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Data indicate that jagged 1 protein (JAG1)-mediated Notch (show NOTCH1 Proteins) signaling regulates differentiation of basal cells (BC) into secretory cells.
these results show that the Notch (show NOTCH1 Proteins) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 (show JAG2 Proteins) on DCs is not required
Bruceine D inhibits hepatocellular carcinoma growth by targeting beta-catenin/jagged1 signaling pathways.
Results showed that JAG1 was significantly downregulated in miR (show MLXIP Proteins)-26a-overexpressing osteosarcoma cells and is a direct target of miR (show MLXIP Proteins)-26a.
the effects of two Notch (show NOTCH1 Proteins) ligands, i.e., Jagged1 and DLL1 (show DLL1 Proteins), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 Proteins) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Specific Notch3 (show NOTCH3 Proteins) and Jag1 subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 targeting in triple-negative breast cancer patients.
there is a cross-talk between Jagged1/Notch3 (show NOTCH3 Proteins) and VEGF (show VEGFA Proteins) in TNBC angiogenesis. Jagged1/Notch3 (show NOTCH3 Proteins) is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
By studying leprosy as a model, we provide evidence that upregulation of JAG1 on endothelium instructs monocytes to differentiate into M1 macrophages with antimicrobial activity.
Epidermal stem cells accelerate diabetic wound healing via the Notch1 (show NOTCH1 Proteins) signaling pathway; Jag1 overexpression improves diabetic wound healing in vivo.
Notch (show NOTCH1 Proteins) signaling in ECs was induced by cocultures of ECs with tumor cells expressing the Notch (show NOTCH1 Proteins) ligands DLL4 (show DLL4 Proteins) and JAG1 in vitro, and NICD (show NOTCH1 Proteins) expression was induced in ECs by tumor-infiltrating myeloid cells in vivo
pre-coated Notch1 (show NOTCH1 Proteins) protein promotes Notch1 (show NOTCH1 Proteins)-knocked down B cells to produce antibody in LPS (show TLR4 Proteins)-stimulated B cells suggesting that Notch1 (show NOTCH1 Proteins) in other cells may promote antibody production by binding its ligands Dll1 (show DLL1 Proteins) and Jag1 in B cells.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (show HEY1 Proteins) signal might mediate the impairment of angiogenesis induced by Ang II (show AGT Proteins) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (show STAT3 Proteins) by physical binding, and nuclear STAT3 (show STAT3 Proteins) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (show GDF9 Proteins) and BMP15 (show BMP15 Proteins).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 Proteins) signalling regulates cardiac homeostasis in the postnatal heart.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1