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A functional polymorphism in the premiR146a gene influences the prognosis of glioblastoma multiforme by interfering with the balance between Notch1 (show NOTCH1 ELISA Kits) and Notch2
Results suggest that Notch2 pathway and miR (show MLXIP ELISA Kits)-23b interplay in a reciprocal regulation loop in gastric cancer cells and this axis plays an important role in gastric carcinogenesis.
These findings suggested that the NOTCH2 signaling may confer aggressive behavior and immature morphology in human hepatocellular carcinoma cells.
Notch (show NOTCH1 ELISA Kits) signaling sustains chronic lymphocytic leukemia cell survival by promoting Mcl-1 (show MCL1 ELISA Kits) expression and eIF4E (show EIF4E ELISA Kits) activity, and given the oncogenic role of these factors, underscores the therapeutic potential of Notch (show NOTCH1 ELISA Kits) inhibition in chronic lymphocytic leukemia.
High Notch2 expression is associated with chronic myeloid leukemia (show BCL11A ELISA Kits).
miR (show MLXIP ELISA Kits)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9 (show CDK9 ELISA Kits), NOTCH2, and RPS6KA3 (show RPS6KA3 ELISA Kits).
C8orf4 negatively regulates the self-renewal of liver CSCs via suppression of NOTCH2 signalling
NOTCH2 inhibition triggers the Epstein-Barr virus lytic cycle and cell apoptosis; and NOTCH2 inhibition may represent an appealing therapeutic strategy against Epstein-Barr virus-associated malignancies.
Notch2 controls prolactin (show PRL ELISA Kits) and insulin-like growth factor binding protein-1 (show IGFBPI ELISA Kits) expression in decidualizing human stromal cells of early pregnancy.
Expression of Notch1 (show NOTCH1 ELISA Kits), -2, and -3, CDK2 (show CDK2 ELISA Kits), and CCNE1 (show CCNE1 ELISA Kits) was significantly decreased by upregulation of ALDH1A1 (show ALDH1A1 ELISA Kits) in A549 cells, but increased by its interruption in A549s cells.
In this study, authors use a smooth muscle-specific (show EIF3K ELISA Kits) deletion of Notch2 together with a global Notch3 (show NOTCH3 ELISA Kits) deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells
6955C-->T mutation in the Notch2 locus leading to cancellous and cortical bone osteopenia.
Data (including data from studies in transgenic/knockout mice) suggest deletion of Notch1 (show NOTCH1 ELISA Kits) in podocytes prevents diabetic nephropathy development and up-regulates Notch2 expression; overexpression of Notch2 does not promote diabetic nephropathy.
Expression of Notch1 and Notch2 was decreased in regenerated epidermis of wounds, where features of keratinocytes were altered. Notch1 and Notch2 down-regulation contributed to the induction of interleukin-36alpha expression.
data indicate distinct effects of Notch (show NOTCH1 ELISA Kits) signaling on invariant natural killer T cells in the thymus and liver, which are at least partly independent of RBP-j (show RBPJ ELISA Kits) in the thymus.
Notch1 (show NOTCH1 ELISA Kits) and Notch2 intracellular domains are functionally equivalent during development and carcinogenesis
NOTCH2 inhibits PDGF-B (show PDGFB ELISA Kits)-dependent proliferation and its expression is decreased by PDGF-B (show PDGFB ELISA Kits).
BTK (show BTK ELISA Kits) synergizes with Notch2 to govern marginal zone B cells in non-obese diabetic mice.
Surface expression of NOTCH2 was seen in specified E11 (show PDPN ELISA Kits) AGM (show IGFBP7 ELISA Kits) (CD45 (show PTPRC ELISA Kits)+VE-cadherin (show CDH5 ELISA Kits)+) hematopoietic progenitors. NOTCH (show NOTCH1 ELISA Kits) activation by Delta1 can increase long-term engrafting HSC (show FUT1 ELISA Kits) numbers from these cells.
Notch1 (show NOTCH1 ELISA Kits) is the primary receptor regulating intestinal stem cell function and Notch1 (show NOTCH1 ELISA Kits) and Notch2 together regulate epithelial cell proliferation, cell fate determination, and post-injury regeneration
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (show NOTCH1 ELISA Kits) and Notch3 (show NOTCH3 ELISA Kits), suggesting that ORF2 interfered with the trans-activation potential of Notch (show NOTCH1 ELISA Kits).
DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
, neurogenic locus notch homolog protein 2-like
, Notch homolog 2
, neurogenic locus notch homolog protein 2
, Motch B
, Notch gene homolog 2
, notch gene homolog 2
, notch receptor protein 6