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TRAF6 Proteins

(TNF Receptor-Associated Factor 6 (TRAF6))
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012].
TRAF6 Protein (AA 1-522) (GST tag) TRAF6 Protein (AA 1-522) (GST tag) TRAF6 Protein (AA 1-522) (GST tag) (ABIN1323514)

TRAF6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

TRAF6 Protein (AA 413-522) (GST tag) TRAF6 Protein (AA 413-522) (GST tag) TRAF6 Protein (AA 413-522) (GST tag) (ABIN1323516)

TRAF6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

TRAF6 Protein (AA 1-522) (His tag) TRAF6 Protein (AA 1-522) (His tag) TRAF6 Protein (AA 1-522) (His tag) (ABIN3096041)

Crystallography grade TRAF6 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

TRAF6 Proteins by Grade

Find TRAF6 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

TRAF6 Proteins by Origin

Find TRAF6 Proteins for a variety of species such as anti-Human TRAF6, anti-Mouse TRAF6, anti-Chicken TRAF6. The species listed below are among those available. Click on a link to go to the corresponding products.

TRAF6 Proteins by Source

Here you will find TRAF6 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

TRAF6 Proteins by Protein Type

Here you can find TRAF6 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

TRAF6 Proteins by Application

Find TRAF6 Proteins validated for a specific application such as WB, SDS, ELISA, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular TRAF6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1323514
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323516
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096041
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134619
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2734115
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416514
Quantity 100 μg
Datasheet Datasheet
Reactivity Chicken
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7422352
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399067
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710550
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751823
Quantity 5 applications
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1475363
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TRAF6 Proteins

Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: "Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling." in: The Journal of biological chemistry, Vol. 290, Issue 36, pp. 22236-49, (2015) (PubMed).

Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: "Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1." in: Nature, Vol. 466, Issue 7309, pp. 941-6, (2010) (PubMed).

Aliases for TRAF6 Proteins

TNF receptor associated factor 6 (TRAF6) Proteins
TNF receptor-associated factor 6 (Traf6) Proteins
TNF receptor associated factor 6 L homeolog (traf6.L) Proteins
TNF-receptor-associated factor 6 (Traf6) Proteins
TNF receptor associated factor 6 (Traf6) Proteins
TNF receptor associated factor 6 (traf6) Proteins
TNF receptor-associated factor 6 (LOC551819) Proteins
TNF receptor-associated factor 6 (traf6) Proteins
TNF receptor associated factor 6 S homeolog (traf6.S) Proteins
2310003F17Rik Proteins
AI851288 Proteins
C630032O20Rik Proteins
CG10961 Proteins
Dmel\\CG10961 Proteins
DTRAF2 Proteins
dTRAF2 Proteins
dTraf2 Proteins
dtraf2 Proteins
dTRAF6 Proteins
fi15f02 Proteins
GB10539 Proteins
MGC:3310 Proteins
RNF85 Proteins
rnf85 Proteins
TRAF Proteins
TRAF2 Proteins
Traf2 Proteins
traf6 Proteins
TRAF6 Proteins
wu:fi15f02 Proteins
xtraf6 Proteins
zgc:63704 Proteins
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