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Rat (Rattus) ADAM17 Protein expressed in Human Cells - ABIN2009530
Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (show IL6 Proteins) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (show TNF Proteins)-induced AP-2alpha (show TFAP2A Proteins) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (show RHBDF2 Proteins) in the regulation of the ADAM17 and EGFR (show EGFR Proteins), and ADAM17 and TNFalpha (show TNF Proteins) signaling pathways, was examined.
Findings provide evidence that ADAM10 (show ADAM10 Proteins), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Proteins) signaling.
this study shows that the iRhom2 (show RHBDF2 Proteins)/ADAM17 pathway plays an important role in regulating CSF1R (show CSF1R Proteins) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (show TNF Proteins) and TNFR2 (show TNFRSF1B Proteins), thereby preventing overactivation of endogenous TNFR2 (show TNFRSF1B Proteins) signaling in cells of the vasculature.
Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Proteins) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Proteins) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
Thus, Leda-1/Pianp (show C12orf53 Proteins) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 Proteins)/17 and intramembrane protease gamma-secretase.
Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Proteins)kinase (Axl) in lupus-prone leukocytes.
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (show RPS6KA1 Proteins)-dependent C/EBPbeta (show CEBPB Proteins) signaling pathway, which in turn initiates binding of C/EBPbeta (show CEBPB Proteins) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (show TNFSF11 Proteins) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Our data demonstrated that elevated serum Semaphorin5A (Sema5A (show SEMA5A Proteins)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (show SEMA5A Proteins).
ADAM17 and ADAM10 (show ADAM10 Proteins) cleave Nectin-4 (show PVRL4 Proteins) and release soluble Nectin-4 (show PVRL4 Proteins) (sN4).
ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.
FHL2 (show FHL2 Proteins) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (show FHL2 Proteins) complex in the development of colorectal cancer.
The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (show EGFR Proteins)-PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling pathway
ADAM17 was involved in porcine CD16 (show CD16 Proteins) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Proteins) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (show FYN Proteins)-induced c-Src (show SRC Proteins)-dependent manner mediates proteolytic activation of the EGF (show EGF Proteins)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE, and RhoA (show RHOA Proteins) through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Proteins) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme