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Human DLL4 Protein expressed in Human Cells - ABIN2002238
Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002
Show all 5 references for ABIN2002238
Mouse (Murine) DLL4 Protein expressed in Human Cells - ABIN2008088
Dufraine, Funahashi, Kitajewski: Notch signaling regulates tumor angiogenesis by diverse mechanisms. in Oncogene 2008
Show all 4 references for ABIN2008088
Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180973
Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004
Show all 2 references for ABIN2180973
Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.
Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (show VEGFA Proteins) isoform-dependent manner, and in perivascular cells in a VEGF (show VEGFA Proteins)-independent manner. The contribution of VEGF-A (show VEGFA Proteins) isoforms to disease progression also indicates that IH may be associated with altered splicing.
Dll4 modulates liver inflammatory response by down-regulating chemokine (show CCL1 Proteins) expression
Positive Jagged1 (show JAG1 Proteins) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.
Data show that the IgA/delta-like protein 4 (Delta-4)/Notch (show NOTCH1 Proteins) receptor (Notch (show NOTCH1 Proteins)) axis is not observed in IgG-dendritic cells (DCs).
Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.
our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.
Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 Proteins) Signaling
DLL4 and JAG1 (show JAG1 Proteins) may have opposing effects on tumor angiogenesis in glioblastoma.
Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like (show DLK1 Proteins) ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.
The results demonstrate that the Vegf (show VEGFA Proteins)-Dll4/Notch (show NOTCH1 Proteins) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.
miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression
Dll4/Notch (show NOTCH1 Proteins) signaling and HIF-1alpha (show HIF1A Proteins) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (show NOTCH1 Proteins) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like (show DLK1 Proteins) 4 targeting therapies.
The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning.
DLL4 is an efficient cis (show CISH Proteins)-inhibitor of Notch (show NOTCH1 Proteins) signaling during embryogenesis.
Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells.
Thsd7a (show THSD7A Proteins) could regulate ISV angiogenesis via Notch (show NOTCH1 Proteins)-dll4 signaling. Thus, Thsd7a (show THSD7A Proteins) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (show NOTCH1 Proteins) signalling via down-regulation of dll4
Microinjection of miR (show MYLIP Proteins)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (show NOTCH1 Proteins) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 Proteins) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (show NOTCH1 Proteins) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (show VEGFC Proteins)/Flt4 (show FLT4 Proteins) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2