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Browse our CRB1 Proteins (CRB1)

Full name:
Crumbs Homolog 1 (Drosophila) Proteins (CRB1)
On are 5 Crumbs Homolog 1 (Drosophila) (CRB1) Proteins from 2 different suppliers available. Additionally we are shipping CRB1 Antibodies (7) and many more products for this protein. A total of 14 CRB1 products are currently listed.
7530426H14Rik, A930008G09Rik, CRB1, LCA8, RP12, si:dkey-114d20.6, si:dkey-114d20.7
list all proteins Gene Name GeneID UniProt
CRB1 23418 P82279
CRB1 170788 Q8VHS2
Rat CRB1 CRB1 304825  

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CRB1 Proteins (CRB1) by Origin

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More Proteins for CRB1 Interaction Partners

Zebrafish Crumbs Homolog 1 (Drosophila) (CRB1) interaction partners

  1. This study show that the undifferentiated CNS expresses Crb1, Crb2a, and Crb2b in distinct spatial and temporal patterns.

  2. Data suggest that the Crb (show MYBL2 Proteins)/Moe (show EPB41L5 Proteins) complex and Notch (show NOTCH1 Proteins) play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.

Human Crumbs Homolog 1 (Drosophila) (CRB1) interaction partners

  1. We present the case of a child who presented during screening for uveitis associated with juvenile idiopathic arthritis with macular oedema and was found to have early onset retinal dystrophy (show MERTK Proteins) and mutations in CRB1.

  2. Two novel variants were detected: c.2536G>T (p.G846X) in the CRB1 gene and c.4929delA (p.Lys1643fsX2) in the CEP290 gene.

  3. CRB1 mutations may be associated with intraretinal cystoid spaces. The use of carbonic anhydrase inhibitors can result in improved visual acuity in some patients.

  4. Comprehensive retinal dystrophy (show MERTK Proteins) panel revealed a homozygous mutation in CRB1 (p.Pro836Thr:c.2506C>A) in both twins.

  5. Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 (show MPP5 Proteins) may be regulated by intradomain contacts or by protein-protein interaction.

  6. The phenotypic spectrum of recessive CRB1 mutation includes childhood cone-rod dystrophy with macular cystic degeneration and the associated ERG (show ERG Proteins) can be electronegative.

  7. The phenotypes of these novel mutations for early-onset retinal dystrophy (show MERTK Proteins) (EORD) are typical of CRB1-associated EORD

  8. Study showed that CRB1 and CRB2 (show CRB2 Proteins) in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 (show CRB2 Proteins) influences the severity of the murine Crb1-linked retinal dystrophies.

  9. the mammalian apical CRB1 complex might control retinogenesis and prevents onset of Leber congenital amaurosis or retinitis pigmentosa.

  10. Macular nummular pigmentation is a gene-specific indication for CRB1associated retinal dystrophy (show MERTK Proteins).

Mouse (Murine) Crumbs Homolog 1 (Drosophila) (CRB1) interaction partners

  1. This study showed that The geographic distribution of subretinal microglia/macrophages changes with age in both Crb1 rd8/rd8 and C57BL mice, but the total number of microglia only increases in Crb1 rd8/rd8 mice,and pro-inflamatory phenotype.

  2. The retinal phenotype of Grk1 (show GRK1 Proteins)-/- mice is compromised by a Crb1 rd8 mutation.

  3. Presence of rd8 (Crb1) mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model carrying the Ctrp5 (show C1QTNF5 Proteins) mutation.

  4. Study showed that CRB1 and CRB2 (show CRB2 Proteins) in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 (show CRB2 Proteins) influences the severity of the murine Crb1-linked retinal dystrophies.

  5. These findings suggest that CRB1 and CRB2 (show CRB2 Proteins) suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways.

  6. The C57BL/6NJ-Crb1(rd8) mutation and its associated retinal phenotypes were corrected efficiently by TALEN-mediated homology-directed repair.

  7. This study demonistrated that the Rd8 mutation in the Crb1 gene of CD11c (show ITGAX Proteins)-eYFP transgenic reporter mice results in abnormal numbers of CD11c (show ITGAX Proteins)-positive cells in the retina.

  8. Data show the deletion of Pals1 (show MPP5 Proteins) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 (show CRB2 Proteins) and Crb3 (show CRB3 Proteins) in retinal progenitors and the adult retina.

  9. CRB1 mutations lead to early-onset severe loss of vision with thickened, disorganized, nonseeing retina. Impaired peripheral vision can persist in late disease stages.

  10. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain.

CRB1 Protein Profile

Protein Summary

This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.

Alternative names and synonyms associated with CRB1

  • crumbs homolog 1 (Drosophila) (CRB1)
  • crumbs homolog 1 (Drosophila) (crb1)
  • crumbs homolog 1 (Drosophila) (Crb1)
  • 7530426H14Rik protein
  • A930008G09Rik protein
  • CRB1 protein
  • LCA8 protein
  • RP12 protein
  • si:dkey-114d20.6 protein
  • si:dkey-114d20.7 protein

Protein level used designations for CRB1

crumbs homolog 1 (Drosophila) , crumbs homolog 1 , crumbs-like 1 , crumbs homolog 1-like , protein crumbs homolog 1

469626 Pan troglodytes
560942 Danio rerio
424352 Gallus gallus
520406 Bos taurus
100061068 Equus caballus
490260 Canis lupus familiaris
710991 Macaca mulatta
100026638 Monodelphis domestica
100074591 Ornithorhynchus anatinus
100339170 Oryctolagus cuniculus
100385306 Callithrix jacchus
100448356 Pongo abelii
100484937 Ailuropoda melanoleuca
100493588 Xenopus (Silurana) tropicalis
100542177 Meleagris gallopavo
100601606 Nomascus leucogenys
23418 Homo sapiens
170788 Mus musculus
304825 Rattus norvegicus
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