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Human JAG1 Protein expressed in Human Cells - ABIN2004473
Li, Milner, Deng, Iwata, Banta, Graf, Marcovina, Friedman, Trask, Hood, Torok-Storb: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. in Immunity 1998
Show all 4 references for ABIN2004473
AGS is caused by mutations in one of two genes, namely, JAG1 or NOTCH2 (show NOTCH2 Proteins). These genes are part of the Notch (show NOTCH1 Proteins) signaling pathway, which is involved in cell fate determination. JAG1 mutations have been identified in 70-94% of individuals with clinically diagnosed AGS
On complete gene sequencing of JAG1 gene as described before, the patient was shown to be heterozygous for a known pathogenic mutationc.270delG (p.C92AfsX69) in exon 2
JAG1 protein expression was significant positive correlation with lymph node metastasis, pathological grades invasive ductal carcinoma of breast.JAG1 gene methylation level in breast cancer.
these findings demonstrate that 50 microM EGCG protects against ox-LDL-induced endothelial dysfunction through the Jagged-1/Notch (show NOTCH1 Proteins) signaling pathway.
PKCalpha (show PKCa Proteins) Attenuates Jagged-1-Mediated Notch (show NOTCH1 Proteins) Signaling in ErbB-2 (show ERBB2 Proteins)-Positive Breast Cancer to Reverse Trastuzumab Resistance
Immunohistochemical panel of CDX2, p120ctn, c-Myc, and Jagged1 proteins would be to distinguish between low/high grade dysplasia in histologically challenging cases of Barrett's esophagus.
High Jagged1 expression is associated with colorectal cancer.
High Jagged1 expression is associated with Prostatic Intraepithelial Neoplasia.
findings provide evidence for a novel cell-autonomous pro-inflammatory Jagged1-Notch1 (show NOTCH1 Proteins) pathway in endothelial cells
DLL4 (show DLL4 Proteins) and JAG1 may have opposing effects on tumor angiogenesis in glioblastoma.
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 Proteins) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
Jag1-induced Notch (show NOTCH1 Proteins) activity and the subsequent (or concomitant) downregulation of the Dll4 (show DLL4 Proteins)-mediated signalling are both required for generating haematopoietic stem cells in the embryo.
miR (show MLXIP Proteins)-34c overexpression inhibits the Notch (show NOTCH1 Proteins) signaling pathway by targeting Notch1 (show NOTCH1 Proteins) and Jaggged1 in high glucose-treated podocytes.
miR-199b targeted the Notch ligand JAG1, resulting in vascular endothelial growth factor (VEGF) transcriptional activation and secretion through the transcription factor STAT3.
study reports mesenchymal stromal cell-mediated immune modulation involves education and expansion of regulatory immune cells in a Jagged-1 dependent manner and reports the importance of Jagged-1 signalling in MSC (show MSC Proteins) protection against inflammation in vivo.
Dll1 (show DLL1 Proteins) and Jag1, Notch (show NOTCH1 Proteins) ligands, function redundantly and are necessary to maintain the centroacinar cells as an environmental niche in the developing pancreas.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1