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anti-Human AKAP13 Antibodies:
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Human Polyclonal AKAP13 Primary Antibody for IP - ABIN261128
Manukyan, Nalbant, Luxen, Hahn, Knaus: RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 2 Pubmed References
Human Monoclonal AKAP13 Primary Antibody for IF, ELISA - ABIN564877
Hu, Wang, Li, Yang, Zhang, Chen, Wang, Zhou: The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer. in Clinical and experimental medicine 2010
evaluation of MAGT1 (show MAGT1 Antibodies) and AKAP13 expression in clinical hepatocellular carcinoma tissues by immunohistochemistry suggested that both proteins were strongly expressed in tumor tissues with significantly higher average immunoreactive scores of Remmele and Stegner (IRS (show IARS Antibodies)) than in non-tumor tissues
Studied molecular interactions involving anchoring protein AKAP13 in the process of PKA-induced tamoxifen resistance in breast cancer specimens and cell lines.
Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA (show RHOA Antibodies), which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF (show SLC2A4RG Antibodies) inhibitors.
pleckstrin (show PLEK Antibodies) homology (PH) domain of Lbc is located at the C-terminal end of the protein and is shown here to specifically recognize activated RhoA (show RHOA Antibodies) rather than lipids
activation of IKKbeta (show IKBKB Antibodies) within the AKAP-Lbc complex promotes NF-kappaB (show NFKB1 Antibodies)-dependent production of interleukin-6 (show IL6 Antibodies)
Shp2 (show PTPN11 Antibodies) is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart.
Thus AKAP-Lbc may serve an ancillary cardioprotective role by favouring the association of PKA with Hsp20 (show HSPB6 Antibodies).
Amplification of AKAP-13 is associated with metastatic and aggressive papillary thyroid carcinomas.
One SNP (rs11638762), in the GATA-3 (show GATA3 Antibodies) binding site upstream of the AKAP13 gene, was significantly replicated in another cohort for systolic blood pressure
A-kinase anchoring protein (AKAP)-Lbc anchors a PKN (show PKN1 Antibodies)-based signaling complex involved in alpha1-adrenergic receptor-induced p38 (show CRK Antibodies) activation.
These findings suggest that Akap13 haploinsufficient mice have a deficiency in early osteogenesis with a corresponding reduction in osteoblast number, but no impairment of mature osteoblast activity.
Our results show that AKAP13-PKD1 (show PKD1 Antibodies) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
AKAP13 Rho-GEF (show ARHGEF2 Antibodies) and PKD (show PRKD1 Antibodies)-binding domains are important for normal cardiac contractility.
AKAP-Lbc assembles a signaling complex composed of the kinases PKN (show PKN1 Antibodies), MLTK (show ZAK Antibodies), MKK3 (show MAP2K3 Antibodies), and p38 alpha (show MAPK14 Antibodies) that mediates the activation of p38 (show CRK Antibodies) in cardiomyocytes in response to stress signals.
Cardiomyocytes of Akap13-null mice had deficient sarcomere formation, and developing hearts were thin-walled and mice died at embryonic day 10.5-11.0.
AKAP13 plays a role in TLR2 (show TLR2 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation; GEF (show ARHGEF2 Antibodies)-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
A kinase (PRKA) anchor protein 13
, A kinase anchor protein 13 isoform-like
, A-kinase anchor protein 13-like
, A-kinase anchor protein 13
, a-kinase anchor protein 13-like
, A-kinase anchoring protein
, LBC oncogene
, breast cancer nuclear receptor-binding auxiliary protein
, guanine nucleotide exchange factor Lbc
, human thyroid-anchoring protein 31
, lymphoid blast crisis oncogene
, non-oncogenic Rho GTPase-specific GTP exchange factor
, protein kinase A-anchoring protein 13
, protein kinase A anchoring protein Rt31
, type II cAMP-dependent protein kinase anchoring protein Ht31