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Browse our ADAM17 Proteins (ADAM17)

Full name:
ADAM Metallopeptidase Domain 17 Proteins (ADAM17)
On are 14 ADAM Metallopeptidase Domain 17 (ADAM17) Proteins from 8 different suppliers available. Additionally we are shipping ADAM17 Antibodies (245) and ADAM17 Kits (28) and many more products for this protein. A total of 296 ADAM17 products are currently listed.
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
list all proteins Gene Name GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

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ADAM17 Proteins (ADAM17) by Origin

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Top referenced ADAM17 Proteins

  1. Rat (Rattus) ADAM17 Protein expressed in Human Cells - ABIN2009530 : Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013 (PubMed)

More Proteins for ADAM17 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Data show that caveolin 1 (CAV1 (show CAV1 Proteins)) is required for transforming growth factor-beta (TGF-beta)-induced reactive oxygen species production, mediated by NADPH oxidase (show NOX1 Proteins) NOX1 (show NOX1 Proteins), that is necessary for a disintegrin and metalloproteinase 17 (ADAM17) activation.

  2. ADAM12 (show ADAM12 Proteins) and ADAM17 are essential molecules for the impairment of barrier function of retinal vasculature under hypoxia.

  3. 4-Hydroxyisoleucine improved insulin (show INS Proteins) resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 (show TIMP3 Proteins) and the insulin (show INS Proteins) signaling pathway.

  4. Hypercapnic acidosis blocks stretch-mediated activation of ADAM17. ADAM17 is an important proximal mediator of ventilator-induced lung injury.

  5. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease

  6. Overexpression of ADAM17 increases shed ACE2 (show ACE2 Proteins) and decreases cellular ACE2 (show ACE2 Proteins) levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2 (show ACE2 Proteins), ADAM17 does not deplete ACE2 (show ACE2 Proteins) from pancreatic islets in diabetic db/db (show LEPR Proteins) mice.

  7. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)

  8. These data demonstrated that ADAM17 contributed to microglial cell survival, predominantly by EGFR (show EGFR Proteins) signalling, following spinal cord injury

  9. These results demonstrate that ADAM17-mediated TNF-alpha (show TNF Proteins) signaling from intestinal epithelial cell has a significant role in the development of the proinflammatory state and mucosal atrophy observed in total parenteral nutrition - treated mice.

  10. Results strongly suggest that TACE contributes to the development of psoriatic lesions through releasing two kinds of psoriasis mediators, TNF-a (show TNF Proteins) and EGFR (show EGFR Proteins) ligands.

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. The production of ADAM17-positive microvesicless from smoke-exposed neutrophils provides a novel molecular mechanism for the vastly accelerated risk of AAA (show APP Proteins) in smokers.

  2. miR (show MLXIP Proteins)-338-3p is significantly decreased in gastric cancer, and inhibits cell proliferation, migration and invasion partially via the downregulation of ADAM17.

  3. results explain how loss of the amino terminus in iRhom1 (show RHBDF1 Proteins) and iRhom2 (show RHBDF2 Proteins) impairs TNF (show TNF Proteins) signaling, despite enhancing ADAM17 activity

  4. Estrogen upregulates MICA (show MICA Proteins)/B expression in human non-small cell lung cancer through the regulation of ADAM17.

  5. The effects of ADAM17 inhibition on the cancer stem cells phenotype and chemosensitivity to 5-fluorouracil (5-FU) in colorectal cancer cells were examined. siRNA knockdown and TAPI-2 decreased the protein levels of cleaved Notch1 (show NOTCH1 Proteins)

  6. Data indicate a potent and specific ADAM metallopeptidase domain 17 (ADAM17) inhibitory antibody, MEDI3622, which induces tumor regression or stasis in many epidermal growth factor receptor (EGFR (show EGFR Proteins))-dependent tumor models.

  7. ADAM17 is important for the migratory potential of immortalized human dermal lymphatic endothelial cells.

  8. High ADAM17 expression was associated with lymph node metastasis, vascular invasion, the presence of recurrence in patients with gastric cancer who underwent curative gastrectomy.

  9. N-terminal cleavage and release of the ectodomain of Flt1 (show FLT1 Proteins) is mediated via ADAM10 (show ADAM10 Proteins) and ADAM 17 and regulated by VEGFR2 (show KDR Proteins) and the Flt1 (show FLT1 Proteins) intracellular domain.

  10. Adam17, a target of Mir (show MLXIP Proteins)-326, promotes epithelial-mesenchymal transition-induced cells invasion in lung adenocarcinoma.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (show CD16 Proteins) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Proteins) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (show FYN Proteins)-induced c-Src (show SRC Proteins)-dependent manner mediates proteolytic activation of the EGF (show EGF Proteins)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE, and RhoA (show RHOA Proteins) through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Proteins) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Protein Profile

Protein Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17)
  • a disintegrin and metallopeptidase domain 17b (adam17b)
  • ADAM metallopeptidase domain 17 (adam17)
  • a disintegrin and metallopeptidase domain 17 (Adam17)
  • ADAM metallopeptidase domain 17 (Adam17)
  • adam17 protein
  • ADAM18 protein
  • CD156B protein
  • CSVP protein
  • NISBD protein
  • si:dkey-81b15.2 protein
  • Tace protein

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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