TRAF6 Protein (AA 1-522, full length) (His-SUMO Tag)

Catalog No. ABIN5710550

Product Details

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Protein Type: Recombinant

Protein Characteristics: AA 1-522, full length

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TRAF6 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MSLLNCENSC GFSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Alternative Name: TRAF6 (TRAF6 Products)

Synonyms: MGC:3310 Protein, RNF85 Protein, 2310003F17Rik Protein, AI851288 Protein, C630032O20Rik Protein, rnf85 Protein, traf6 Protein, xtraf6 Protein, CG10961 Protein, DTRAF2 Protein, Dmel\\CG10961 Protein, TRAF Protein, TRAF2 Protein, TRAF6 Protein, Traf2 Protein, dTRAF2 Protein, dTRAF6 Protein, dTraf2 Protein, dtraf2 Protein, GB10539 Protein, fi15f02 Protein, wu:fi15f02 Protein, zgc:63704 Protein, TNF receptor associated factor 6 Protein, TNF receptor-associated factor 6 Protein, TNF receptor associated factor 6 L homeolog Protein, TNF-receptor-associated factor 6 Protein, TNF receptor associated factor 6 S homeolog Protein, TRAF6 Protein, Traf6 Protein, traf6.L Protein, traf6 Protein, LOC551819 Protein, traf6.S Protein

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Ses to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that ses to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production

Molecular Weight: 75.6 kDa

UniProt: Q9Y4K3

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway