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Browse our anti-AKAP13 (AKAP13) Antibodies

Full name:
anti-A Kinase (PRKA) Anchor Protein 13 Antibodies (AKAP13)
On are 35 A Kinase (PRKA) Anchor Protein 13 (AKAP13) Antibodies from 12 different suppliers available. Additionally we are shipping AKAP13 Kits (10) and and many more products for this protein. A total of 50 AKAP13 products are currently listed.
1700026G02Rik, 5730522G15Rik, 5830460E08Rik, AKAP-13, AKAP-Lbc, AKAP13, ARHGEF13, BRX, c-lbc, HA-3, Ht31, LBC, MGC81410, p47, PRKA13, PROTO-LB, PROTO-LBC
list all antibodies Gene Name GeneID UniProt
AKAP13 11214 Q12802
Anti-Rat AKAP13 AKAP13 293024  
Anti-Mouse AKAP13 AKAP13 75547  

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anti-Human AKAP13 Antibodies:

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Top referenced anti-AKAP13 Antibodies

  1. Human Monoclonal AKAP13 Primary Antibody for IF - ABIN393825 : Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010 (PubMed)
    Show all 5 references for ABIN393825

  2. Human Monoclonal AKAP13 Primary Antibody for WB - ABIN393706 : Larsen, Kornblit, Larsen, Masmas, Nielsen, Thiim, Garred, Stryhn, Lund, Buus, Vindelov: Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010 (PubMed)
    Show all 5 references for ABIN393706

  3. Human Polyclonal AKAP13 Primary Antibody for IHC, ELISA - ABIN1533849 : Toksoz, Williams: Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. in Oncogene 1994 (PubMed)
    Show all 2 references for ABIN1533849

  4. Human Monoclonal AKAP13 Primary Antibody for IF, ELISA - ABIN564877 : Hu, Wang, Li, Yang, Zhang, Chen, Wang, Zhou: The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer. in Clinical and experimental medicine 2010 (PubMed)

More Antibodies against AKAP13 Interaction Partners

Human A Kinase (PRKA) Anchor Protein 13 (AKAP13) interaction partners

  1. Studied molecular interactions involving anchoring protein AKAP13 in the process of PKA-induced tamoxifen resistance in breast cancer specimens and cell lines.

  2. Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA (show RHOA Antibodies), which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF (show SLC2A4RG Antibodies) inhibitors.

  3. pleckstrin (show PLEK Antibodies) homology (PH) domain of Lbc is located at the C-terminal end of the protein and is shown here to specifically recognize activated RhoA (show RHOA Antibodies) rather than lipids

  4. activation of IKKbeta (show IKBKB Antibodies) within the AKAP-Lbc complex promotes NF-kappaB (show NFKB1 Antibodies)-dependent production of interleukin-6 (show IL6 Antibodies)

  5. Shp2 (show PTPN11 Antibodies) is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart.

  6. Thus AKAP-Lbc may serve an ancillary cardioprotective role by favouring the association of PKA with Hsp20 (show HSPB6 Antibodies).

  7. Amplification of AKAP-13 is associated with metastatic and aggressive papillary thyroid carcinomas.

  8. One SNP (rs11638762), in the GATA-3 (show GATA3 Antibodies) binding site upstream of the AKAP13 gene, was significantly replicated in another cohort for systolic blood pressure

  9. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN (show PKN1 Antibodies)-based signaling complex involved in alpha1-adrenergic receptor-induced p38 (show CRK Antibodies) activation.

  10. third new locus (rs6496932), on 15q25.3 (beta = 0.13, P = 1.4 x 10(-8)), was within a wide linkage disequilibrium block extending into the 5' end of the AKAP13 gene, encoding a scaffold protein (show HOMER1 Antibodies) concerned with signal transduction from the cell surface

Mouse (Murine) A Kinase (PRKA) Anchor Protein 13 (AKAP13) interaction partners

  1. These findings suggest that Akap13 haploinsufficient mice have a deficiency in early osteogenesis with a corresponding reduction in osteoblast number, but no impairment of mature osteoblast activity.

  2. Our results show that AKAP13-PKD1 (show PKD1 Antibodies) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.

  3. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.

  4. AKAP13 Rho-GEF (show ARHGEF2 Antibodies) and PKD (show PRKD1 Antibodies)-binding domains are important for normal cardiac contractility.

  5. AKAP-Lbc assembles a signaling complex composed of the kinases PKN (show PKN1 Antibodies), MLTK (show ZAK Antibodies), MKK3 (show MAP2K3 Antibodies), and p38 alpha (show MAPK14 Antibodies) that mediates the activation of p38 (show CRK Antibodies) in cardiomyocytes in response to stress signals.

  6. Cardiomyocytes of Akap13-null mice had deficient sarcomere formation, and developing hearts were thin-walled and mice died at embryonic day 10.5-11.0.

  7. AKAP13 plays a role in TLR2 (show TLR2 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation; GEF (show ARHGEF2 Antibodies)-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs

AKAP13 Antigen Profile

Antigen Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

Alternative names and synonyms associated with AKAP13

  • A kinase (PRKA) anchor protein 13 (AKAP13) antibody
  • A kinase (PRKA) anchor protein 13 (akap13) antibody
  • A kinase (PRKA) anchor protein 13 (Akap13) antibody
  • 1700026G02Rik antibody
  • 5730522G15Rik antibody
  • 5830460E08Rik antibody
  • AKAP-13 antibody
  • AKAP-Lbc antibody
  • AKAP13 antibody
  • ARHGEF13 antibody
  • BRX antibody
  • c-lbc antibody
  • HA-3 antibody
  • Ht31 antibody
  • LBC antibody
  • MGC81410 antibody
  • p47 antibody
  • PRKA13 antibody
  • PROTO-LB antibody
  • PROTO-LBC antibody

Protein level used designations for AKAP13

A kinase (PRKA) anchor protein 13 , A kinase anchor protein 13 isoform-like , A-kinase anchor protein 13-like , A-kinase anchor protein 13 , a-kinase anchor protein 13-like , A-kinase anchoring protein , LBC oncogene , breast cancer nuclear receptor-binding auxiliary protein , guanine nucleotide exchange factor Lbc , human thyroid-anchoring protein 31 , lymphoid blast crisis oncogene , non-oncogenic Rho GTPase-specific GTP exchange factor , protein kinase A-anchoring protein 13 , protein kinase A anchoring protein Rt31 , type II cAMP-dependent protein kinase anchoring protein Ht31

397631 Sus scrofa
414621 Xenopus laevis
415502 Gallus gallus
479032 Canis lupus familiaris
557441 Danio rerio
743772 Pan troglodytes
100078722 Ornithorhynchus anatinus
100342409 Oryctolagus cuniculus
100390018 Callithrix jacchus
100454484 Pongo abelii
100469605 Ailuropoda melanoleuca
698172 Macaca mulatta
504288 Bos taurus
100551220 Meleagris gallopavo
11214 Homo sapiens
293024 Rattus norvegicus
75547 Mus musculus
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