coronary vasodilator response to mental stress, predominantly through actions at the level of coronary resistance vessels.

  2. These findings highlight a key role of the TLR4 (show TLR4 Proteins)-NOS1-AP1 (show FOSB Proteins) signaling axis in regulating macrophage polarization

  3. Association between NOS1 and PTSD severity and stress was found. NOS1 was associated with resilience.

  4. Data show that metastasis associated 1 (MTA1 (show MTA1 Proteins)) represses neuronal nitric oxide synthase (nNOS) expression upon oxygen glucose deprivation (OGD (show FGFR1 Proteins))-induced oxidative stress.

  5. Superoxide generation from NOS1 splice variants and its potential involvement in redox signal regulation has been described.

  6. expression of neuronal NOS heterodimers in insect cells, where we take advantage of an exogenous heme-triggered chaperone-assisted assembly process, provides an approximately 43% yield in heterodimeric NOS.

  7. NOS1 ex1f-VNTR is associated with anxiety-related traits.

  8. The NOS1 exon18 variants might play a role in the risk of Parkinson's disease (Meta-Analysis)

  9. nNOS gene variants contribute to OCD pathogenesis.

  10. Findings demonstrate that the upregulation of cardiac NOS1 is not accompanied by an increase in NOS activity; it is partially translocated to the sarcolemma in ischemic hearts with direct relationship between its protein levels and systolic ventricular function. These results indicate that NOS1 may be significant in the pathophysiology of human ischemic heart disease.

Cow (Bovine) Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. glutamate (show GRIN2A Proteins)-induced apoptosis was strongly reversed by nNOS inhibitors and weakly by iNOS (show NOS2 Proteins) inhibitors, thus indicating nNOS involvement in glutamate (show GRIN2A Proteins)-mediated apoptosis.

  2. The expression, localization, and distribution of 3 nitric oxide synthase enzymes through the estrous cycle in bovien fallopian tubes are reported.

  3. Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin (show KRIT1 Proteins) binding, increase FMN (show FMN1 Proteins) shielding, and suppress interflavin electron transfer

Rabbit Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. findings indicate that spinal transection affects nNOS and parvalbumin (show PVALB Proteins) in different neuronal circuits

  2. amyloid and oxidative stress-related disease proteins like NOS 1 is increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  3. Motoneurons in the ventral horns respond more sensitively to ischemia/reperfusion than do neurons localized in the other spinal cord regions. Changes in cNOS (show NOS3 Proteins) activity may also influence the axonal conductance in the white matter.

  4. Distribution pattern of the enzyme responsible for the synthesis of NO, nitric oxide synthase, in the population of primary afferent neurons of the trigeminal ganglion and mesencephalic trigeminal nucleus of the rabbit.

  5. The regional distribution of nitric oxide synthase activity and neuronal nitric oxide synthase immunoreactivity, measured segment by segment shows that nitric oxide may play a significant role in the stepping cycle in the quadrupeds.

  6. NOS via Nitric oxide production may play a neuroprotective role in ischemic/reperfusion injury.

Guinea Pig Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. form-deprivation myopia upregulates the expression of NMDAR1 (show GRIN1 Proteins) and ncNOS and increases cGMP content in the retina. NMDAR1 (show GRIN1 Proteins)/NO-cGMP pathway may contribute to abnormal visual signals during myopic progression.

Pig (Porcine) Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.

  2. Our results suggest that the presence of low mycotoxin doses in feed slows down the mRNA expression of nitric oxide synthase-1 and nitric oxide synthase-2 genes which probably lowers the concentrations of nitric oxide, a common precursor of inflammation.

  3. nNOS is an important regulator of renal hemodynamics in the newborn kidney, but not in the adult.

  4. Data suggest that pig sperm contain bNOS, iNOS (show NOS2 Proteins), and eNOS (show NOS3 Proteins); up-regulation of NOS by leptin (show LEP Proteins) during acrosome reaction and inhibition of acrosome reaction by inhibitors of nitric oxide synthases suggests these enzymes are involved in acrosome reaction.

  5. Periodic acceleration (pGz) acutely increases endothelial and neuronal nitric oxide synthase expression in endomyocardium of normal swine.

  6. Regional difference in blood flow has no effect on nNOS protein content in different sized conduit arteries.

  7. study concludes that in the cerebral cortex of newborn piglets, the mechanism of hypoxia-induced increased tyrosine phosphorylation of nNOS is mediated by nNOS-derived nitric oxide.

  8. Data suggest that angiotensin II regulates nNOS and eNOS expression and NOS activity in afferent arterioles of the developing kidney via angiotensin 1 and 2 receptors.

Mouse (Murine) Nitric Oxide Synthase 1, Neuronal (NOS1) interaction partners

  1. aerobic exercise training could improve cardiac systolic function and alleviate LV chamber dilation, cardiac fibrosis and hypertrophy in heart failure mice. The mechanism responsible for the protective effects of aerobic exercise is associated with the activation of the beta3-AR-nNOS-NO pathway.

  2. These findings highlight a key role of the TLR4 (show TLR4 Proteins)-NOS1-AP1 (show JUN Proteins) signaling axis in regulating macrophage polarization

  3. The findings indicate that the activation of sigma1R (show SIGMAR1 Proteins) can alleviate postpartum "depression" through increasing nNOS-NO-CREB (show CREB1 Proteins) activities.

  4. To optimize a dystrophin (show DMD Proteins) cDNA construct for therapeutic application we designed and produced four human minidystrophins within the packaging capacity of lentiviral vectors. Two novel minidystrophins retained the centrally located neuronal nitric oxide synthase (nNOS)-anchoring domain in order to achieve sarcolemmal nNOS restoration, which is lost in most internally deleted dystrophin (show DMD Proteins) constructs.

  5. nNOSmu is not essential for skeletal muscle glucose uptake during exercise, and the higher skeletal muscle glucose uptake during exercise in nNOSmu(-/-) mice may be due to compensatory increases in AMPK (show PRKAA1 Proteins) activation.

  6. nNOS expression levels increased with age in the hippocampus and cerebellum, but not in the cortex. Moreover, environmental enrichment reduced anxiety-like behaviors in aged mice and reduced nNOS expression levels in the cerebellum, but not in the cortex.

  7. results hint towards an involvement of NOS-I/NOS1AP (show NOS1AP Proteins) interaction in the regulation of dendritic spine plasticity

  8. that endothelial dysfunction in the mesenteric arteries of DOCA-salt-hypertensive mice is associated with reduced expression and functioning of nNOS

  9. The present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  10. 14. These findings indicated that an upregulation of nNOS and iNOS (show NOS2 Proteins) in the spinal cord is associated with bone cancer pain and suggests that exogenously administered L-NMMA may have beneficial effects to alleviate bone cancer pain.

NOS1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Alternative names and synonyms associated with NOS1

  • nitric oxide synthase 1 (neuronal) (nos1)
  • nitric oxide synthase 1 (neuronal) (NOS1)
  • nitric oxide synthase (NNOS)
  • nitric oxide synthase 1 (neuronal) (Nos1)
  • nitric oxide synthase 1, neuronal (Nos1)
  • 2310005C01Rik protein
  • bNOS protein
  • IHPS1 protein
  • N-NOS protein
  • NC-NOS protein
  • nNOS protein
  • NO protein
  • NOS protein
  • Nos-1 protein
  • NOS-I protein
  • NOS1 protein

Protein level used designations for NOS1

nitric oxide synthase, brain , nitric oxide synthase 1 (neuronal) , Nitric oxide synthase, brain , NOS type I , constitutive NOS , neuronal NOS , peptidyl-cysteine S-nitrosylase NOS1 , N-NOS , NC-NOS , bNOS , nNOS , neuronal nitric oxide synthase , nitric oxidase synthase

GENE ID SPECIES
60658 Danio rerio
467139 Pan troglodytes
100597250 Nomascus leucogenys
443533 Ovis aries
4842 Homo sapiens
536132 Bos taurus
100009243 Oryctolagus cuniculus
100729682 Cavia porcellus
477498 Canis lupus familiaris
100520934 Sus scrofa
427721 Gallus gallus
101100342 Felis catus
24598 Rattus norvegicus
18125 Mus musculus
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