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Human JAG1 Protein expressed in Human Cells - ABIN2004473
Li, Milner, Deng, Iwata, Banta, Graf, Marcovina, Friedman, Trask, Hood, Torok-Storb: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. in Immunity 1998
Show all 4 references for ABIN2004473
DLL4 (show DLL4 Proteins) and JAG1 may have opposing effects on tumor angiogenesis in glioblastoma.
Expression of Jag-1 in dermal microvessels was enhanced from 20 weeks of gestation to 85 years.
Alagille syndrome type 1 patients have an increased risk of nonautoimmune hypothyroidism, and that variations in JAG1 gene can contribute to the pathogenesis of variable congenital thyroid defects.
bone marrow stroma induces Jagged1 expression in bone metastatic prostate cancer PC3 (show PCSK1 Proteins) cells, and this enhanced expression is mechanistically linked to the promotion of cell migration
SCC (show CYP11A1 Proteins) patients with higher JAG1 transcription had poor overall survival.
Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4 (show NOTCH4 Proteins)-dependent cancer stem cell activity.
Data do not support association of biliary atresia with JAG1 mutations, at least in Czech patients. Rapid testing for JAG1 mutations could prevent misdiagnosis of Alagille syndrome in early infancy and improve their outcome.
Jag1 is upregulated preferentially in pulmonary capillary endothelial cells in individuals with interstitial pulmonary fibrosis compared to normal lung.
Jagged1 expression was correlated with higher tumor grade and invasion of breast carcinomas.
Case Report: JAGGED1 gene variations in Chinese twin sisters with Alagille syndrome.
Jagged1 intracellular domain-mediated inhibition of Notch1 (show NOTCH1 Proteins) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
Jag1-induced Notch (show NOTCH1 Proteins) activity and the subsequent (or concomitant) downregulation of the Dll4 (show DLL4 Proteins)-mediated signalling are both required for generating haematopoietic stem cells in the embryo.
miR (show MLXIP Proteins)-34c overexpression inhibits the Notch (show NOTCH1 Proteins) signaling pathway by targeting Notch1 (show NOTCH1 Proteins) and Jaggged1 in high glucose-treated podocytes.
miR-199b targeted the Notch ligand JAG1, resulting in vascular endothelial growth factor (VEGF) transcriptional activation and secretion through the transcription factor STAT3.
study reports mesenchymal stromal cell-mediated immune modulation involves education and expansion of regulatory immune cells in a Jagged-1 dependent manner and reports the importance of Jagged-1 signalling in MSC (show MSC Proteins) protection against inflammation in vivo.
Dll1 (show DLL1 Proteins) and Jag1, Notch (show NOTCH1 Proteins) ligands, function redundantly and are necessary to maintain the centroacinar cells as an environmental niche in the developing pancreas.
Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1