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anti-Human TRAF3 Antibodies:
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Human Polyclonal TRAF3 Primary Antibody for EIA, IF - ABIN501026
van Eyndhoven, Gamper, Cho, Mackus, Lederman: TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation. in Molecular immunology 1999
Show all 3 references for ABIN501026
Human Polyclonal TRAF3 Primary Antibody for IHC, IHC (p) - ABIN4361674
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (show TRAF1 Antibodies) proteins demonstrated different preferences for binding to members of the CD40 (show CD40 Antibodies) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.
Taken all together, Helicobacter pylori toxin Tip-alpha might activate NF-kappaB (show NFKB1 Antibodies) to promote inflammation and carcinogenesis by inhibiting miR (show MLXIP Antibodies)-3178 expression, which directly targets TRAF3, during Helicobacter pylori infection in gastric mucosal epithelial cells.
OPN (show SPP1 Antibodies) acts as a positive regulator in innate antiviral immunity through stabilization of TRAF3.
PLK1 (show PLK1 Antibodies) overexpression in prostate epithelial cells triggers oncogenic transformation. The signaling mechanisms underlying the observed cellular effects of PLK1 (show PLK1 Antibodies) involve direct PLK1 (show PLK1 Antibodies)-dependent phosphorylation of CRAF (show RAF1 Antibodies) with subsequent stimulation of the MEK1 (show MAP2K1 Antibodies)/2-ERK1/2 (show MAPK1/3 Antibodies)-Fra1 (show FOSL1 Antibodies)-ZEB1 (show ZEB1 Antibodies)/2 signaling pathway.
These findings suggest that RNF166 positively regulates RNA virus-triggered IFN-beta (show IFNB1 Antibodies) production by enhancing the ubiquitination of TRAF3 and TRAF6 (show TRAF6 Antibodies).
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
findings identify TRAF3 and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 in the regulation of plasma cell differentiation
TRAF3 regulates B-cell survival via inhibition of CREB (show CREB1 Antibodies) stability
ESR1 (show ESR1 Antibodies) directly interacts with TRAF3 and promotes K48-linked proteasomal degradation of TRAF3.
these findings demonstrate that WDR82 (show WDR82 Antibodies) is a negative regulator of virus-triggered type I IFNs pathway through mediating TRAF3 polyubiquitination status and stability on mitochondria.
Hepatocyte TRAF3 promotes liver steatosis and insulin (show INS Antibodies) resistance through targeting TAK1 (show NR2C2 Antibodies)-dependent signaling.
TRAF3 expressed in myeloid cells regulates immune responses in myeloid cells and acts to inhibit inflammation and tumor development in mice.
The MYSM1 (show MYSM1 Antibodies) SWIRM domain interacts with TRAF3 to terminate PRR (show PVRL1 Antibodies) pathways for pro-inflammatory and type I interferon (show IFNA Antibodies) responses.
Data show that the degradation of TNF receptor-associated factor 3 (TRAF3) and TNF (show TNF Antibodies) receptor-associated Ffactor 6 (TRAF6 (show TRAF6 Antibodies)) was accelerated in ubiquitin-specific protease 25 (show USP25 Antibodies) knockout (USP25 (show USP25 Antibodies)-/-) cells after viral infection.
Maternal diabetes and high glucose negatively regulate miR (show MLXIP Antibodies)-322 through oxidative stress. miR (show MLXIP Antibodies)-322 interacts with the 3'-UTR (show UTS2R Antibodies) of TRAF3 and represses its translation.
These results indicate that the involvement of TRAF3 in IL-15 (show IL15 Antibodies) mediated signaling to T cells plays a previously unappreciated and critical role in CD8 (show CD8A Antibodies)+ central memory T cells regulation and maintenance.
TRAF3 is a central regulator of ischemic pathways, including nuclear factor kappaB, Rac-1, and c-Jun (show JUN Antibodies) kinase (show MAPK9 Antibodies) signaling, via its interaction with and activation of TAK1 (show NR2C2 Antibodies).
Tumor necrosis factor (show TNF Antibodies) receptor-associated factor 3 (TRAF3) is a positive regulator of pathological cardiac hypertrophy in mice and humans.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
CD40 associated protein 1
, CD40 binding protein
, CD40 receptor associated factor 1
, LMP1-associated protein 1
, CD40 receptor-associated factor 1
, TNF receptor-associated factor 3