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Browse our DLL4 Proteins (DLL4)

Full name:
delta-Like 4 Proteins (DLL4)
On are 22 delta-Like 4 (DLL4) Proteins from 9 different suppliers available. Additionally we are shipping DLL4 Antibodies (163) and DLL4 Kits (21) and many more products for this protein. A total of 216 DLL4 products are currently listed.
Delta4, hdelta2, si:ch211-244p18.5, zgc:136596
list all proteins Gene Name GeneID UniProt
DLL4 54567 Q9NR61
DLL4 54485 Q9JI71
DLL4 311332  

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DLL4 Proteins (DLL4) by Origin

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Top referenced DLL4 Proteins

  1. Human DLL4 Protein expressed in Human Cells - ABIN2002238 : Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002 (PubMed)
    Show all 5 references for ABIN2002238

  2. Mouse (Murine) DLL4 Protein expressed in Human Cells - ABIN2008088 : Dufraine, Funahashi, Kitajewski: Notch signaling regulates tumor angiogenesis by diverse mechanisms. in Oncogene 2008 (PubMed)
    Show all 4 references for ABIN2008088

  3. Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180973 : Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004 (PubMed)
    Show all 2 references for ABIN2180973

More Proteins for DLL4 Interaction Partners

Human delta-Like 4 (DLL4) interaction partners

  1. Positive Jagged1 (show JAG1 Proteins) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.

  2. Data show that the IgA/delta-like protein 4 (Delta-4)/Notch (show NOTCH1 Proteins) receptor (Notch (show NOTCH1 Proteins)) axis is not observed in IgG-dendritic cells (DCs).

  3. Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.

  4. our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.

  5. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 Proteins) Signaling

  6. DLL4 and JAG1 (show JAG1 Proteins) may have opposing effects on tumor angiogenesis in glioblastoma.

  7. Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like (show DLK1 Proteins) ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.

  8. Antagonism of the DLL4-Notch (show NOTCH1 Proteins) signaling pathway might provide a potential therapeutic approach for breast cancer treatment by preventing angiogenesis.

  9. Activation of Dll4/Notch (show NOTCH1 Proteins) signaling led to increased expression of ephrin-B2 (show EFNB2 Proteins) and subsequent inhibition of endothelial progenitor cells activity.

  10. DLL4 is a unique functional molecule of human circulating dendritic cells critical for directing Th1 (show TH1L Proteins) and Th17 differentiation

Mouse (Murine) delta-Like 4 (DLL4) interaction partners

  1. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 Proteins) Signaling

  2. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression

  3. Dll4/Notch (show NOTCH1 Proteins) signaling and HIF-1alpha (show HIF1A Proteins) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.

  4. Dll4-induced Notch1 (show NOTCH1 Proteins) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.

  5. Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like (show DLK1 Proteins) 4 targeting therapies.

  6. The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning.

  7. DLL4 is an efficient cis (show CISH Proteins)-inhibitor of Notch (show NOTCH1 Proteins) signaling during embryogenesis.

  8. Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells.

  9. work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature.

  10. Delta-like (show DLK1 Proteins) 4-mediated Notch (show NOTCH1 Proteins) signaling is required for early T-cell development in a three-dimensional thymic structure.

Zebrafish delta-Like 4 (DLL4) interaction partners

  1. Thsd7a (show THSD7A Proteins) could regulate ISV angiogenesis via Notch (show NOTCH1 Proteins)-dll4 signaling. Thus, Thsd7a (show THSD7A Proteins) is a potent angioneurin involved in the development of both neural and vascular systems.

  2. show that blood flow suppresses vascular Notch (show NOTCH1 Proteins) signalling via down-regulation of dll4

  3. Microinjection of miR (show MYLIP Proteins)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.

  4. Notch (show NOTCH1 Proteins) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 Proteins) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.

  5. These studies imply critical roles for Dll4/Notch (show NOTCH1 Proteins) signaling in the formation and wiring of the lymphatic network.

  6. Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.

  7. Vegfc (show VEGFC Proteins)/Flt4 (show FLT4 Proteins) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

DLL4 Protein Profile

Protein Summary

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Alternative names and synonyms associated with DLL4

  • delta-like 4 (Drosophila) (DLL4)
  • delta-like 4 (Drosophila) (Dll4)
  • delta-like 4 (Drosophila) (dll4)
  • Delta4 protein
  • hdelta2 protein
  • si:ch211-244p18.5 protein
  • zgc:136596 protein

Protein level used designations for delta-Like 4 Proteins (DLL4)

delta-like protein 4 , delta 4 , delta ligand 4 , delta-like 4 homolog , delta-like 4 protein , delta4 , drosophila Delta homolog 4 , notch ligand DLL4 , notch ligand delta-2

100057073 Equus caballus
100152163 Sus scrofa
54567 Homo sapiens
54485 Mus musculus
311332 Rattus norvegicus
453344 Pan troglodytes
607575 Canis lupus familiaris
518746 Bos taurus
563920 Danio rerio
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