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Browse our TRAF6 Proteins (TRAF6)

Full name:
TNF Receptor-Associated Factor 6 Proteins (TRAF6)
On www.antibodies-online.com are 14 TNF Receptor-Associated Factor 6 (TRAF6) Proteins from 8 different suppliers available. Additionally we are shipping TRAF6 Antibodies (155) and TRAF6 Kits (17) and many more products for this protein. A total of 206 TRAF6 products are currently listed.
Synonyms:
2310003F17Rik, AI851288, C630032O20Rik, CG10961, Dmel\\CG10961, dtraf2, dTRAF6, fi15f02, GB10539, MGC:3310, RNF85, TRAF, Traf2, TRAF6, wu:fi15f02, xtraf6, zgc:63704
list all proteins Gene Name GeneID UniProt
TRAF6 22034 P70196
TRAF6 7189 Q9Y4K3
TRAF6 311245 B5DF45

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TRAF6 Proteins (TRAF6) by Origin

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Top referenced TRAF6 Proteins

  1. Human TRAF6 Protein expressed in HEK-293 Cells - ABIN2734115 : Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015 (PubMed)

  2. Human TRAF6 Protein expressed in Wheat germ - ABIN1323514 : Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010 (PubMed)

More Proteins for TRAF6 Interaction Partners

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Proteins) activity by dissociating Atg9 (show ATG9A Proteins)/mAtg9 (show ATG9A Proteins) from dTRAF2/TRAF6 in Drosophila.

  2. null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired

Mouse (Murine) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. the SH3 domain of NOSTRIN (show NOSTRIN Proteins) is involved in the NOSTRIN (show NOSTRIN Proteins)-TRAF6 interaction and is required for NOSTRIN (show NOSTRIN Proteins)-induced down-regulation of endothelial cell proteins

  2. this study shows that TRAF6 overexpression in hematopoietic stem/progenitor cells results in impaired hematopoiesis and bone marrow failure

  3. TRAF6 and H2AX (show H2AFX Proteins) overexpression and gammaH2AX (show H2AFX Proteins)-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  4. By studying the response of T (show IFT122 Proteins)raf6(+/+) and Traf6(-/-)mouse embryonic fibroblasts to S. typhimurium infection, this study showed that TRAF6 promoted apoptosis by increasing reactive oxygen species accumulation, which led to increased Bax/Bcl-2 ratio, Bax recruitment to mitochondrial membrane, and release of Cyt c into the cytoplasm.

  5. BAT3 (show BAT3 Proteins) negatively regulates lipopolysaccharide-induced NF-kappaB (show NFKB1 Proteins) signaling through TRAF6.

  6. these data identify Trim13 as a positive regulator of NF-kappaB activation and suggest that lysine 29-linked polyubiquitination is a specific ubiquitin-linked pattern involved in the control of TLR2 signaling.

  7. this study shows that the absence TRAF6 expression by dendritic cells leads to spontaneous generation of Th2-associated immune responses and increased susceptibility to model antigen-induced asthma

  8. MiR (show MLXIP Proteins)-144 reduces the antiviral response by attenuating the TRAF6-IRF7 (show IRF7 Proteins) pathway to alter the cellular antiviral transcriptional landscape.

  9. Data indicate a role of microRNA miR (show MLXIP Proteins)-146a in the modulation of host defense against mycobacterial infection by repressing nitric oxide (NO) production via targeting tumor necrosis factor (TNF (show TNF Proteins)) receptor-associated factor 6 (TRAF6), which may provide a promising therapeutic target for tuberculosis.

  10. CD137 (show TNFRSF9 Proteins) Regulates NFATc1 (show NFATC1 Proteins) Expression in Mouse VSMCs through TRAF6/NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) Signaling Pathway.

Zebrafish TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity

  2. Full-length traf6 was functionally characterized.

Human TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. Results suggest that overexpression of miR (show MLXIP Proteins)-146a could promote IDD (show COL9A3 Proteins) through the TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.

  2. TRAF6 and H2AX (show H2AFX Proteins) overexpression and gammaH2AX (show H2AFX Proteins)-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  3. These findings show that SopB (show IFT122 Proteins) suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial reactive oxygen species generation.

  4. HCV infection suppressed the host innate immune response through the induction of autophagic degradation of TRAF6. This finding provided important information for further understanding how HCV evades host immunity to establish persistence

  5. Vav3 (show VAV3 Proteins) is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.

  6. TRAF6 expression was decreased in tympanic membrane of otitis media patients.

  7. Peripheral blood levels of S100A8 (show S100A8 Proteins) and TRAF6 in SAE patients were elevated and might be related to the severity of SAE and predict the outcome of SAE.

  8. Low TRAF6 expression is associated with Graves' disease.

  9. MiR (show MLXIP Proteins)-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17 (show IL17A Proteins)/ICAM-1 (show ICAM1 Proteins) pathway.

  10. Study demonstrates that TRAF6 is upregulated in human lung cancer cells, and siRNA-induced TRAF6 knockdown inhibits the invasion of lung cancer cells and promotes apoptosis.

TRAF6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Alternative names and synonyms associated with TRAF6

  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6-b)
  • TNF-receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6 (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6)
  • TNF receptor-associated factor 6 (traf6)
  • TNF receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (Traf6)
  • 2310003F17Rik protein
  • AI851288 protein
  • C630032O20Rik protein
  • CG10961 protein
  • Dmel\\CG10961 protein
  • dtraf2 protein
  • dTRAF6 protein
  • fi15f02 protein
  • GB10539 protein
  • MGC:3310 protein
  • RNF85 protein
  • TRAF protein
  • Traf2 protein
  • TRAF6 protein
  • wu:fi15f02 protein
  • xtraf6 protein
  • zgc:63704 protein

Protein level used designations for TRAF6

TNF receptor-associated factor 6-B , E3 ubiquitin-protein ligase TRAF6 , CG10961-PA , TNF-receptor-associated factor 2 , Traf6-PA , TNF receptor-associated factor 6 , TNF receptor-associated factor 6-like , RING finger protein 85 , interleukin-1 signal transducer , TNF-receptor associated factor 6

GENE ID SPECIES
444777 Xenopus laevis
31746 Drosophila melanogaster
423163 Gallus gallus
451702 Pan troglodytes
493524 Xenopus (Silurana) tropicalis
551819 Apis mellifera
100010055 Monodelphis domestica
100174890 Gasterosteus aculeatus
100395364 Callithrix jacchus
100449432 Pongo abelii
100510771 Anolis carolinensis
100544809 Meleagris gallopavo
100595327 Nomascus leucogenys
22034 Mus musculus
539124 Bos taurus
554561 Danio rerio
7189 Homo sapiens
311245 Rattus norvegicus
100688110 Canis lupus familiaris
396629 Sus scrofa
716907 Macaca mulatta
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