Browse our anti-FGD4 (FGD4) Antibodies

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anti-FYVE, RhoGEF and PH Domain Containing 4 Antibodies (FGD4)
On are 29 FYVE, RhoGEF and PH Domain Containing 4 (FGD4) Antibodies from 12 different suppliers available. Additionally we are shipping FGD4 Proteins (4) and many more products for this protein. A total of 35 FGD4 products are currently listed.
9030023J02Rik, 9330209B17Rik, CMT4H, Frabp, ZFYVE6

Most Popular Reactivities for anti-FGD4 (FGD4) Antibodies

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anti-Human FGD4 Antibodies:

anti-Mouse (Murine) FGD4 Antibodies:

anti-Rat (Rattus) FGD4 Antibodies:

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Top referenced anti-FGD4 Antibodies

  1. Human Polyclonal FGD4 Primary Antibody for EIA, WB - ABIN952304 : Houlden, Hammans, Katifi, Reilly: A novel Frabin (FGD4) nonsense mutation p.R275X associated with phenotypic variability in CMT4H. in Neurology 2009 (PubMed)
    Show all 3 references for 952304

  2. Human Polyclonal FGD4 Primary Antibody for WB - ABIN656907 : Stendel, Roos, Deconinck, Pereira, Castagner, Niemann, Kirschner, Korinthenberg, Ketelsen, Battaloglu, Parman, Nicholson, Ouvrier, Seeger, De Jonghe, Weis, Krüttgen, Rudnik-Schöneborn, Bergmann, Suter, Zerres, Timmerman, Relvas, Senderek: Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. in American journal of human genetics 2007 (PubMed)
    Show all 2 references for 656907

More Antibodies against FGD4 Interaction Partners

Human FYVE, RhoGEF and PH Domain Containing 4 (FGD4) interaction partners

  1. FGD4 c.2044-236 A-allele carriers had an increased risk of paclitaxel dose reduction (HR per A-allele=1.38, P=0.036) when adjusted for total cumulative paclitaxel dose

  2. identified two different pairs of novel compound heterozygous mutations in the FGD4 gene from nonconsanguineous Korean Charcot-Marie-Tooth disease type 4H families

  3. Our results suggest that FGD4 should be screened in other early-onset CMT subtypes, regardless of the severity of the phenotype, and particularly in patients of consanguineous descent.

  4. A single nucleotide polymorphism in FGD4 was associated with the onset of paclitaxel-induced sensory peripheral neuropathy.

  5. LMP1 (show PDLIM7 Antibodies), through its transmembrane domains, directly bound FGD4 and enhanced FGD4 activity toward Cdc42 (show CDC42 Antibodies), leading to actin cytoskeleton rearrangement and increased motility of NPC (show NPC1 Antibodies) cells.

  6. we have identified two novel missense mutations in FGD4 in two patients affected by autosomal recessive demyelinating Charcot-Marie-Tooth disease

  7. role of frabin, a guanine nucleotide exchange factor (show RASGRF1 Antibodies) specific for Cdc42 (show CDC42 Antibodies), in the activation of Cdc42 (show CDC42 Antibodies) during Cryptosporidium parvum infection of biliary epithelial cells

  8. The identification of mutations in FGD4, encoding FGD4 or FRABIN (FGD1-related F-actin binding protein), in families with Charcot-Marie-Tooth type 4H.

  9. We report that disruption of frabin/FGD4, a GEF (show SLC2A4RG Antibodies) for the Rho GTPase (show RACGAP1 Antibodies) cell-division cycle 42 (Cdc42 (show CDC42 Antibodies)), causes peripheral nerve demyelination in patients with autosomal recessive Charcot-Marie-Tooth (CMT) neuropathy.

  10. A novel homozygous Frabin (FGD4) nonsense mutation p.R275X is identified in a family with Charcot-Marie Tooth disease (CMT4H) from Northern Ireland.

Mouse (Murine) FYVE, RhoGEF and PH Domain Containing 4 (FGD4) interaction partners

  1. The enrichment of activated Cdc42 (show CDC42 Antibodies) in SSeCKS (show AKAP12 Antibodies)-null leading edge filopodia correlated with recruitment of the Cdc42 (show CDC42 Antibodies)-specific guanine nucleotide exchange factor (show ARHGEF12 Antibodies), Frabin.

  2. This study demonistrated that the disease-initiating event in CMT4H is loss of a Schwann cell-specific cellular function of Frabin/Fgd4.

FGD4 Antigen Profile

Antigen Summary

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

Alternative names and synonyms associated with FGD4

  • FYVE, RhoGEF and PH domain containing 4 (FGD4) antibody
  • FYVE, RhoGEF and PH domain containing 4 (Fgd4) antibody
  • 9030023J02Rik antibody
  • 9330209B17Rik antibody
  • CMT4H antibody
  • Frabp antibody
  • ZFYVE6 antibody

Protein level used designations for FGD4

FGD1 family, member 4 , FGD1-related F-actin-binding protein , FYVE, RhoGEF and PH domain-containing protein 4 , actin-filament binding protein frabin , zinc finger FYVE domain-containing protein 6 , Fgd1-related F-actin-binding protein , actin filament-binding protein frabin , frabin

121512 Homo sapiens
224014 Mus musculus
246174 Rattus norvegicus
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