IL1RAP antibody (AA 279-313)

Catalog No. ABIN6242411

This Rabbit Polyclonal antibody specifically detects IL1RAP in WB, FACS and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for IL1RAP antibody (AA 279-313) (ABIN6242411)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RAP antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB57768

Product Details anti-IL1RAP Antibody

Binding Specificity: AA 279-313

Predicted Reactivity: H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids of human IL1RAP.

Isotype: IgG

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Alternative Name: IL1RAP

Background: Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Molecular Weight: 65418

UniProt: Q9NPH3

Pathways: NF-kappaB Signaling, Growth Factor Binding