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Browse our ADAM17 Proteins (ADAM17)

Full name:
ADAM Metallopeptidase Domain 17 Proteins (ADAM17)
On www.antibodies-online.com are 15 ADAM Metallopeptidase Domain 17 (ADAM17) Proteins from 8 different suppliers available. Additionally we are shipping ADAM17 Antibodies (262) and ADAM17 Kits (33) and many more products for this protein. A total of 319 ADAM17 products are currently listed.
Synonyms:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
list all proteins Gene Name GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

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ADAM17 Proteins (ADAM17) by Origin

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Top referenced ADAM17 Proteins

  1. Rat (Rattus) ADAM17 Protein expressed in Human Cells - ABIN2009530 : Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013 (PubMed)

More Proteins for ADAM17 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (show TNF Proteins) and TNFR2 (show TNFRSF1B Proteins), thereby preventing overactivation of endogenous TNFR2 (show TNFRSF1B Proteins) signaling in cells of the vasculature.

  2. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Proteins) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Proteins) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  3. Thus, Leda-1/Pianp (show C12orf53 Proteins) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 Proteins)/17 and intramembrane protease gamma-secretase.

  4. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (show AXL Proteins)kinase (Axl) in lupus-prone leukocytes.

  5. These findings suggest that maintaining ADAM17-EGFR (show EGFR Proteins) epithelial signaling is necessary for the recovery from UC and would be beneficial to therapeutic strategies targeting ADAM17-mediated TNF-a (show TNF Proteins) shedding.

  6. Data show that caveolin 1 (CAV1 (show CAV1 Proteins)) is required for transforming growth factor-beta (TGF-beta)-induced reactive oxygen species production, mediated by NADPH oxidase (show NOX1 Proteins) NOX1 (show NOX1 Proteins), that is necessary for a disintegrin and metalloproteinase 17 (ADAM17) activation.

  7. ADAM12 (show ADAM12 Proteins) and ADAM17 are essential molecules for the impairment of barrier function of retinal vasculature under hypoxia.

  8. 4-Hydroxyisoleucine improved insulin (show INS Proteins) resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 (show TIMP3 Proteins) and the insulin (show INS Proteins) signaling pathway.

  9. Hypercapnic acidosis blocks stretch-mediated activation of ADAM17. ADAM17 is an important proximal mediator of ventilator-induced lung injury.

  10. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  2. Aging and obesity cooperatively reduce caveolin-1 (show CAV1 Proteins) expression and increase vascular endothelial ADAM17 activity and soluble TNF (show TNF Proteins) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  3. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (show SEMA5A Proteins)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (show SEMA5A Proteins).

  4. ADAM17 and ADAM10 (show ADAM10 Proteins) cleave Nectin-4 (show PVRL4 Proteins) and release soluble Nectin-4 (show PVRL4 Proteins) (sN4).

  5. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  6. FHL2 (show FHL2 Proteins) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (show FHL2 Proteins) complex in the development of colorectal cancer.

  7. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (show EGFR Proteins)-PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling pathway

  8. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (show AXL Proteins)) is rescued by combined matrix metalloproteases ADAM10 (show ADAM10 Proteins) and TACE (ADAM17) inhibition.

  9. the TLR4 (show TLR4 Proteins)/Gal-1 (show LGALS1 Proteins) signaling pathway regulates lactate-mediated EMT (show ITK Proteins) processes through the activation of ADAM10 (show ADAM10 Proteins) and ADAM17 in colon cancer cells.

  10. The HNE-TACE signalling pathway has an important role in the process of MUC5AC overexpression in chronic rhinosinusitis.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (show CD16 Proteins) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (show CD163 Proteins) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (show FYN Proteins)-induced c-Src (show SRC Proteins)-dependent manner mediates proteolytic activation of the EGF (show EGF Proteins)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE, and RhoA (show RHOA Proteins) through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (show EGF Proteins) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Protein Profile

Protein Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17)
  • a disintegrin and metallopeptidase domain 17b (adam17b)
  • ADAM metallopeptidase domain 17 (adam17)
  • a disintegrin and metallopeptidase domain 17 (Adam17)
  • ADAM metallopeptidase domain 17 (Adam17)
  • adam17 protein
  • ADAM18 protein
  • CD156B protein
  • CSVP protein
  • NISBD protein
  • si:dkey-81b15.2 protein
  • Tace protein

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPECIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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