Browse our DLL4 Proteins (DLL4)

Full name:
delta-Like 4 Proteins (DLL4)
On are 28 delta-Like 4 (DLL4) Proteins from 9 different suppliers available. Additionally we are shipping DLL4 Antibodies (170) and DLL4 Kits (24) and many more products for this protein. A total of 232 DLL4 products are currently listed.
Delta4, hdelta2, si:ch211-244p18.5, zgc:136596
list all proteins Gene Name GeneID UniProt
DLL4 54567 Q9NR61
DLL4 54485 Q9JI71
DLL4 311332  

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DLL4 Proteins (DLL4) by Origin

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Top referenced DLL4 Proteins

  1. Human DLL4 Protein expressed in Human Cells - ABIN2002238 : Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002 (PubMed)
    Show all 5 references for 2002238

  2. Mouse (Murine) DLL4 Protein expressed in Human Cells - ABIN2008088 : Dufraine, Funahashi, Kitajewski: Notch signaling regulates tumor angiogenesis by diverse mechanisms. in Oncogene 2008 (PubMed)
    Show all 4 references for 2008088

  3. Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180973 : Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004 (PubMed)
    Show all 2 references for 2180973

More Proteins for DLL4 Interaction Partners

Human delta-Like 4 (DLL4) interaction partners

  1. The authors present novel structures of human ligands Jagged2 (show JAG2 Proteins) and Delta-like4 and human Notch2 (show NOTCH2 Proteins), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Proteins) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Proteins) signalling.

  2. Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (show BCL2 Proteins) expression, while decreasing Bax (show BAX Proteins) expression, apoptosis rate and DNA damage

  3. In gastric epithelial cells co-cultured with Helicobacter pylori, the expression level of the ligand DLL4 was found to be significantly increased.

  4. Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.

  5. Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (show VEGFA Proteins) isoform-dependent manner, and in perivascular cells in a VEGF (show VEGFA Proteins)-independent manner. The contribution of VEGF-A (show VEGFA Proteins) isoforms to disease progression also indicates that IH may be associated with altered splicing.

  6. Dll4 modulates liver inflammatory response by down-regulating chemokine (show CCL1 Proteins) expression

  7. Positive Jagged1 (show JAG1 Proteins) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.

  8. Data show that the IgA/delta-like protein 4 (Delta-4)/Notch (show NOTCH1 Proteins) receptor (Notch (show NOTCH1 Proteins)) axis is not observed in IgG-dendritic cells (DCs).

  9. Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.

  10. our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.

Mouse (Murine) delta-Like 4 (DLL4) interaction partners

  1. Dll4 seems to promote Apc (show APC Proteins) (Min/+) tumorigenesis.

  2. Dll4-Notch1 (show NOTCH1 Proteins) signalling couples sprouting angiogenesis and artery formation.

  3. Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.

  4. DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.

  5. The results demonstrate that the Vegf (show VEGFA Proteins)-Dll4/Notch (show NOTCH1 Proteins) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.

  6. Dll4 modulates liver inflammatory response by down-regulating chemokine (show CCL1 Proteins) expression

  7. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 Proteins) Signaling

  8. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression

  9. Dll4/Notch (show NOTCH1 Proteins) signaling and HIF-1alpha (show HIF1A Proteins) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.

  10. Dll4-induced Notch1 (show NOTCH1 Proteins) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.

Zebrafish delta-Like 4 (DLL4) interaction partners

  1. Thsd7a (show THSD7A Proteins) could regulate ISV angiogenesis via Notch (show NOTCH1 Proteins)-dll4 signaling. Thus, Thsd7a (show THSD7A Proteins) is a potent angioneurin involved in the development of both neural and vascular systems.

  2. show that blood flow suppresses vascular Notch (show NOTCH1 Proteins) signalling via down-regulation of dll4

  3. Microinjection of miR (show MYLIP Proteins)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.

  4. Notch (show NOTCH1 Proteins) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 Proteins) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.

  5. These studies imply critical roles for Dll4/Notch (show NOTCH1 Proteins) signaling in the formation and wiring of the lymphatic network.

  6. Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.

  7. Vegfc (show VEGFC Proteins)/Flt4 (show FLT4 Proteins) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

DLL4 Protein Profile

Protein Summary

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Alternative names and synonyms associated with DLL4

  • delta-like 4 (Drosophila) (DLL4)
  • delta-like 4 (Drosophila) (Dll4)
  • delta-like 4 (Drosophila) (dll4)
  • Delta4 protein
  • hdelta2 protein
  • si:ch211-244p18.5 protein
  • zgc:136596 protein

Protein level used designations for delta-Like 4 Proteins (DLL4)

delta-like protein 4 , delta 4 , delta ligand 4 , delta-like 4 homolog , delta-like 4 protein , delta4 , drosophila Delta homolog 4 , notch ligand DLL4 , notch ligand delta-2

100057073 Equus caballus
100152163 Sus scrofa
54567 Homo sapiens
54485 Mus musculus
311332 Rattus norvegicus
453344 Pan troglodytes
607575 Canis lupus familiaris
518746 Bos taurus
563920 Danio rerio
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