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anti-Human IL1RAP Antibodies:
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Human Polyclonal IL1RAP Primary Antibody for CyTOF, FACS - ABIN4899586
Michaud, Al-Akoum, Akoum: Blood soluble interleukin 1 receptor accessory protein levels are consistently low throughout the menstrual cycle of women with endometriosis. in Reproductive biology and endocrinology : RB&E 2014
Show all 2 Pubmed References
Human Polyclonal IL1RAP Primary Antibody for FACS, WB - ABIN4899584
Barreyro, Will, Bartholdy, Zhou, Todorova, Stanley, Ben-Neriah, Montagna, Parekh, Pellagatti, Boultwood, Paietta, Ketterling, Cripe, Fernandez, Greenberg, Tallman, Steidl, Mitsiades, Verma, Steidl: Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. in Blood 2012
Show all 2 Pubmed References
Human Polyclonal IL1RAP Primary Antibody for ELISA - ABIN2682161
Southcombe, Redman, Sargent, Granne: Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia. in Clinical and experimental immunology 2015
Human Monoclonal IL1RAP Primary Antibody for FACS - ABIN4896354
Bianchetti, Marini, Isgrò, Bellini, Schmidt, Mattoli: IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. in Biochemical and biophysical research communications 2012
IL1B (show IL1B Antibodies) regulates expression of IL1R1 (show IL1RN Antibodies) and IL1RAP and stimulates expression of PTGS1 (show PTGS1 Antibodies) and PTGS2 (show PTGS2 Antibodies) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (show PLIN1 Antibodies)-implantation period of pregnancy in pigs.
Reconstitution of ST2 (show SULT2A1 Antibodies) (IL-1R4) specific for IL-33 (show IL33 Antibodies) activity; no suppression by IL-1Ra (show IL1RN Antibodies) though a common chain IL-1R3 (IL-1RAcP) shared with IL-1 (show IL1A Antibodies).
These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells.
single nucleotide polymorphism A471T in the Toll (show TLR4 Antibodies)-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 (show IL1RL2 Antibodies) that is present in approximately 2% of the human population, down-regulated IL-36R (show IL1RL2 Antibodies) signaling by a decrease of interaction with IL-1RAcP.
The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework.
The SNP rs4624606 in IL-1RAcP was nominally associated with CAD (show CAD Antibodies) risk.
Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis.
Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 (show SULT2A1 Antibodies) possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution.
MARCH8 (show MARCH8 Antibodies)-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta (show IL1B Antibodies)-induced signaling pathways.
Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML (show RUNX1 Antibodies) cells.
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt (show AKT1 Antibodies) kinase.
These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1 (show IL1RAPL1 Antibodies)/IL-1RAcP.
In experimental biliary atresia, miR (show MLXIP Antibodies)-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 (show IGF1 Antibodies) and Il1RAP are down-regulated by miR (show MLXIP Antibodies)-29.
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.
IL-1RAcP is essential for physiological activities of peripheral IL-1 (show IL1A Antibodies).
Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling
data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 (show IL1A Antibodies) complex by binding to epitopes on domain III of the IL-1RI created following IL-1 (show IL1A Antibodies) binding to the IL-1RI
IL-33 (show IL33 Antibodies) and ST2 (show SULT2A1 Antibodies) form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex.
IL-1RAcP is used by more than one alpha-chain (show FCGRT Antibodies) of the IL-1 (show IL1A Antibodies) receptor family and thus may resemble a common beta-chain (show CSF2RB Antibodies) of that family
these observations establish AcP (show NDUFAB1 Antibodies) as co-receptor for IL-33 (show IL33 Antibodies) signaling via ST2 (show SULT2A1 Antibodies) and suggest a novel role for sAcP in modulating the biological activity of IL-33 (show IL33 Antibodies)
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
interleukin 1 receptor accessory protein
, interleukin-1 receptor accessory protein
, interleukin-1 receptor accessory protein-like
, IL-1 receptor accessory protein
, interleukin-1 receptor 3
, interleukin-1 receptor accessory protein beta