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Neutrophil rolling over E-selectin (show SELE ELISA Kits) at precise shear stress transmits tension and catch-bond formation with L-selectin (show SELL ELISA Kits) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
CD177 (show CD177 ELISA Kits) signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration.
Extracellular ISG15 (show ISG15 ELISA Kits) signals cytokine secretion through the LFA-1 (show ITGAL ELISA Kits) integrin receptor (CD11a (show ITGAL ELISA Kits)/CD18) in natural killer cells.
findings suggest the partitioning in soluble CD18 to reflect a compensatory anti-inflammatory response syndrome and hyperinflammation, respectively, manifested as part of sepsis.
activation of LFA-1 (show ITGAL ELISA Kits) (alphaLbeta2) and Mac-1 (show ITGAM ELISA Kits) (alphaMbeta2), two subfamilies of integrin beta2 complexes, on human primary monocytes following platelet releasate treatment
data suggest that regulation of LFA-1 (show ITGAL ELISA Kits) is one reason for the different activity of NK cells during differentiation
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (show SIGLEC1 ELISA Kits) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (show YWHAZ ELISA Kits) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
this study shows that cross-talk between LFA-1 (show ITGAL ELISA Kits) and Notch1 (show NOTCH1 ELISA Kits) through the Akt (show AKT1 ELISA Kits)/ERK (show EPHB2 ELISA Kits)-GSK3beta (show GSK3b ELISA Kits) signaling enhances T cell differentiation toward Th1 (show TH1L ELISA Kits)
FRbeta (show FOLR2 ELISA Kits) as a novel CD11b/CD18 (show ITGAM ELISA Kits) regulator for trafficking and homing of a subset of macrophages on collagen.
The results show that with LFA-1 (show ITGAL ELISA Kits) antibodies, we can activate LFA-1 (show ITGAL ELISA Kits) and inhibit alpha4beta1, inhibit both LFA-1 (show ITGAL ELISA Kits) and alpha4beta1, inhibit LFA-1 (show ITGAL ELISA Kits) but not alpha4beta1, or not affect LFA-1 (show ITGAL ELISA Kits) or alpha4beta1
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (show ITGAL ELISA Kits) in naive CD8 (show CD8A ELISA Kits)(+) T cells plays a key role in T cell activation and differentiation.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (show CA5A ELISA Kits))1in membrane organization and beta2 integrin Lfa1 (show ITGAL ELISA Kits) function in primary CD8 (show CD8A ELISA Kits) T cells.
Coro1A (show CORO1A ELISA Kits) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
These results identify CD47 (show CD47 ELISA Kits) as an important regulator of LFA-1 (show ITGAL ELISA Kits) and VLA-4 integrin-adhesive functions in T cell proliferation.
both GDF-15 (show GDF15 ELISA Kits) and TGF-beta1 (show TGFB1 ELISA Kits) counteract chemokine (show CCL1 ELISA Kits)-induced integrin activation on neutrophils via the ALK-5 (show TGFBR1 ELISA Kits)/TGF-betaRII heterodimer.
the Slam (show SLAMF1 ELISA Kits) locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (show CD244 ELISA Kits). This effect is influenced by cytokines and leads to suppression of LFA-1 (show ITGAL ELISA Kits) activity.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18(-/-) mice.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (show SELL ELISA Kits) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (show CA2 ELISA Kits)+]i, diminished annexin V (show ANXA5 ELISA Kits) expression on the cell surface, and decreased caspase 3 (show CASP3 ELISA Kits) activity in lysates
The I-EGF (show EGF ELISA Kits)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (show ORM1 ELISA Kits) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (show POLG ELISA Kits) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (show ITGAM ELISA Kits) plays a cardinal (show CARD8 ELISA Kits) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (show ZP3 ELISA Kits) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (show IRF6 ELISA Kits) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (show ITGAX ELISA Kits)/CD18 alpha-chain (show FCGRT ELISA Kits) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)