Browse our CD40 Proteins (CD40)

Full name:
CD40 Molecule, TNF Receptor Superfamily Member 5 Proteins (CD40)
On are 55 CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Proteins from 10 different suppliers available. Additionally we are shipping CD40 Antibodies (892) and CD40 Kits (64) and many more products for this protein. A total of 1035 CD40 products are currently listed.
2310042E05Rik, AI326936, Bp50, C87049, C130077D06Rik, CDW40, DCTN-50, GMP23-48K, GP39, HIGM1, IGM, IMD3, p50, RBP50, T-BAM, TNFRSF5, TNFSF5, TRAP
list all proteins Gene Name GeneID UniProt
CD40 21939 P27512
CD40 958 P25942
CD40 171369  

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CD40 Proteins (CD40) by Origin

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Top referenced CD40 Proteins

  1. Human CD40 Protein expressed in HEK-293 Cells - ABIN2859199 : Banchereau, Bazan, Blanchard, Brière, Galizzi, van Kooten, Liu, Rousset, Saeland: The CD40 antigen and its ligand. in Annual review of immunology 1994 (PubMed)
    Show all 5 references for 2859199

  2. Dog (Canine) CD40 Protein expressed in Human Cells - ABIN2008977 : Ni, Welsh, Leo, Chiou, Wu, Reed, Ely: Molecular basis for CD40 signaling mediated by TRAF3. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 4 references for 2008977

  3. Human CD40 Protein expressed in Human Cells - ABIN2003375 : Ferrari, Giliani, Insalaco, Al-Ghonaium, Soresina, Loubser, Avanzini, Marconi, Badolato, Ugazio, Levy, Catalan, Durandy, Tbakhi, Notarangelo, Plebani: Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 references for 2003375

  4. Mouse (Murine) CD40 Protein expressed in Human Cells - ABIN2007668 : Bhushan, Covey: CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. in Immunologic research 2001 (PubMed)
    Show all 4 references for 2007668

  5. Rhesus Monkey CD40 Protein expressed in Human Cells - ABIN2009830 : Pype, Declercq, Ibrahimi, Michiels, Van Rietschoten, Dewulf, de Boer, Vandenabeele, Huylebroeck, Remacle: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for 2009830

More Proteins for CD40 Interaction Partners

Mouse (Murine) CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) interaction partners

  1. Adoptively transferred Th40 cells (CD4 (show CD4 Proteins)+CD40+ Tcells) are present in lesions in the CNS and are associated with wide spread demyelination.

  2. this study reports that anti-CD40 mAb administration <3 d in advance of chemotherapy is lethal in more than half of treated C57BL/6 mice in pancreatic cancer model

  3. The data show that CD40-mediated inhibition of PC generation is via engagement of multiple pathway and constitutive CD40 signaling in vivo involving bystander T-B interactions can calibrate B cell differentiation outcomes

  4. BAFF (show TNFSF13B Proteins) upregulates CD28 (show CD28 Proteins)/B7 and CD40/CD154 (show CD40LG Proteins) expression, and promotes the interactions between T and B cells in a BAFF-R (show TNFRSF13C Proteins)-dependent manner

  5. CD40 in Muller cells is sufficient to upregulate retinal inflammatory markers and appears to promote experimental diabetic retinopathy and that Muller cells orchestrate inflammatory responses in myeloid cells through a CD40-ATP-P2X7 (show P2RX7 Proteins) pathway.

  6. Taken together, our data demonstrate the importance of CD40 signaling in the conversion of CTL exhaustion and its ability to enhance PD-1 (show PDCD1 Proteins) antagonist action in rescuing exhausted CTLs in chronic infection.

  7. Upon miR (show MLXIP Proteins)-155 overexpression, Cd40 expression was significantly upregulated with a negative correlation to the miR (show MLXIP Proteins)-155 primary target Ship1 (show INPP5D Proteins) expression in mice.

  8. These results suggest that Il23a (show IL23A Proteins) expression in DCs is synergistically triggered by the PG E2-EP4 (show PTGER4 Proteins)-cAMP-PKA pathway and canonical/non-canonical NF-kappaB (show NFKB1 Proteins) pathways and CREB (show CREB1 Proteins) activated by CD40 stimulation.

  9. Results suggest that altered CD40 signaling and granulocyte recruitment in response to infection are responsible for the Ity5-associated Salmonella susceptibility of A/J mice.

  10. our results highlight new roles for CD40 and cysteine-238-mediated CD40 homodimers in cell biology and identify a potential new target for therapeutic strategies against CD40-associated chronic inflammatory diseases.

Human CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) interaction partners

  1. autologous CD4 (show CD4 Proteins)(+) T cells that are exposed to EVs from CD40/IL-4 (show IL4 Proteins)-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells.

  2. Cytokine expression upon simultaneous stimulation of TSHR and CD40 is greater than levels achieved with TSH or CD40L alone. Increased expression of CD40 by TSH is a potential mechanism for this process

  3. glatiramer acetate treatment also significantly reduced CD40-mediated P65 (show GORASP1 Proteins) phosphorylation in RRMS patients, suggesting that reducing CD40-mediated p-P65 (show GORASP1 Proteins) induction may be a general mechanism by which some current therapies modulate Multiple Sclerosis disease.

  4. Circulating sCD40L levels are increased in patients with cystic fibrosis (show S100A8 Proteins) and P. aeruginosa infection

  5. Our results support an important association of rs4810485 in CD40 gene and rs763361 in CD226 (show CD226 Proteins) gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of systemic lupus erythematosus.

  6. CD40 activity in thyrocytes is prominently mediated via NF-kappaB (show NFKB1 Proteins).

  7. polymorphisms in the TP63 and CD40 genes are associated with lung cancer in a Chinese Han population

  8. Increased CD40 ligation and reduced B-cell receptor signalling leads to higher IL-10 (show IL10 Proteins) production in B Cells from tolerant kidney transplant recipients.

  9. Essential hypertension patients showed increased expression of platelet CD40.

  10. CD40 monocyte is a novel inflammatory monocyte subset that could be used as a biomarker for chronic kidney disease severity.

Pig (Porcine) CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) interaction partners

  1. These results therefore may help understand the molecular mechanism of CD40L (show CD40LG Proteins) signaling that contributes to the pathophysiology of atherosclerosis.

  2. This study shows that xenogeneic interaction between hCD40L and pCD40 can activate porcine endothelial cells through NF-kappaB (show NFKB1 Proteins) signaling.

  3. The appearance of CD25 (show IL2RA Proteins) after activation of porcine dendritic cells, is reported.

Cow (Bovine) CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) interaction partners

  1. Results demonstrated greater CD40 and CD40L (show CD40LG Proteins) expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

  2. study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages

CD40 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with CD40

  • CD40 antigen (LOC100349106)
  • CD40 antigen (Cd40)
  • CD40 molecule, TNF receptor superfamily member 5 (CD40)
  • CD40 molecule, TNF receptor superfamily member 5 (Cd40)
  • dynactin 2 (Dctn2)
  • 2310042E05Rik protein
  • AI326936 protein
  • Bp50 protein
  • C87049 protein
  • C130077D06Rik protein
  • CDW40 protein
  • DCTN-50 protein
  • GMP23-48K protein
  • GP39 protein
  • HIGM1 protein
  • IGM protein
  • IMD3 protein
  • p50 protein
  • RBP50 protein
  • T-BAM protein
  • TNFRSF5 protein
  • TNFSF5 protein
  • TRAP protein

Protein level used designations for CD40

B-cell surface antigen CD40 , CD40L receptor , T-cell differentiation antigen , tumor necrosis factor receptor superfamily member 5 , tumor necrosis factor receptor superfamily, member 5 , B cell surface antigen CD40 , B cell-associated molecule , CD40 antigen (TNF receptor superfamily member 5) , CD40 type II isoform , nerve growth factor receptor-related B-lymphocyte activation molecule , CD40 antigen, TNF receptor superfamily member 5 , human CD40-homologue , 50 kDa dynein-associated polypeptide , dynactin complex 50 kDa subunit , dynactin subunit 2 , growth cone membrane protein 23-48K , p50 dynamitin

100349106 Oryctolagus cuniculus
21939 Mus musculus
958 Homo sapiens
397395 Sus scrofa
171369 Rattus norvegicus
286849 Bos taurus
395385 Gallus gallus
403469 Canis lupus familiaris
100034049 Equus caballus
100385800 Callithrix jacchus
69654 Mus musculus
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