Insulin Receptor Protein (INSR) (AA 28-944) (His tag)
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- Target See all Insulin Receptor (INSR) Proteins
- Insulin Receptor (INSR)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 28-944
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Insulin Receptor protein is labelled with His tag.
- Sequence
- AA 28-944
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Insulin Receptor (INSR) (AA 1023-1298) protein (His-IF2DI Tag)
INSR Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Insulin Receptor (INSR) (AA 881-980) protein (GST tag)INSR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin Receptor (INSR) (Active) protein (GST tag,His tag)INSR Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE. Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- Insulin Receptor (INSR)
- Alternative Name
- Insulin R (INSR Products)
- Synonyms
- CD220 Protein, HHF5 Protein, 4932439J01Rik Protein, D630014A15Rik Protein, IR Protein, IR-A Protein, IR-B Protein, 18402 Protein, CG18402 Protein, DIHR Protein, DILR Protein, DIR Protein, DIRH Protein, DIRbeta Protein, DInR Protein, DInr Protein, Dir-a Protein, Dir-b Protein, Dmel\\CG18402 Protein, INR Protein, INS Protein, Inr Protein, Inr-alpha Protein, Inr-beta Protein, InsR Protein, dINR Protein, dIR Protein, dIRH Protein, dInR Protein, dInr Protein, dInsR Protein, dinr Protein, dir Protein, er10 Protein, inr Protein, insulin/insulin-like growth factor receptor Protein, l(3)05545 Protein, l(3)93Dj Protein, l(3)er10 Protein, lnR Protein, ir-A Protein, CTK-1 Protein, ir Protein, INSR Protein, NV14476 Protein, cd220 Protein, hhf5 Protein, insulin receptor Protein, Insulin-like receptor Protein, insulin receptor L homeolog Protein, INSR Protein, Insr Protein, InR Protein, LOC100122567 Protein, LOC100451802 Protein, insr.L Protein
- Background
- Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
- Molecular Weight
- 106.5 kDa
- NCBI Accession
- NP_000199
- Pathways
- NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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