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Browse our DLL4 Proteins (DLL4)

Full name:
delta-Like 4 Proteins (DLL4)
On www.antibodies-online.com are 22 delta-Like 4 (DLL4) Proteins from 9 different suppliers available. Additionally we are shipping DLL4 Antibodies (141) and DLL4 Kits (15) and many more products for this protein. A total of 189 DLL4 products are currently listed.
Synonyms:
Delta4, hdelta2, si:ch211-244p18.5, zgc:136596
list all proteins Gene Name GeneID UniProt
DLL4 54567 Q9NR61
DLL4 54485 Q9JI71
DLL4 311332  

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DLL4 Proteins (DLL4) by Origin

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Top referenced DLL4 Proteins

  1. Human DLL4 Protein expressed in Human Cells - ABIN2002236 : Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002 (PubMed)
    Show all 6 references for ABIN2002236

  2. Mouse (Murine) DLL4 Protein expressed in Human Cells - ABIN2008088 : Dufraine, Funahashi, Kitajewski: Notch signaling regulates tumor angiogenesis by diverse mechanisms. in Oncogene 2008 (PubMed)
    Show all 4 references for ABIN2008088

  3. Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180971 : Corazza, Rennella, Schanda, Mimmi, Cutuil, Raimondi, Giorgetti, Fogolari, Viglino, Frydman, Gal, Bellotti, Brutscher, Esposito: Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN2180971

  4. Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180973 : Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004 (PubMed)
    Show all 2 references for ABIN2180973

More Proteins for DLL4 Interaction Partners

Human delta-Like 4 (DLL4) interaction partners

  1. DLL4 and JAG1 (show JAG1 Proteins) may have opposing effects on tumor angiogenesis in glioblastoma.

  2. Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like (show DLK1 Proteins) ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.

  3. Antagonism of the DLL4-Notch (show NOTCH1 Proteins) signaling pathway might provide a potential therapeutic approach for breast cancer treatment by preventing angiogenesis.

  4. Activation of Dll4/Notch (show NOTCH1 Proteins) signaling led to increased expression of ephrin-B2 (show EFNB2 Proteins) and subsequent inhibition of endothelial progenitor cells activity.

  5. DLL4 is a unique functional molecule of human circulating dendritic cells critical for directing Th1 (show TH1L Proteins) and Th17 differentiation

  6. The expression of DLL4 was positively correlated with CD105-labeled MVD (show MVD Proteins).

  7. The detection of Notch1 (show NOTCH1 Proteins) and Delta-like (show DLK1 Proteins) 4 expression in peripheral blood lymphocytes of renal transplant recipients can serve as a positive indicator for evaluating the diagnosis and treatment efficacy of the AR reaction.

  8. Among all the Notch (show NOTCH1 Proteins) ligands, Delta-like4 (Dll4) is specifically involved in angiogenesis. hD4R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay.

  9. DLL4 and VEGFA (show VEGFA Proteins) expression was closely related to tumour diameter, clinical stage, histological grade and lymph node metastasis.

  10. DLL4/Notch1 (show NOTCH1 Proteins) and BMP9 (show GDF2 Proteins) interdependent signaling induces endothelial cell quiescence via P27KIP1 (show CDKN1B Proteins)/thrombospondin pathway.

Mouse (Murine) delta-Like 4 (DLL4) interaction partners

  1. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression

  2. Dll4/Notch (show NOTCH1 Proteins) signaling and HIF-1alpha (show HIF1A Proteins) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.

  3. Dll4-induced Notch1 (show NOTCH1 Proteins) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.

  4. Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like (show DLK1 Proteins) 4 targeting therapies.

  5. The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning.

  6. DLL4 is an efficient cis (show CISH Proteins)-inhibitor of Notch (show NOTCH1 Proteins) signaling during embryogenesis.

  7. Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells.

  8. work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature.

  9. Delta-like (show DLK1 Proteins) 4-mediated Notch (show NOTCH1 Proteins) signaling is required for early T-cell development in a three-dimensional thymic structure.

  10. Snail1 (show SNAI1 Proteins) acts as a VEGF (show VEGFA Proteins)-induced regulator of Notch1 (show NOTCH1 Proteins) signalling and Dll4 expression. Results document a Snail1 (show SNAI1 Proteins)-Dll4/Notch1 (show NOTCH1 Proteins) axis that controls embryonic vascular development.

Zebrafish delta-Like 4 (DLL4) interaction partners

  1. show that blood flow suppresses vascular Notch (show NOTCH1 Proteins) signalling via down-regulation of dll4

  2. Microinjection of miR (show MYLIP Proteins)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.

  3. Notch (show NOTCH1 Proteins) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 Proteins) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.

  4. These studies imply critical roles for Dll4/Notch (show NOTCH1 Proteins) signaling in the formation and wiring of the lymphatic network.

  5. Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.

  6. Vegfc (show VEGFC Proteins)/Flt4 (show FLT4 Proteins) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

DLL4 Protein Profile

Protein Summary

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Alternative names and synonyms associated with DLL4

  • delta-like 4 (Drosophila) (DLL4)
  • delta-like 4 (Drosophila) (Dll4)
  • delta-like 4 (Drosophila) (dll4)
  • Delta4 protein
  • hdelta2 protein
  • si:ch211-244p18.5 protein
  • zgc:136596 protein

Protein level used designations for delta-Like 4 Proteins (DLL4)

delta-like protein 4 , delta 4 , delta ligand 4 , delta-like 4 homolog , delta-like 4 protein , delta4 , drosophila Delta homolog 4 , notch ligand DLL4 , notch ligand delta-2

GENE ID SPECIES
100057073 Equus caballus
100152163 Sus scrofa
54567 Homo sapiens
54485 Mus musculus
311332 Rattus norvegicus
453344 Pan troglodytes
607575 Canis lupus familiaris
518746 Bos taurus
563920 Danio rerio
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