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Deltex (show DTX1 Proteins) can act as a negative regulator of Notch (show NOTCH1 Proteins) signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch (show NOTCH1 Proteins) signals during thymocyte development
DTX2 is a gene encoding a WWE-RING-finger protein (show TRIM31 Proteins) and involved in regulating heart development and heart functions.
It is reported that BBAP (show DTX3L Proteins) and the human family of DTX (show DTX1 Proteins) proteins (DTX1 (show DTX1 Proteins), DTX2, and DTX3 (show DTX3 Proteins)) function as E3 ligases based on their capacity for self-ubiquitination.
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003
, deltex homolog 2 (Drosophila)
, deltex 2
, protein deltex-2-like
, probable E3 ubiquitin-protein ligase DTX2
, ring finger protein 58
, zinc ion binding protein
, deltex 2 homolog