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the L341V mutation limits the critical step of SQSTM1 recruitment to the phagophore
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
LC3 (show MAP1LC3A ELISA Kits) and p62/SQSTM1 have roles in early-stage non-small cell lung cancer
LC3B and p62 have roles in autophagy in esophageal adenocarcinoma
ALS (show IGFALS ELISA Kits)-FTLD associated mutations of SQSTM1 disrupt Keap1 (show KEAP1 ELISA Kits) binding and disable Nrf2 (show GABPA ELISA Kits) signaling.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A ELISA Kits) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 interacts with the phosphorylated p62 (show GTF2H1 ELISA Kits) to impair autophagic degradation of mutant huntingtin (show HTT ELISA Kits) protein aggregates.
CAL (show FBLIM1 ELISA Kits) suppresses the expression of pro-inflammatory cytokines via p62 (show GTF2H1 ELISA Kits)/Nrf2 (show GABPA ELISA Kits)-linked HO-1 (show HMOX1 ELISA Kits) induction in RASFs.
Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
casein kinase 1 (show CSNK1A1 ELISA Kits) phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 (show HSF1 ELISA Kits) stress
this study proved that SYVN1 (show SYVN1 ELISA Kits) enhances SERPINA1 (show SERPINA1 ELISA Kits)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (show SERPINA1 ELISA Kits)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (show MAP1LC3A ELISA Kits)-II/Map1lc3 (show MAP1LC3B ELISA Kits) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 ELISA Kits) and down-regulates Lc3 (show MAP1LC3A ELISA Kits)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (show MAP1LC3A ELISA Kits)-II/Map1lc3 (show MAP1LC3B ELISA Kits) = microtubule-associated protein (show SPAG5 ELISA Kits) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (show PTH ELISA Kits) promotes selective autophagy via induction of DAPK2 (show DAPK2 ELISA Kits)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
serine 351 phosphorylation of p62 (show GTF2H1 ELISA Kits) did not enhance its binding to Keap1 (show KEAP1 ELISA Kits) or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 ELISA Kits)) transcription factor in this neuronal context. Nrf2 (show NFE2L2 ELISA Kits) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (show NFE2L2 ELISA Kits) gene
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein