Browse our Obscurin Proteins (OBSCN)

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Obscurin Proteins (OBSCN)
On are 2 Obscurin (OBSCN) Proteins from 1 different suppliers available. Additionally we are shipping Obscurin Antibodies (5) and many more products for this protein. A total of 7 Obscurin products are currently listed.
ARHGEF30, BC046431, Gm878, OTTMUSG00000005786, UNC89
list all proteins Gene Name GeneID UniProt
OBSCN 84033 Q5VST9
Mouse OBSCN OBSCN 380698  

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Human Obscurin (OBSCN) interaction partners

  1. OBSCN mutations may result in the development of a familial dilated cardiomyopathy (DCM) phenotype via haploinsufficiency. These mutations should be considered as a significant causal factor of DCM, alone or in concert with other mutations.

  2. Gene-based association analyses shows nominal significant association with multifocal fibromuscular dysplasia for obscurin.

  3. Loss of the obscurin-RhoGEF downregulates RhoA (show RHOA Proteins) signaling and increases microtentacle formation and attachment of breast epithelial cells.

  4. this study presents here the X-ray structure of the human titin:obscurin M10:O1 complex extending our previous work on the M10:OL1 interaction.

  5. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

  6. OBSCN polymorphisms, in particular, highly conserved nonsynonymous Leu2116Phe variant, might contribute to aspirin hypersensitivity in asthmatics

  7. Results describe the molecular basis for the head-to-tail interaction of the carboxyl terminus of titin and the amino-terminus of obscurin-like-1 by X-ray crystallography.

  8. Results suggest that obscurin binds small ankyrin 1, and document a specific and direct interaction between proteins of the sarcomere and the sarcoplasmic reticulum.

  9. The complete gene giant muscle protein obscurin was analysed. The fusion of the conventional obscurin A, containing only the GEF (show SLC2A4RG Proteins) domain, and obscurin B, fusing into the 3' kinase exons, was experimentally confirmed and analysed.

  10. OBSCN and C9orf65 (show PRUNE2 Proteins) comprise a highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.

Mouse (Murine) Obscurin (OBSCN) interaction partners

  1. Altogether, these results suggest that obscurin is required for the maintenance of morphological and ultrastructural integrity of skeletal muscle fibers against damage induced by intense mechanical stress and point to the diaphragm as the skeletal muscle most severely affected in obscurin-deficient mice.

  2. obscurins are not restricted to striated (show NSDHL Proteins) muscles, but are abundantly expressed in several tissues and organs including brain, skin, kidney, liver, spleen, and lung.

  3. the obscurin kinase domains, SK1 and SK2, are active enzymes with distinct substrate specificities.

  4. Obscurin, by targeting ankB (show ANKH Proteins) at the M band, contributes to the organization of subsarcolemma microtubules, localization of dystrophin (show DMD Proteins) at costameres, and maintenance of sarcolemmal integrity.

  5. Results support a role of obscurin in mediating the subcellular localization of small ankyrin1 isoforms in striated (show NSDHL Proteins) muscle cells.

  6. the Rho-GEF (show ARHGEF2 Proteins) domain of obscurin interacts with RanBP9 (show RANBP9 Proteins) and that both can interact with the N-terminal region of titin (show TTN Proteins) to influence the formation of the Z-disk and A/I junction

  7. ANK2 is subject to alternative splicing that gives rise to unique polypeptides with diverse roles in cardiac function.

  8. the organization of obscurin at different locations in the sarcomere changes during muscle development and that this might affect the interaction with ank1.5.

Obscurin (OBSCN) Protein Profile

Protein Summary

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with Obscurin (OBSCN)

  • obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN)
  • obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (Obscn)
  • ARHGEF30 protein
  • BC046431 protein
  • Gm878 protein
  • OTTMUSG00000005786 protein
  • UNC89 protein

Protein level used designations for Obscurin Proteins (OBSCN)

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF , obscurin , obscurin, myosin light chain kinase , obscurin-MLCK , obscurin-RhoGEF , obscurin-myosin light chain kinase

420395 Gallus gallus
457798 Pan troglodytes
537193 Bos taurus
84033 Homo sapiens
380698 Mus musculus
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