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CD40 functions as a non-redundant mechanism to convert the tumor microenvironment immunologically.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 (show STAT1 Proteins) expression and NF-kappaB (show NFKB1 Proteins) activity.
CD40 plays a critical role in the pathogenesis of type 1 diabetes, influencing lymphocyte trafficking, T-cell receptor expression, and T-cell pathogenesis.
CD40 signaling in adipose tissue macrophages regulates major histocompatibility complex class II and CD86 (show CD86 Proteins) expression to control the expansion of CD4 (show CD4 Proteins)(+) T cells.
Adoptively transferred Th40 cells (CD4 (show CD4 Proteins)+CD40+ Tcells) are present in lesions in the CNS and are associated with wide spread demyelination.
this study reports that anti-CD40 mAb administration <3 d in advance of chemotherapy is lethal in more than half of treated C57BL/6 mice in pancreatic cancer model
The data show that CD40-mediated inhibition of PC generation is via engagement of multiple pathway and constitutive CD40 signaling in vivo involving bystander T-B interactions can calibrate B cell differentiation outcomes
BAFF (show TNFSF13B Proteins) upregulates CD28 (show CD28 Proteins)/B7 and CD40/CD154 (show CD40LG Proteins) expression, and promotes the interactions between T and B cells in a BAFF-R (show TNFRSF13C Proteins)-dependent manner
CD40 in Muller cells is sufficient to upregulate retinal inflammatory markers and appears to promote experimental diabetic retinopathy and that Muller cells orchestrate inflammatory responses in myeloid cells through a CD40-ATP-P2X7 (show P2RX7 Proteins) pathway.
Taken together, our data demonstrate the importance of CD40 signaling in the conversion of CTL exhaustion and its ability to enhance PD-1 (show PDCD1 Proteins) antagonist action in rescuing exhausted CTLs in chronic infection.
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (show IL1B Proteins) rs16944, IL1R2 (show IL1R2 Proteins) rs2071008, PLA2G7 (show Lp-PLA2 Proteins) rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 (show CD36 Proteins) rs2065666 were associated with coronary heart disease (CHD (show CHDH Proteins)), suggesting an important role of inflammation in the risk of CHD (show CHDH Proteins).
miR (show MLXIP Proteins)-145 is involved in the anti-proliferation and anti-inflammation effects of aspirin on vascular smooth muscle cells by inhibiting the expression of CD40.
CD40 activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Proteins) to permit ASK1 (show MAP3K5 Proteins) activation and apoptosis. Although soluble receptor (show IFNAR1 Proteins) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 (show MLL Proteins) was functionally equivalent to the signal triggered by mCD40L.
autologous CD4 (show CD4 Proteins)(+) T cells that are exposed to EVs from CD40/IL-4 (show IL4 Proteins)-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells.
Cytokine expression upon simultaneous stimulation of TSHR and CD40 is greater than levels achieved with TSH or CD40L alone. Increased expression of CD40 by TSH is a potential mechanism for this process
glatiramer acetate treatment also significantly reduced CD40-mediated P65 (show GORASP1 Proteins) phosphorylation in RRMS patients, suggesting that reducing CD40-mediated p-P65 (show GORASP1 Proteins) induction may be a general mechanism by which some current therapies modulate Multiple Sclerosis disease.
Circulating sCD40L levels are increased in patients with cystic fibrosis (show S100A8 Proteins) and P. aeruginosa infection
Our results support an important association of rs4810485 in CD40 gene and rs763361 in CD226 (show CD226 Proteins) gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of systemic lupus erythematosus.
These results therefore may help understand the molecular mechanism of CD40L (show CD40LG Proteins) signaling that contributes to the pathophysiology of atherosclerosis.
This study shows that xenogeneic interaction between hCD40L and pCD40 can activate porcine endothelial cells through NF-kappaB (show NFKB1 Proteins) signaling.
The appearance of CD25 (show IL2RA Proteins) after activation of porcine dendritic cells, is reported.
Results demonstrated greater CD40 and CD40L (show CD40LG Proteins) expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.
study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
B-cell surface antigen CD40
, CD40L receptor
, T-cell differentiation antigen
, tumor necrosis factor receptor superfamily member 5
, tumor necrosis factor receptor superfamily, member 5
, B cell surface antigen CD40
, B cell-associated molecule
, CD40 antigen (TNF receptor superfamily member 5)
, CD40 type II isoform
, nerve growth factor receptor-related B-lymphocyte activation molecule
, CD40 antigen, TNF receptor superfamily member 5
, human CD40-homologue
, 50 kDa dynein-associated polypeptide
, dynactin complex 50 kDa subunit
, dynactin subunit 2
, growth cone membrane protein 23-48K
, p50 dynamitin