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The present results have uncovered new factors underlying successful axon regeneration in the fish CNS: Binding of Nogo (show RTN4 ELISA Kits)-66 of fish RTN-4 (show RTN4 ELISA Kits) to NgR is growth promoting on fish retinal ganglion cell axon growth
Data suggest that localized Nogo (show RTN4 ELISA Kits)/Nogo66 expression defines inhibitory territories that through repulsion restrict axon growth to permissive regions.
Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS.
Authors highlight the structural and biochemical aspects of the interaction of Nogo (show RTN4 ELISA Kits) receptors (R1 and R2) with myelin inhibitors such as MAG (show MAG ELISA Kits), Nogo A (show RTN4 ELISA Kits) and OMgp (show OMG ELISA Kits).[Review]
NgR1 (show NEUROG1 ELISA Kits) is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus.
Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR (show NGFR ELISA Kits)).
This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene.
knockdown of NgR enhanced invasion and adhesion but increased cell apoptosis in C6 cells, suggesting that Nogo (show RTN4 ELISA Kits)-66/NgR might have complex effects on glioma cells.
After optic nerve crush injury, transgenic NgR1 (show NEUROG1 ELISA Kits)-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice.
Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy.
Nogo receptor 3, a paralog of NgR1 (show NEUROG1 ELISA Kits),functions as a NgR1 (show NEUROG1 ELISA Kits) co-receptor for Nogo (show RTN4 ELISA Kits)-66.
These results indicate that a lack of NgR1 (show NEUROG1 ELISA Kits)/2 expression promotes the adhesion of DCs to myelin.
Rtn4r expression was reduced in spinal motor neurons from mice with a transgenic model of ALS.
This study detected the expression of NgR1 (show NEUROG1 ELISA Kits) in microglia during development and found that NgR1 (show NEUROG1 ELISA Kits) protein expression increased significantly in microglia with aging.
Ngr1 (show NEUROG1 ELISA Kits) regulates tactile and motor task performance, it does not limit the rate of tactile or motor learning nor determine the low set point for synaptic turnover in adult sensory cortex.
the Nogo (show RTN4 ELISA Kits)/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases.
Genetic ablation of NgR1 (show NEUROG1 ELISA Kits) may lead to significant recovery in locomotor function after spinal cord injury
NgR1 (show NEUROG1 ELISA Kits) is required for efficient infection of primary cortical neurons by reovirus.
NogoA (show RTN4 ELISA Kits) receptors, NogoR1 and PirB (show LILRB3 ELISA Kits), are expressed in the ventricular zone where neural stem cells reside.
NgR1 (show NEUROG1 ELISA Kits) functions with parvalbumin (show PVALB ELISA Kits) interneurons to limit plasticity of binocularity, but its expression is required more extensively to limit improvement of visual acuity following chronic deprivation.
NgR1 (show NEUROG1 ELISA Kits) has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS.
ngr(-/-) animals show slower acquisition of a spatial learning and memory task
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
, reticulon-4 receptor
, reticulon-4/Nogo receptor
, reticulon 4 receptor
, nogo receptor
, nogo receptor; Nogo-66 receptor
, Nogo66 receptor
, nogo-66 receptor