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anti-Human Notch1 Antibodies:
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Human Monoclonal Notch1 Primary Antibody for ICS, IHC - ABIN967360
Anderson, Robey, Huang: Notch signaling in lymphocyte development. in Current opinion in genetics & development 2001
Show all 8 Pubmed References
Human Polyclonal Notch1 Primary Antibody for DB, ELISA - ABIN152590
Bertrand, Eckfeldt, Lysholm, LeBien: Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. in Leukemia 2001
Show all 10 Pubmed References
Human Monoclonal Notch1 Primary Antibody for FACS, ICC - ABIN807924
Kefas, Comeau, Floyd, Seleverstov, Godlewski, Schmittgen, Jiang, diPierro, Li, Chiocca, Lee, Fine, Abounader, Lawler, Purow: The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 6 Pubmed References
Human Polyclonal Notch1 Primary Antibody for IHC - ABIN966679
Ellisen, Bird, West, Soreng, Reynolds, Smith, Sklar: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. in Cell 1991
Show all 7 Pubmed References
Human Polyclonal Notch1 Primary Antibody for IHC - ABIN966681
Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: Human ligands of the Notch receptor. in The American journal of pathology 1999
Show all 7 Pubmed References
Human Polyclonal Notch1 Primary Antibody for IHC - ABIN966680
Wu, Sun, Kobayashi, Gao, Griffin: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. in Molecular and cellular biology 2002
Show all 7 Pubmed References
Human Monoclonal Notch1 Primary Antibody for IHC (f), ICC - ABIN2749161
Tagami, Okochi, Yanagida, Ikuta, Fukumori, Matsumoto, Ishizuka-Katsura, Nakayama, Itoh, Jiang, Nishitomi, Kamino, Morihara, Hashimoto, Tanaka, Kudo, Chiba, Takeda: Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. in Molecular and cellular biology 2007
Show all 6 Pubmed References
Human Monoclonal Notch1 Primary Antibody for CyTOF, FACS - ABIN256488
Ray, Yao, Nowotny, Mumm, Zhang, Wu, Kopan, Goate: Evidence for a physical interaction between presenilin and Notch. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 5 Pubmed References
Human Monoclonal Notch1 Primary Antibody for FACS, ICC - ABIN807923
Espinosa, Santos, Inglés-Esteve, Muñoz-Canoves, Bigas: p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. in Journal of cell science 2002
Show all 7 Pubmed References
Human Monoclonal Notch1 Primary Antibody for ICC, IF - ABIN4340379
Groeneweg, Hall, Zhang, Kim, Byron, Tambouret, Sathayanrayanan, Foster, Rueda, Growdon: Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model. in Gynecologic oncology 2014
Show all 3 Pubmed References
NOTCH1 inhibits activation of ATM (show ATM Antibodies) by impairing the formation of an ATM (show ATM Antibodies)-FOXO3a (show FOXO3 Antibodies)-KAT5 (show KAT5 Antibodies) complex.
Data demonstrate the possible involvement of Notch1 signaling in the pathogenesis and development of endometriosis, via regulating proliferation and migration of endometrial epithelial and stromal stem cells.
Studies suggest that embryonic signaling pathways, the likes of Notch, Wnt (show WNT2 Antibodies), and Hedgehog (show SHH Antibodies) and tumor marker Oct-4 (show POU5F1 Antibodies) offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth.
Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer.
RBPJ (show RBPJ Antibodies) interacts with L3MBTL3 (show L3MBTL3 Antibodies) to promote repression of Notch signaling via histone demethylase (show MBD2 Antibodies) KDM1A (show KDM1A Antibodies).
Notch1/Snail1 (show SNAI1 Antibodies)/E-cadherin (show CDH1 Antibodies) pathway facilitates the EMT (show ITK Antibodies) through HIF-1alpha (show HIF1A Antibodies) in SRA01/04 cells during hypoxia and promotes LEC motility.
Data suggest that activation of Notch1 signaling inhibits apoptosis of dental follicle stem cells via both canonical mitochondrial pathway and non-canonical Akt (show AKT1 Antibodies) signaling pathway (which is dependent on intracellular domain of Notch1), together with regulation of nuclear gene expression (repression of p53 (show TP53 Antibodies) gene expression).
Data indicate that jagged 1 (show JAG1 Antibodies) protein (JAG1 (show JAG1 Antibodies))-mediated Notch signaling regulates differentiation of basal cells (BC) into secretory cells.
Results indicate that Notch1 is significantly displaced and accumulated in fibrillary structures in the susceptible hippocampal and cortical regions of sporadic Alzheimer's disease (AD) patients. The dominant deposition of Notch1 in the brain parenchyma and its general signal reduction in neurons is consistent in all the AD patients analyzed and suggests that Notch1 may potentially be considered a novel hallmark of AD.
Diffuse NICD1 positivity in adenoid cystic carcinomas correlates with solid growth pattern, the presence of NOTCH1 gain-of-function mutations, and unfavorable outcome.
Induction of autophagy required ligand-dependent, Notch intracellular domain (NIC (show NCSTN Antibodies)) activity, which controlled mitochondrial organization and survival of activated Tregs.
Our data demonstrate the role of endothelial Notch1 in the proper development of the semilunar valves and cardiac outflow tract.
BLOS2 (show BLOC1S2 Antibodies) physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 (show BLOC1S2 Antibodies) is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.
pre-coated Notch1 protein promotes Notch1-knocked down B cells to produce antibody in LPS (show TLR4 Antibodies)-stimulated B cells suggesting that Notch1 in other cells may promote antibody production by binding its ligands Dll1 (show DLL1 Antibodies) and Jag1 (show JAG1 Antibodies) in B cells.
behavioral and functional studies demonstrated that POMC (show POMC Antibodies)-Notch1(-/-) mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Notch1 haploinsufficiency decreased the expression of Ctgf (show CTGF Antibodies) in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 intracellular domain (NICD) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1, not Notch3 (show NOTCH3 Antibodies), directly modulates the expression of CTGF (show CTGF Antibodies)
Notch signaling has roles in distinct aspects of prostate cancer biology, promoting metastasis in a prostate-specific Pten (show PTEN Antibodies)-null mouse model
Dll4 (show DLL4 Antibodies)-Notch1 signalling couples sprouting angiogenesis and artery formation.
Notch initially destabilises beta-catenin (show CTNNB1 Antibodies) in a process that does not depend on its phosphorylation by GSK3 (show GSK3b Antibodies)
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Antibodies) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Antibodies) gene or the constitutively active form of Notch (IC).
ZFP423 (show 104125 Antibodies) coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Antibodies) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Antibodies)) pathway has a significant role in the PGC (show PGC Antibodies) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (show BCL6 Antibodies) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Antibodies)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin (show Actbeta Antibodies)-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (show SMAD2 Antibodies) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Antibodies) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Antibodies), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog