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Human LTBR Protein expressed in HEK-293 Cells - ABIN2181486
Rooney, Butrovich, Glass, Borboroglu, Benedict, Whitbeck, Cohen, Eisenberg, Ware: The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. in The Journal of biological chemistry 2000
Show all 3 references for ABIN2181486
DC-derived LTBR ligands are critical mediators of lymph node cells survival, and LTBR signaling on reticular stromal cells is mediated by Pdpn (show PDPN Proteins) expression.
LTbR plays a role in macrophage-driven inflammation in atherosclerotic lesions from ApoE (show APOE Proteins) knockout mice, probably by augmenting the Ccl5 (show CCL5 Proteins)-mediated recruitment of monocytes.
M1 macrophages as inducer cells that trigger the expression of chemokines by vascular smooth muscle cell independently of lymphotoxin beta receptor signalling
lymphotoxin beta receptor regulates the development of the CCL21 (show CCL21 Proteins)-expressing subset rather than the Aire (show AIRE Proteins)-expressing subset of postnatal Medullary thymic epithelial cells.
LTbetaR activation on macrophages by T cell-derived lymphotoxin alpha(1)beta(2) controls proinflammatory responses by activation of a TRIM30alpha-controlled, counterregulatory signaling pathway to protect against exacerbating inflammatory reactions.
LTbetaR signaling in gut (show GUSB Proteins) lymphoid follicles regulates IL-22 (show IL22 Proteins) production by innate lymphoid cells in response to mucosal pathogen challenge.
expression of tumor necrosis factor (show TNF Proteins) superfamily member 14 and lymphotoxin-beta receptor by motoneurons in vivo correlates with the preferential expression of interferon-gamma (show IFNG Proteins) at disease onset and symptomatic stage in amyotrophic lateral sclerosis mice
LTBR-pathway in Sjogren's syndrome: CXCL13 (show CXCL13 Proteins) levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR.
Following infection of LTbetaR(-/-) mice with the Gram-negative pathogen Citrobacter rodentium, IL-22 (show IL22 Proteins) production from NCR22 cells was not affected.
Lymphotoxin-beta receptor activation by lymphotoxin-alpha(1)beta(2) and LIGHT promotes tumor growth in an NFkappaB-dependent manner.
activation enhances the LPS (show IRF6 Proteins)-induced expression of IL-8 (show IL8 Proteins) through NF-kappaB (show NFKB1 Proteins) and IRF-1 (show IRF1 Proteins)
LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine (show CCL1 Proteins) production by bronchial epithelial cells.
Relative expression of HVEM (show TNFRSF14 Proteins) and LTbetaR modulates canonical NF-kappaB (show NFKB1 Proteins) and pro-apoptotic signals stimulated by LIGHT.
lymphotoxin-B (show LTB Proteins)-specific receptor.
LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children
Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 (show ITGAM Proteins) and Bcl-2 (show BCL2 Proteins)/Bax (show BAX Proteins) expression in blood leukocytes and improves microcirculatory status in aged patients with kidney deficiency and blood stasis syndrome.
show that a cognate interaction between LTalphabeta on CD4 (show CD4 Proteins)(+) helper T cells and LTbeta (show LTB Proteins) receptor on DCs results in unique signals that are necessary for optimal CD8 (show CD8A Proteins)(+) T-cell expansion via a type I IFN-dependent mechanism
These results indicated that AdipoR1 (show ADIPOR1 Proteins) interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappaB (show NFKB1 Proteins) pathway.
Increased potential for LTbeta (show LTB Proteins) receptor signaling, coupled with increased bioavailability due to lower decoy receptor-3 (DcR3 (show TNFRSF6B Proteins)) avidity, provides a mechanism for polymorphic variants in LIGHT to contribute to the pathogenesis of inflammatory diseases.
Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways.
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
lymphotoxin B receptor
, tumor necrosis factor receptor superfamily member 3
, LT beta-R
, LT-beta receptor
, TNF receptor-related protein
, lymphotoxin-beta receptor
, tumor necrosis factor receptor superfamily, member 3
, tumor necrosis factor C receptor
, tumor necrosis factor receptor 2-related protein
, tumor necrosis factor receptor type III