Browse our Insulin Receptor Proteins (INSR)

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Insulin Receptor Proteins (INSR)
On www.antibodies-online.com are 35 Insulin Receptor (INSR) Proteins from 12 different suppliers available. Additionally we are shipping Insulin Receptor Antibodies (352) and Insulin Receptor Kits (39) and many more products for this protein. A total of 452 Insulin Receptor products are currently listed.
Synonyms:
18402, 4932439J01Rik, cd220, CG18402, CTK-1, D630014A15Rik, DIHR, DILR, dinr, dInsR, dir, Dir-a, Dir-b, DIRbeta, dIRH, Dmel\\CG18402, er10, hhf5, inr, Inr-alpha, Inr-beta, INS, INSR, insulin/insulin-like growth factor receptor, ir, ir-A, IR-B, l(3)05545, l(3)93Dj, l(3)er10, lnR, NV14476
list all proteins Gene Name GeneID UniProt
INSR 3643 P06213
INSR 16337 P15208
INSR 24954  

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Insulin Receptor Proteins (INSR) by Origin

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Top referenced Insulin Receptor Proteins

  1. Human Insulin Receptor Protein expressed in Human Cells - ABIN2003949 : Kan, Kanai, Iida, Jinnouchi, Todaka, Imanaka, Ito, Nishioka, Ohnishi, Kamohara: Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM. in Diabetes 1995 (PubMed)
    Show all 5 references for 2003949

  2. Human Insulin Receptor Protein expressed in HEK-293 Cells - ABIN2181403 : Menting, Whittaker, Margetts, Whittaker, Kong, Smith, Watson, Záková, Kletvíková, Jirá?ek, Chan, Steiner, Dodson, Brzozowski, Weiss, Ward, Lawrence: How insulin engages its primary binding site on the insulin receptor. in Nature 2013 (PubMed)
    Show all 4 references for 2181403

  3. Human Insulin Receptor Protein expressed in Baculovirus infected Insect Cells - ABIN2003927 : Kadowaki, Kadowaki, Accili, Taylor et al.: Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity ... in The Journal of biological chemistry 1990 (PubMed)
    Show all 3 references for 2003927

More Proteins for Insulin Receptor Interaction Partners

Fruit Fly (Drosophila melanogaster) Insulin Receptor (INSR) interaction partners

  1. Mactosylceramide, an early product in GSL (show CTSA Proteins) biosynthesis, prevents inappropriate activation of insulin (show INS Proteins) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.

  2. Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.

  3. Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress

  4. results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep

  5. This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.

  6. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.

  7. InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.

  8. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.

  9. Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis

  10. Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain

Human Insulin Receptor (INSR) interaction partners

  1. IGF2 and insulin receptor A are important for uterine leiomyoma stem cell proliferation and may represent paracrine signaling between leiomyoma cell types.

  2. Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells

  3. Results show that IR expression level in renal cell carcinoma (show MOK Proteins) tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases.

  4. Findings suggest that the induction of microRNA miR (show MLXIP Proteins)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS Proteins) resistance by targeting insulin receptor (INSR) and insulin receptor substrate 1 (show IRS1 Proteins) protein (IRS-1 (show IRS1 Proteins)) in hepatocytes.

  5. Study reveals an important function of CHIP-mediated proteolysis in insulin (show INS Proteins) and IGF1 (show IGF1 Proteins) signaling; upon proteotoxic stress conditions and during aging, CHIP is recruited toward disposal of misfolded proteins, reducing its capacity to degrade the INSR; identify a degradation pathway that controls the level of active DAF-2/INSR in C. elegans, Drosophila and human cells.

  6. EGF (show EGF Proteins) and insulin receptor tyrosine kinase exemplify how receptor location is coupled to signal transduction. (Review)

  7. a straightforward protocol for production of recombinant IGF-II and prepared six IGF-II analogs with IGF-I-like mutations. All modified molecules exhibit significantly reduced affinity toward IR-A, particularly the analogs with a Pro-Gln insertion in the C-domain. Moreover, one of the analogs has enhanced binding affinity for IGF-1R due to a synergistic effect of the Pro-Gln insertion and S29N point mutation.

  8. Conus geographus G1 (Con (show DISP1 Proteins)-Ins (show INS Proteins) G1), is the smallest known insulin (show INS Proteins) found in nature and lacks the C-terminal segment of the B chain that, in human insulin (show INS Proteins), mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. This study found that Con (show DISP1 Proteins)-Ins (show INS Proteins) G1 is monomeric, strongly binds the human insulin receptor and activates receptor signaling.

  9. Mutations of the INSR gene is associated with acanthosis nigricans and hyperandrogenism.

  10. Identification of a Novel Homozygous INSR Variant in a Patient with Rabson-Mendenhall Syndrome from the United Arab Emirates.

Mouse (Murine) Insulin Receptor (INSR) interaction partners

  1. These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (show PRKCE Proteins) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (show INS Proteins) resistance.

  2. Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. Mice lacking the insulin receptor in AgRP (show AGRP Proteins) neurons (AgRP (show AGRP Proteins) IR KO) exhibited impaired hepatic insulin (show INS Proteins) action because the ability of insulin (show INS Proteins) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (show INS Proteins) to suppress lipolysis was unaltered. To the contrary, in POMC (show POMC Proteins) IR KO mice, insulin (show INS Proteins) lowered hGP but failed to suppress adipose tissue lipolysis.

  4. Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (show TXLNA Proteins), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.

  5. Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB Proteins) inhibition required the expression and activation of the insulin receptor (IR)/insulin (show INS Proteins) growth-like factor receptor (IGF1R (show IGF1R Proteins)) for tumor cell proliferation and survival.

  6. The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (show GIP Proteins) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (show INS Proteins)-resistant states.

  7. In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Proteins)/PDPK1 (show PDPK1 Proteins)/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1 (show PDPK1 Proteins). This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati

  8. Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a (show PPP2R2A Proteins)). Inheritance of either allele results in insulin (show INS Proteins) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Proteins) resistance and diabetes type 2 without increase in body weight.

  9. ZIP14 (show SLC39A14 Proteins)-mediated zinc transport contributes to regulation of endosomal insulin receptor activity and glucose homeostasis in hepatocytes.

  10. Suggest that overexpression of IGF-IR or IRA isoform, as homodimers or as part of IRA/IGF-IR hybrid receptors, confers a stronger migratory capability to vascular smooth muscle cells and might occur in early stages of atherosclerotic process.

Cow (Bovine) Insulin Receptor (INSR) interaction partners

  1. studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Proteins), IGF-2, IGFBP-2, IGFBP-3 (show IGFBP3 Proteins), IGF-1R (show IGF1R Proteins), IGF-2R, GHR (show GHR Proteins), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum

  2. insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments

  3. FSH (show BRD2 Proteins), but not E2, stimulated the expression of IR and GHR (show GHR Proteins) genes during follicular development.

  4. Data conclude that insulin (show INS Proteins) and IGF-I (show IGF1 Proteins) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.

Insulin Receptor (INSR) Protein Profile

Protein Summary

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Insulin Receptor (INSR)

  • Insulin-like receptor (InR)
  • insulin receptor (INSR)
  • insulin receptor (Insr)
  • insulin receptor (insr)
  • insulin receptor precursor (DAF-2)
  • 18402 protein
  • 4932439J01Rik protein
  • cd220 protein
  • CG18402 protein
  • CTK-1 protein
  • D630014A15Rik protein
  • DIHR protein
  • DILR protein
  • dinr protein
  • dInsR protein
  • dir protein
  • Dir-a protein
  • Dir-b protein
  • DIRbeta protein
  • dIRH protein
  • Dmel\\CG18402 protein
  • er10 protein
  • hhf5 protein
  • inr protein
  • Inr-alpha protein
  • Inr-beta protein
  • INS protein
  • INSR protein
  • insulin/insulin-like growth factor receptor protein
  • ir protein
  • ir-A protein
  • IR-B protein
  • l(3)05545 protein
  • l(3)93Dj protein
  • l(3)er10 protein
  • lnR protein
  • NV14476 protein

Protein level used designations for Insulin Receptor Proteins (INSR)

CG18402-PA , CG18402-PB , CG18402-PC , CG18402-PD , InR-PA , InR-PB , InR-PC , InR-PD , drosophila insulin receptor , insulin , insulin receptor , insulin receptor homolog , insulin receptor homologue , insulin-like receptor , insulin-receptor , lethal(3)93Dj , insulin receptor-like , IR , XTK-1b , insulin receptor, beta-subunit , xe-InsR , insulin receptor tyrosine kinase , tyrosine kinase

GENE ID SPECIES
42549 Drosophila melanogaster
455649 Pan troglodytes
455650 Pan troglodytes
100027215 Monodelphis domestica
100066248 Equus caballus
100122567 Nasonia vitripennis
100126753 Papio anubis
100127108 Felis catus
100403400 Callithrix jacchus
100451802 Pongo abelii
100473956 Ailuropoda melanoleuca
3643 Homo sapiens
16337 Mus musculus
396755 Sus scrofa
408017 Bos taurus
443431 Ovis aries
100141504 Oryctolagus cuniculus
24954 Rattus norvegicus
398006 Xenopus laevis
484990 Canis lupus familiaris
420133 Gallus gallus
100718484 Cavia porcellus
706009 Macaca mulatta
100008911 Oryctolagus cuniculus
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