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Browse our TRAF6 Proteins (TRAF6)

Full name:
TNF Receptor-Associated Factor 6 Proteins (TRAF6)
On are 14 TNF Receptor-Associated Factor 6 (TRAF6) Proteins from 8 different suppliers available. Additionally we are shipping TRAF6 Antibodies (151) and TRAF6 Kits (15) and many more products for this protein. A total of 200 TRAF6 products are currently listed.
2310003F17Rik, AI851288, C630032O20Rik, CG10961, Dmel\\CG10961, dtraf2, dTRAF6, fi15f02, GB10539, MGC:3310, RNF85, TRAF, Traf2, TRAF6, wu:fi15f02, xtraf6, zgc:63704
list all proteins Gene Name GeneID UniProt
TRAF6 22034 P70196
TRAF6 7189 Q9Y4K3
TRAF6 311245 B5DF45

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TRAF6 Proteins (TRAF6) by Origin

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Top referenced TRAF6 Proteins

  1. Human TRAF6 Protein expressed in Human - ABIN2734115 : Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015 (PubMed)

  2. Human TRAF6 Protein expressed in Wheat germ - ABIN1323514 : Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010 (PubMed)

More Proteins for TRAF6 Interaction Partners

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (show MAPK8 Proteins) activity by dissociating Atg9 (show ATG9A Proteins)/mAtg9 (show ATG9A Proteins) from dTRAF2/TRAF6 in Drosophila.

  2. null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired

Mouse (Murine) TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. this study shows that the absence TRAF6 expression by dendritic cells leads to spontaneous generation of Th2-associated immune responses and increased susceptibility to model antigen-induced asthma

  2. MiR (show MLXIP Proteins)-144 reduces the antiviral response by attenuating the TRAF6-IRF7 (show IRF7 Proteins) pathway to alter the cellular antiviral transcriptional landscape.

  3. Data indicate a role of microRNA miR (show MLXIP Proteins)-146a in the modulation of host defense against mycobacterial infection by repressing nitric oxide (NO) production via targeting tumor necrosis factor (TNF (show TNF Proteins)) receptor-associated factor 6 (TRAF6), which may provide a promising therapeutic target for tuberculosis.

  4. CD137 (show TNFRSF9 Proteins) Regulates NFATc1 (show NFATC1 Proteins) Expression in Mouse VSMCs through TRAF6/NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) Signaling Pathway.

  5. TRAF6 was required for the activation of MAPKs ERK1/2 and JNK1 (show MAPK8 Proteins)/2

  6. Results suggest that microRNA-146a-5p attenuates neuropathic pain partly through inhibition of tumor necrosis factor (show TNF Proteins) receptor associated factor-6 and its downstream c-jun N-terminal kinase/CCL2 (show CCL2 Proteins) signaling.

  7. we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 (show DOK3 Proteins) via interaction with an E3 ligase TNFR (show TNFRSF1A Proteins)-associated factor 6 (TRAF6).

  8. TRAF6 is determined to be a direct E3 ligase for GSK3beta, and TRAF6-mediated GSK3beta ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 (show TLR3 Proteins) adaptor protein TRIF (show RNF138 Proteins)-assembled signalling complex.

  9. TIFAB (show TIFAB Proteins) loss increases TRAF6 protein and the dynamic range of TLR4 (show TLR4 Proteins) signaling

  10. The MYSM1 (show MYSM1 Proteins) SWIRM domain interacts with TRAF6 to terminate PRR (show PVRL1 Proteins) pathways for pro-inflammatory and type I interferon (show IFNA Proteins) responses.

Zebrafish TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity

  2. Full-length traf6 was functionally characterized.

Human TNF Receptor-Associated Factor 6 (TRAF6) interaction partners

  1. TRAF6 expression was decreased in tympanic membrane of otitis media patients.

  2. Peripheral blood levels of S100A8 (show S100A8 Proteins) and TRAF6 in SAE patients were elevated and might be related to the severity of SAE and predict the outcome of SAE.

  3. Low TRAF6 expression is associated with Graves' disease.

  4. MiR (show MLXIP Proteins)-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17 (show IL17A Proteins)/ICAM-1 (show ICAM1 Proteins) pathway.

  5. Study demonstrates that TRAF6 is upregulated in human lung cancer cells, and siRNA-induced TRAF6 knockdown inhibits the invasion of lung cancer cells and promotes apoptosis.

  6. High TRAF6 expression is associated with melanoma invasion and metastasis.

  7. The expression of TRAF6 was positively correlated with an advanced N stage and acted as a predictor of a poor prognosis in patients with gastric cancer

  8. DK1 inhibits the formation of the TAK1 (show MAP3K7 Proteins)-TAB2 (show TAB2 Proteins)-TRAF6 complex and leads to the inhibition of TRAF6 ubiquitination.

  9. DAT (show SLC6A3 Proteins) stabilized IkBa (show NFKBIA Proteins) by inhibiting the phosphorylation of Ika by the IkB (show NFKBIB Proteins) kinase (IKK (show CHUK Proteins)) complex. DAT (show SLC6A3 Proteins) induced proteasomal degradation of TRAF6, and DAT (show SLC6A3 Proteins) suppressed IKKb (show IKBKB Proteins)-phosphorylation through downregulation of TRAF6

  10. TRAF6 may be involved in cell migration, invasion, and apoptosis of SPC (show UCN3 Proteins)-A-1 cells, possibly through regulating the NF-B-CD24 (show CD24 Proteins)/CXCR4 (show CXCR4 Proteins) pathway..

TRAF6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Alternative names and synonyms associated with TRAF6

  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6-b)
  • TNF-receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6 (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6)
  • TNF receptor-associated factor 6 (traf6)
  • TNF receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (Traf6)
  • 2310003F17Rik protein
  • AI851288 protein
  • C630032O20Rik protein
  • CG10961 protein
  • Dmel\\CG10961 protein
  • dtraf2 protein
  • dTRAF6 protein
  • fi15f02 protein
  • GB10539 protein
  • MGC:3310 protein
  • RNF85 protein
  • TRAF protein
  • Traf2 protein
  • TRAF6 protein
  • wu:fi15f02 protein
  • xtraf6 protein
  • zgc:63704 protein

Protein level used designations for TRAF6

TNF receptor-associated factor 6-B , E3 ubiquitin-protein ligase TRAF6 , CG10961-PA , TNF-receptor-associated factor 2 , Traf6-PA , TNF receptor-associated factor 6 , TNF receptor-associated factor 6-like , RING finger protein 85 , interleukin-1 signal transducer , TNF-receptor associated factor 6

444777 Xenopus laevis
31746 Drosophila melanogaster
423163 Gallus gallus
451702 Pan troglodytes
493524 Xenopus (Silurana) tropicalis
551819 Apis mellifera
100010055 Monodelphis domestica
100174890 Gasterosteus aculeatus
100395364 Callithrix jacchus
100449432 Pongo abelii
100510771 Anolis carolinensis
100544809 Meleagris gallopavo
100595327 Nomascus leucogenys
22034 Mus musculus
539124 Bos taurus
554561 Danio rerio
7189 Homo sapiens
311245 Rattus norvegicus
100688110 Canis lupus familiaris
396629 Sus scrofa
716907 Macaca mulatta
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