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Browse our Insulin Receptor Proteins (INSR)

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Insulin Receptor Proteins (INSR)
On are 32 Insulin Receptor (INSR) Proteins from 10 different suppliers available. Additionally we are shipping Insulin Receptor Antibodies (295) and Insulin Receptor Kits (31) and many more products for this protein. A total of 384 Insulin Receptor products are currently listed.
18402, 4932439J01Rik, cd220, CG18402, CTK-1, D630014A15Rik, DIHR, DILR, dinr, dInsR, dir, Dir-a, Dir-b, DIRbeta, dIRH, Dmel\\CG18402, er10, hhf5, inr, Inr-alpha, Inr-beta, INS, INSR, insulin/insulin-like growth factor receptor, ir, ir-A, IR-B, l(3)05545, l(3)93Dj, l(3)er10, lnR, NV14476
list all proteins Gene Name GeneID UniProt
INSR 3643 P06213
INSR 16337 P15208
INSR 24954  

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Insulin Receptor Proteins (INSR) by Origin

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Top referenced Insulin Receptor Proteins

  1. Human Insulin Receptor Protein expressed in Human Cells - ABIN2003925 : Kan, Kanai, Iida, Jinnouchi, Todaka, Imanaka, Ito, Nishioka, Ohnishi, Kamohara: Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM. in Diabetes 1995 (PubMed)
    Show all 4 references for ABIN2003925

  2. Human Insulin Receptor Protein expressed in Baculovirus infected Insect Cells - ABIN2003927 : Kadowaki, Kadowaki, Accili, Taylor et al.: Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity ... in The Journal of biological chemistry 1990 (PubMed)
    Show all 3 references for ABIN2003927

More Proteins for Insulin Receptor Interaction Partners

Fruit Fly (Drosophila melanogaster) Insulin Receptor (INSR) interaction partners

  1. Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.

  2. Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress

  3. results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep

  4. This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.

  5. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.

  6. InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.

  7. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.

  8. Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis

  9. Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain

  10. The phospholipase C (show PLC Proteins)-gamma (PLC (show PLC Proteins)-gamma) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK (show MAPK1 Proteins) outputs once activated by the insulin (show INS Proteins) pathway.

Human Insulin Receptor (INSR) interaction partners

  1. In silico characterization of nsSNPs affecting INSR gene function can aid in better understanding of genetic differences in disease susceptibility.

  2. The INSR gene is potentially associated with eating difficulties in preterm infants.

  3. Study describes a revised structure of the human insulin receptor ectodomain revealing new features within the receptor insert domain and corrects errors in the first and third fibronectin (show FN1 Proteins) type III domains. The new structure allows improved resolution of the insert domain, a critical element to ligand binding and signal transduction.

  4. C1008T SNP at exon 17 of INSR is associated with insulin (show INS Proteins) resistance in Indian women with polycystic ovarian syndrome.

  5. A novel insertion/deletion (indel) mutation was found in INSR gene.

  6. mTORC2 (show CRTC2 Proteins) promotes rapamycin- and ligand-induced type I insulin (show INS Proteins)-like growth factor receptor (show RYK Proteins) / insulin receptor phosphorylation.

  7. remarkable therapeutic window observed for BI 885578 is achieved by virtue of the distinctive pharmacokinetic properties of the compound capitalizing on the physiologic mechanism of glucose homeostasis and differential levels of IGF1R (show IGF1R Proteins) and INSR expression

  8. Given the limited number of patients treated with KW-2450 in our study, it is not possible to make a meaningful comparison of efficacy with other IGF-1R (show IGF1R Proteins)/IR dual kinases inhibitors

  9. Data indicate that a highly specific qRT-PCR assay to quantify levels of the insulin (show INS Proteins)-like growth factor receptor (show RYK Proteins) and insulin receptor isoforms (IR-A, IR-B, and IGF-1R (show IGF1R Proteins)) on the same scale to provide a critical diagnostic and predictive tool.

  10. Low-oxygen tension can modify the IGF-1 (show IGF1 Proteins) or IGF-2 signaling via the IGF-1R (show IGF1R Proteins) and IR in placental mesenchymal stem cells.

Mouse (Murine) Insulin Receptor (INSR) interaction partners

  1. Acute knockdown of Insr or both Irs1 (show IRS1 Proteins) and Irs2 (show IRS2 Proteins) in adipocytes increased Adipoq (show ADIPOQ Proteins) mRNA expression but reduced adiponectin (show ADIPOQ Proteins) secretion.

  2. unsuppressed lipolysis in adipocytes elicited by HFD feeding is linked with enhanced gluconeogenesis from glycerol and with alterations in BA physiology in Insr(P1195L/+)/HFD liver.

  3. NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr-Ccnd2 (show CCND2 Proteins)/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.

  4. Therefore, overexpression of insulin receptor improves obese and diabetic phenotypes in db/db (show LEPR Proteins) mice, with consequences on growth.

  5. only Ptprj (show PTPRJ Proteins) was co-expressed with the IR in major insulin (show INS Proteins) target tissues : the skeletal muscle, liver and adipose tissue. the activation of IR and Akt (show AKT1 Proteins) by insulin (show INS Proteins) was enhanced, and glucose and insulin (show INS Proteins) tolerance was improved in Ptprj (show PTPRJ Proteins)-deficient mice

  6. the insulin (show INS Proteins)-InsR signaling drives multipotent progenitors differentiation into lymphoid lineages in early lymphopoiesis.

  7. Data reports that IRA in beta cells confers a stronger proliferation capability favoring the mitogenic effects of IGF-I (show IGF1 Proteins) and also increasing glucose uptake of these cells, a key factor in pancreatic beta cell proliferation.

  8. Our results indicate that the insulin receptor may have some role in controlling the rate of rod response decay, but they exclude a major role of the insulin receptor pathway in phototransduction.

  9. Mutation in the insulin receptor attenuated the oxidative stress and apoptosis in beta-cells.

  10. Our results highlight the mitogenic role of the IR in mammary tumor progression with a direct link to CD24 (show CD24 Proteins) expression

Cow (Bovine) Insulin Receptor (INSR) interaction partners

  1. studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Proteins), IGF-2, IGFBP-2, IGFBP-3 (show IGFBP3 Proteins), IGF-1R (show IGF1R Proteins), IGF-2R, GHR (show GHR Proteins), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum

  2. insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments

  3. FSH (show BRD2 Proteins), but not E2, stimulated the expression of IR and GHR (show GHR Proteins) genes during follicular development.

  4. Data conclude that insulin (show INS Proteins) and IGF-I (show IGF1 Proteins) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.

Insulin Receptor (INSR) Protein Profile

Protein Summary

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Insulin Receptor (INSR)

  • Insulin-like receptor (InR)
  • insulin receptor (INSR)
  • insulin receptor (Insr)
  • insulin receptor (insr)
  • insulin receptor precursor (DAF-2)
  • 18402 protein
  • 4932439J01Rik protein
  • cd220 protein
  • CG18402 protein
  • CTK-1 protein
  • D630014A15Rik protein
  • DIHR protein
  • DILR protein
  • dinr protein
  • dInsR protein
  • dir protein
  • Dir-a protein
  • Dir-b protein
  • DIRbeta protein
  • dIRH protein
  • Dmel\\CG18402 protein
  • er10 protein
  • hhf5 protein
  • inr protein
  • Inr-alpha protein
  • Inr-beta protein
  • INS protein
  • INSR protein
  • insulin/insulin-like growth factor receptor protein
  • ir protein
  • ir-A protein
  • IR-B protein
  • l(3)05545 protein
  • l(3)93Dj protein
  • l(3)er10 protein
  • lnR protein
  • NV14476 protein

Protein level used designations for Insulin Receptor Proteins (INSR)

CG18402-PA , CG18402-PB , CG18402-PC , CG18402-PD , InR-PA , InR-PB , InR-PC , InR-PD , drosophila insulin receptor , insulin , insulin receptor , insulin receptor homolog , insulin receptor homologue , insulin-like receptor , insulin-receptor , lethal(3)93Dj , insulin receptor-like , IR , XTK-1b , insulin receptor, beta-subunit , xe-InsR , insulin receptor tyrosine kinase , tyrosine kinase

42549 Drosophila melanogaster
455649 Pan troglodytes
455650 Pan troglodytes
100027215 Monodelphis domestica
100066248 Equus caballus
100122567 Nasonia vitripennis
100126753 Papio anubis
100127108 Felis catus
100403400 Callithrix jacchus
100451802 Pongo abelii
100473956 Ailuropoda melanoleuca
3643 Homo sapiens
16337 Mus musculus
396755 Sus scrofa
408017 Bos taurus
443431 Ovis aries
100141504 Oryctolagus cuniculus
24954 Rattus norvegicus
398006 Xenopus laevis
484990 Canis lupus familiaris
420133 Gallus gallus
100718484 Cavia porcellus
706009 Macaca mulatta
100008911 Oryctolagus cuniculus
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