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anti-Human TRAF3 Antibodies:
anti-Mouse (Murine) TRAF3 Antibodies:
anti-Rat (Rattus) TRAF3 Antibodies:
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Human Polyclonal TRAF3 Primary Antibody for EIA, IF - ABIN501026
van Eyndhoven, Gamper, Cho, Mackus, Lederman: TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation. in Molecular immunology 1999
Show all 3 references for ABIN501026
These data suggest an interplay between CELF2 (show CELF2 Antibodies) and hnRNP C (show HNRNPC Antibodies) as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8.
DDX3 (show DDX3X Antibodies) directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS (show MAVS Antibodies).
The NleB effector limited host IFN-beta (show IFNB1 Antibodies) production by inhibiting Lys (show LYZ Antibodies)(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase (show GTDC2 Antibodies) activity of NleB.
TRAF3 epigenetics may significantly contribute to the variability of clopidogrel response and recurrence of ischemic events in patients with stroke.
Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (show TRAF1 Antibodies) proteins demonstrated different preferences for binding to members of the CD40 (show CD40 Antibodies) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.
Taken all together, Helicobacter pylori toxin Tip-alpha might activate NF-kappaB (show NFKB1 Antibodies) to promote inflammation and carcinogenesis by inhibiting miR (show MLXIP Antibodies)-3178 expression, which directly targets TRAF3, during Helicobacter pylori infection in gastric mucosal epithelial cells.
OPN (show SPP1 Antibodies) acts as a positive regulator in innate antiviral immunity through stabilization of TRAF3.
PLK1 (show PLK1 Antibodies) overexpression in prostate epithelial cells triggers oncogenic transformation. The signaling mechanisms underlying the observed cellular effects of PLK1 (show PLK1 Antibodies) involve direct PLK1 (show PLK1 Antibodies)-dependent phosphorylation of CRAF (show RAF1 Antibodies) with subsequent stimulation of the MEK1 (show MAP2K1 Antibodies)/2-ERK1/2 (show MAPK1/3 Antibodies)-Fra1 (show FOSL1 Antibodies)-ZEB1 (show ZEB1 Antibodies)/2 signaling pathway.
These findings suggest that RNF166 positively regulates RNA virus-triggered IFN-beta (show IFNB1 Antibodies) production by enhancing the ubiquitination of TRAF3 and TRAF6 (show TRAF6 Antibodies).
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Antibodies) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)), and Tank-binding kinase 1 (TBK1 (show TBK1 Antibodies)) via impairing K63-linked polyubiquitination of TRAF3 and TRIF (show RNF138 Antibodies).
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Antibodies) signaling by suppressing Pellino 1 (show PELI1 Antibodies)-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 Antibodies), K48-linked ubiquitination, and degradation of TRAF3.
Hepatocyte TRAF3 promotes liver steatosis and insulin (show INS Antibodies) resistance through targeting TAK1 (show NR2C2 Antibodies)-dependent signaling.
findings identify TRAF3 and PTPN22 (show PTPN22 Antibodies) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 in the regulation of plasma cell differentiation
TRAF3 expressed in myeloid cells regulates immune responses in myeloid cells and acts to inhibit inflammation and tumor development in mice.
The MYSM1 (show MYSM1 Antibodies) SWIRM domain interacts with TRAF3 to terminate PRR (show PVRL1 Antibodies) pathways for pro-inflammatory and type I interferon (show IFNA Antibodies) responses.
Data show that the degradation of TNF receptor-associated factor 3 (TRAF3) and TNF (show TNF Antibodies) receptor-associated Ffactor 6 (TRAF6 (show TRAF6 Antibodies)) was accelerated in ubiquitin-specific protease 25 (show USP25 Antibodies) knockout (USP25 (show USP25 Antibodies)-/-) cells after viral infection.
Maternal diabetes and high glucose negatively regulate miR (show MLXIP Antibodies)-322 through oxidative stress. miR (show MLXIP Antibodies)-322 interacts with the 3'-UTR (show UTS2R Antibodies) of TRAF3 and represses its translation.
These results indicate that the involvement of TRAF3 in IL-15 (show IL15 Antibodies) mediated signaling to T cells plays a previously unappreciated and critical role in CD8 (show CD8A Antibodies)+ central memory T cells regulation and maintenance.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
CD40 associated protein 1
, CD40 binding protein
, CD40 receptor associated factor 1
, LMP1-associated protein 1
, CD40 receptor-associated factor 1
, TNF receptor-associated factor 3