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Human JAG1 Protein expressed in Human Cells - ABIN2004473
Li, Milner, Deng, Iwata, Banta, Graf, Marcovina, Friedman, Trask, Hood, Torok-Storb: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. in Immunity 1998
Show all 4 references for ABIN2004473
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
By studying leprosy as a model, we provide evidence that upregulation of JAG1 on endothelium instructs monocytes to differentiate into M1 macrophages with antimicrobial activity.
High Jag1 expression is associated with metastasis in colorectal cancer.
amplification of Jagged1 contributed to mRNA expression that activates the Jagged1-Notch (show NOTCH1 Proteins) signaling pathway in liver cancer and led to poor outcome.
Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.
Positive Jagged1 and DLL4 (show DLL4 Proteins) expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.
miR (show MLXIP Proteins)-199a-3p targets YAP1 (show YAP1 Proteins), downregulates Jagged1 and suppresses the Notch (show NOTCH1 Proteins) signaling to inhibit hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation and promote apoptosis. These findings provide new insights into the mechanism by which miR (show MLXIP Proteins)-199a-3p suppresses HCC (show FAM126A Proteins) cell proliferation and induces apoptosis.
Jagged1 activation of Notch3 (show NOTCH3 Proteins) resulted in a significant decrease in cell proliferation while concomitantly promoting Hemangioma-pericyte maturation.
expression of JAG1 is regulated by various pathways and is associated with poor prognosis through promoting the epithelial to mesenchymal transition and cell proliferation or maintaining cell survival in colorectal cancer
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (show HEY1 Proteins) signal might mediate the impairment of angiogenesis induced by Ang II (show AGT Proteins) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (show STAT3 Proteins) by physical binding, and nuclear STAT3 (show STAT3 Proteins) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (show GDF9 Proteins) and BMP15 (show BMP15 Proteins).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 Proteins) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
Jag1-induced Notch (show NOTCH1 Proteins) activity and the subsequent (or concomitant) downregulation of the Dll4 (show DLL4 Proteins)-mediated signalling are both required for generating haematopoietic stem cells in the embryo.
miR (show MLXIP Proteins)-34c overexpression inhibits the Notch (show NOTCH1 Proteins) signaling pathway by targeting Notch1 (show NOTCH1 Proteins) and Jaggged1 in high glucose-treated podocytes.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1