Insulin Receptor Protein (INSR) (AA 28-944) (His tag)

Catalog No. ABIN6809906

Product Details

Target: Insulin Receptor (INSR)

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 28-944

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Insulin Receptor protein is labelled with His tag.

Sequence: AA 28-944

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: Insulin Receptor (INSR)

Alternative Name: Insulin R (INSR Products)

Synonyms: CD220 Protein, HHF5 Protein, 4932439J01Rik Protein, D630014A15Rik Protein, IR Protein, IR-A Protein, IR-B Protein, 18402 Protein, CG18402 Protein, DIHR Protein, DILR Protein, DIR Protein, DIRH Protein, DIRbeta Protein, DInR Protein, DInr Protein, Dir-a Protein, Dir-b Protein, Dmel\\CG18402 Protein, INR Protein, INS Protein, Inr Protein, Inr-alpha Protein, Inr-beta Protein, InsR Protein, dINR Protein, dIR Protein, dIRH Protein, dInR Protein, dInr Protein, dInsR Protein, dinr Protein, dir Protein, er10 Protein, inr Protein, insulin/insulin-like growth factor receptor Protein, l(3)05545 Protein, l(3)93Dj Protein, l(3)er10 Protein, lnR Protein, ir-A Protein, CTK-1 Protein, ir Protein, INSR Protein, NV14476 Protein, cd220 Protein, hhf5 Protein, insulin receptor Protein, Insulin-like receptor Protein, insulin receptor L homeolog Protein, INSR Protein, Insr Protein, InR Protein, LOC100122567 Protein, LOC100451802 Protein, insr.L Protein

Background: Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

Molecular Weight: 106.5 kDa

NCBI Accession: NP_000199

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity