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NOG Proteins

(Noggin (NOG))
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
NOG Protein (Noggin) (AA 20-232) NOG Protein (Noggin) (AA 20-232) NOG Protein (Noggin) (AA 20-232) (ABIN2018288)

NOG Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

NOG Protein (Noggin) (AA 28-232) NOG Protein (Noggin) (AA 28-232) NOG Protein (Noggin) (AA 28-232) (ABIN2018291)

NOG Origin: Human Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

NOG Protein (Noggin) NOG Protein (Noggin) NOG Protein (Noggin) (ABIN7275358)

NOG Origin: Human Host: CHO Cells Recombinant > 95% as determined by Tris-Bis PAGE

NOG Proteins by Grade

Find NOG Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

NOG Proteins by Origin

Find NOG Proteins for a variety of species such as anti-Human NOG, anti-Mouse NOG, anti-Rat NOG. The species listed below are among those available. Click on a link to go to the corresponding products.

NOG Proteins by Source

Find NOG Proteins with a specific Source. The Source listed below are among those available. Click on a link to go to the corresponding products.

NOG Proteins by Protein Type

Find NOG Proteins with a specific Protein Type. The Protein Type listed below are among those available. Click on a link to go to the corresponding products.

NOG Proteins by Application

Find NOG Proteins validated for a specific application such as WB, SDS, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

NOG Proteins by Biological Activity

Find NOG Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular NOG Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2181545
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3084703
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3121208
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source
Validations
  • (1)
Cat. No. ABIN1111863
Quantity 5 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN6239823
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312765
Quantity 10 μg
Datasheet Datasheet
Reactivity Dog
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010969
Quantity 100 μg
Datasheet Datasheet
Reactivity Chicken
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010967
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN988177
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7086391
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7086395
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7086398
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7124188
Quantity 50 μg
Datasheet Datasheet
Reactivity Pig
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7086394
Quantity 50 μg
Datasheet Datasheet
Reactivity Dog
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7086396
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our NOG Proteins

Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).

Guan, Du, Lv, Qu, Fu, Yuan et al.: "Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling ..." in: Clinical and experimental pharmacology & physiology, Vol. 43, Issue 1, pp. 125-34, (2016) (PubMed).

Ye, Ge, Zhang, Cheng, Zhang, He, Wang, Lin, Yang, Liu, Zhao, Deng: "Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds." in: Cell research, Vol. 26, Issue 1, pp. 34-45, (2016) (PubMed).

Miyagi, Mikawa, Sato, Hasegawa, Kobayashi, Matsuyama, Sato: "BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord." in: Neuroscience, Vol. 203, pp. 12-26, (2012) (PubMed).

Umezu, Yamanouchi, Iida, Miura, Tomooka: "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 10, pp. 4601-6, (2010) (PubMed).

Aliases for NOG Proteins

noggin (NOG) Proteins
noggin (Nog) Proteins
noggin L homeolog (nog.L) Proteins
noggin protein (noggin) Proteins
nog-A Proteins
nog1 Proteins
noggin Proteins
noggin-1 Proteins
SYM1 Proteins
SYNS1 Proteins
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