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Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
A higher regeneration rate in the CF102 treatment group was observed compared with the control group, suggesting that CF102 had a positive effect on the proliferation of hepatocytes following hepatectomy. CF102 had a protective effect on the liver of Wistar rats subsequent to IR injury during hepatectomy. This may be due to an antiinflammatory and antiapoptotic effect mediated by the A3AR (show ADORA3 Proteins).
Low level of ADORA1/ADORA2A expression increased susceptibility of brain tumor-associated epilepsy.
No association was found between the ADORA2A rs2298383 polymorphism and panic disorder. The ADORA2A TT homozygous wild-type genotype and the ACCN2 (show ACCN2 Proteins) TT/ADORA2A CT diplotype were more represented in controls.
gene expression of A2AR in PBMCs was significantly lower in idiopathic normal-pressure hydrocephalus patients than controls
crystal structure of the adenosine A(2A) receptor bound to an engineered G protein at 3.4 A resolution
This review will provide insight into the phenotypic changes that underline the resistance to death of liver cells preconditioned by pharmacological activation of A2aR and their implications to develop innovative strategies against liver IR damage
Data suggest that A2aR binding of antagonist (here, ZM241385) exhibits multistep drug-dissociation process, with antagonist consecutively interacting with topographically distinct regions/binding sites of A2aR.
activation of the A2AR reduced oxidative stress-induced (show SQSTM1 Proteins) DNA damage and caspase 3 (show CASP3 Proteins) activation in GABAergic neurons
(19)F nuclear magnetic resonance is used to quantify the conformational landscape occupied by the adenosine A2A receptor (A2AR), a prototypical class A G-protein-coupled receptor (show ADRA1A Proteins)
ST1535 metabolites ST3932 and ST4206 are effective adenosine A2A receptor antagonists which maybe useful in treating Parkinson disease.
Results indicate that neuroprotection by caffeine in the MPTP (show PTPN2 Proteins) model of Parkinson's disease relies on the A2AR, although the specific cellular localization of these receptors remains to be determined
Diabetes resulted in an increased A2A/A2B (show ADORA2B Proteins) receptor expression in coronary arteries which resulted in enhanced A2A/A2B (show ADORA2B Proteins)-mediated increase in coronary flow observed in diabetic hearts.
Thsi study demonstrated thata complex involvement of A2aR in the pathogenesis of chronic neuroinflammation in mice.
In the adenosine A2A receptor knock-out mouse, pulmonary hypertension develops through activation of RhoA (show RHOA Proteins)/ROCK signaling pathway.
A2AR deletion is sufficient to prevent memory defects, hippocampal plasticity impairments as well as Tau hyperphosphorylation, in a mouse model of Alzheimer's disease
A2AR signaling regulates both basal and LPS (show TLR4 Proteins)-induced DUSP1 (show DUSP1 Proteins) levels in macrophages via activating the adenylate cyclase pathway.
Plasminogen (show PLG Proteins) activation contributes to wound repair and suggest that adenosine A2A receptor activation promotes wound closure by a mechanism that depends on tPA (show PLAT Proteins).
These results show that the dysfunction of astrocytic A2AR, by controlling GLT (show SLC1A2 Proteins)-I activity, triggers an astrocyte-to-neuron wave of communication resulting in disrupted glutamate (show GRIN1 Proteins) homeostasis.
This study showed that the recruitment of intracellular A2AR signaling in the hippocampus is sufficient to trigger memory dysfunction.
A novel mutual suppression feedback loop between A2AR signaling and miR (show MLXIP Proteins)-214 in inflammation.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 Proteins) production by LPS (show IRF6 Proteins)-stimulated equine neutrophils in a cAMP-dependent manner.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, A2a adenosine receptor
, adenosine receptor A2a-like
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor